Advanced glycation endproducts and pro-inflammatory cytokines in transgenic Tg2576 mice with amyloid plaque pathology

Journal of Neurochemistry

Volumn 86, Issue 2, 2003, Pages 283-289

  Münch, Gerald ^a   Apelt, Jenny ^b   Kientsch Engel, Rosemarie ^d   Stahl, Peter ^d   Lüth, Hans Joachim ^c   Schliebs, Reinhard ^b  

^a UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^b Paul Flechsig Institute for Brain Research   (Germany)

^c Department of Neuroanatomy ^*  (Germany)

^d ROCHE DIAGNOSTICS GMBH   (Germany)

Author keywords

Advanced glycation endproducts; Alzheimer's disease; Amyloid plaques; Astrocytes; Immunocytochemistry; Transgenic mouse brain

Indexed keywords

ADVANCED GLYCATION END PRODUCT; AMYLOID; BUFFER; CYTOKINE; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLIA; GLIA CELL; GLYCATION; HUMAN; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENILE PLAQUE; SOLUBILITY; STAINING; TISSUE DISTRIBUTION; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CYTOKINES; DISEASE MODELS, ANIMAL; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; INTERLEUKIN-1; MICE; MICE, TRANSGENIC; NEUROGLIA; NEURONS; SENILE PLAQUES; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; MURINAE; MUS MUSCULUS;

EID: 2542489864     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01837.x     Document Type: Article

References (28)

