Cation-π interaction in the polyolefin cyclization cascade uncovered by incorporating unnatural amino acids into the catalytic sites of squalene cyclase

Journal of the American Chemical Society

Volumn 128, Issue 40, 2006, Pages 13184-13194

  Morikubo, Noriko ^a   Fukuda, Yoriyuki ^a   Ohtake, Kazumasa ^c   Shinya, Naoko ^b   Kiga, Daisuke ^b,f   Sakamoto, Kensaku ^b   Asanuma, Miwako ^b   Hirota, Hiroshi ^b,d   Yokoyama, Shigeyuki ^b,c,e   Hoshino, Tsutomu ^a  

^a NIIGATA UNIVERSITY   (Japan)

^b RIKEN YOKOHAMA INSTITUTE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d YOKOHAMA CITY UNIVERSITY   (Japan)

^e Harima Institute ^*  (Japan)

^f TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANTS; PHENYLALANINE; POLYCYCLIZATION;

AMINO ACIDS; CARRIER CONCENTRATION; CATALYST ACTIVITY; HIGH TEMPERATURE EFFECTS; PROTEINS; REACTION KINETICS;

ORGANIC POLYMERS;

AMINO ACID; FLUORINE; PHENYLALANINE; POLYOLEFIN; SQUALENE CYCLASE; SQUALENE DERIVATIVE; SQUALENE HOPENE CYCLASE; TRITERPENE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

ALICYCLOBACILLUS ACIDOCALDARIUS; ARTICLE; BIOSYNTHESIS; CATALYSIS; CYCLIZATION; ELECTRON; REACTION ANALYSIS; TEMPERATURE;

ALANINE; AMINO ACIDS; BACILLUS; CATIONS; CYCLIZATION; ESCHERICHIA COLI; KINETICS; LYASES; MOLECULAR CONFORMATION; MUTAGENESIS, SITE-DIRECTED; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SQUALENE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33749529751     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja063358p     Document Type: Article

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