Regulation of signal transduction through protein cysteine oxidation

Antioxidants and Redox Signaling

Volumn 8, Issue 9-10, 2006, Pages 1819-1827

  Cross, Janet V ^a   Templeton, Dennis J ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CYSTEINE; PHOSPHATASE; PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; THIOL GROUP; TRANSCRIPTION FACTOR;

CELL STIMULATION; ENZYME REGULATION; HUMAN; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN MODIFICATION; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION;

ANIMALS; CYSTEINE; HUMANS; MODELS, BIOLOGICAL; OXIDATION-REDUCTION; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 33750915802     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2006.8.1819     Document Type: Review

References (78)

1. Adachi T, Pimentel DR, Heibeck T, Hou X, Lee YJ, Jiang B, Ido Y, and Cohen RA. S-glutathiolation of Ras mediates redox-sensitive signaling by angiotensin II in vascular smooth muscle cells. J Biol Chem 279: 29857-2986, 2004.
2. Adler V, Yin Z, Fuchs SY, Benezra M, Rosario L, Tew KD, Pincus MR, Sardana M, Henderson CJ, Wolf CR, Davis RJ, and Ronai Z. Regulation of JNK signaling by GSTp. EMBO J 18: 1321-1334, 1999.
3. Asehnoune K, Strassheim D, Mitra S, Kim JY, and Abraham E. Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. J Immunol 172: 2522-2529, 2004.
4. Azevedo-Martins AK, Lortz S, Lenzen S, Curi R, Eizirik DL, and Tiedge M. Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells. Diabetes 52: 93-101, 2003.
5. Barrett WC, DeGnore JP, Konig S, Fales HM, Keng YF, Zhang ZY, Yim MB, and Chock PB. Regulation of PTP1B via glutathionylation of the active site cysteine 215. Biochemistry 38: 6699-6705, 1999.
6. Bokoch GM and Diebold BA. Current molecular models for NADPH oxidase regulation by Rac GTPase. Blood 100: 2692-2696, 2002.
7. Caselli A, Marzocchini R, Camici G, Manao G, Moneti G, Pieraccini G, and Ramponi G. The inactivation mechanism of low molecular weight phosphotyrosine-protein phosphatase by H2O2. J Biol Chem 273: 32554-32560, 1998.
8. Chu F, Ward NE, and O'Brian CA Potent inactivation of representative members of each PKC isozyme subfamily and PKD via 5-thiolation by the tumor-promotion/progression antagonist glutathione but not by its precursor cysteine. Carcinogenesis 22: 1221-1229, 2001.
9. Chu F, Ward NE, and O'Brian CA. PKC isozyme S-cysteinylation by cystine stimulates the pro-apoptotic isozyme PKC delta and inactivates the oncogenic isozyme PKC epsilon. Carcinogenesis 24: 317-325, 2003.
10. Cross JV and Templeton DJ. Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP binding domain. Biochem J 381: 675-683, 2004.
11. Cross JV and Templeton DJ. Thiol oxidation of cell signaling proteins: Controlling an apoptotic equilibrium. J Cell Biochem 93: 104-111, 2004.
12. Dedon PC and Tannenbaum SR. Reactive nitrogen species in the chemical biology of inflammation. Arch Biochem Biophys 423: 12-22, 2004.
13. Denu JM and Tanner KG. Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation. Biochemistry 37: 5633-5642, 1998.
14. Devadas S, Zaritskaya L, Rhee SG, Oberley L, and Williams MS. Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression. J Exp Med 195: 59-70, 2002.
15. Dorion S, Lambert H, and Landry J. Activation of the p38 signaling pathway by heat shock involves the dissociation of glutathione S-transferase Mu from Ask1. J Biol Chem 277: 30792-30797, 2002.
16. Eaton P, Byers HL, Leeds N, Ward MA, and Shattock MJ. Detection, quantitation, purification, and identification of cardiac proteins 5-thiolated during ischemia and reperfusion. J Biol Chem 277: 9806-9811, 2002.
17. Finkel T. Reactive oxygen species and signal transduction. IUBMB Life 52: 3-6, 2001.
