Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): Implications for altered drug disposition and central nervous system drug entry

Journal of Biological Chemistry

Volumn 280, Issue 10, 2005, Pages 9610-9617

  Lee, Wooin ^a   Glaeser, Hartmut ^a   Smith, L Harris ^a   Roberts, Richard L ^b   Moeckel, Gilbert W ^b   Gervasini, Guillermo ^c   Leake, Brenda F ^a   Kim, Richard B ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF EXTREMADURA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BRAIN; MOLECULAR BIOLOGY; NEGATIVE IONS; NEUROLOGY; POLYPEPTIDES; SUBSTRATES;

CLINICAL USE; GLYCOSYLATION; HUMAN BRAIN CAPILLARY; ORGANIC ANION-TRANSPORTING POLYPEPTIDE 1A2 (OATP1A2); POLYMORPHISMS; TRANSPORT ACTIVITY;

DRUG PRODUCTS;

GENOMIC DNA; ORGANIC ANION TRANSPORTER;

ARTICLE; BIOTINYLATION; BRAIN CAPILLARY; CELL MEMBRANE; CELL SURFACE; CENTRAL NERVOUS SYSTEM; CONFOCAL MICROSCOPY; DRUG BRAIN LEVEL; DRUG DISPOSITION; DRUG PENETRATION; DRUG PROTEIN BINDING; ENZYME SPECIFICITY; ETHNIC DIFFERENCE; FUNCTIONAL ASSESSMENT; GENE FREQUENCY; GENETIC VARIABILITY; GENOME ANALYSIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MOLECULAR SIZE; NEPHRON; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN TRANSPORT; SINGLE NUCLEOTIDE POLYMORPHISM;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BRAIN; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ESTRONE; HUMANS; KIDNEY; KINETICS; LIVER; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; ORGAN SPECIFICITY; ORGANIC ANION TRANSPORT POLYPEPTIDE C; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY;

EID: 15744367808     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411092200     Document Type: Article

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