Recent progress in discovery of small-molecule CCR5 chemokine receptor ligands as HIV-1 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 13, 2003, Pages 2663-2676

  Kazmierski, Wieslaw ^a   Bifulco, Neil ^a   Yang, Hanbiao ^a,b   Boone, Larry ^a   DeAnda, Felix ^a   Watson, Chris ^a   Kenakin, Terry ^a  

^a GLAXOSMITHKLINE   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; E 913; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 41; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; PROTEIN; PROTEIN P140; RANTES; SCH 350634; SCH C; SCH C 32; UNCLASSIFIED DRUG; VICRIVIROC; VIRUS ENVELOPE PROTEIN; WO 200039125; WO 200066551;

ALLOSTERISM; ANTIVIRAL ACTIVITY; DISEASE COURSE; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SELECTIVITY; GENE TARGETING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IC 50; INFECTION PREVENTION; INFECTION RISK; NONHUMAN; POINT MUTATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR INTRINSIC ACTIVITY; REVIEW; SIDE EFFECT; STEADY STATE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TARGET CELL DESTRUCTION; VIROGENESIS; VIRUS INFECTION; VIRUS REPLICATION; VIRUS RESISTANCE; VIRUS STRAIN;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0037872129     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00161-5     Document Type: Review

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