Activation of the immune system by bacterial CpG-DNA

Immunology

Volumn 105, Issue 3, 2002, Pages 245-251

  Häcker, Georg ^a   Redecke, Vanessa ^a   Häcker, Hans ^a,b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b San Diego   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; DNA; LIPOPOLYSACCHARIDE; LIPOTEICHOIC ACID;

ANTIGEN PRESENTATION; CELLULAR IMMUNITY; CPG ISLAND; DENDRITIC CELL; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOLOGY; IMMUNOSTIMULATION; MACROPHAGE; MOLECULAR DYNAMICS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

CPG ISLANDS; DNA, BACTERIAL; DROSOPHILA PROTEINS; HUMANS; IMMUNITY, CELLULAR; MEMBRANE GLYCOPROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 0036226045     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0019-2805.2001.01350.x     Document Type: Review

References (47)

1. Innate immune recognition and control of adaptive immune responses
2. How BCG led to the discovery of immunostimulatory DNA
3. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth
4. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity
5. CpG motifs in bacterial DNA trigger direct B-cell activation
6. Bacterial CpG DNA activates immune cells to signal infectious danger
7. + T cells: Implications for tumor immunotherapy
8. Introduction to immunostimulatory DNA sequences
9. CpG-oligodeoxynucleotides enhance T-cell receptor-triggered interferon-gamma production and up-regulation of CD69 via induction of antigen-presenting cell-derived interferon type I and interleukin-12
10. Poly-guanosine motifs costimulate antigen-reactive CD8 T cells while bacterial CpG-DNA affect T-cell activation via antigen-presenting cell-derived cytokines
11. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
12. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis
13. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
14. Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism
15. Macrophages ingest and are activated by bacterial DNA
16. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
17. CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry
18. NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses
19. The I kappa B kinase (IKK) and NF kappa B: Key elements of proinflammatory signalling
20. Phosphorylation meets ubiquitination: The control of NF-κB activity
21. MAP3K-related kinase involved in NF-kappa B induction by TNF, CD95 and IL-1
22. JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?
23. CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species
24. Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF) 6
25. DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA
26. Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages
27. Control of development and immunity by rel transcription factors in Drosophila
28. AP-1 function and regulation
29. Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells
30. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
31. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
32. The Toll/interleukin-1 receptor domain: A molecular switch for inflammation and host defence
33. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
34. MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
35. Identification of TRAF6, a novel tumor necrosis factor receptor- associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region
36. Signaling by proinflammatory cytokines: Oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain
37. An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways
38. Activation of the Ikappa B kinases by RIP via IKKgamma/NEMO-mediated oligomerization
39. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
40. Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88
41. A Toll-like receptor recognizes bacterial DNA
42. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG-motif recognition
43. The DNA-dependent protein kinase
44. Activation of DNA-dependent protein kinase by single-stranded DNA ends
45. Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12
46. Human Nod1 confers responsiveness to bacterial lipopolysaccharides
47. Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds