Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis

Oncogene

Volumn 23, Issue 3, 2004, Pages 706-715

  Dan, Han C ^a   Jiang, Kun ^a,b   Coppola, Domenico ^a   Hamilton, Andrew ^c   Nicosia, Santo V ^a   Sebti, Said M ^a,b   Cheng, Jin Q ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^c YALE UNIVERSITY   (United States)

Author keywords

Akt; Apoptosis; GGTI; Ovarian cancer; PI3K; Survivin

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; GERANYLTRANSFERASE; GGTI 2166; GGTI 298; GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53; SURVIVIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENZYME INHIBITION; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALKYL AND ARYL TRANSFERASES; APOPTOSIS; BENZAMIDES; CELL LINE, TUMOR; ENZYME INHIBITORS; FEMALE; HUMANS; IN SITU NICK-END LABELING; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; OVARIAN NEOPLASMS;

EID: 1242273586     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207171     Document Type: Article

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