Moderate iron deficiency in infancy: Biology and behavior in young rats

Behavioural Brain Research

Volumn 170, Issue 2, 2006, Pages 224-232

  Beard, John L ^a   Felt, Barbara ^b   Schallert, Tim ^c   Burhans, Maggie ^a   Connor, James R ^d   Georgieff, Michael K ^e  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c University of Austin   (United States)

^d PENN STATE COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Anemia; Brain iron; Catecholamines; Development; Developmental delays; Dopamine; Iron deficiency; Rat; Serotonin

Indexed keywords

BRAIN MONOAMINE; DOPAMINE 2 RECEPTOR; NEUROTRANSMITTER;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BIRTH WEIGHT; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DIET RESTRICTION; FEMALE; GROWTH DISORDER; INFANCY; IRON DEFICIENCY; LACTATION; MALE; MONOAMINE METABOLISM; MONOAMINERGIC SYSTEM; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; STATISTICAL SIGNIFICANCE; WEANING;

AGE FACTORS; ANEMIA, IRON-DEFICIENCY; ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; BIOGENIC MONOAMINES; BRAIN; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEMATOCRIT; IRON; LACTATION; MALE; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2;

EID: 33646529841     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2006.02.024     Document Type: Article

References (53)

1. Altman J., and Bayer S.A. Epilogue: behavior consequences of experimental interference with cerebellar development. Development of the cerebellar system: in relation to its evolution structure and function (1997), CRC Press Inc., Boca Raton p. 726-51
2. Andrews A.M., Ladenheim B., Epstein C.J., Cadet J.L., and Murphy D.L. Transgenic mice with high levels of superoxide dismutase activity are protected from the neurotoxic effects of 2′-NH2-MPTP on serotonergic and noradrenergic nerve terminals. Mol Pharmacol 50 6 (1996) 1511-1519
3. Angulo-Kinzler R.M., Peirano P., Lin E., Algarin C., Garrido M., and Lozoff B. Twenty-four-hour motor activity in human infants with and without iron deficiency anemia. Early Hum Dev 70 1-2 (2002) 85-101
4. Ashkenazi R., Ben-Shachar A., and Youdim M.B.H. Nutritional iron and dopamine binding sites in the rat brain. Pharmacol Biochem Behav 17 (1982) 43-47
5. Beard J.L., and Connor J. Iron status and neural functioning. Ann Rev Nutr 23 (2003) 41-58
6. Beard J.L., Erikson K., and Jones B.C. Neurobehavioral analysis of developmental iron deficiency in rats. Behav Brain Res 134 (2002) 517-524
7. Benefiel-Kunkel A.C., and Greenough W.T. Effects of experience and environment upon the developing and mature brain: implications for laboratory animal housing. ILAR J 39 (1998) 5-11
8. Bouet V., Wubbels R.J., de Jong H.A.A., and Gramsbergen A. Behavioural consequences of hypergravity in developing rats. Dev Brain Res 153 (2004) 69-78
9. de Ungria M., Rao R., Wobken J.D., Luciana M., Nelson C.A., and Georgieff M.K. Perinatal iron deficiency decreases cytochrome c oxidase [CytOx] activity in selected regions of neonatal rat brain. Pediatr Res 48 2 (2000) 169-176
10. Erikson K.M., Pinero D.J., Connor J.R., and Beard J.L. Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats. J Nutr 127 (1997) 2030-2038
11. 2 receptors in brains of iron deficient rats. Pharmacol Biochem Behav 69 (2001) 409-418
12. Erikson K., Jones B.C., and Beard J.L. Iron deficiency alters dopamine transporter functioning in rat striatum. J Nutr 130 (2000) 2831-2837
13. Felt B.T., and Lozoff B. Brain iron and behaviour of rats are not normalized by treatment of iron deficiency anemia during early development. J Nutr 126 (1986) 693-701
