PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis

Kidney International

Volumn 59, Issue 4, 2001, Pages 1324-1332

  Gilbert, Richard E ^a,b   Kelly, Darren J ^a,b   McKay, Tara ^a,b   Chadban, Steven ^a,b   Hill, Prudence A ^a,b   Cooper, Mark E ^a,b   Atkins, Robert C ^a,b   Nikolic Paterson, David J ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Cell proliferation; Extracellular matrix; Platelet derived growth factor; Progressive renal disease; STI 571

Indexed keywords

ALPHA ACTIN; COLLAGEN TYPE 4; FIBROBLAST GROWTH FACTOR 2; IMATINIB; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY OX 7; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR; THYMIDINE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; EXTRACELLULAR MATRIX; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FUNCTION; MALE; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROLIFERATIVE GLOMERULONEPHRITIS; PROTEINURIA; RAT; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 0035074267     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2001.0590041324.x     Document Type: Article

References (47)

1. The role of vasoactive compounds, growth factors and cytokines in the progression of renal disease
2. Role of platelet-derived growth factor in glomerular disease
3. Transforming growth factor-β in diabetic nephropathy
4. Increased distal nephron EGF content and altered distribution of peptide in compensatory renal hypertrophy
5. Increased epidermal growth factor expression in diabetes related kidney growth
6. Multiple roles for platelet-derived growth factor in renal disease
7. Mesangial cells express PDGF mRNAs and proliferate in response to PDGF
8. Visceral glomerular epithelial cells can proliferate in vivo and synthesize platelet-derived growth factor B-chain
9. Macrophages in immune renal injury
10. Mesangial cells express PDGF mRNA and proliferate in response to PDGF
11. Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycation end products is mediated via platelet-derived growth factor
12. PDGF and TGF-beta mediate collagen production by mesangial cells exposed to advanced glycosylation end products
13. Renal injury from angiotensin-mediated hypertension
14. Endothelin stimulates PDGF secretion in human mesangial cells
15. Platelet-derived growth factor synthesis in mesangial cells: Induction by multiple peptide mitogens
16. Effects of selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-abl positive cells
17. The kinetics of antibody binding to membrane antigens in solution and at the cell surface
18. The heterogeneity of mononuclear phagocytes in lymphoid organs: Distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3
19. Differential control of mesangial cell proliferation by interferon-gamma
20. De novo CD44 expression by proliferating mesangial cells in rat anti-Thy-1 nephritis
21. New micro-turbidimetric method for determination of protein in cerebrospinal fluid and urine
22. Creatinine assay by a reaction-kinetic principle
23. Vascular hypertrophy in experimental diabetes: Role of advanced glycation end products
24. Role of interleukin-1 in mesangial cell proliferation and matrix deposition in experimental mesangioproliferative nephritis
25. Application of photoshop-based image analysis to quantification of hormone receptor expression in breast cancer
26. Complete chromogen separation and analysis in double immunohistochemical stains using photoshop-based image analysis
27. The progression of renal disease
28. Studies of progressive glomerular sclerosis in the rat
29. Structural-functional relationships in diabetic nephropathy
30. Infusion of PDGF or basic FGF induces selective glomerular mesangial cell proliferation and matrix accumulation in rats
31. Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis: Alpha-smooth muscle actin is a marker of mesangial cell proliferation
32. Platelet-derived growth factor in renal development and disease
33. Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class
34. Could platelet-derived growth factor have a role in the pathogenesis of lupus nephritis?
35. Platelet-derived growth factor expression in mesangial proliferative glomerulonephritis
36. Platelet-derived growth factor mesangial deposits in mesangial IgA glomerulonephritis
37. Platelet-derived growth factor receptors in the kidney: Upregulated expression in inflammation
38. Expression of cytokines and growth factors in human glomerulonephritides
39. Demonstration of PDGF B-chain mRNA in glomeruli in mesangial proliferative nephritis by in situ hybridization
40. Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the rat remnant kidney model
41. Low-protein diet attenuates increased gene expression of platelet-derived growth factor and transforming growth factor-beta in experimental glomerular sclerosis
42. Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor
43. Novel approach to specific growth factor inhibition in vivo: Antagonism of platelet-derived growth factor in glomerulonephritis by aptamers
44. Anticancer drug targets: Growth factors and growth factor signaling
45. Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia
46. Tyrosine-kinase inhibition in treatment of chronic myeloid leukaemia
47. The commonest glomerulonephritis in the world: IgA nephropathy