Discovery of novel, highly potent and selective β-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 24, 2006, Pages 8396-8404

  DeMarco, Steven J ^a   Henze, Heiko ^a   Lederer, Alexander ^a   Moehle, Kerstin ^a   Mukherjee, Reshmi ^a   Romagnoli, Barbara ^a   Robinson, John A ^a   Brianza, Federico ^b   Gombert, Frank O ^b   Lociuro, Sergio ^b   Ludin, Christian ^b   Vrijbloed, Jan Willem ^b   Zumbrunn, Jürg ^b   Obrecht, Jean Pierre ^b   Obrecht, Daniel ^b   Brondani, Vincent ^c   Hamy, François ^c   Klimkait, Thomas ^c  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b Polyphor Ltd   (Switzerland)

^c InPheno AG   (Switzerland)

Author keywords

CXCR4 inhibitor; Drug design; Peptide; Protein epitope mimetics

Indexed keywords

CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; ENFUVIRTIDE; MACROCYCLIC COMPOUND; PEPTIDE; POL 1638; POL 2438; POL 3026; POLYPHEMUSIN II; STROMAL CELL DERIVED FACTOR 1ALPHA; TC 14011; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIANGIOGENIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; BOLUS INJECTION; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOG; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STABILITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IC 50; IN VITRO STUDY; INFLAMMATION; MALE; METASTASIS; MOLECULAR MIMICRY; NONHUMAN; RAT; RECEPTOR DOWN REGULATION; STEM CELL TRANSPLANTATION; TUMOR VASCULARIZATION;

ANIMALS; ANTI-HIV AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CALCIUM; CHEMOKINES, CXC; CHEMOTAXIS; DOGS; DRUG DESIGN; HIV-1; HUMANS; LEUKEMIA; MICROSOMES; MOLECULAR MIMICRY; OLIGOPEPTIDES; PEPTIDES, CYCLIC; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, CXCR4; TUMOR CELLS, CULTURED;

CANIS FAMILIARIS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33750527761     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.09.003     Document Type: Article

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