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Volumn 122, Issue 8, 2000, Pages 1840-1841

NMR evidence for an unusually low N1 pK(a) for uracil bound to uracil DNA glycosylase: Implications for catalysis [20]

Author keywords

[No Author keywords available]

Indexed keywords

PYRIMIDINE NUCLEOSIDE; URACIL; URACIL DNA GLYCOSYLTRANSFERASE;

EID: 0034090941     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja993254x     Document Type: Letter
Times cited : (78)

References (27)
  • 18
    • 0343107610 scopus 로고    scopus 로고
    • note
    • 5 and the complementary oligonucleotides were 5′-GCGCAX-AGTCG-3′, and 5′-CGACTATGCGC-3′, where X denotes the abasic site.
  • 19
    • 0004176449 scopus 로고
    • Oxford University Press Inc.: New York
    • ex. It is unlikely that the enzyme selectively binds the N1-deprotonated tautomer of free uracil from solution because the NMR spectrum in Figure 2B shows that both anionic and neutral forms are bound at pH 6.3.
    • (1995) Nuclear Magnetic Resonance , pp. 47
    • Hore, P.J.1
  • 21
    • 0343979466 scopus 로고    scopus 로고
    • Unpublished results
    • 13C KIE of 1.005 ± 0.013, consistent with a late oxycarbenium ion transition state in which the N1-C1′ bond is largely broken.
    • Werner, R.M.1    Stivers, J.T.2
  • 23
    • 0001110143 scopus 로고
    • T (see Chiang, Y.; Kresge, A. J. Science 1991, 253, 395-400). This possibility is being tested.
    • (1991) Science , vol.253 , pp. 395-400
    • Chiang, Y.1    Kresge, A.J.2
  • 27
    • 0007239817 scopus 로고    scopus 로고
    • Erithacus Software Ltd.; Staines, U.K.
    • Leatherbarrow, R. J. GraFit 4.0; Erithacus Software Ltd.; Staines, U.K., 1998.
    • (1998) GraFit 4.0
    • Leatherbarrow, R.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.