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Volumn 11, Issue 9, 2006, Pages 815-836

Subtyping schizophrenia: Implications for genetic research

Author keywords

Endophenotypes; Genetics; Heterogeneity; Pleiotropy; Schizophrenia; Subtypes

Indexed keywords

AFFECT LADEN PARAPHRENIA; AGITATED DEMENTIA PRAECOX; ANXIETY HAPPINESS PSYCHOSIS; AUDITORY HALLUCINATION; CATAPHASIA; CATATONIC SCHIZOPHRENIA; CIRCULAR DEMENTIA PRAECOX; CLINICAL FEATURE; COGNITION; COGNITIVE DEFECT; CONFUSION PSYCHOSIS; DELUSION; DEMENTIA PRAECOX SIMPLEX; DEPRESSIVE DEMENTIA PRAECOX; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE CLASSIFICATION; GENETIC HETEROGENEITY; HEBEPHRENIA; HUMAN; INTERNATIONAL CLASSIFICATION OF DISEASES; MEDICAL GENETICS; MEDICAL RESEARCH; MOOD DISORDER; MOTILITY PSYCHOSIS; MUTISM; NEGATIVE SYNDROME; NEUROIMAGING; NEUROPHYSIOLOGY; PARANOID SCHIZOPHRENIA; PERIODIC DEMENTIA PRAECOX; PERSONALITY; PERSONALITY DISORDER; PHENOTYPE; PLEIOTROPY; POSITIVE SYNDROME; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; REVIEW; SCHIZOPHASIA; SCHIZOPHRENIA; SYMPTOMATOLOGY;

EID: 33748052338     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/sj.mp.4001857     Document Type: Review
Times cited : (199)

