Oxygen Activation by the Noncoupled Binuclear Copper Site in Peptidylglycine α-Hydroxylating Monooxygenase. Spectroscopic Definition of the Resting Sites and the Putative CuIIM-OOH Intermediate

Biochemistry

Volumn 43, Issue 19, 2004, Pages 5735-5747

  Chen, Peng ^a   Bell, Joseph ^b   Eipper, Betty A ^b   Solomon, Edward I ^a  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; COPPER; ELECTRONIC STRUCTURE; ENZYMES; OXYGEN; PARAMAGNETIC RESONANCE; SPECTROSCOPIC ANALYSIS;

ABSTRACTION REACTIONS; EQUATORIAL LIGANDS; GEOMETRIC MODELS; NONCOUPLED BINUCLEAR COPPER SITES;

BIOCHEMISTRY;

AZIDE; COPPER COMPLEX; COPPER PROTEIN; HISTIDINE; HYDROGEN; METHIONINE; OXYGEN; PEPTIDE; PEPTIDYLGLYCINE ALPHA HYDROXYLATING MONOOXYGENASE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; WATER;

ARTICLE; CRYSTAL STRUCTURE; DENSITY FUNCTIONAL THEORY; ELECTRON SPIN RESONANCE; ENZYME ACTIVATION; GEOMETRY; LIGAND FIELD ANALYSIS; MATHEMATICAL MODEL; MOLECULAR MODEL; OPTICAL ROTATION; OXIDATION; PRIORITY JOURNAL; SPECTROSCOPY; SPECTRUM;

BINDING SITES; CATALYTIC DOMAIN; CIRCULAR DICHROISM; COPPER; ELECTRON SPIN RESONANCE SPECTROSCOPY; HYDROXYLATION; LIGANDS; MIXED FUNCTION OXYGENASES; MODELS, CHEMICAL; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; NITRITES; OXYGEN; THERMODYNAMICS; WATER;

EID: 2442444490     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0362830     Document Type: Article

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