Mechanistic origins of the substrate selectivity of serine proteases

Biochemistry

Volumn 42, Issue 11, 2003, Pages 3335-3348

  Case, April ^a   Stein, Ross L ^a  

^a The Harvard Center for Neurodegeneration & Repair   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE CHAINS;

CATALYST SELECTIVITY; CHEMICAL BONDS; CONFORMATIONS; HYDROLYSIS; RATE CONSTANTS; SUBSTRATES;

ENZYMES;

ANILIDE; CHYMOTRYPSIN A; ISOTOPE; N SUCCINYLALANYLALANYLPHENYLALANINE 4 NITROANILIDE; N SUCCINYLALANYLPHENYLALANINE 4 NITROANILIDE; N SUCCINYLPHENYLALANINE 4 NITROANILIDE; SERINE PROTEINASE; SOLVENT; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CATALYSIS; CATALYST; ENTHALPY; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; HYDROLYSIS; ISOMERISM; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; TEMPERATURE DEPENDENCE; THERMODYNAMICS;

CATALYSIS; CHYMOTRYPSIN; HYDROGEN-ION CONCENTRATION; ISOTOPES; KINETICS; SERINE ENDOPEPTIDASES; SOLVENTS; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 0037465824     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi020668l     Document Type: Article

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