The role of geranylgeranylated proteins in human mesangial cell proliferation

Kidney International

Volumn 70, Issue 7, 2006, Pages 1296-1304

  Khwaja, A ^a   Sharpe, C C ^a   Noor, M ^a   Hendry, B M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Apoptosis; Geranylgeranyl; Mesangial; Proliferation; Rho

Indexed keywords

ACTIN; BROXURIDINE; CLOSTRIDIUM TOXIN; EXOENZYME C3; GERANYLGERANYL PYROPHOSPHATE; GGTI 298; HOE 33342; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLATELET DERIVED GROWTH FACTOR; PROTEIN; PROTEIN KINASE B; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSKELETON; CYTOSOL; ENZYME ACTIVATION; ENZYME INHIBITION; GLOMERULUS; HEMODYNAMICS; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; KIDNEY FIBROSIS; MESANGIUM CELL; PRENYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STAINING; WESTERN BLOTTING;

ALKYL AND ARYL TRANSFERASES; APOPTOSIS; BENZAMIDES; BLOTTING, WESTERN; BROMODEOXYURIDINE; CELL PROLIFERATION; CELLS, CULTURED; CULTURE MEDIA; CYTOSKELETON; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOHISTOCHEMISTRY; LOVASTATIN; MESANGIAL CELLS; PROTEIN ISOPRENYLATION; PROTEIN PRENYLATION; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; STAINING AND LABELING;

EID: 33748949083     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5001713     Document Type: Article

References (53)

