Response of nitric oxide production to CpG oligodeoxynucleotides in turkey and chicken peripheral blood monocytes

FEMS Immunology and Medical Microbiology

Volumn 48, Issue 1, 2006, Pages 99-106

  He, Haiqi ^a   Genovese, Kenneth J ^a   Lowry, Virginia K ^b   Nisbet, David J ^a   Kogut, Michael H ^a  

^a SOUTHERN PLAINS AGRICULTURAL RESEARCH CENTER   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Chicken; CpG oligodeoxynucleotides; Immune response; Monocytes; Nitric oxide; Turkey

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; NITRIC OXIDE; PHOSPHOROTHIOIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; CELL STIMULATION; CELLULAR IMMUNITY; CHICKEN; CONTROLLED STUDY; IMMUNE RESPONSE; NONHUMAN; NUCLEOTIDE METABOLISM; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; TURKEY (BIRD);

ANIMALS; CELL CULTURE TECHNIQUES; CHICKENS; CYTOKINES; MACROPHAGES; MONOCYTES; NITRIC OXIDE; OLIGODEOXYRIBONUCLEOTIDES; TURKEYS;

EID: 33748603503     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2006.00129.x     Document Type: Article

References (60)

1. Alam MS, Akaike T, Okamoto S, Kubota T, Yoshitake J, Sawa T, Miyamoto Y, Tamura F & Maeda H (2002) Role of nitric oxide in host defense in murine salmonellosis as a function of its antibacterial and antiapoptotic activities. Infect Immun 70: 3130-3142.
2. Ashkar AA & Rosenthal KL (2002) Toll-like receptor 9, CpG DNA and innate immunity. Curr Mol Med 2: 545-556.
3. Ballas ZK, Krieg AM, Warren T, Rasmussen W, Davis HL, Waldschmidt M & Weiner GJ (2001) Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs. J Immunol 167: 4878-4886.
4. Bauer S, Kirschning CJ, Hächer H, Redecke V, Hausmann S, Akira S, Wagner H & Lipford GB (2001) Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci USA 98: 9237-9242.
5. Bird AP (1987) CpG islands as gene markers in the vertebrate nucleus. Trends Genet 3: 342-347.
6. Chace JH, Hooker NA, Mildenstein KL, Krieg AM & Cowdery JS (1997) Bacterial DNA-induced NK cell IFN-γ production is dependent on macrophage secretion of IL-12. Clin Immunol Immunopathol 84: 185-193.
7. Colognato R, Slupsky JR, Jendrach M, Burysek L, Syrovets T & Simmet T (2003) Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells. Blood 102: 2645-2652.
8. Dalloul RA, Lillehoj HS, Okamura M, Xie H, Min W, Ding X & Heckert RA (2004) In vivo effects of CpG oligodeoxynucleotide on Eimeria infection in chickens. Avian Dis 48: 783-790.
9. DaMatta RA, Manhaes L, Seabra SH & de Souza W (1998) Coculture of chicken thrombocytes and monocytes: morphological changes and lectin binding. Biocell 22: 45-52.
10. Datta N, Mukherjee S, Das L & Das PK (2003) Targeting of immunostimulatory DNA cures experimental visceral leishmaniasis through nitric oxide up-regulation and T cell activation. Eur J Immunol 33: 1508-1518.
11. Deng JC, Moore TA, Newstead MW, Zeng X, Krieg AM & Standiford TJ (2004) CpG oligodeoxynucleotides stimulate protective innate immunity against pulmonary Klebsiella infection. J Immunol 173: 5148-5155.
12. Elkord E, Williams PE, Kynaston H & Rowbottom AW (2005) Human monocyte isolation methods influence cytokine production from in vitro generated dendritic cells. Immunology 114: 204-212.
13. Gomis S, Babiuk L, Godson DL, Allan B, Thrush T, Townsend H, Willson P, Waters E, Hecker R & Potter A (2003) Protection of chickens against Escherichia coli infections by DNA containing CpG motifs. Infect Immun 71: 857-863.
14. Gomis S, Babiuk L, Allan B, Willson P, Waters E, Ambrose N, Hecker R & Potter A (2004) Protection of neonatal chicks against a lethal challenge of Escherichia coli using DNA containing cytosine-phosphodiester-guanine motifs. Avian Dis 48: 813-822.
15. Gramzinski RA, Doolan DL, Sedegah M, Davis HL, Krieg AM & Hoffman SL (2001) Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice. Infect Immun 69: 1643-1649.
16. 15N]nitrate in biological fluids. Anal Biochem 126: 131-138.
17. Gu BJ, Sluyter R, Skarratt KK, Shemon AN, Dao-Ung LP, Fuller SJ, Barden JA, Clarke AL, Petrou S & Wiley JS (2004) An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor. J Biol Chem 279: 31287-31295.
