Accumulation of dolichol in older tissues satisfies the proposed criteria to be qualified a biomarker of aging

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 60, Issue 1, 2005, Pages 39-43

  Parentini, Ilaria ^a   Cavallini, Gabriella ^a   Donati, Alessio ^a   Gori, Zina ^a   Bergamini, Ettore ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DIGOXIN; DOLICHOL;

AGE; AGING; ARTICLE; BIOACCUMULATION; CALORIC RESTRICTION; EXERCISE; GENDER; HUMAN; LIFESPAN; MAMMAL; MODEL; NONHUMAN; PRIORITY JOURNAL; RELIABILITY; TIME; TRISOMY 21;

EID: 14644440847     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/60.1.39     Document Type: Article

References (54)

1. Sprott RL, Baker GT (eds). Special Issue on Biomarkers of Aging. Exp Gerontol. 1988;23:223-438.
2. Mooradian AD. Biomarkers of aging: do we know what to look for? J Gerontol. 1990;45:B183-B186.
3. Rip JW, Rupar CA, Ravi K, Carroll KK. Distribution, metabolism and function of dolichol and polyprenols. Prog Lipid Res. 1985;24: 269-309.
4. Chojnacki T, Dallner G. The biological role of dolichol. Biochem J. 1988;251:1-9.
5. Burgos J, Hemming FW, Pennock JF, Morton RA. Dolichol: a naturally occurring C100 isoprenoid alcohol. Biochem J. 1963;88:470-482.
6. Carroll KK, Guthrie N, Ravi K. Dolichol: function, metabolism, and accumulation in human tissues. Biochem Cell Biol. 1992;70:382-384.
7. Eggens I, Chojnacki T, Kenne L, Dallner G. Separation, quantitation and distribution of dolichol and dolichyl phosphate in rat and human tissues. Biochim Biophys Acta. 1983;751:355-368.
8. Keller RK. Squalene synthase inhibition alters metabolism of non-sterols in rat liver. Biochim Biophys Acta. 1996;1303:169-179.
9. Marinari UM, Pronzato MA, Dapino D, Gazzo P. Traverse N, Cottalasso D, Odetti P. Effects of simvastatin on liver and plasma levels of cholesterol, dolichol and ubiquinol in hypercholesterolemic rats. Ital J Biochem. 1995;44:1-9.
10. Sakakihara Y, Hoa TJ, Kamoshita S. Age-associated decrease of total dolichol in human serum. Clin Chim Acta. 1989;184:333-334.
11. Yasugi E, Oshima M. Sequential microanalysis of free dolichol, dolichyl fatty acid ester and dolichyl phosphate levels in human serum. Biochim Biophys Acta. 1994;1211:107-113.
12. Elmberger PG, Kalen A, Brunk UT, Dallner G. Discharge of newly-synthesized dolichol and ubiquinone with lipoproteins to rat liver perfusate and to the bile. Lipids. 1989;24:919-930.
13. Cavallini G, Bergamini E, Di Stefano R, Donati A, Maccheroni M, Masini M, Mosca F, Parentini I, Pollera M, Gori Z. The fate of dolichol in rat cells and tissues. Biogerontology. 2003;4:347-351.
14. Humaloja K, Salaspuro M, Roine RP. Biliary excretion of dolichols and beta-hexosaminidase-effect of ethanol and glucagon. Lipids. 1997; 32:1169-1172.
15. Humaloja K, Roine RP, Vuoristo M, Farkkila M, Hockerstedt K, Salaspuro M. Serum dolichols in chronic cholestatic liver diseases. J Hepatol. 1999;31:1014-1019.
16. Parentini I, Bergamini E, Cecchi L, Cavallini G, Donati A, Maccheroni M, Tamburini I, Gori Z. The effect of carbon tetrachloride and ultraviolet radiation on dolichol levels in liver cells isolated from 3- and 24-month-old male Sprague-Dawley rats. Biogerontology. 2003;4:365-370.
17. Bizzarri R, Cerbai B, Signori F, Solaro R, Bergamini E, Tamburini I, Chiellini E. New perspectives for (S)-dolichol and (S)- nor dolichol synthesis and biological functions. Biogerontology. 2003;4:353-363.