References (331)
  • 2
    • 0003530957 scopus 로고
    • Reprinted English translation: Krieger Publishing: Huntington, New York
    • [Reprinted English translation: Dementia Praecox and Paraphrenia. Krieger Publishing: Huntington, New York, 1971].
    • (1971) Dementia Praecox and Paraphrenia
  • 5
    • 0037308528 scopus 로고    scopus 로고
    • Genes for schizophrenia? Recent findings and their pathophysiological implications
    • Harrison PJ, Owen MJ. Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet 2003; 361: 417-419.
    • (2003) Lancet , vol.361 , pp. 417-419
    • Harrison, P.J.1    Owen, M.J.2
  • 6
    • 12344327212 scopus 로고    scopus 로고
    • Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence
    • Harrison PJ, Weinberger DR. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 2004; 10: 40-68.
    • (2004) Mol Psychiatry , vol.10 , pp. 40-68
    • Harrison, P.J.1    Weinberger, D.R.2
  • 8
    • 0023791590 scopus 로고
    • Abandoning the concept of 'schizophrenia': Some implications of validity arguments for psychological research into psychotic phenomena
    • Bentall RP, Jackson HF, Pilgrim D. Abandoning the concept of 'schizophrenia': some implications of validity arguments for psychological research into psychotic phenomena. Br J Clin Psychol 1988; 27: 303-324.
    • (1988) Br J Clin Psychol , vol.27 , pp. 303-324
    • Bentall, R.P.1    Jackson, H.F.2    Pilgrim, D.3
  • 10
    • 18644386195 scopus 로고    scopus 로고
    • The beginning of the end for the Kraepelinian dichotomy
    • Craddock N, Owen MJ. The beginning of the end for the Kraepelinian dichotomy. Br J Psychiatry 2005; 186: 364-366.
    • (2005) Br J Psychiatry , vol.186 , pp. 364-366
    • Craddock, N.1    Owen, M.J.2
  • 11
    • 0034529505 scopus 로고    scopus 로고
    • Epidemiology of schizophrenia: The global burden of disease and disability
    • Jablensky A. Epidemiology of schizophrenia: the global burden of disease and disability. Eur Arch Psychiatry Clin Neurosci 2000; 250: 274-285.
    • (2000) Eur Arch Psychiatry Clin Neurosci , vol.250 , pp. 274-285
    • Jablensky, A.1
  • 12
    • 4243070237 scopus 로고    scopus 로고
    • The epidemiological horizon
    • Hirsch SR, Weinberger DR (eds). Blackwell Publishing: Massachusetts, USA
    • Jablensky A. The epidemiological horizon. In: Hirsch SR, Weinberger DR (eds). Schizophrenia, 2nd edn. Blackwell Publishing: Massachusetts, USA, 2003, pp. 203-231.
    • (2003) Schizophrenia, 2nd Edn. , pp. 203-231
    • Jablensky, A.1
  • 13
    • 0026436979 scopus 로고
    • Schizophrenia: Manifestations, incidence and course in different cultures. A World Health Organization ten-country study
    • Jablensky A, Sartorius N, Ernberg G, Anker M, Korten A, Cooper JE et al. Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychol Med Nonogr Suppl 1992; 20: 1-97.
    • (1992) Psychol Med Nonogr Suppl , vol.20 , pp. 1-97
    • Jablensky, A.1    Sartorius, N.2    Ernberg, G.3    Anker, M.4    Korten, A.5    Cooper, J.E.6
  • 14
    • 0042896654 scopus 로고
    • Current controversies in schizophrenia research. I. Is schizophrenia a heterogeneous disorder?
    • DeLisi LE, Nasrallah HA. Current controversies in schizophrenia research. I. Is schizophrenia a heterogeneous disorder? Schizophr Res 1995; 17: 133.
    • (1995) Schizophr Res , vol.17 , pp. 133
    • DeLisi, L.E.1    Nasrallah, H.A.2
  • 15
    • 0028880409 scopus 로고
    • A continuum of psychosis, one human gene, and not much else - The case for homogeneity
    • Crow TJ. A continuum of psychosis, one human gene, and not much else - the case for homogeneity. Schizophr Res 1995; 17: 135-145.
    • (1995) Schizophr Res , vol.17 , pp. 135-145
    • Crow, T.J.1
  • 16
    • 0028822383 scopus 로고
    • A case against subtyping in schizophrenia
    • Goldberg TE, Weinberger DR. A case against subtyping in schizophrenia. Schizophr Res 1995; 17: 147-152.