1. Griffin SV, Pichler R, Dittrich M et al. Cell cycle control in glomerular disease. Springer Semin Immunopathol 2003; 24: 441-457.
2. Schocklmann HO, Lang S, Sterzel RB. Regulation of mesangial cell proliferation. Kidney Int 1999; 56: 1199-1207.
3. Floege J, Ostendorf T, Janssen U et al. Novel approach to specific growth factor inhibition in vivo: antagonism of platelet-derived growth factor in glomerulonephritis by aptamers. Am J Pathol 1999; 154: 169-179.
4. Jefferson JA, Johnson RJ. Experimental mesangial proliferative glomerulonephritis (the anti-Thy-1.1 model). J Nephrol 1999; 12: 297-307.
5. Gilbert RE, Kelly DJ, McKay T et al. PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis. Kidney Int 2001; 59: 1324-1332.
6. Downward J. Cell cycle: routine role for Ras. Curr Biol 1997; 7: R258-R260.
7. Downward J. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 2003; 3: 11-22.
8. Sharpe CC, Dockrell ME, Scott R et al. Evidence of a role for Ki-Ras in the stimulated proliferation of renal fibroblasts. J Am Soc Nephrol 1999; 10: 1186-1192.
9. Sharpe CC, Dockrell ME, Noor MI et al. Role of Ras isoforms in the stimulated proliferation of human renal fibroblasts in primary culture. J Am Soc Nephrol 2000; 11: 1600-1606.
10. Clarke HC, Kocher HM, Khwaja A et al. Ras antagonist farnesylthiosalicylic acid (FTS) reduces glomerular cellular proliferation and macrophage number in rat thy-1 nephritis. J Am Soc Nephrol 2003; 14: 848-854.
11. Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature 2002; 420: 629-635.
12. Olson MF, Ashworth A, Hall A. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 1995; 269: 1270-1272.
13. Nobes CD, Hall A. Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility. Biochem Soc Trans 1995; 23: 456-459.
14. Bishop AL, Hall A. Rho GTPases and their effector proteins. Biochem J 2000; 348(Part 2): 241-255.
15. Roskoski Jr R. Protein prenylation: a pivotal posttranslational process. Biochem Biophys Res Commun 2003; 303: 1-7.
16. Massy ZA, Guijarro C, Oda H et al. Importance of geranylgeranyl pyrophosphate for mesangial cell DNA synthesis. Kidney Int Suppl 1999; 71: S80-S83.
17. Laufs U, Marra D, Node K, Liao JK. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1). J Biol Chem 1999; 274: 21926-21931.
18. Kamiyama M, Utsunomiya K, Taniguchi K et al. Contribution of Rho A and Rho kinase to platelet-derived growth factor-BB-induced proliferation of vascular smooth muscle cells. J Atheroscler Thromb 2003; 10: 117-123.
19. Yoshimura A, Nemoto T, Sugenoya Y et al. Effect of simvastatin on proliferative nephritis and cell-cycle protein expression. Kidney Int Suppl 1999; 71: S84-S87.
20. Heusinger-Ribeiro J, Fischer B, Goppelt-Struebe M. Differential effects of simvastatin on mesangial cells. Kidney Int 2004; 66: 187-195.
21. Blanco-Colio LM, Villa A, Ortego M et al. 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. Atherosclerosis 2002; 161: 17-26.
22. Du W, Prendergast GC. Geranylgeranylated RhoB mediates suppression of human tumor cell growth by farnesyltransferase inhibitors. Cancer Res 1999; 59: 5492-5496.
23. Mazieres J, Tillement V, Allal C et al. Geranylgeranylated, but not farnesylated, RhoB suppresses Ras transformation of NIH-3T3 cells. Exp Cell Res 2005; 304: 354-364.
24. Forsberg M, Blomgran R, Lerm M et al. Differential effects of invasion by and phagocytosis of Salmonella typhimurium on apoptosis in human macrophages: potential role of Rho-GTPases and Akt. J Leukoc Biol 2003; 74: 620-629.
25. Hendry BM, Qu QY, Monia BP, Shankland S. Distinct functions for Ras GTPases in the control of proliferation and apoptosis in mouse and human mesangial cells. Kidney Int 2006; 69: 99-104.
26. Khwaja A, Dockrell ME, Hendry BM, Sharpe CC. Prenylation is not necessary for endogenous Ras activation in non-malignant cells. J Cell Biochem 2006; 97: 412-422.
27. Bassa BV, Roh DD, Vaziri ND et al. Effect of inhibition of cholesterol synthetic pathway on the activation of Ras and MAP kinase in mesangial cells. Biochim Biophys Acta 1999; 1449: 137-149.
28. Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000; 406: 532-535.
29. Hirai A, Nakamura S, Noguchi Y et al. Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells. J Biol Chem 1997; 272: 13-16.
30. Adnane J, Bizouarn FA, Qian Y et al. p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA. Mol Cell Biol 1998; 18: 6962-6970.
31. Danesh FR, Sadeghi MM, Amro N et al. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: implications for diabetic nephropathy. Proc Natl Acad Sci USA 2002; 99: 8301-8305.
32. Welsh CF, Roovers K, Villanueva J et al. Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol 2001; 3: 950-957.
33. Frost JA, Xu S, Hutchison MR et al. Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. Mol Cell Biol 1996; 16: 3707-3713.
34. Stork PJ. Does Rap1 deserve a bad Rap? Trends Biochem Sci 2003; 28: 267-275.
35. Ridley AJ, Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 1992; 70: 389-399.
36. Ridley AJ, Paterson HF, Johnston CL et al. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 1992; 70: 401-410.
37. Crean JK, Furlong F, Finlay D et al. Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization. FASEB J 2004; 18: 1541-1543.
38. Adamson P, Paterson HF, Hall A. Intracellular localization of the P21rho proteins. J Cell Biol 1992; 119: 617-627.
39. Porter KE, Turner NA, O'Regan DJ et al. Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. Cardiovasc Res 2004; 61: 745-755.
40. Michaelson D, Silletti J, Murphy G et al. Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding. J Cell Biol 2001; 152: 111-126.
41. Bivona TG, Perez De Castro I, Ahearn IM et al. Phospholipase Cgamma activates Ras on the golgi apparatus by means of RasGRP1. Nature 2003; 424: 694-698.
42. Dan HC, Jiang K, Coppola D et al. Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis. Oncogene 2004; 23: 706-715.
43. Murga C, Zohar M, Teramoto H, Gutkind JS. Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB. Oncogene 2002; 21: 207-216.
44. Feral CC, Nishiya N, Fenczik CA et al. CD98hc (SLC3A2) mediates integrin signaling. Proc Natl Acad Sci USA 2005; 102: 355-360.
45. Li X, Liu L, Tupper JC et al. Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells. J Biol Chem 2002; 277: 15309-15316.
46. Shimizu A, Kitamura H, Masuda Y et al. Apoptosis in the repair process of experimental proliferative glomerulonephritis. Kidney Int 1995; 47: 114-121.
47. Sugiyama H, Kashihara N, Makino H et al. Apoptosis in glomerular sclerosis. Kidney Int 1996; 49: 103-111.
48. Sharpe CC, Hendry BM. Signaling: focus on Rho in renal disease. J Am Soc Nephrol 2003; 14: 261-264.
49. Kanda T, Wakino S, Hayashi K et al. Effect of fasudil on rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats. Kidney Int 2003; 64: 2009-2019.
50. Cavarape A, Bauer J, Bartoli E et al. Effects of angiotensin II, arginine vasopressin and tromboxane A2 in renal vascular bed: role of Rho-kinase. Nephrol Dial Transplant 2003; 18: 1764-1769.
51. Cavarape A, Endlich N, Assaloni R et al. Rho-kinase inhibition blunts renal vasoconstriction induced by distinct signaling pathways in vivo. J Am Soc Nephrol 2003; 14: 37-45.
52. Pollack IF, Bredel M, Erff M et al. Inhibition of Ras and related guanosine triphosphate-dependent proteins as a therapeutic strategy for blocking malignant glioma growth: II - preclinical studies in a nude mouse model. Neurosurgery 1999; 45: 1208-1214; discussion 1214-1205.
53. Arthur WT, Ellerbroek SM, Der CJ et al. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. J Biol Chem 2002; 277: 42964-42972.