pH dependence of peptidylglycine monooxygenase. Mechanistic implications of Cu-methionine binding dynamics

Biochemistry

Volumn 45, Issue 37, 2006, Pages 11140-11150

  Bauman, Andrew T ^a   Jaron, Shula ^a,b   Yukl, Erik T ^a   Burchfiel, Joel R ^a   Blackburn, Ninian J ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION SPECTROSCOPY; CATALYSIS; CHEMICAL BONDS; COMPUTER SIMULATION; CONFORMATIONS; MATHEMATICAL MODELS; PH EFFECTS; X RAY ANALYSIS;

ACTIVE SPECIES; BUFFER SYSTEMS; PEPTIDYLGLYCINE; VIBRATIONAL MODE COUPLING;

ENZYMES;

ACETIC ACID; ALPHA AMIDATING ENZYME; BUFFER; COPPER; DANSYL CHLORIDE; DANSYLTYROSYLVALYLGLYCINE; HYDROGEN; LIGAND; METHIONINE; PEPTIDE; PEPTIDYLGLYCINE MONOOXYGENASE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ABSORPTION SPECTROSCOPY; ANIMAL CELL; ARTICLE; BINDING SITE; CHEMICAL PARAMETERS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEBYE WALLER FACTOR; DEPROTONATION; DISSOCIATION CONSTANT; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INACTIVATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; MICHAELIS CONSTANT; MOLECULAR MODEL; NONHUMAN; OXYGENATION; PH; PKA; PRIORITY JOURNAL; PROTON TRANSPORT; X RAY ANALYSIS;

BINDING SITES; COPPER; DANSYL COMPOUNDS; HYDROGEN-ION CONCENTRATION; METHIONINE; MIXED FUNCTION OXYGENASES; MULTIENZYME COMPLEXES; PROTEIN BINDING;

EID: 33748775782     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060905a     Document Type: Article

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