Respirometric screening technology for ADME-Tox studies

Expert Opinion on Drug Metabolism and Toxicology

Volumn 2, Issue 2, 2006, Pages 313-323

  Papkovsky, Dmitri B ^a,b   Hynes, James ^a   Will, Yvonne ^c  

^a Luxcel Biosciences Ltd   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c PFIZER INC   (United States)

Author keywords

Biological oxygen consumption; Mechanisms of toxicity; Mitochondrial function; Optical oxygen sensing; Phosphorescent oxygen probes; Respirometric assays; Screening

Indexed keywords

OXYGEN;

CELL FUNCTION; CELL ISOLATION; CELL METABOLISM; CELLULAR DISTRIBUTION; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FLUORESCENCE ANALYSIS; MEDICAL ASSESSMENT; OXYGEN CONSUMPTION; OXYGEN SENSING; RESPIROMETRY; REVIEW; SCREENING TEST; ANIMAL; BIOLOGICAL MODEL; DRUG EFFECT; DRUG SCREENING; GENETIC PROCEDURES; HUMAN; METABOLISM; METHODOLOGY; MITOCHONDRION; PHARMACEUTICS; TOXICITY TESTING;

ANIMALS; BIOSENSING TECHNIQUES; DRUG EVALUATION; HUMANS; MITOCHONDRIA; MODELS, BIOLOGICAL; OXYGEN; OXYGEN CONSUMPTION; TECHNOLOGY, PHARMACEUTICAL; TOXICITY TESTS;

EID: 33750459776     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425255.2.2.313     Document Type: Review

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