Selective elimination of human lymphoid cells with unstable chromosome aberrations by p53-dependent apoptosis

Carcinogenesis

Volumn 18, Issue 1, 1997, Pages 201-205

  Schwartz, Jeffrey L ^a   Jordan, Robert ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN P53;

APOPTOSIS; ARTICLE; B LYMPHOBLAST; CELL CYCLE; CHROMOSOME ABERRATION; DICENTRIC CHROMOSOME; HUMAN; HUMAN CELL; LYMPHOID CELL; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; X RAY;

APOPTOSIS; CELL LINE; CHROMOSOME ABERRATIONS; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE;

EID: 0031409634     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.1.201     Document Type: Article

References (47)

1. DiLeonardo,A. Linke,S.P., Clarkin,K. and Wahl,G.M. (1994) DNA damage triggers a prolonged p53-dependent G l arrest and long-term induction of Cip 1 in normal human fibroblasts. Genes Develop., 8, 2540-2551.
2. Kuerbitz,S.J., Plunkett,B.S., Walsh,W.V. and Kastan,M.B. (1992) Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl Acad. Sci. USA, 89, 7491-7495.
3. Yount,G.L., Haas-Kigan,D.A., Vidair,C.A., Haas,M., Dewey,W.C. and Israel,M.A. (1996) Cell cycle synchrony unmasks the influence of p53 function on radiosensitivity of human glioblastoma cells. Cancer Res., 56, 500-506.
4. Clarke,A.R., Purdie,C.A., Harrison,D.J., Morris,R.G., Bird,C.C., Hooper,M.L. and Wyllie,A.H. (1993) Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature, 362, 849-852.
5. Donehower,L.A. and Bradley,A. (1993) The tumor suppressor p53. Biochim. Biophys. Acta, 1151, 181-205.
6. Lowe,S.W., Schmitt,E.M., Smith,S.W., Osborne,B.A. and Jacks,T (1993) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature, 362, 847-849.
7. Radford,I.R. (1994) Radiation response of mouse lymphoid and myeloid cell lines. Part I. Sensitivity to killing by ionizing radiation, rate of loss of viability, and cell type of origin. Int. J. Radiat. Biol., 65, 203-215.
8. McIlwrath,A.J., Vasey,P.A., Ross,G.M. and Brown,R. (1994) Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity. Cancer Res., 54, 3718-3722.
9. O'Connor,P.M., Jackman,J., Jondle,D., Bhatia,K., Magrath,I. and Kohn,K.W. (1993) Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines. Cancer Res., 53, 4776-4780.
10. Livingstone,L.R., White,A., Sprouse,J., Livanos,E., Jacks,T. and Tlsty,T.D. (1992) Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell, 70, 923-935.
11. Yin,Y., Tainsky,M.A., Bischoff,F.Z., Strong,L.C. and Wahl,G.M. (1992) Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell, 70, 937-948.
12. Amundson,S.A., Xia,F., Wolfson,K. and Liber,H.L. (1993) Different cytotoxic and mutagenic responses induced by X-rays in two human lymphoblastoid cell lines derived from a single donor. Mutat. Res., 286, 233-241.
13. 1 arrest in two closely related human lymphoblast cell lines that differ in p53 status. J. Biol Chem., 270, 11033-11036.
14. Zhen,W., Denault,C.M., Loviscek,K., Walter,S., Geng,L. and Vaughan,A.T.M. (1995) The relative radiosensitivity of TK6 and WI-L2-NS lymphoblastoid cells derived from a common source is primarily determined by their p53 mutational status. Mutat. Res., 346, 85-92.
15. Xia,F., Wang,X., Wang,Y-H., Tsang,N-M., Yandell,D.W., Kelsey,K.T. and Liber, H.L. (1995) Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines. Cancer Res., 55, 12-15.
16. Schwartz,J.L., Jordan,R., Sedita,B.A., Swenningson,M.J., Banáth,J.P. and Olive,P.L. (1995) Different sensitivity to cell killing and chromosome mutation induction by gamma rays in two human lymphoblastoid cell lines derived from a single donor: Possible role of apoplosis. Mutagenesis, 10, 227-233.
17. Gorczyca,W. (1993) Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res., 53, 1-7.
18. Jordan,R. and Schwartz,J.L. (1994) Noninvolvement of the X chromosome in radiation-induced chromosome translocations in the human lymphoblastoid cell line TK6. Radiat. Res., 137, 290-294.
19. Schwartz,J.L., Banda,M.J. and Wolff,S. (1982) 12-O-Tetradecanoylphorbol-13-acetate (TPA) induces sister chromatid exchanges and delays in cell progression in Chinese hamster ovary cells and in human cell lines. Mutat. Res., 92, 393-409.
20. Savage,J.R.K. (1975) Classification and relationships of induced chromosomal structural changes. J. Med. Genet., 12, 103-122.
21. Lucas,J., Awa,A., Straume,T., Poggensee,M., Kodama,Y., Nakano,M., Ohtaki,K., Weier,H.-U., Pinkel,D., Gray,J. and Littlefield,G. (1992) Rapid translocation frequency analysis in humans decades after exposure to ionizing radiation. Int. J. Radiat. Biol., 62, 53-63.
22. Mayall,B.H., Carrano,A.V., Moore II,D.H., Ashworth,L.K., Bennet,D.E. and Mendelsohn,M.L. (1984) The DNA-based human karyotype. Cytometry, 5, 376-385.
23. Warters,R. (1992) Radiation-induced apoptosis in a murine T-cell hybridoma. Cancer Res., 52, 883-890.
24. Stewart,B.W. (1994) Mechanisms of apoptosis: Integration of genetic, biochemical, and cellular indicators. J. Natl Cancer Inst., 86, 1286-1295.
25. Barr,P.J. and Tomei,L.D. (1994) Apoptosis and its role in human disease. Bio/Technology, 12, 487-493.
26. Potten,C.S., Merritt,A., Hickman,J., Hall,P. and Faranda,A. (1994) Characterization of radiation-induced apoptosis in the small intestine and its biological implications. Int. J. Radiat. Biol., 65, 71-78.
27. Natarajan,A.T, Vyas,R.C., Darroudi,F and Vermeulen,S. (1992) Frequencies of X-ray-induced chromosome translocations in human peripheral lymphocytes as detected by in situ hybridization using chromosome-specific DNA libraries. Int. J. Radiat. Biol., 61, 199-203.
28. Schmid,E., Zitzelsberger,H., Braselmann,H., Gray,J.W. and Bauchinger,M. (1992) Radiation-induced chromosome aberrations analyzed by fluorescence in situ hybridization with a triple combination of composite whole chromosome-specific DNA probes. Int. J. Radiat. Biol., 62, 673-678.
29. Tucker,J.D., Ramsey,M.J., Lee,D.A. and Minkler,J.L. (1993) Validation of chromosome painting as a biodosimeter in human peripheral lymphocytes following acute exposure to ionizing radiation in vitro. Int. J. Radiat. Biol., 64, 27-37.
30. Tucker,J.D., Lee,D.A. and Moore II,D.H. (1995) Validation of chromosome painting. II. A detailed analysis of aberrations following high doses of ionizing radiation in vitro. Int. J. Radiat. Biol., 67, 19-28.
31. Straume,T. and Lucas,J.N. (1993) A comparison of the yields of translocations and dicentrics measured using fluorescence in situ hybridization. Int. J. Radiat. Biol., 64, 185-187.
32. Bauchinger,M., Schmid,E., Zitzelsberger,H., Braselmann,H. and Nahrstedt,U. (1993) Radiation-induced chromosome aberrations analyzed by two-color fluorescence in situ hybridization with composite whole chromosome-specific DNA probes and a pancentromeric DNA probe. Int. J. Radiat. Biol., 64, 179-184.
33. Bahari,I.B., Bedford,J.S., Giaccia,A.J. and Stamato,T.D. (1990) Measurement of the relative proportion of symmetrical and asymmetrical chromosome-type interchanges induced by γ radiation in human-hamster hybrid cells. Radiat. Res., 123, 105-107.
34. Natarajan,A.T., Balajee,A.S., Boei,J.J.W.A., Chatterjee,S., Darroudi,F., Grigorova,M., Noditi,M., Oh,H.J., Slijepcevic,P. and Vermeulen,S. (1994) Recent developments in the assessment of chromosomal damage. Int. J. Radiat. Biol., 66, 615-623.
35. Langley,R.E., Palayoor,S.T, Coleman,C.N. and Bump,E.A. (1993) Modifiers of radiation-induced apoptosis. Radiat. Res., 136, 320-326.
36. Radford,I.R. (1994) p53 status, DNA double-strand break repair proficiency, and radiation response of mouse lymphoid and myeloid cell lines. Int. J. Radiat. Res., 66, 557-560.
37. Sherwood,S.W., Rush,D., Ellsworth,J.L. and Schimke,R.T. (1988) Defining cellular senescence in IMR-90 cells: a flow cytometric analysis. Proc. Natl Acad. Sci. USA, 85, 9086-9090.
38. Thompson,K.V.A. and Holliday,R. (1975) Chromosome changes during the in vitro ageing of MRC-5 human fibroblasts. Exp. Cell Res., 96, 1-6.
39. Allsopp,R.C, Vaziri,H., Patterson,C., Goldstein,S., Younglai,E-V., Futcher,A.B., Greider,C.W. and Harley,C.B. (1992) Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl Acad. Sci. USA, 89, 10114-10118.
40. Wright,W.E., Pereira-Smith,O.M. and Shay,J.W. (1989) Reversible cellular senescence: Implications for immortalization of normal human diploid fibroblasts. Mol. Cell Biol., 9, 3088-3092.
41. Paules,R.S., Levedakou,E.N., Wilson,S.J., Innes,C., Rhodes,N., Tlsty.T.D., Galloway,D.A., Donehower,L.A., Tainsky,M.A. and Kaufmann,W.K. (1995) Defective G2 checkpoint function in cells from individuals with familial cancer syndromes. Cancer Res., 55, 1763-1773.
42. White,A.E., Livanos,E.M. and Tlsty,T.D. (1994) Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins. Genes Develop., 8, 666-677.
43. Kovacs,M.S., Evans J.W., Johnstone,I.M. and Brown,J.M. (1994) Radiation-induced damage, repair and exchange formation in different chromosomes of human fibroblasts determined by fluorescence in situ hybridization. Radiat. Res., 137, 34-43.
44. Fukasawa,K., Choi,T., Kuriyama,R., Rulong,S. and Vande Woude,G.F. (1996) Abnormal centrosome amplification in the absence of p53. Science, 271, 1744-1747.
45. Cross,S.M., Sanchez,C.A., Morgan,C.A., Schimke,M.K., Ramel,S., Idzerda,R.L., Raskind,W.H. and Reid,B.J. (1995) A p53-dependent mouse spindle checkpoint. Science, 267, 1353-1356.
46. Nelson,W.G. and Kastan,M.B. (1994) DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol. Cell Biol., 14, 1815-1823.
47. Marder,B.A. and Morgan,W.F. (1993) Delayed chromosomal instability induced by DNA damage. Mol. Cell Biol., 13, 6667-6677.