In vitro micronucleus assay with Chinese hamster V79 cells - Results of a collaborative study with in situ exposure to 26 chemical substances

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 468, Issue 2, 2000, Pages 137-163

  Von Der Hude, Wilhelm ^a   Kalweit, Sabine ^a   Engelhardt, Günter ^b   McKiernan, Sinead ^b   Kasper, Peter ^c   Slacik Erben, Renate ^d   Miltenburger, Herbert G ^e   Honarvar, Naveed ^e   Fahrig, Rudolf ^f   Görlitz, Bernd ^f   Albertini, Silvio ^g   Kirchner, Stephan ^g   Utesch, Dietmar ^h   Pötter Locher, Franziska ⁱ   Stopper, Helga ^j   Madle, Stephan ^a  

^a Fed Inst Hlth Protect C   (Germany)

^b BASF SE   (Germany)

^c Fed Inst Drugs and Med Devices   (Germany)

^d ALTANA PHARMA AG   (Germany)

^e CCR Cytotest Cell Research   (Germany)

^f FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^g F HOFFMANN LA ROCHE LTD   (Switzerland)

^h MERCK KGAA   (Germany)

ⁱ NOVARTIS PHARMA AG   (Switzerland)

^j UNIVERSITY OF WÜRZBURG   (Germany)

more..

Author keywords

Collaborative study; In vitro micronucleus test; V79 cells

Indexed keywords

BENZENE; BENZYL ACETATE; BLEOMYCIN SULFATE; CADMIUM SULFATE; CARBENDAZIM; CHEMICAL AGENT; CYTARABINE; DACTINOMYCIN; DEMECOLCINE; DIAZEPAM; DIETHYLSTILBESTROL; DIMETHYLBENZ[A]ANTHRACENE; DRUG; FLUOROURACIL; GRISEOFULVIN; HYDROQUINONE; MESYLIC ACID ETHYL ESTER; METHOTREXATE; METHYLUREA; MITOMYCIN C; N (2 FLUORENYL)ACETAMIDE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PYRENE; RETINOL; RETINOL ACETATE; TIABENDAZOLE; TOLUENE; TRICHLOROETHYLENE; URETHAN; VINBLASTINE;

ANIMAL CELL; ARTICLE; CELL STRAIN V 79; CHROMOSOME ABERRATION; CONTROLLED STUDY; CYTOTOXICITY; GENOTOXICITY; HAMSTER; MICRONUCLEUS TEST; MUTAGEN TESTING; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; LUNG; MICRONUCLEUS TESTS; MITOTIC INDEX; MUTAGENICITY TESTS; MUTAGENS; REPRODUCIBILITY OF RESULTS;

EID: 0034632256     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(00)00045-0     Document Type: Article

References (39)