18. Yamada K, Yokohama H, Abe S, Katayama K, Sato T. High-per-formance liquid Chromatographic method for the determination of dolichols in tissues and plasma. Anal Biochem. 1985;150:26-31.
19. Pullarkat RK, Reha H. Accumulation of dolichols in brains of elderly. J Biol Chem. 1982;257:5991-5993.
20. Kalen A, Appelkvist EL, Dallner G. Age-related changes in the lipid compositions of rat and human tissues. Lipids. 1989;24:579-584.
21. Pullarkat RK, Reha H, Pullarkat PS. Age-associated increase of free dolichol levels in mice. Biochim Biophys Acta. 1984;793:494-496.
22. Daniels I, Hemming FW. Changes in murine tissue concentrations of dolichol and dolichol derivatives associated with age. Lipids. 1990; 25:586-593.
23. Thelin A, Runquist M, Ericsson J, Swiezewska E, Dallner G. Age-dependent changes in rat liver prenyltransferases. Mech Ageing Dev. 1994;76:165-176.
24. Ishinaga M. Effects of aging and diet on the accumulation of dolichol in rat tissues. Biochem Cell Biol. 1996;74:265-270.
25. Marino M, Dolfi C, Paradiso C, Cavallini G, Masini M, Gori Z, Pollera M, Trentalance A, Bergamini E. Age-dependent accumulation of dolichol in rat liver: is tissue dolichol a biomarker of aging? J Gerontol Biol Sci. 1998;53:B87-B93.
26. Dini B, Dolfi C, Santucci V, Cavallini G, Donati A, Gori Z, Maccheroni M, Bergamini E. Effects of ageing and increased haemolysis on the levels of dolichol in rat spleen. Exp Gerontol. 2001;37:99-105.
27. Cavallini G, Dolfi C, Donati A, Maccheroni M, Parentini I, Gori Z, Bergamini E. Effect of increasing age on tissue dolichol levels in ad libitum fed and food-restricted rats. Biogerontology. 2003;4:341-345.
28. Dolfi C, Bergamini E, Carresi C, Cavallini G, Donati A, Maccheroni M, Parentini I, Marino M, Gori Z. The age-related accumulation of dolichol in rat liver may correlate with expectation of life. Biogerontology. 2003;4:113-118.
29. Marino M, Pallottini V, D'Eramo C, Cavallini G, Bergamini E, Trentalance A. Age-related changes of cholesterol and dolichol biosynthesis in rat liver. Mech Ageing Dev. 2002;123:1183-1189.
30. Dolfi C, Cavallini G, Donati A, Gori Z, Innocenti B, Maccheroni M, Paradiso C, Pollera M, Bergamini E. Accumulo senile del dolicolo: un biomarcatore di invecchiamento? G Gerontol. 1999;47:275-276.
31. 4 on the retinol and dolichol content of rat liver parenchymal and non-parenchymal cells. Life Sci. 2000;67:2293-2304.
32. Casu A, Bassi AM, Canepa C, Maloberti G, Nanni G. Thioacetamide impairs retinol storage and dolichol content in rat liver cells in vivo. Biochim Biophys Acta. 2002;1583:266-272.
33. Schedin S, Pentchev PG, Brunk U, Dallner G. Changes in the levels of dolichol and dolichyl phosphate in a murine model of Niemann-Pick's type C disease. J Neurochem. 1995;65:670-676.
34. Eggens I, Backman L, Jakobsson A, Valtersson C. The lipid composition of highly differentiated human hepatomas, with special reference to fatty acids. Br J Exp Pathol. 1988;69:671-683.
35. Edlund C, Soderberg M, Kristensson K. Isoprenoids in aging and neurodegeneration. Neurochem Int. 1994;25:35-38.
36. Brooksbank BW, Martinez M. Lipid abnormalities in the brain in adult Down's syndrome and Alzheimer's disease. Mol Chem Neuropathol. 1989;11:157-185.
