Change in protein flexibility upon complex formation: Analysis of Ras-Raf using molecular dynamics and a molecular framework approach

Proteins: Structure, Function and Genetics

Volumn 56, Issue 2, 2004, Pages 322-337

  Gohlke, Holger ^a   Kuhn, Leslie A ^b   Case, David A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Michigan State University   (United States)

Author keywords

Allostery; Conformational change; Correlated motions; FIRST; Flexibility rigidity; Induced fit; Mobility dynamics; Protein protein interactions

Indexed keywords

RAF PROTEIN; RAS PROTEIN;

ARTICLE; BETA SHEET; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; COVALENT BOND; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

ALGORITHMS; ANIMALS; BINDING SITES; COMPUTER SIMULATION; HUMANS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOTION; PLIABILITY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-RAF; PROTO-ONCOGENE PROTEINS P21(RAS); RATS; SOFTWARE;

EID: 3042806330     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.20116     Document Type: Article

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