18. Forman HJ and Torres M. Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling. Am J Respir Crit Care Med 166: S4-8, 2002.
19. Forman HJ, Fukuto JM, and Torres M. Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers. Am J Physiol Cell Physiol 287: C246-256, 2004.
20. Genot E and Cantrell DA. Ras regulation and function in lymphocytes. Curr Opin Immunol 12: 289-294, 2000.
21. Ghezzi P. Regulation of protein function by glutathionylation. Free Radic Res 39: 573-580, 2005.
22. Ghosh S, May MJ, and Kopp EB. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16: 225-260, 1998.
23. Ghosh S and Karin M. Missing pieces in the NF-kappaB puzzle. Cell 109 Suppl: S81-96, 2002.
24. Ha YJ and Lee JR. Role of TNF receptor-associated factor 3 in the CD40 signaling by production of reactive oxygen species through association with p40phox, a cytosolic subunit of nicotinamide adenine dinucleotide phosphate oxidase. J Immunol 172: 231-239, 2004.
25. Hennet T, Richter C, and Peterhans E. Tumour necrosis factor-alpha induces superoxide anion generation in mitochondria of L929 cells. Biochem J 289: 587-592, 1993.
26. Hess DT, Matsumoto A, Kim SO, Marshall HE, and Stamler JS. Protein 5-nitrosylation: purview and parameters. Nat Rev Mol Cell Biol 6: 150-166, 2005.
27. Higuchi M, Aggarwal BB, and Yeh ET. Activation of CPP32-like protease in tumor necrosis factor-induced apoptosis is dependent on mitochondrial function. J Clin Invest 99: 1751-1758, 1997.
28. Holmgren A. Thioredoxin structure and mechanism: conformational changes on oxidation of the active-site sulfhydryls to a disulfide. Structure 3: 239-243, 1995.
29. Hughes G, Murphy MP, and Ledgerwood EC. Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants. Biochem J 389: 83-89, 2005.
30. Humphries KM, Juliano C, and Taylor SS. Regulation of cAMP-dependent protein kinase activity by glutathionylation. J Biol Chem 277: 43505-43511, 2002.
31. Humphries KM, Deal MS, and Taylor SS. Enhanced dephosphorylation of cAMP-dependent protein kinase by oxidation and thiol modification. J Biol Chem 280: 2750-2758, 2005.
32. Janssen-Heininger YM, Persinger RL, Korn SH, Pantano C, McElhinney B, Reynaert NL, Langen RC, Ckless K, Shrivastava P, and Poynter ME. Reactive nitrogen species and cell signaling: implications for death or survival of lung epithelium. Am J Respir Crit Care Med 166: S9-S16, 2002.
33. Kallis GB and Holmgren A. Differential reactivity of the functional sulfhydryl groups of cysteine-32 and cysteine-35 present in the reduced form of thioredoxin from Escherichia coli. J Biol Chem 255: 10261-10265, 1980.
34. Klatt P, Molina EP, De Lacoba MG, Padilla CA, Martinez-Galesteo E, Barcena JA, and Lamas S. Redox regulation of c-Jun DNA binding by reversible 5-glutathiolation. FASEB J 11: 1481-1490, 1999.
35. Korn SH, Wouters EF, Vos N, and Janssen-Heininger YM. Cytokine-induced activation of nuclear factor-kappa B is inhibited by hydrogen peroxide through oxidative inactivation of IkappaB kinase. J Biol Chem 276: 35693-35700, 2001.
36. Lajarin F, Rubio G, Lorenzo N, Gamiz P, Hernandez-Caselles T, and Garcia-Penarrubia P. Implication of reactive oxygen species in the antibacterial activity against Salmonella typhimurium of hepatocyte cell lines. Free Radic Biol Med 27: 1008-1018, 1999.
37. Lee JR. Reactive oxygen species play roles on B cell surface receptor CD40-mediated proximal and distal signaling events: effects of an antioxidant, N-acetyl-L-cysteine treatment. Mol Cell Biochem 252: 1-7, 2003.
38. Lee LF, Li G, Templeton DJ, and Ting JP. Paclitaxel (Taxol)-induced gene expression and cell death are both mediated by the activation of c-Jun NH2-terminal kinase (JNK/SAPK). J Biol Chem 273: 28253-28260, 1998.
