A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression

Pharmacogenomics Journal

Volumn 2, Issue 3, 2002, Pages 191-196

  Roberts, R L ^a   Joyce, P R ^a   Mulder, R T ^a   Begg, E J ^a   Kennedy, M A ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

ABC transporters; ABCB1; Affective disorders; Antidepressants; Fluoxetine; Multidrug resistance gene MDR1; Pharmacogenetics

Indexed keywords

AMITRIPTYLINE; DRUG METABOLITE; FLUOXETINE; GLYCOPROTEIN P; HYPNOTIC AGENT; MULTIDRUG RESISTANCE PROTEIN 1; NORTRIPTYLINE; PSYCHOTROPIC AGENT; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; ALLELE; ARTICLE; BLOOD BRAIN BARRIER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG PENETRATION; DRUG RESPONSE; EXTENSION GENE; FEMALE; GENETIC ASSOCIATION; GENETIC CODE; GENETIC CORRELATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; ORTHOSTATIC HYPOTENSION; PRIORITY JOURNAL; PROTEIN FUNCTION; RANDOMIZED CONTROLLED TRIAL; REGULATORY MECHANISM; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIDEPRESSIVE AGENTS, TRICYCLIC; DEPRESSIVE DISORDER; DNA; FEMALE; FLUOXETINE; GENOTYPE; HUMANS; HYPOTENSION, ORTHOSTATIC; MALE; NORTRIPTYLINE; P-GLYCOPROTEIN; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0036361009     PISSN: 1470269X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.tpj.6500099     Document Type: Article

References (40)

1. Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1 a P-glycoprotein gene disruption
2. Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
3. Pharmacology of antidepressants
4. Are all antidepressants the same?
5. Antidepressant treatment and side effect considerations
6. Falls among older people: Relationship to medication use and orthostatic hypotension
7. Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins
8. P-glycoprotein gene (MDR1) cDNA from human adrenal: Normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance
9. Biochemistry of multidrug resistance mediated by the multidrug transporter
10. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
11. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
12. Genetic polymorphism in MDR-1: A tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors
13. Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects
14. The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56(+) natural killer cells
15. MDR1 pharmacogenetics: Frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity
16. Rapid and comprehensive determination of cytochrome P450 CYP2D6 poor metabolizer genotypes by multiplex polymerase chain reaction
17. Treatment of postural hypotension
18. Drug-induced orthostatic hypotension in the elderly: Avoiding its onset
19. Postural hypotension: Causes, clinical features, investigation, and management
20. Drug-induced orthostatic hypotension
21. Do antidepressants cause postural hypotension by blocking cardiovascular reflexes?
22. Tricyclic anti-depressants: Therapeutic properties and affinity for alpha-norad-renergic receptor binding sites in the brain
23. Effects of desipramine hydrochloride on peripheral sympathetic nerve activity
24. Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects
25. Frequency of C3435T polymorphism of MDR1 gene in African people
26. Treating the depressed patient with cardiovascular problems
27. Cardiovascular effects of tricyclic antidepressants
28. Clinical characteristics of imipramine-induced orthostatic hypotension
29. Age-related changes in vascular responses
30. Gender differences in the presentation of depressed outpatients: A comparison of descriptive variables
31. Social adjustment in depression: The impact of depression severity, personality and clinic versus community sampling
32. Patterns and predictors of response, remission and recovery in major depression treated with fluoxetine or nortriptyline
33. The Structured Clinical Interview for DSM-III-R (SCID). I: History, rationale, and description
34. A rating scale for depression
35. A new depression scale designed to be sensitive to change
36. A specific gas-chromatographic method for the measurement of 'steady-state' plasma levels of amitriptyline and nortriptyline in patients
37. A simple method for DNA purification from peripheral blood
38. Primer3 on the WWW for general users and for biologist programmers
39. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
40. Expression of P-glycoprotein in human placenta: Relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene