Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain

Biochemical Journal

Volumn 381, Issue 3, 2004, Pages 675-683

  Cross, Janet V ^a   Templeton, Dennis J ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Apoptosis signal regulating kinase 1 (ASK1); Glutathionylation; MEKK1; Oxidative stress; Redox; S thiolation

Indexed keywords

CELLS; GELS; OXIDATION; PROTEINS;

OXIDATIVE STRESSES; SIGNAL-TRANSDUCTION;

BIOCHEMISTRY;

ADENOSINE TRIPHOSPHATE; APOPTOSIS SIGNAL REGULATING KINASE 1; CYSTEINE; DITHIOTHREITOL; GLUTATHIONE; MENADIONE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; N ETHYLMALEIMIDE; STRESS ACTIVATED PROTEIN KINASE; SULFENIC ACID DERIVATIVE;

ALKYLATION; ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING SITE; CONTROLLED STUDY; DISULFIDE BOND; ELECTROPHORETIC MOBILITY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REACTIVATION; ENZYME SPECIFICITY; GLUTATHIONYLATION; IN VITRO STUDY; MASS SPECTROMETRY; NITROSYLATION; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MODIFICATION; RAT;

ADENOSINE TRIPHOSPHATE; ALKYLATION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; CATALYTIC DOMAIN; CELL LINE, TUMOR; CYSTEINE; DITHIOTHREITOL; ENZYME INHIBITORS; ETHYLMALEIMIDE; GLUTATHIONE; HUMANS; LYMPH NODES; MALE; MAP KINASE KINASE KINASE 1; MOLECULAR SEQUENCE DATA; MUTATION; OXIDANTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PEPTIDES; PROSTATIC NEOPLASMS; PROTEIN STRUCTURE, TERTIARY; VALINE;

ANIMALIA;

EID: 4344686072     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040591     Document Type: Article

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