Formation of the C ring in the lanosterol biosynthesis from squalene

Organic Letters

Volumn 5, Issue 2, 2003, Pages 165-167

  Hess Jr , B Andes ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXANE DERIVATIVE; LANOSTEROL; SQUALENE;

AB INITIO CALCULATION; ARTICLE; BIOSYNTHESIS; CHEMICAL BINDING; CONFORMATIONAL TRANSITION; CYCLIZATION; RING OPENING; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION;

CYCLIZATION; LANOSTEROL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; SQUALENE;

EID: 0038341792     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol027449c     Document Type: Article

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19. In fact at first this structure was thought to be a π complex; however, no bicyclic structure could be found with a "normal" C-C bond length.
20. It is difficult to assess which of the correlated methods (DFT or MP2) gives the more realistic structure for8. If the DFT method is closer to reality, then this has definite implications about the mechanism of the ring expansion of ring C and formation of ringD. Future studies will address this point.