1. Kirsch-Volders M., Sofuni T., Aardema M., Albertini S., Eastmond D., Fenech M., Ishidate M. Jr., Lorge E., Norppa H., Surrallés J., von der Hude W., Wakata A. Report from the in vitro micronucleus assay working group. Environ. Mol. Mutagen. 2000;. in press.
2. Fenech M. The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat. Res. 285:1993;35-44.
3. Kalweit S., Utesch D., von der Hude W., Madle S. Chemically induced micronuclei formation in V79 cells - comparison of three different test approaches. Mutat. Res. 439:1999;183-190.
4. Matsuoka, Yamazaki N., Suzuki T., Hayashi M., Sofuni T. Evaluation of the micronucleus test using a Chinese hamster cell line as an alternative to the conventional in vitro chromosomal aberration test. Mutat. Res. 272:1993;223-236.
5. Countryman P.I., Heddle J.A. The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes. Mutat. Res. 41:1976;321-332.
6. Han C., Wu G., Yin Y., Shen M. Inhibition by germanium oxide of the mutagenicity of cadmium chloride in various genotoxicity assays. Food Chem. Toxicol. 30:1992;521-524.
7. Bean C.L., Armstrong M.J., Galloway S.M. Effect of sampling time on chromosome aberration yield for 7 chemicals in Chinese hamster ovary cells. Mutat. Res. 292:1992;31-44.
8. Matsushima T., Hayashi M., Matsuoka A., Ishidate M. Jr., Miura K.F., Shimizu H., Suzuki Y., Morimoto K., Ogura H., Mure K., Koshi K., Sofuni T. Validation study of the in vitro micronucleus test in a Chinese hamster lung cell line (CHL/IU). Mutagenesis. 14:1999;569-580.
9. Maier P., Schmid W. Ten model mutagens evaluated by the micronucleus test. Mutat. Res. 40:1976;325-338.
10. Sato S., Kitajima H., Konishi S., Takizawa H., Inui N. Mouse strain differences in the induction of micronuclei by polycyclic aromatic hydrocarbons. Mutat. Res. 192:1987;185-192.
11. Ishidate M., Harnois M.C., Sofuni T. A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat. Res. 195:1988;151-213.
12. Stopper H., Kühnel A., Podschun B. Combination of the chemotherapheutic agent 5-Fluorouracil with an inhibitor of its catabolism results in increased micronucleus induction. Biochem. Biophys. Res. Commun. 2:1994;1124-1130.
13. Jagetia G.C., Aruna R. Hydroquinone increases the frequency of micronuclei in a dose-dependent manner in mouse bone marrow. Toxicol. Lett. 93:1997;205-213.
14. Grawe J., Nuesse M., Adler I.D. Quantitative and qualitative studies of micronuclei induction in mouse erythrocytes using flow cytometry: I. Measurement of micronucleus induction in peripheral blood polychromatic erythrocytes by chemicals with known and suspected genotoxicity. Mutagenesis. 12:1997;1-8.
15. Galloway S.M., Armstrong M.J., Reuben C., Colman, Brown B., Cannon C., Bloom A.D., Nakamura F., Ahmed M., Duk S., Rimpo J., Margolin B.H., Resnick M.A., Anderson B. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ. Mol. Mutagen. 10(Suppl. 10):1987;1-175.
16. Vian L., Van Hummelen P., Bichet N., Gouy D., Kirsch-Volders M. Evaluation of hydroquinone and chloral hydrate on the in vitro micronucleus test on isolated lymphocytes. Mutat. Res. 334:1995;1-7.
17. Ellard S., Parry E.M. Induction of micronuclei in V79 Chinese hamster cells by hydroquinone and econazole nitrate. Mutat. Res. 287:1993;87-91.
18. Busk L., Sjoestroem B., Ahlborg U.G. Effects of vitamin A on cyclophosphamide mutagenicity in vitro (Ames test) and in vivo (mouse micronucleus test). Food Chem. Toxicol. 22:1984;725-730.
19. Hite M., Pecharo M., Smith I., Thorton S. The effect of benzene in the micronucleus test. Mutat. Res. 77:1980;149-155.
20. Gulati D.K., Witt K., Anderson B., Zeiger E., Shelby M.D. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro III: Results with 27 chemicals. Environ. Mol. Mutagen. 13:1989;133-193.
21. Fritzenschaf H., Kohlpoth M., Rusche B., Schiffmann D. Testing of known carcinogens and non-carcinogens in the Syrian hamster embryo (SHE) micronucleus test in vitro; correlations with in vivo micronucleus formation and cell transformation. Mutat. Res. 319:1993;47-53.
22. Dean B.J. Recent findings on the genetic toxicology of benzene, toluene, xylenes and phenols. Mutat. Res. 154:1985;153-181.
23. Valentine J.L., Lee S.S., Seaton M.J., Asgharian B., Farris G., Corton J.C., Gonzalez F.J., Medinsky M.A. Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression. Toxicol. Appl. Pharmacol. 141:1996;205-213.
24. Burke D.A., Wedd D.J., Herriott D., Bayliss M.K., Spalding D.J., Wilcox P. Evaluation of pyrazole and ethanol induced S9 fraction in bacterial mutagenicity testing. Mutagenesis. 9:1994;23-29.
25. Westmoreland, Plumstead M., Gatehouse D. Activity of urethane in rat and mouse micronucleus test after oral administration. Mutat. Res. 262:1991;247-251.
26. Sofuni T., Honma M., Hayashi M., Shimada H., Tanaka N., Wakuri S., Awogi T., Yamamoto K.I., Nishi Y., Nakadate M. Detection of in vitro clastogens and spindle poisons by the mouse lymphoma assay using the microwell method: interim report of an international collaborative study. Mutagenesis. 11:1996;349-355.
27. Kasahara Y., Wakata A., Nakai Y., Yuno K., Miura D., Yagi K., Hirabayashi K., Makita T. The micronucleus test using peripheral blood reticulocytes from methotrexate-treated mice. Mutat. Res. 278:1992;145-151.
28. Yamamoto K.I. Induction of micronuclei with chemical mutagens. J. Takeda Res. Lab. 42:1983;253-283.
29. Mondello, Giorgi R., Nuzzo F. Chromosomal effects of methotrexate on cultured human lymphocytes. Mutat. Res. 139:1984;67-70.
30. Galloway S., Aardema M.J., Ishidate M., Ivett J.L., Kirkland D., Morita T., Mosesso M., Sofuni T. Report from working group on in vitro tests for chromosomal aberrations (Report of the International Workshop on Standardisation of Genotoxicity Test Procedures). Mutat. Res. 312:1994;241-261.
31. Kesheva, Kesheva N., Whong W.-Z., Nath J., Ong T. Inhibition of methotrexate-induced chromosomal damage by vanillin and chlorophyllin in V79 cells. Teratog., Carcinog., Mutagen. 17:1997/1998;313-326.
32. Kesheva C., Kesheva N., Whong W.-Z., Nath J., Ong T. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat. Res. 397:1998;221-228.
33. Miller B., Pötter-Locher F., Seelbach A., Stopper H., Utesch D., Madle S. Evaluation of the in vitro micronucleus test as an alternative to the in vitro chromosomal aberration assay: position of the GUM working group on the in vitro micronucleus test. Mutat. Res. 410:1998;81-116.
34. Miller B., Albertini S., Locher F., Thybaud V., Lorge E. Comparative evaluation of the in vitro micronucleus test and the in vitro chromosome aberration test: industrial experience. Mutat. Res. 392:1997;187-208.
35. Albertini S., Miller B., Chetelat A.A., Locher F. Detailed data on in vitro MNT and in vitro CA: industrial experience. Mutat. Res. 392:1997;187-208.
36. Doerr C.L., Harrington-Brock K., Moore M.M. Micronucleus, chromosome aberration, and small-colony TK mutant analysis to quantitiate chromosomal damage in L5178Y mouse lymphoma cells. Mutation Res. 222:1989;191-203.
37. Anderson D., Basaran N., Blowers S.D., Edwards A.J. The effect of antioxidants on bleomycin treatment in in vitro and in vivo genotoxicity assays. Mutation Res. 329(1):1995;37-47.
38. Darroudi F., Natarajan A.T., Lohmann P.H.M. Cytogenetical characterisation of UV-sensitive repair-deficient CHO cell line 43-3B. II. Induction of cell killing, chromosomal aberrations and sister-chromatid exchanges by 4NQO, mono- and bi-functional alkylating agents. Mutation Res. 212:1989;103-112.
39. Armstrong M.J., Bean C.L., Galloway S.M. A quantitative assessment of cytotoxicity associated with chromosomal aberration detection in Chinese hamster ovary cells. Mutation Res. 265:1992;45-60.