18. Häcker G, Redecke V & Häcker H (2002) Activation of the immune system by bacterial CpG-DNA. Immunology 105: 245-251.
19. Harandi AM, Eriksson K & Holmgren J (2003) A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection. J Virol 77: 953-962.
20. Hartmann G & Krieg AM (2000) Mechanism and function of a newly identified CpG DNA motif in human primary B cells. J Immunol 164: 944-952.
21. Hartmann G, Weeratna RD, Ballas ZK et al. (2000) Delineation of CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo. J Immunol 164: 1617-1624.
22. Hartmann G, Battiany J, Poeck H, Wagner M, Kerkmann M, Lubenow N, Rothenfusser S & Endres S (2003) Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells. Eur J Immunol 33: 1633-1641.
23. He H & Kogut MH (2003) CpG ODN-induced nitric oxide production is mediated through Clathrin-dependent endocytosis, endosomal maturation, and activation of PKC, MEK1/2 and p38 MAPK, and NF-κB pathways in avian macrophage cells (HD11). Cell Signal 15: 911-917.
24. He H, Crippen TL, Farnell MB & Kogut MH (2003) Identification of CpG oligodeoxynucleotide motifs that stimulate nitric oxide and cytokine production in avian macrophage and peripheral blood mononuclear cells. Dev Comp Immunol 27: 621-627.
25. He H, Lowry VK, Swaggerty CL, Ferro PJ & Kogut MH (2005) In vitro activation of chicken leukocytes and in vivo protection against Salmonella enteritidis organ invasion and peritoneal S. enteritidis infection-induced mortality in neonatal chickens by immunostimulatory CpG oligodeoxynucleotide. FEMS Immunol Med Microbiol 43: 81-89.
26. Hemmi H, Takeuchi O, Kawai T et al. (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408: 740-745.
27. Jakob T, Walker PS, Krieg AM, Von Stebut E, Udey MC & Vogel JC (1999) Bacterial DNA and CpG-containing oligodeoxynucleotides activate cutaneous dendritic cells and induce IL-12 production: implications for the augmentation of Th1 responses. Int Arch Allergy Immunol 118: 457-461.
28. Janeway CA Jr & Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20: 197-216.
29. Jorgensen JB, Johansen A, Stenersen B & Sommer AI (2001a) CpG oligodeoxynucleotides and plasmid DNA stimulate Atlantic salmon (Salmo salar L.) leucocytes to produce supernatants with antiviral activity. Dev Comp Immunol 25: 313-321.
30. Jorgensen JB, Zou J, Johansen A & Secombes CJ (2001b) Immunostimulatory CpG oligodeoxynucleotides stimulate expression of IL-1beta and interferon-α like cytokines in rainbow trout macrophages via a chloroquine-sensitive mechanism. Fish Shellfish Immunol 11: 673-682.
31. Kamstrup S, Verthelyi D & Klinamn DM (2001) Response of porcine peripheral blood mononuclear cells to CpG-containing oligodeoxynucleotides. Vet Microbiol 78: 353-362.
32. Klinman DM (2004) Use of CpG oligodeoxynucleotides as immunoprotective agents. Expert Opin Biol Ther 4: 937-946.
33. Klinman DM, Yi A, Beaucage SL, Conover J & Krieg AM (1996) CpG motifs expressed by bacterial DNA apidly induce lymphocytes to secrete IL-6, IL-12 and IFNγ. Proc Natl Acad Sci USA 93: 2879-2883.
34. Klinman DM, Conover J & Coban C (1999) Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection. Infect Immun 67: 5658-5663.
35. Kogut MH, McGruder ED, Hargis BM, Corrier DE & DeLoach JR (1995) In vivo activation of heterophil function in chickens following injection with Salmonella enteritidis-immune lymphokines. J Leukoc Biol 57: 56-62.
36. Krieg AM (2002) CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 20: 709-760.
37. Krieg AM, Yi A, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, Koretzky GA & Klinman DM (1995) CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374: 546-549.
38. Krieg AM, Love-Homan L, Yi AK & Harty JT (1998) CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J Immunol 161: 2428-2434.
39. Krug A, Rothenfusser S, Hornung V, Jahrsdörfer B, Blackwell S, Ballas ZK, Endres S, Krieg AM & Hartmann G (2001) Identification of CpG oligonucleotides sequences with high induction of IFN-α/β in plasmacytoid dendritic cells. Eur J Immunol 31: 2154-2163.
