Mitochondria as targets for nitric oxide-induced protection during simulated ischemia and reoxygenation in isolated neonatal cardiomyocytes

Circulation

Volumn 103, Issue 21, 2001, Pages 2617-2623

  Rakhit, Roby D ^a   Mojet, Mart H ^b   Marber, Michael S ^a   Duchen, Michael R ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Calcium; Cells; Ischemia; Nitric oxide; Reperfusion

Indexed keywords

FURA 2; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; PROPIDIUM IODIDE;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL CULTURE; CELL DEATH; CELL ISOLATION; CELL MEMBRANE; CONTROLLED STUDY; FLUORESCENCE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; REOXYGENATION; SIMULATION;

EID: 0035967481     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.103.21.2617     Document Type: Article

References (35)

1. Calcium overload and ischemic myocardial injury
2. Myocardial calcium and magnesium in acute ischemic injury
3. Changes in mitochondrial matrix free calcium in perfused rat hearts subjected to hypoxiareoxygenation
4. Relation of mitochondrial and cytosolic free calcium to cardiac myocyte recovery after exposure to anoxia
5. The nitric oxide hypothesis of late preconditioning
6. Nitric oxide-induced cardioprotection in cultured rat ventricular myocytes
7. Pharmacological evidence that inducible nitric oxide synthase is a mediator of delayed preconditioning
8. Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide
9. Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport
10. Modulation of the mitochondrial permeability transition by nitric oxide
11. Transient mitochondrial depolarizations reflect focal sarcoplasmic reticular calcium release in single rat cardiomyocytes
12. Differential protection of primary rat cardiocytes by transfection of specific heat stress proteins
13. Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition
14. A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′-tetrachloro-1,1′,3,3′ tetraethylbenzimidazolcarbocyanine iodide (JC-1)
15. Hypoxia-induced catecholamine secretion in isolated newborn rat adrenal chromafin cells is mimicked by inhibition of mitochondrial respiration
16. Interaction of peroxynitrite with mitochondrial cytochrome oxidase: Catalytic production of nitric oxide and irreversible inhibition of enzyme activity
17. Diffusion of nitric oxide in the aorta wall monitored in situ by porphyrinic microsensors
18. Mechanical transduction of nitric oxide synthesis in the beating heart
19. Relation between spontaneous contraction and sarcoplasmic reticulum function in cultured neonatal rat cardiac myocytes
20. Effects of thapsigargin and cyclopiazonic acid on intracellular calcium activity in newborn rat cardiomyocytes during their development in primary culture
21. Effect of nitric oxide on endoplasmic reticulum calcium homeostasis, protein synthesis and energy metabolism
22. The expression of constitutively active isotypes of protein kinase C to investigate preconditioning
23. An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia
24. 2+ waves in rat cortical astrocytes
25. 0 are all required for normal muscarinic inhibition of the cardiac calcium channels in nodal/atrial-like cultured cardiocytes
26. Mitochondrial free calcium regulation in hypoxia and reoxygenation: Relation to cellular injury
27. Role of calcium ions in regulation of mammalian intramitochondrial metabolism
28. On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury
29. Mechanisms by which mitochondria transport calcium
30. Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose
31. 2 sensor
32. Endogenous endothelial nitric oxide synthase - Derived nitric oxide is a physiological regulator of myocardial oxygen consumption
33. Effect of ischemic preconditioning on myocardial oxygen consumption during ischemia
34. Glutamate-induced neuron death requires mitochondrial calcium uptake
35. Suppression of cellular injury during the calcium paradox in rat heart by factors which reduce calcium uptake by mitochondria