39. Lee SR, Kwon KS, Kim SR, and Rhee SG. Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor. J Biol Chem 273: 15366-15372, 1998.
40. Lee SR, Yang KS, Kwon J, Lee C, Jeong W, and Rhee SG. Reversible inactivation of the tumor suppressor PTEN by H2O2. J Biol Chem 277: 20336-20342, 2002.
41. Liu H, Nishitoh H, Ichijo H, and Kyriakis JM. Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin. Mol Cell Biol 20: 2198-2208, 2000.
42. Mallis RJ, Buss JE, and Thomas JA. Oxidative modification of H-ras: S-thiolation and S-nitrosylation of reactive cysteines. Biochem J 355: 145-153, 2001.
43. Martinez-Ruiz A and Lamas S. S-nitrosylation: a potential new paradigm in signal transduction. Cardiovasc Res 62: 43-52, 2004.
44. Matsuzawa A, Saegusa K, Noguchi T, Sadamitsu C, Nishitoh H, Nagai S, Koyasu S, Matsumoto K, Takeda K, and Ichijo H. ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat Immunol 6: 587-592, 2005.
45. Matthews JR, Wakasugi N, Virelizier JL, Yodoi J, and Hay RT. Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res 20: 3821-3830, 1992.
46. Meier B, Radeke HH, Selle S, Younes M, Sies H, Resch K, and Habermehl GG. Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-alpha. Biochem J263: 539-545, 1989.
47. Munoz C, Pascual-Salcedo D, Castellanos MC, Alfranca A, Aragones J, Vara A, Redondo MJ, and de Landazuri MO. Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kappa B and AP-1 transcription factors activity. Blood 88: 3482-3490, 1996.
48. Murata H, Ihara Y, Nakamura H, Yodoi J, Sumikawa K, and Kondo T. Glutaredoxin exerts an antiapoptotic effect by regulating the redox state of Akt. J Biol Chem 278: 50226-50233, 2003.
49. Nordberg J and Arner ES. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic Biol Med 31: 1287-1312, 2001.
50. O'Brian CA and Chu F. Post-translational disulfide modifications in cell signaling-role of inter-protein, intraprotein, S-glutathionyl, and S-cysteaminyl disulfide modifications in signal transmission. Free Radic Res 39: 471-480, 2005.
51. Park HS, Jung HY, Park EY, Kim J, Lee WJ, and Bae YS. Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B. J Immunol 173: 3589-3593, 2004.
52. Pearson GD and Merrill GF. Deletion of the Saccharomyces cerevisiae TRR1 gene encoding thioredoxin reductase inhibits p53-dependent reporter gene expression. J Biol Chem 273: 5431-5434, 1998.
53. Pineda-Molina E, Klatt P, Vazquez J, Marina A, Garcia de Lacoba M, Perez-Sala D, and Lamas S. Glutathionylation of the p50 subunit of NF-kappaB: a mechanism for redox-induced inhibition of DNA binding. Biochemistry 40: 14134-14142, 2001.
54. Robinson JM, Ohira T, and Badwey JA. Regulation of the NADPH-oxidase complex of phagocytic leukocytes. Recent insights from structural biology, molecular genetics, and microscopy. Histochem Cell Biol 122: 293-304, 2004.
55. Ryan KA, Smith MF Jr, Sanders MK, and Ernst PB. Reactive oxygen and nitrogen species differentially regulate Toll-like receptor 4-mediated activation of NF-kappa B and interleukin-8 expression. Infect Immun 72: 2123-2130, 2004.
56. Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, Miyazono K, and Ichijo H. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 17: 2596-2606, 1998.
57. Salisbury SM and Calhoun WJ. Modulation of human peripheral blood monocyte superoxide release by interferon-gamma and lipopolysaccharide. Wis Med J 89: 271-274, 1990.
58. Salmeen A, Andersen JN, Myers MP, Meng TC, Hinks JA, Tonks NK, and Barford D. Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature 423: 769-773, 2003.