37. Kothapalli R, Guthrie N, Haines MD, Carroll KK. Variations in serum levels of dolichol and its occurrence in human atherosclerotic plaques. Biochem Cell Biol 1994;72:62-65.
38. Cerami A. Hypothesis. Glucose as a mediator of aging. J Am Geriatr Soc. 1985;33:626-634.
39. Sharma C, Depaolo CJ 3rd, Dalferes ER Jr, Radhakrishnamurthy B, Berenson GS. Dolichol synthesis in liver slices of streptozotocin diabetic rats. Proc Soc Exp Biol Med. 1987;185:347-351.
40. Cavallini G, Parentini I, Di Stefano R, Maccheroni M, Masini M, Pollera M, Gori Z, Mosca F, Bergamini E. Dolichol levels in younger and older rat hearts heterotopically transplanted in younger recipients. Lipids. 2002;37:913-916.
41. Cavallini G, Di Stefano R, Parentini I, Rossi S, Mosca F, Odetti P, Bergamini E. Effects of transplantation in a younger recipeints on the levels of dolichol and pentosidine in older rat hearts. Biogerontology. 2002;3(suppl 1):4-5.
42. Cavallini G, Donati A, Gori Z, Parentini I, Bergamini E. Low level dietary restriction retards age-related dolichol accumulation. Aging Clin Exp Res. 2002;14:152-154.
43. Duffy PH, Seng JE, Lewis SM, Mayhugh MA, Aidoo A, Hattan DG, Casciano DA, Feuers RJ. The effects of different levels of dietary restriction on aging and survival in the Sprague-Dawley rat: implications for chronic studies. Aging (Milano). 2001;13:263-272.
44. Zhang Y, Appelkvist EL, Kristensson K, Dallner G. The lipid compositions of different regions of rat brain during development and aging. Neurobiol Aging. 1996;17:869-875.
45. Andersson M, Aberg F, Teclebrhan H, Edlund C, Appelkvist EL. Age-dependent modifications in the metabolism of mevalonate pathway lipids in rat brain. Mech Ageing Dev. 1995;85:1-14.
46. Gronar Y, Elson A. Down syndrome, molecular genetics. In: Dulbecco R, ed. Encyclopedia of Human Biology, 2nd Ed. New York: Academic Press; 1997:463-464.
47. Kurup RK, Kurup PA. Hypothalamic digoxin-mediated model for trisomy 21. Pediatr Pathol Mol Med. 2003;22:411-422.
48. Humaloja K, Roine RP, Salmela K, Halmesmaki E, Jokelainen K, Salaspuro M. Serum dolichols in different clinical conditions. Scand J Clin Lab Invest. 1991;51:705-709.
49. Di Stefano R, Bonanomi G, Cavallini G, Masini M, Rio A, Bergamini E, Mosca F. Influence of a younger environment on organ transplantation from elderly donors. Transplant Proc. 2001;33:901-902.
50. Berg JM, Tymoczko JL, Stryer L. Biochemistry, 5th Intl Ed. San Francisco: WH Freeman & Co; 2002:726-727.
51. Pallottini V, Pascolini A, Cavallini G, Gori Z, Bergamini E, Incerpi S, Trentalance A. ROS influence on HMG-CoA reductase: a study on the key enzyme of cholesterologenesis [Abstract]. Proc 55th Congr Soc It Fisiol. 2004:96.
52. De Cabo R, Cabello R, Lopez-Lluch G, Ingram DK, Lane MA, Navas P. Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liver. Exp Gerontol. 2004;39: 297-304.
53. Tamburini I, Quartacci MF, Izzo R, Bergamini E. Effects of caloric restriction on age-related changes in the phospholipid fatty acid composition of various rat tissues. Aging Clin Exp Res. In press.
54. Bergamini E, Bizzarri R, Cavallini G, Cerbai B, Chiellini E, Donati A, Gori Z, Manfrini A, Parentini I, Signori F, Tamburini I. Ageing and oxidative stress: a role for dolichol in the antioxidant machinery of cell membranes? J Alzheimers Dis. 2004;6:129-135.