Expression of hypoxia-inducible factor 1α in human normal, benign, and malignant prostate tissue

Chinese Medical Journal

Volumn 116, Issue 12, 2003, Pages 1936-1939

  Du, Zhenxian ^a   Fujiyama, Chisato ^a   Chen, Yongxin ^a   Masaki, Zenjiro ^a  

^a SAGA UNIVERSITY   (Japan)

Author keywords

Benign prostatic hyperplasia; Hypoxia inducible factor 1; Prostate cancer

Indexed keywords

FORMALDEHYDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PARAFFIN;

ADULT; AGED; ARTICLE; BENIGN TUMOR; CANCER STAGING; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; PROSTATE ADENOCARCINOMA; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION; PROTEIN FUNCTION; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; TISSUE FIXATION;

AGED; AGED, 80 AND OVER; DNA-BINDING PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NUCLEAR PROTEINS; PROSTATE; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 0742271629     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Huang LE, Arany Z, Livingston DM, et al. Activation of hypoxia-inducible transcriptional factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 1996;271:32253-32259.
2. 2-dependent degradation domain via the ubiquitin proteasome pathway. Proc Natl Acad Sci U S A 1998;95:7987-7992.
3. Feldser D, Agani F, Iyer NV, et al. Reciprocal positive regulation of hypoxia-inducible factor 1 alpha and insulin-like growth factor 2. Cancer Res 1999;59:3915-3918.
4. Ravi R, Mookerjee B, Bhujwalla ZM, et al. Regulation of tumor angiogenesis by P53-induced degradation of hypoxia-inducible factor 1α. Genes Dev 2000;14:34-44.
5. Laughner E, Taghavi P, Chiles K, et al. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1 alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 2001;21:3995-4004.
6. Zhong H, De Marzo A, Laughner E, et al. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res 1999;59:5830-5835.
7. Talks K, Turley H, Gatter K, et al. The expression and distribution of the hypoxia inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. American J Patho 2000;157:411-421.
8. Birner P, Schindl M, Obermair A, et al. Overexpression of hypoxia-inducible factor 1 alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 2000;60:4693-4696.
9. Birner P, Gatterbauer B, Oberhuber G, et al. Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis. Cancer 2001; 92:165-171.
10. Aebersold DM, Burri P, Beer KT, et al. Expression of hypoxia-inducible factor-1 alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 2001;61:2911-2916.