Design, synthesis, and structure - Activity relationships for chimeric inhibitors of Hsp90

Journal of Organic Chemistry

Volumn 71, Issue 20, 2006, Pages 7618-7631

  Shen, Gang ^a   Wang, Mingwen ^a   Welch, Timothy R ^a   Blagg, Brian S J ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; AGENTS; DEGRADATION; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

ANTIPROLIFERATIVE ACTIVITY; MACROCYLIC CHIMERAS; MOLECULAR MODELING;

PROTEINS;

CHAPERONE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90 INHIBITOR; NATURAL PRODUCT; RADANAMYCIN; RADICICOL; UNCLASSIFIED DRUG;

ARTICLE; CANCER THERAPY; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR MODEL; PROTEIN DEGRADATION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BENZOQUINONES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MACROLIDES; MOLECULAR CHAPERONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33749132153     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo061054f     Document Type: Article

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