14. Felt B.T., Schallert T., Shao J., Liu Y., Li X., and Barks J.D. Early appearance of functional deficits after neonatal excitotoxic and hypoxic-ischemic injury: fragile recovery after development and role of the NMDA receptor. Dev Neurosci 24 5 (2002) 418-425
15. Fox W.M. Reflex-ontogeny and behavioural development of the mouse. Anim. Behav 13 (1995) 234-241
16. Gaboyard S., Sans A., and Lehouelleur J. Differential impact of hypergravity on maturating innervation in vestibular epithelia during rat development. Dev Brain Res 143 (2003) 15-23
17. Georgieff M.K., Miklls M.M., Gordon K., and Wobken J.D. Reduced neonatal liver iron concentrations after uteroplacental insufficiency. J Pediatr 27 2 (1995) 304-308
18. Grantham-McGregor S., and Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr 131 (2001) 649S-666S
19. Guiang S.F., Georgieff M.K., Lambert D.J., Schmidt R.K., and Widness J.A. Intravenous iron supplementation effect on tissue iron and hemoproteins in chronically phlebotomized lambs. Am J Physiol 273 (1997) R2124-R2131
20. Hua Y., Schallert T., Keep R.F., Wu J., Hoff J.T., and Xi G. Behavioral tests after intracerebral hemorrhage in the rat. Stroke 33 10 (2002) 2478-2484
21. Jones T.A., Hawrylak N., Klintsova A.Y., and Greenough W.T. Brain damage, behavior, rehabilitation, recovery and brain plasticity. Mental Ret Devel Disabil Res Rev 4 (1998) 231-237
22. Jorgenson L.A., Wobken J.D., and Georgieff M.K. Perinatal iron deficiency alters apical dendritic growth in hippocampal CA1 pyramidal neurons. Dev Neurosci 25 (2003) 412-420
23. Kretchmer N., Beard J.L., and Carlson S. The role of nutrition in the development of normal cognition. Am J Clin Nutr 63 (1996) 997S-1001S
24. Kolb B., Forgie M., Gibb R., Gorny G., and Rowntree S. Age, experience and the changing brain. Neuro Biobehav Rev 22 (1998) 143-159
25. Kwik-Uribe C.L., Gietzen D., German J.B., Golub M.S., and Keen C.L. Chronic marginal iron intakes during early development in mice result in persistent changes in dopamine metabolism and myelin composition. J Nutr 130 (2000) 2821-2830
26. Lapointe G., and Nosal G. A rat model of neurobehavioral development. Experientia 17 (1979) 205-207
27. Levine S., Haltmeyer G.C., Karas G.G., and Denenberg V.H. Physiological and behavioral effects of infantile stimulation. Physiol Behav 2 (1967) 55-59
28. Lozoff B., De Andraca I., Castillo M., Smith J.B., Walter T., and Pino P. Behavioral and developmental effects of preventing iron deficiency anemia in healthy full term infants. Pediatrics 112 (2003) 846-854
29. Lozoff B., Jimenez E., and Wolf A.W. Long-term developmental outcome of infants with iron deficiency. N Engl J Med 325 (1991) 687-694
30. Nelson C., Erikson K., Pinero D.J., and Beard J. In vivo dopamine metabolism is altered in iron deficient anemic rats. J Nutr 127 (1997) 2282-2288
31. Ortiz E., Tasquini J.M., Thomspon K., Felt B., Butkus G., Beard J.L., et al. Effect of manipulation of iron storage, transport, or availability on myelin composition and brain iron content using 3 different animal models. J Neurosci Res 77 5 (2004) 681-689
32. Papadeas S.T., Blake B.L., Knapp D.J., and Breese G.R. Sustained extracellular signal-regulated kinase 1/2 phosphorylation in neonate 6-hydroxydopamine-lesioned rats after repeated D1-dopamine receptor agonist administration: implications for NMDA receptor involvement. J Neurosci 24 (2004) 5863-5876
