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Volumn 99, Issue 3, 2006, Pages 679-689

Gene-specific mechanisms of p53 transcriptional control and prospects for cancer therapy

Author keywords

DNA binding; Gene expression; p53; Target site selectivity; Transcription; Tumor suppressor

Indexed keywords

PROTEIN P53;

EID: 33749459941     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.20925     Document Type: Article
Times cited : (22)

References (50)
  • 1
    • 0034818446 scopus 로고    scopus 로고
    • Post-translational modifications and activation of p53 by genotoxic stresses
    • Appella E, Anderson CW. 2001. Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 268:2764-2772.
    • (2001) Eur J Biochem , vol.268 , pp. 2764-2772
    • Appella, E.1    Anderson, C.W.2
  • 2
    • 0033020147 scopus 로고    scopus 로고
    • Regulation of p53 function and stability by phosphorylation
    • Ashcroft M, Kubbutat MH, Vousden KH. 1999. Regulation of p53 function and stability by phosphorylation. Mol Cell Biol 19:1751-1758.
    • (1999) Mol Cell Biol , vol.19 , pp. 1751-1758
    • Ashcroft, M.1    Kubbutat, M.H.2    Vousden, K.H.3
  • 5
    • 0036145018 scopus 로고    scopus 로고
    • Multiple roles of the tumor suppressor p53
    • Bargonetti J, Manfredi JJ. 2002. Multiple roles of the tumor suppressor p53. Curr Opin Oncol 14:86-91.
    • (2002) Curr Opin Oncol , vol.14 , pp. 86-91
    • Bargonetti, J.1    Manfredi, J.J.2
  • 6
    • 0027749169 scopus 로고
    • A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein
    • Bargonetti J, Manfredi JJ, Chen X, Marshak DR, Prives C. 1993. A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein. Genes Dev 7:2565-2574.
    • (1993) Genes Dev , vol.7 , pp. 2565-2574
    • Bargonetti, J.1    Manfredi, J.J.2    Chen, X.3    Marshak, D.R.4    Prives, C.5
  • 7
  • 11
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
    • Cho Y, Gorina S, Jeffrey PD, Pavletich NP. 1994. Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations. Science 265:346-355.
    • (1994) Science , vol.265 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffrey, P.D.3    Pavletich, N.P.4
  • 13
    • 0018743916 scopus 로고
    • Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse
    • DeLeo AB, Jay G, Appella E, Dubois GC, Law LW, Old LJ. 1979. Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc Natl Acad Sci USA 76:2420-2424.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 2420-2424
    • DeLeo, A.B.1    Jay, G.2    Appella, E.3    Dubois, G.C.4    Law, L.W.5    Old, L.J.6
  • 16
    • 0034881964 scopus 로고    scopus 로고
    • Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment
    • Espinosa JM, Emerson BM. 2001. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol Cell 8:57-69.
    • (2001) Mol Cell , vol.8 , pp. 57-69
    • Espinosa, J.M.1    Emerson, B.M.2
  • 18
    • 0029783722 scopus 로고    scopus 로고
    • A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis
    • Friedlander P, Haupt Y, Prives C, Oren M. 1996. A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis. Mol Cell Biol 16:4961-4971.
    • (1996) Mol Cell Biol , vol.16 , pp. 4961-4971
    • Friedlander, P.1    Haupt, Y.2    Prives, C.3    Oren, M.4
  • 21
    • 0026650531 scopus 로고
    • A transcriptionally active DNA-binding site for human p53 protein complexes
    • Funk WD, Pak DT, Karas RH, Wright WE, Shay JW. 1992. A transcriptionally active DNA-binding site for human p53 protein complexes. Mol Cell Biol 12:2866-2871.
    • (1992) Mol Cell Biol , vol.12 , pp. 2866-2871
    • Funk, W.D.1    Pak, D.T.2    Karas, R.H.3    Wright, W.E.4    Shay, J.W.5
  • 22
    • 0030797585 scopus 로고    scopus 로고
    • Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    • Gu W, Roeder RG. 1997. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90:595-606.
    • (1997) Cell , vol.90 , pp. 595-606
    • Gu, W.1    Roeder, R.G.2
  • 24
    • 0032475885 scopus 로고    scopus 로고
    • Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2
    • Iwabuchi K, Li B, Massa HF, Trask BJ, Date T, Fields S. 1998. Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2. J Biol Chem 273:26061-26068.
    • (1998) J Biol Chem , vol.273 , pp. 26061-26068
    • Iwabuchi, K.1    Li, B.2    Massa, H.F.3    Trask, B.J.4    Date, T.5    Fields, S.6
  • 25
    • 0037039319 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo
