Role of electrophilic and general base catalysis in the mechanism of Escherichia coli uracil DNA glycosylase

Biochemistry

Volumn 38, Issue 37, 1999, Pages 11866-11875

  Drohat, Alexander C ^a   Jagadeesh, Jayashree ^a   Ferguson, Eric ^a   Stivers, James T ^a  

^a UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

URACIL DNA GLYCOSYLTRANSFERASE;

ARTICLE; CATALYSIS; DNA REPAIR; ENZYME MECHANISM; ESCHERICHIA COLI; HYDROLYSIS; NONHUMAN; PH; PRIORITY JOURNAL; REACTION ANALYSIS;

ASPARAGINE; ASPARTIC ACID; BINDING SITES; CATALYSIS; DEUTERIUM OXIDE; DNA GLYCOSYLASES; ESCHERICHIA COLI; GLUTAMINE; HISTIDINE; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; MUTAGENESIS, SITE-DIRECTED; N-GLYCOSYL HYDROLASES; SOLVENTS; SUBSTRATE SPECIFICITY; URACIL; URACIL-DNA GLYCOSIDASE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; FELIS CATUS; STAPHYLOCOCCUS PHAGE 187;

EID: 0033554424     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9910878     Document Type: Article

References (31)

1. Friedberg, E. C. (1985) in DNA Repair, W. H. Freeman, New York.
2. Mosbaugh, D. W., and Bennett, S. E. (1994) Prog. Nucleic Acid Res. Mol. Biol. 48, 315-370.
3. Horenstein, B. A., Parkin, D. W., Estupinan, B., and Schramm, V. L. (1991) Biochemistry 30, 10788-10795.
4. Mentch, F., Parkin, D. W., and Schramm, V. L. (1987) Biochemistry 26, 921-930.
5. Zoltewicz, J. A., Clark, F. D., Sharpless, T. W., and Grahe, G. (1970) J. Am. Chem. Soc. 92, 1741-1750.
6. Garrett, E. R., and Mehta, P. J. (1972) J. Am. Chem. Soc. 94, 8542-8547.
7. Parkin, D. W., and Schramm, V. L. (1987) Biochemistry 26, 913-920.
8. Shapiro, R., and Kang, S. (1969) Biochemistry 8, 1806-1810.
9. Shapiro, R., and Danzig, M. (1972) Biochemistry 11, 23-29.
10. Parikh, S. S., Mol, C. D., Slupphaug, G., Bharati, S., Krokan, H. E., and Tainer, J. A. (1998) EMBO J. 17, 5214-5226.
11. Mol, C. D., Arvai, A. S., Slupphaug, G., Kavli, B., Alseth, I., Krokan, H. E., and Tainer, J. A. (1995) Cell 80, 869-878.
12. Savva, R., McAuley-Hecht, K., Brown, T., and Pearl, L. (1995) Nature 373, 487-493.
13. Slupphaug, G., Mol, C. D., Kavli, B., Arvai, A. S., Krokan, H. E., and Tainer, J. A. (1996) Nature 384, 87-92.
14. Xiao, G., Tordova, M., Jagadeesh, J., Drohat, A. C., Stivers, J. T., and Gilliland, G. L. (1999) Proteins 35, 13-24.
15. Stivers, J. T., Pankiewicz, K. W., and Watanabe, K. A. (1999) Biochemistry 38, 952-963.
16. Drohat, A. C., Xiao, G., Tordova, M., Jagadeesh, J., Pankiewicz, K. W., Watanabe, K. A., Gilliland, G. L., and Stivers, J. T. (1999) Biochemistry 38, 11876-11886.
17. Fasman, G. D. (1975) in Handbook of Biochemistry and Molecular Biology: Nucleic Acids, Vol. 1, CRC Press, Boca Raton, FL.
18. Stivers, J. T. (1998) Nucleic Acids Res. 26, 3837-3844.
19. Lindahl, T., Ljungquist, S., Siegert, W., Nyberg, B., and Sperens, B. (1977) J. Biol. Chem. 252, 3286-3294.
20. Kuzmic, P. (1996) Anal. Biochem. 237, 260-273.
21. Leatherbarrow, R. J. (1998) GraFit 4.0, Erithacus Software Ltd., Staines, U.K.
22. Varshney, U., and van de Sande, J. H. (1991) Biochemistry 30, 4055-4061.
23. Stivers, J. T., Abeygunawardana, C., Mildvan, A. S., Hajipour, G., and Whitman, C. P. (1996) Biochemistry 35, 814-823.
24. Saenger, W. (1984) in Principles of Nucleic Acid Structure, Springer-Verlag, New York.
25. Cleland, W. W. (1977) Adv. Enzymol. Relat. Areas Mol. Biol. 45, 273-387.
26. Quinn, D. M., and Sutton, L. D. (1990) in Enzyme Mechansim from Isotope Effects (Cook, P. F., Ed.) CRC Press, Boca Raton, FL.
27. Wells, J. A. (1990) Biochemistry 29, 8509-8517.
28. Sinnott, M. L. (1990) Chem. Rev. 90, 1171-1202.
29. Stivers, J. T., Shuman, S., and Mildvan, A. S. (1994) Biochemistry 33, 327-339.
30. Degano, M., Gopaul, D. N., Scapin, G., Schramm, V. L., and Sacchettini, J. C. (1996) Biochemistry 35, 5971-5981.
31. Guan, Y., Manuel, R. C., Arvai, A. S., Parikh, S. S., Mol, C. D., Miller, J. H., Lloyd, S., and Tainer, J. A. (1998) Nat. Struct. Biol. 5, 1058-1064.