59. Satriano JA, Shuldiner M, Hora K, Xing Y, Shan Z, and Schlondorff D. Oxygen radicals as second messengers for expression of the monocyte chemoattractant protein, JE/MCP-1, and the monocyte colony-stimulating factor, CSF-1, in response to tumor necrosis factor-alpha and immunoglobulin G. Evidence for involvement of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase. J Clin Invest 92: 1564-1571, 1993.
60. Savitsky PA and Finkel T. Redox regulation of Cdc25C. J Biol Chem 277: 20535-20540, 2002.
61. Schafer FQ and Buettner GR. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med 30: 1191-1212, 2001.
62. Schenk H, Klein M, Erdbrugger W, Droge W, and Schulze-Osthoff K. Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1. Proc Natl Acad Sci USA 91: 1672-1676, 1994.
63. Schroder E and Ponting CP. Evidence that peroxiredoxins are novel members of the thioredoxin fold superfamily. Protein Sci 7: 2465-2468, 1998.
64. Schulze-Osthoff K, Bakker AC, Vanhaesebroeck B, Beyaert R, Jacob WA, and Fiers W. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. J Biol Chem 267: 5317-5323, 1992.
65. Schulze-Osthoff K, Beyaert R, Vandevoorde V, Haegeman G, and Fiers W. Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF. EMBO J 12: 3095-3104, 1993.
66. Shelton MD, Chock PB, and Mieyal JJ. Glutaredoxin: role in reversible protein S-glutathionylation and regulation of redox signal transduction and protein translocation. Antioxid Redox Signal 1: 348-366, 2005.
67. Shrivastava A and Aggarwal BB. Antioxidants differentially regulate activation of nuclear factor-kappa B, activator protein-1, c-jun amino-terminal kinases, and apoptosis induced by tumor necrosis factor: evidence that JNK and NF-kappa B activation are not linked to apoptosis. Antioxid Redox Signal 1: 181-191, 1999.
68. Sidoti-de Fraisse C, Rincheval V, Risler Y, Mignotte B, and Vayssiere JL. TNF-alpha activates at least two apoptotic signaling cascades. Oncogene 17: 1639-1651, 1998.
69. Song JJ, Rhee JG, Suntharalingam M, Walsh SA, Spitz DR, and Lee YJ. Role of glutaredoxin in metabolic oxidative stress. Glutaredoxin as a sensor of oxidative stress mediated by H2O2. J Biol Chem 277: 46566-46575, 2002.
70. Thannickal VJ and Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 279: L1005-1028, 2000.
71. Tuosto L, Costanzo A, Guido F, Marinari B, Vossio S, Moretti F, Levrero M, and Piccolella E. Mitogen-activated kinase kinase kinase 1 regulates T cell receptor- and CD28-mediated signaling events which lead to NF-kappaB activation. Eur J Immunol 30: 2445-2454, 2000.
72. van Montfort RL, Congreve M, Tisi D, Carr R, and Jhoti H. Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B. Nature 423: 773-777, 2003.
73. Williams MS and Henkart PA. Role of reactive oxygen intermediates in TCR-induced death of T cell blasts and hybridomas. J Immunol 157: 2395-2402, 1996.
74. Winston BW, Lange-Carter CA, Gardner AM, Johnson GL, and Riches DW. Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages. Proc Natl Acad Sci USA 92: 1614-1618, 1995.
75. Winyard PG, Moody CJ, and Jacob C. Oxidative activation of antioxidant defence. Trends Biochem Sci 30: 453-461, 2005.
76. Wood ZA, Schroder E, Robin Harris J, and Poole LB. Structure, mechanism and regulation of peroxiredoxins. Trends Biochem Sci 28: 32-40, 2003.
77. Yagisawa M, Yuo A, Kitagawa S, Yazaki Y, Togawa A, and Takaku F. Stimulation and priming of human neutrophils by IL-1 alpha and IL-1 beta: complete inhibition by IL-1 receptor antagonist and no interaction with other cytokines. Exp Hematol 23: 603-608, 1995.
78. Yujiri T, Fanger GR, Garrington TP, Schlesinger TK, Gibson S, and Johnson GL. MEK kinase 1 (MEKK1) transduces c-Jun NH2-terminal kinase activation in response to changes in the microtubule cytoskeleton. J Biol Chem 274: 12605-12610, 1999.