    • (1995) Schizophr Res , vol.17 , pp. 147-152
    • Goldberg, T.E.1    Weinberger, D.R.2
  • 17
    • 0028805389 scopus 로고
    • The case for or against heterogeneity in the etiology of schizophrenia. The genetic evidence
    • Cardno AG, Farmer AE. The case for or against heterogeneity in the etiology of schizophrenia. The genetic evidence. Schizophr Res 1995; 17: 153-159.
    • (1995) Schizophr Res , vol.17 , pp. 153-159
    • Cardno, A.G.1    Farmer, A.E.2
  • 18
    • 0028858104 scopus 로고
    • The case for heterogeneity in the etiology of schizophrenia
    • Tsuang MT, Faraone SV. The case for heterogeneity in the etiology of schizophrenia. Schizophr Res 1995; 17: 161-175.
    • (1995) Schizophr Res , vol.17 , pp. 161-175
    • Tsuang, M.T.1    Faraone, S.V.2
  • 19
    • 4043067972 scopus 로고    scopus 로고
    • Meta-analysis and the science of schizophrenia: Variant evidence or evidence of variants?
    • Heinrichs RW. Meta-analysis and the science of schizophrenia: variant evidence or evidence of variants? Neurosci Biobehav Rev 2004; 28: 379-394.
    • (2004) Neurosci Biobehav Rev , vol.28 , pp. 379-394
    • Heinrichs, R.W.1
  • 20
    • 0033764737 scopus 로고    scopus 로고
    • The Finland-United States Investigation of Non-Insulin-Dependent Diabetes Mellitus Genetics (FUSION) Study. I. An autosomal genome scan for genes that predispose to Type 2 diabetes
    • Ghosh S, Watanabe RM, Valle TT, Hauser ER, Magnuson VL, Langefeld CD et al. The Finland-United States Investigation of Non-Insulin-Dependent Diabetes Mellitus Genetics (FUSION) Study. I. An autosomal genome scan for genes that predispose to Type 2 diabetes. Am J Hum Genet 2000; 67: 1174-1185.
    • (2000) Am J Hum Genet , vol.67 , pp. 1174-1185
    • Ghosh, S.1    Watanabe, R.M.2    Valle, T.T.3    Hauser, E.R.4    Magnuson, V.L.5    Langefeld, C.D.6
  • 21
    • 0035030767 scopus 로고    scopus 로고
    • A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population
    • letter
    • Laitinen T, Daly MJ, Rioux JD, Kauppi P, Laprise C, Petäys T et al. A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population. Nat Genet 2001; 28: 87-91 (letter).
    • (2001) Nat Genet , vol.28 , pp. 87-91
    • Laitinen, T.1    Daly, M.J.2    Rioux, J.D.3    Kauppi, P.4    Laprise, C.5    Petäys, T.6
  • 22
    • 0042767676 scopus 로고    scopus 로고
    • Parkinson's disease: Piecing together a genetic jigsaw
    • Dekker MCJ, Bonifati V, van Duijn CM. Parkinson's disease: piecing together a genetic jigsaw. Brain 2003; 126: 1722-1733.
    • (2003) Brain , vol.126 , pp. 1722-1733
    • Dekker, M.C.J.1    Bonifati, V.2    Van Duijn, C.M.3
  • 25
    • 0014625336 scopus 로고
    • On lumpers and splitters, or the nosology of genetic disease
    • Winter
    • McKusick VA. On lumpers and splitters, or the nosology of genetic disease. Perspect Biol Med 1969; Winter: 298-312.
    • (1969) Perspect Biol Med , pp. 298-312
    • McKusick, V.A.1
  • 26
    • 0001395571 scopus 로고
    • Testing for heterogeneity of recombinant values in human genetics
    • Smith CAB. Testing for heterogeneity of recombinant values in human genetics. Ann Hum Genet 1963; 27: 175-182.
    • (1963) Ann Hum Genet , vol.27 , pp. 175-182
    • Smith, C.A.B.1
  • 27
    • 0023896149 scopus 로고
    • A new statistical test for linkage heterogeneity
    • Risch N. A new statistical test for linkage heterogeneity. Am J Hum Genet 1988; 42: 353-364.
    • (1988) Am J Hum Genet , vol.42 , pp. 353-364
    • Risch, N.1
  • 28
    • 0037095736 scopus 로고    scopus 로고
    • Retinitis pigmentosa and allied diseases: Numerous diseases, genes, and inheritance patterns
    • Rivolta C, Sharon D, De Angelis MM, Dryja TP. Retinitis pigmentosa and allied diseases: numerous diseases, genes, and inheritance patterns. Hum Mol Genet 2002; 11: 1219-1227.
    • (2002) Hum Mol Genet , vol.11 , pp. 1219-1227
