The role of the MAP-kinase superfamily in β-amyloid toxicity

Metabolic Brain Disease

Volumn 16, Issue 3-4, 2001, Pages 175-185

  Daniels, Willie M U ^a   Hendricks, Jacobus ^a   Salie, Ruduwaan ^b   Taljaard, Joshua J F ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b MRC Diabetes Research Group   (South Africa)

Author keywords

amyloid toxicity; ERK; MAP kinase pathway; MTT; p38

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMYLOID; AMYLOID BETA PROTEIN; DIHYDROCHLOROFLUORESCEIN DIACETATE; FLUORESCEIN; GLUTAMIC ACID; GROWTH FACTOR; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TETRAZOLIUM; UNCLASSIFIED DRUG;

CELL HYPOXIA; CELL VIABILITY; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME REGULATION; FLUORESCENCE MICROSCOPY; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; NEUROBLASTOMA; NEUROTOXICITY; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; STIMULUS RESPONSE; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; BLOTTING, WESTERN; COLORING AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN PEROXIDE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROBLASTOMA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; TETRAZOLIUM SALTS; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 0035215568     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012541011123     Document Type: Conference Paper

References (30)

1. Differential induction of immediate early gene proteins in cultured neurons by β-amyloid (Aβ): Association of c-Jun with Aβ-induced apoptosis
2. Hydrogen peroxide mediates amyloid β protein toxicity
3. A sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
4. Oxidative stress and Alzheimer disease
5. Stimulation of "stress-regulated" Mitogen-activated protein kinases (Stress-activated protein kinases/c-jun N-terminal kinases and p38-Mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses
6. Selective activation of p38α and p38γ by Hypoxia
7. Melatonin prevents β-amyloid-induced lipid peroxidation
8. β-amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation
9. β-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis
10. The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
11. Impairment of glucose and glutamate transport and induction of mitochondria oxidative stress and dysfunction in synaptosomes by amyloid β-peptide: Role of the lipid peroxidation product 4-Hydroxynonenal
12. Beta-amyloid protein enhances macrophage production of oxygen free radicals and glutamate
13. Activation of Mitogen-activated protein kinase in cultured rat hippocampal neurons by stimulation of glutamate receptors
14. Apotosis is induced by β-amyloid in cultured central nervous system neurons
15. 2-induced neuronal apoptosis
16. A critical assessment of the use of microculture tetrazolium assays to measure cell growth and function
17. Calcium, free radicals, and excitotoxic neuronal death in primary cell culture
18. JNK and p38 stresskinases - Degenerative effectors of signal -transductioncascades in the nervous system
19. The p38 MAP kinase pathway and its biological function
20. Activation of Mitogen-activated protein kinases in in vivo ischemia/reperfused myocardium in rats
21. Evidence of oxidative stress and in vivo in a transgenic mouse model of Alzheimer's
22. The inhibitory effects of beta-amyloid on glutamate and glucose uptakes by cultured astrocytes
23. Mitogen-activated protein kinase pathways
24. Inflammatory mediators in the Alzheimer's disease brain
25. Hydrogen peroxide enhances signal-responsive arachidonic acid release from neurons: Role of mitogen-activated protein kinase
26. Neuroprotection of MAPK/ERK kinase inhibition with UO126 against oxidative stress in mouse neuronal cell line and rat primary cultured cortical neurons
27. Contrasting calcium dependencies of SAPK and ERK activations by glutamate in cultured straital neurons
28. The MAPK signaling cascade
29. "Stress-responsive" mitogen protein kinases (c-Jun N-Terminal kinases and p38 Mitogen-activated protein kinases) in the myocardium
30. Inhibitors of p38 MAP kinase increase the survival of transplanted dopamine neurons