40. MacFarlane AS, Schwacha MG & Eisenstein TK (1999) In vivo blockage of nitric oxide with aminoguanidine inhibits immunosuppression induced by an attenuated strain of Salmonella typhimurium, potentiates Salmonella infection, and inhibits macrophage and polymorphonuclear leukocyte influx into the spleen. Infect Immun 67: 891-898.
41. Meng Z, Shao J & Xiang L (2003) CpG oligodeoxynucleotides activate grass carp (Ctenopharyngodon idellus) macrophages. Dev Comp Immunol 27: 313-321.
42. Mena A, Nichani AK, Popowych Y, Godson DL, Dent D, Townsend HG, Mutwiri GK, Hecker R, Babiuk LA & Griebel P (2003a) Innate immune responses induced by CpG oligodeoxyribonucleotide stimulation of ovine blood mononuclear cells. Immunology 110: 250-257.
43. Mena A, Nichani AK, Popowych Y, Ioannou XP, Godson DL, Mutwiri GK, Hecker R, Babiuk LA & Griebel P (2003b) Bovine and ovine blood mononuclear leukocytes differ markedly in innate immune responses induced by Class A and Class B CpG-oligodeoxynucleotide. Oligonucleotides 13: 245-259.
44. Mutwiri G, Pontarollo R, Babiuk S et al. (2003) Biological activity of immunostimulatory CpG DNA motifs in domestic animals. Vet Immunol Immunopathol 91: 89-103.
45. National Research Council. (1994) Nutrient Requirements of Poultry, 9th revised edn. Academic Press, Washington, DC.
46. Rees DG, Gates AJ, Green M, Eastaugh L, Lukaszewski RA, Griffin KF, Krieg AM & Titball RW(2005) CpG-DNA protects against a lethal orthopoxvirus infection in a murine model. Antiviral Res 65: 87-95.
47. Roberts TL, Sweet MJ, Hume DA & Stacey KJ (2005) Cutting edge: species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified oligonucleotides. J Immunol 174: 605-608.
48. Schlaepfer E, Audige A, von Beust B, Manolova V, Weber M, Joller H, Bachmann MF, Kundig TM & Speck RF (2004) CpG oligodeoxynucleotides block human immunodeficiency virus type 1 replication in human lymphoid tissue infected ex vivo. J Virol 78: 12344-12354.
49. Sester DP, Naik S, Beasley SJ, Hume DA & Stacey KJ (2000) Phosphorothioate backbone modification modulates macrophage activation by CpG DNA. J Immunol 165: 4165-4173.
50. Sun S, Zhang X, Tough DF & Sprent J (1998) Type I interferon-mediated stimulation of T cells by CpG DNA. J Exp Med 188: 2335-2342.
51. + T cells. Immunology 99: 1-7.
52. Verthelyi D, Ishii KJ, Gursel M, Takeshita F & Klinman DM (2001) Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs. J Immunol 166: 2372-2377.
53. Vleugels B, Ververken C & Goddeeris BM (2002) Stimulatory effect of CpG sequences on humanoral responses in chickens. Poultry Sci 81: 1317-1321.
54. Vollmer J, Weeratna R, Payette P et al. (2004) Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities. Eur J Immunol 34: 251-262.
55. Wongratanacheewin S, Kespichayawattana W, Intachote P, Pichyangkul S, Sermswan RW, Krieg AM & Sirisinha S (2004) Immunostimulatory CpG oligodeoxynucleotide confers protection in a murine model of infection with Burkholderia pseudomallei. Infect Immun 72: 4494-4502.
56. Xie H, Raybourne RB, Babu US, Lillehoj HS & Heckert RA (2003) CpG-induced immunomodulation and intracellular bacterial killing in a chicken macrophage cell line. Dev Comp Immunol 27: 823-834.
57. Yamamoto S, Yamamoto T, Kataoka T, Kuramoto E, Yano O & Tokunaga T (1992) Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity. J Immunol 148: 4072-4076.
58. Zhang Y, Shoda LK, Brayton KA, Estes DM, Palmer GH & Brown WC (2001) Induction of interleukin-6 and interleukin-12 in bovine B lymphocytes, monocytes and macrophages by a CpG oligodeoxynucleotide (ODN 2059) containing the GTCGTT motif. J Interferon Cytokine Res 21: 871-981.
59. Zhao Q, Temsamani J, Iadarola PL, Jiang Z & Agrawal S (1996) Effect of different chemically modified oligodeoxynucleotides on immune stimulation. Biochem Pharmacol 51: 173-182.
60. Zimmermann S, Egeter O, Hausmann S, Lipford GB, Rocken M, Wagner H & Heeg K (1998) CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. J Immunol 160: 3627-3630.