Influence of modulated structural dynamics on the kinetics of α-chymotrypsin catalysis: Insights through chemical glycosylation, molecular dynamics and domain motion analysis

FEBS Journal

Volumn 273, Issue 23, 2006, Pages 5303-5319

  Solá, Ricardo J ^a   Griebenow, Kai ^a  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

Author keywords

chymotrypsin; Enzyme catalysis; Glycosylation; Molecular dynamics; Serine protease

Indexed keywords

ALANINE; AMINO ACID DERIVATIVE; ANILIDE; CHYMOTRYPSIN A; PHENYLALANINE; PROLINE;

ACYLATION; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CONJUGATION; CORRELATION ANALYSIS; DEACYLATION; GLYCOSYLATION; HYDROLYSIS; HYPOTHESIS; KINETICS; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOTION ANALYSIS SYSTEM; NORMAL DISTRIBUTION; PRIORITY JOURNAL; PROTEIN STRUCTURE; SIMULATION; STATISTICAL ANALYSIS; STATISTICAL MODEL; THEORETICAL STUDY;

CATALYSIS; CHYMOTRYPSIN; COMPUTER SIMULATION; GLYCOSYLATION; KINETICS; MODELS, MOLECULAR; NORMAL DISTRIBUTION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 33751084836     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2006.05524.x     Document Type: Article

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