Nonsteroidal antiinflammatory drugs and a selective cyclooxygenase 2 inhibitor uncouple mitochondria in intact cells

Arthritis and Rheumatism

Volumn 48, Issue 5, 2003, Pages 1438-1444

  Krause, Manja M ^a   Brand, Martin D ^b   Krauss, Stefan ^c   Meisel, Christian ^a   Vergin, Hartmut ^d   Burmester, Gerd Rüdiger ^a   Buttgereit, Frank ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Pharmacia   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 (4 CHLOROPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; ADENOSINE TRIPHOSPHATE; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT;

AMPEROMETRY; ANIMAL CELL; ARTICLE; CELL ENERGY; DIGESTIVE SYSTEM INJURY; DRUG EFFECT; DRUG SELECTIVITY; ENERGY METABOLISM; FEMALE; GASTROINTESTINAL SYMPTOM; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTON TRANSPORT; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DICLOFENAC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INDOMETHACIN; INTRACELLULAR MEMBRANES; ISOENZYMES; MEMBRANE POTENTIALS; MITOCHONDRIA, LIVER; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; RATS; RATS, WISTAR; SULFONAMIDES; THYMUS GLAND;

EID: 0037652327     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.10969     Document Type: Article

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