1. Anderson M. M., Requena J. R., Crowley J. R., Thorpe S. R. and Heinecke J. W. (1999) The myeloperoxidase system of human phagocytes generates N-epsilon-(carboxymethyl) lysine on proteins: a mechanism for producing advances glycation end products at sites of inflammation. J. Clin. Invest. 104, 103-113.
2. Apelt J. and Schliebs R. (2001) Beta-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology. Brain Res. 894, 21-30.
3. Benzing W. C., Wujek J. R., Ward E. K., Shaffer D., Ashe K. H., Younkin S. G. and Brunden K. R. (1999) Evidence for glial-mediated inflammation in aged APP (SW) transgenic mice. Neurobiol. Aging 20, 581-589.
4. Brownlee M. (1995) Advanced protein glycosylation in diabetes and aging. Ann. Rev. Med. 46, 223-234.
5. Castellani R. J., Harris P. L., Sayre L. M., Fujii J., Taniguchi N., Vitek M. P., Founds H., Atwood C. S., Perry G. and Smith M. A. (2001) Active glycation in neurofibrillary pathology of Alzheimer disease: N (epsilon)-(carboxymethyl) lysine and hexitol-lysine. Free Radic. Biol. Med. 31, 175-180.
6. Cooper N. R., Bradt B. M., O'Barr S. and Yu J. X. (2000) Focal inflammation in the brain: role in Alzheimer's disease. Immunol. Res. 21, 159-165.
7. Dyrks T., Dyrks E., Monning U., Urmoneit B., Turner J. and Beyreuther K. (1993) Generation of beta-a4 from the amyloid protein precursor and fragments thereof. FEBS Lett. 335, 89-93.
8. Frautschy S. A., Yang F. S., Irrizarry M., Hyman B., Saido T. C., Hsiao K. and Cole G. M. (1998) Microglial response to amyloid plaques in appsw transgenic mice. Am. J. Pathol 152, 307-317.
9. Games D., Bard F., Grajeda H., Guido T., Khan K., Soriano F., Vasquez N., Wehner N., Johnson-Wood K., Yednock T., Seubert P. and Schenk D. (2000) Prevention and reduction of AD-type pathology in PDAPP mice immunized with A beta 1-42. Ann. NY Acad. Sci. 920, 274-284.
10. Hartlage-Rübsamen M., Apelt J. and Schliebs R. (2001) Fibrillary beta-amyloid deposits are closely associated with atrophic nitric oxide synthase (NOS)-expressing neurons but do not upregulate the inducible NOS in transgenic Tg2576 mouse brain with Alzheimer pathology. Neurosci. Lett. 302, 73-76.
11. Hsiao K. K., Borchelt D. R., Olson K., Johannsdottir R., Kitt C., Yunis W., Xu S., Eckman C., Younkin S., Price D., Iadecola C., Clark H. B. and Carlson G. (1995) Age related cns disorder and early death in transgenic fvb/n mice overexpressing Alzheimer amyloid precursor proteins. Neuron 15, 1203-1218.
12. Kalback W., Watson M. D., Kokjohn T. A., Kuo Y. M., Weiss N., Luehrs D. C., Lopez J., Brune D., Sisodia S. S., Staufenbiel M., Emmerling M. and Roher A. E. (2002) APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques. Biochemistry 41, 922-928.
13. King D. L. and Arendash G. W. (2002) Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months. Physiol. Behav. 75, 627-642.
14. Lue L. F., Walker D. G. and Rogers J. (2001) Modeling microglial activation in Alzheimer's disease with human postmortem microglial cultures. Neurobiol. Aging 22, 945-956.
15. Mehlhorn G., Hollborn M. and Schliebs R. (2000) Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology. Int. J. Dev Neurosci. 18, 423-431.
16. Morgan D., Diamond D. M., Gottschall P. E., Ugen K. E., Dickey C., Hardy J., Duff K., Jantzen P., DiCarlo G., Wilcock D., Connor K., Hatcher J., Hope C., Gordon M. and Arendash G. W. (2000) A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408, 982-985.
17. Neumann A., Schinzel R., Palm D., Riederer P. and Münch G. (1999) High molecular weight hyaluronic acid inhibits advanced glycation endproduct-induced NF-kappa B activation and cytokine expression. FEBS Lett. 453, 283-287.
18. Sasaki N., Takeuchi M., Chowei H., Kikuchi S., Hayashi Y., Nakano N., Ikeda H., Yamagishi S., Kitamoto T., Saito T. and Makita Z. (2002) Advanced glycation end products (AGE) and their receptor (RAGE) in the brain of patients with Creutzfeldt-Jakob disease with prion plaques. Neurosci. Lett. 326, 117-120.
19. Schenk D., Seubert P. and Ciccarelli R. B. (2001) Immunotherapy with beta-amyloid for Alzheimer's disease: a new frontier. DNA Cell Biol. 20, 679-681.
20. Selkoe D. J. (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81, 741-766.
21. Selkoe D. J., Abraham C. R., Podlisny M. B. and Duffy L. K. (1986) Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. J. Neurochem. 46, 1820-1834.
22. Shapira R., Austin G. E. and Mirra S. S. (1988) Neuritic plaque amyloid in Alzheimer's disease is highly racemized. J. Neurochem. 50, 69-74.
23. Smith M. A., Hirai K., Hsiao K., Pappolla M. A., Harris P. L., Siedlak S. L., Tabaton M. and Perry G. (1998) Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress. J. Neurochem. 70, 2212-2215.
24. Takeda A., Yasuda T., Miyata T., Goto Y., Wakai M., Watanabe M., Yasuda Y., Horie K., Inagaki T., Doyu M., Maeda K. and Sobue G. (1998) Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer's disease brain. Acta Neuropathol 95, 555-558.
25. Wong A., Dukic-Stefanovic S., Gasic-Milenkovic J., Schinzel R., Wiesinger H., Riederer P. and Münch G. (2001a) Anti-inflammatory antioxidants attenuate the expression of inducible nitric oxide synthase mediated by advanced glycation endproducts in murine microglia. Eur J. Neurosci. 14, 1961-1967.
26. Wong A., Luth H. J., Deuther-Conrad W., Dukic-Stefanovic S., Gasic-Milenkovic J., Arendt T. and Münch G. (2001b) Advanced glycation endproducts co-localize with inducible nitric oxide synthase in Alzheimer's disease. Brain Res. 920, 32-40.
27. Yan S. D., Yan S. F., Chen X., Fu J., Chen M., Kuppusamy P., Smith M. A., Perry G., Godman G. C., Nawroth P., Zweier J. L. and Stern D. (1995) Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide. Nat. Med. 7, 693-699.
28. Yan S. D., Stern D., Kane M. D., Kuo Y. M., Lampert H. C. and Roher A. E. (1998) RAGE-A beta interactions in the pathophysiology of Alzheimer's disease. Rest Neurol. Neurosci. 12, 167-173.