Solution Structure and Base Perturbation Studies Reveal a Novel Mode of Alkylated Base Recognition by 3-Methyladenine DNA Glycosylase I

Journal of Biological Chemistry

Volumn 278, Issue 48, 2003, Pages 48012-48020

  Cao, Chunyang ^a   Kwon, Keehwan ^a   Jiang, Yu Lin ^a   Drohat, Alexander C ^a   Stivers, James T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; DNA; ENZYMES; HYDROGEN BONDS; MUTAGENESIS; PERTURBATION TECHNIQUES;

BASE RECOGNITION;

BIOCHEMISTRY;

3 METHYLADENINE; 3 METHYLADENINE DNA GLYCOSYLASE 1; ADENINE; CATION; DNA; DNA GLYCOSYLTRANSFERASE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CONFORMATIONAL TRANSITION; DNA REPAIR; ENZYME STRUCTURE; HUMAN; HYDROGEN BOND; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ADENINE; ALKYLATION; BINDING SITES; CARBOXYLIC ACIDS; CATALYSIS; CATIONS; DNA GLYCOSYLASES; DNA REPAIR; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; SPECTROMETRY, FLUORESCENCE; TEMPERATURE; THERMODYNAMICS;

EID: 0348111465     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M307500200     Document Type: Article

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