    • Kaeser MD, Iggo RD. 2002. Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo. Proc Natl Acad Sci USA 99:95-100.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 95-100
    • Kaeser, M.D.1    Iggo, R.D.2
  • 27
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzle and paradigm
    • Ko LJ, Prives C. 1996. p53: Puzzle and paradigm. Genes Dev 10:1054-1072.
    • (1996) Genes Dev , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 28
    • 0018348655 scopus 로고
    • T antigen is bound to a host protein in SV40-transformed cells
    • Lane DP, Crawford LV. 1979. T antigen is bound to a host protein in SV40-transformed cells. Nature 278:261-263.
    • (1979) Nature , vol.278 , pp. 261-263
    • Lane, D.P.1    Crawford, L.V.2
  • 31
    • 0029742781 scopus 로고    scopus 로고
    • Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function
    • Ludwig RL, Bates S, Vousden KH. 1996. Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function. Mol Cell Biol 16:4952-4960.
    • (1996) Mol Cell Biol , vol.16 , pp. 4952-4960
    • Ludwig, R.L.1    Bates, S.2    Vousden, K.H.3
  • 37
    • 0020682479 scopus 로고
    • Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen
    • Oren M, Levine AJ. 1983. Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen. Proc Natl Acad Sci USA 80:56-59.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 56-59
    • Oren, M.1    Levine, A.J.2
  • 38
    • 0029126566 scopus 로고
    • The basic carboxy-terminal domain of human p53 is dispensable for both transcriptional regulation and inhibition of tumor cell growth
    • Pellegata NS, Cajot JF, Stanbridge EJ. 1995. The basic carboxy-terminal domain of human p53 is dispensable for both transcriptional regulation and inhibition of tumor cell growth. Oncogene 11:337-349.
    • (1995) Oncogene , vol.11 , pp. 337-349
    • Pellegata, N.S.1    Cajot, J.F.2    Stanbridge, E.J.3
  • 39
    • 0032931517 scopus 로고    scopus 로고
    • The p53 pathway
    • Prives C, Hall PA. 1999. The p53 pathway. J Pathol 187:112-126.
    • (1999) J Pathol , vol.187 , pp. 112-126
    • Prives, C.1    Hall, P.A.2
  • 40
    • 0037038699 scopus 로고    scopus 로고
    • Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites
    • Qian H, Wang T, Naumovski L, Lopez CD, Brachmann RK. 2002. Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites. Oncogene 21:7901-7911.
    • (2002) Oncogene , vol.21 , pp. 7901-7911
    • Qian, H.1    Wang, T.2    Naumovski, L.3    Lopez, C.D.4    Brachmann, R.K.5
  • 41
    • 0346729917 scopus 로고    scopus 로고
    • Multiple response elements and differential p53 binding control Perp expression during apoptosis
    • Reczek EE, Flores ER, Tsay AS, Attardi LD, Jacks T. 2003. Multiple response elements and differential p53 binding control Perp expression during apoptosis. Mol Cancer Res 1:1048-1057.
    • (2003) Mol Cancer Res , vol.1 , pp. 1048-1057
    • Reczek, E.E.1    Flores, E.R.2    Tsay, A.S.3    Attardi, L.D.4    Jacks, T.5
  • 45
    • 0034142034 scopus 로고    scopus 로고
    • The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
    • Shieh SY, Ahn J, Tamai K, Taya Y, Prives C. 2000. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 14:289-300.
    • (2000) Genes Dev , vol.14 , pp. 289-300
    • Shieh, S.Y.1    Ahn, J.2    Tamai, K.3    Taya, Y.4    Prives, C.5
  • 48
    • 0037075898 scopus 로고    scopus 로고
    • Activation of the p53 tumor suppressor protein
    • Vousden KH. 2002. Activation of the p53 tumor suppressor protein. Biochim Biophys Acta 1602:47-59.
    • (2002) Biochim Biophys Acta , vol.1602 , pp. 47-59
    • Vousden, K.H.1
  • 49
    • 0034671731 scopus 로고    scopus 로고
    • Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function
    • Wadhwa R, Sugihara T, Yoshida A, Nomura H, Reddel RR, Simpson R, Maruta H, Kaul SC. 2000. Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res 60:6818-6821.
    • (2000) Cancer Res , vol.60 , pp. 6818-6821
    • Wadhwa, R.1    Sugihara, T.2    Yoshida, A.3    Nomura, H.4    Reddel, R.R.5    Simpson, R.6    Maruta, H.7    Kaul, S.C.8
  • 50
    • 0037370357 scopus 로고    scopus 로고
    • Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding
    • Wang W, Takimoto R, Rastinejad F, El-Deiry WS. 2003. Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding. Mol Cell Biol 23:2171-2181.
    • (2003) Mol Cell Biol , vol.23 , pp. 2171-2181
    • Wang, W.1    Takimoto, R.2    Rastinejad, F.3    El-Deiry, W.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.