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Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 23, 2000, Pages 2633-2637

Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes

(9) Tamamura, Hirokazu a Omagari, Akane a Oishi, Shinya a Kanamoto, Taisei b Yamamoto, Naoki c Peiper, Stephen C d Nakashima, Hideki b Otaka, Akira a Fujii, Nobutaka a

a KYOTO UNIVERSITY (Japan)

b KAGOSHIMA UNIVERSITY (Japan)

c TOKYO MEDICAL AND DENTAL UNIVERSITY (Japan)

d UNIVERSITY OF LOUISVILLE (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 NAPHTHYL) 3 ALANINE DES[8,13 CYSTEINE 9,12 TYROSINE][10 DEXTRO LYSINE 11 PROLINE 16 CITRULLINE][5,12 TYROSINE 7 LYSINE]POLYPHEMUSIN II; ANTIVIRUS AGENT; ARGININE; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 INHIBITOR; CITRULLINE; LYSINE; T 140; TC 14003; TC 14005; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG SELECTIVITY; DRUG SYNTHESIS; PHARMACOPHORE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; CELL LINE; CIRCULAR DICHROISM; HIV-1; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; RECEPTORS, CXCR4;

HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0034606466 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/S0960-894X(00)00535-7 Document Type: Article

Times cited : (118)

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