33. Petry C.D., Eaton M.A., Wobken J.D., Mills M.M., Johnson D.E., and Georgieff M.K. Iron deficiency of liver, heart, and brain in newborn infants of diabetic mothers. J Pediatr 121 1 (1992) 109-114
34. Pinero D.J., Jones B.C., and Beard J.L. Variations in dietary iron alter behavior in developing rats. J Nutr 131 (2001) 311-318
35. Pinero D.J., Li N.Q., Connor J.R., and Beard J.L. Variations in dietary iron alter brain iron metabolism in developing rats. J Nutr 130 (2000) 254-263
36. Pollit E. Behavioural effects of iron deficiency in childhood. Am J Clin Nutr 50 Suppl (1989) 666-667
37. Rao R., and Georgieff M.K. Neonatal iron nutrition. Semin Neonatol 6 (2001) 425-435
38. Rao R., Tkac I., Townsend E.L., Gruetter R., and Georgieff M.K. Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus. J Nutr 133 10 (2003) 3215-3221
39. Schallert T., Petrie B.F., and Whishaw I.Q. Neonatal dopamine depletion: spared and unspared sensorimotor and attentional disorders and effects of further depletion in adulthood. Psychobiology 17 (1989) 386-396
40. Schallert T., Fleming S.M., Leasure J.L., Tillerson J.L., and Bland S.T. CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacology 39 5 (2000) 777-787
41. Schallert T., and Woodlee M.T. Brain-dependent movements and cerebral-spinal connections: key targets of cellular and behavioral enrichment in CNS injury models. J Rehab Res Develop 40 4 Suppl 1 (2003) 9-17
42. Schwarzkopf S.B., Mitra T., and Bruno J.P. Sensory gating in rats depleted of dopamine as neonates: potential relevance to findings in schizophrenic patients. Biol. Psychiatry 31 (1992) 759-773
43. Siddappa A.J., Rao R.B., Wobken J.D., Casperson K., Leibold E.A., Connor J.R., et al. Iron deficiency alters iron regulatory protein and iron transport protein expression in the perinatal rat brain. Pediatr Res 53 5 (2003) 800-807
44. Siddappa A.M., Georgieff M.K., Wewerka S., Worwa C., Nelson C.A., and Deregnier R.A. Iron deficiency alters auditory recognition memory in newborn infants of diabetic mothers. Pediatr Res 55 6 (2004) 1034-1041
45. Stevens K.E., Luthman J., Lindquist E., Hohnson R.G., and Rose G.M. Effects of neonatal dopamine depletion on sensory inhibition in the rat. Pharmacol Biochem Behav 53 (1996) 817-823
46. Walter T., de Andraca I., Chadud P., and Perales C.G. Iron deficiency anaemia: adverse effects on infant psychomotor development. Paediatrics 84 (1989) 7-17
47. Weinberg J., Kim C.K., and Yu W. Early handling can attenuate adverse effects of fetal ethanol exposure. Alcohol 12 (1995) 317-327
48. Weinberg J., Dallman P.R., and Levine S. Iron deficiency during early development in the rat: behavioral and physiological consequences. Pharmacol Biochem Behav 12 (1980) 493-502
49. Woodlee M.T., Asseo-Garcia A.M., Zhao X., Liu S.-J., Jones T.A., and Schallert T. Testing forelimb placing "across the midline" reveals distinct, lesion-dependent patterns of recovery in rats. Exp Neurol 191 (2005) 310-317
50. World Health Organization. The prevalence of anaemia in women: a tabulation of available information, WHO/MCH/MSM/92. 2. 2nd ed. (1992), WHO Press, Geneva
51. Youdim M.B.H., Ben-Shachar D., and Yehuda S. Putative biological mechanisms of the effect of iron deficiency on brain biochemistry and behavior. Am J Clin Nutr 50 (1989) 607-617
52. Youdim M.B., and Yehuda S. The neurochemical basis of cognitive deficits induced by brain iron deficiency: involvement of dopamine-opiate systems. Cell Mol Biol [Noisy-le-grand] 46 (2000) 491-500
53. Yu G.S., Steinkirchner T.M., Rao G.A., and Larkin E.C. Effect of prenatal iron deficiency on myelination in rat pups. Am J Pathol 125 (1986) 620-624