Quantum chemical calculations and mutational analysis suggest heat shock protein 90 catalyzes trans-cis isomerization of geldanamycin

Chemistry and Biology

Volumn 11, Issue 7, 2004, Pages 991-998

  Lee, Yong Sok ^a   Marcu, Monica G ^b   Neckers, Len ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BENZOQUINONE DERIVATIVE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; MACROCYCLIC LACTAM; QUINONE DERIVATIVE; SERINE;

ARTICLE; CATALYSIS; CHEMISTRY; ISOMERISM; METABOLISM; QUANTUM THEORY; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; BENZOQUINONES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; HSP90 HEAT-SHOCK PROTEINS; ISOMERISM; LACTAMS, MACROCYCLIC; QUANTUM THEORY; QUINONES; SERINE; THERMODYNAMICS;

EID: 3242893125     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2004.05.010     Document Type: Article

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