    • Rivolta, C.1    Sharon, D.2    De Angelis, M.M.3    Dryja, T.P.4
  • 29
    • 0035986122 scopus 로고    scopus 로고
    • The genetics of inflammatory bowel disease
    • Duerr RH. The genetics of inflammatory bowel disease. Gastroenterol Clin North Am 2002; 31: 63-76.
    • (2002) Gastroenterol Clin North Am , vol.31 , pp. 63-76
    • Duerr, R.H.1
  • 31
    • 14344259508 scopus 로고    scopus 로고
    • Nonreplication in genetic studies of complex diseases - Lessons learned from studies of osteoporosis and tentative remedies
    • Shen H, Liu Y, Liu P, Recker RR, Deng HW. Nonreplication in genetic studies of complex diseases - lessons learned from studies of osteoporosis and tentative remedies. J Bone Miner Res 2005; 20: 365-376.
    • (2005) J Bone Miner Res , vol.20 , pp. 365-376
    • Shen, H.1    Liu, Y.2    Liu, P.3    Recker, R.R.4    Deng, H.W.5
  • 32
    • 0141956367 scopus 로고    scopus 로고
    • Identification of novel GDAP1 mutations causing autosomal recessive Charcot-Marie-Tooth disease
    • Ammar N, Nelis E, Merlini L, Barisic N, Amouri R, Ceuterick C et al. Identification of novel GDAP1 mutations causing autosomal recessive Charcot-Marie-Tooth disease. Neuromuscul Disord 2003; 13: 720-728.
    • (2003) Neuromuscul Disord , vol.13 , pp. 720-728
    • Ammar, N.1    Nelis, E.2    Merlini, L.3    Barisic, N.4    Amouri, R.5    Ceuterick, C.6
  • 33
    • 1542298938 scopus 로고    scopus 로고
    • Vocal cord and diaphragm paralysis, as clinical features of a French family with autosomal recessive Charcot-Marie-Tooth disease, associated with a new mutation in the GDAP1 gene
    • Stojkovic T, Latour P, Viet G, de Seze J, Hurtevent JF, Vandenberghe A et al. Vocal cord and diaphragm paralysis, as clinical features of a French family with autosomal recessive Charcot-Marie-Tooth disease, associated with a new mutation in the GDAP1 gene. Neuromuscul Disord 2004; 14: 261-264.
    • (2004) Neuromuscul Disord , vol.14 , pp. 261-264
    • Stojkovic, T.1    Latour, P.2    Viet, G.3    De Seze, J.4    Hurtevent, J.F.5    Vandenberghe, A.6
  • 34
    • 25844451159 scopus 로고    scopus 로고
    • Modifier genetics: Cystic fibrosis
    • Cutting GR. Modifier genetics: cystic fibrosis. Annu Rev Genomics Hum Genet 2005; 6: 237-260.
    • (2005) Annu Rev Genomics Hum Genet , vol.6 , pp. 237-260
    • Cutting, G.R.1
  • 35
    • 25444506869 scopus 로고    scopus 로고
    • Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers
    • Cohn JA, Neoptolemos JP, Feng J, Yan J, Jiang Z, Greenhalf W et al. Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers. Hum Mutat 2005; 26: 303-307.
    • (2005) Hum Mutat , vol.26 , pp. 303-307
    • Cohn, J.A.1    Neoptolemos, J.P.2    Feng, J.3    Yan, J.4    Jiang, Z.5    Greenhalf, W.6
  • 36
    • 24944490471 scopus 로고    scopus 로고
    • Molecular evaluation of CFTR sequence variants in male infertility of testicular origin
    • Larriba S, Bonache S, Sarquella J, Ramos MD, Gimenez J, Bassas L et al. Molecular evaluation of CFTR sequence variants in male infertility of testicular origin. Int J Androl 2005; 28: 284-290.
    • (2005) Int J Androl , vol.28 , pp. 284-290
    • Larriba, S.1    Bonache, S.2    Sarquella, J.3    Ramos, M.D.4    Gimenez, J.5    Bassas, L.6
  • 37
    • 20144386111 scopus 로고    scopus 로고
    • Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
    • Chesler EJ, Lu L, Shou S, Qu Y, Gu J, Wang J et al. Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nat Genet 2005; 37: 233-242.
    • (2005) Nat Genet , vol.37 , pp. 233-242
    • Chesler, E.J.1    Lu, L.2    Shou, S.3    Qu, Y.4    Gu, J.5    Wang, J.6
  • 38
    • 0034010457 scopus 로고    scopus 로고
    • Do susceptibility loci contribute to the expression of more than one mental disorder? A view from the genetics of Alzheimer's disease
    • Zubenko GS. Do susceptibility loci contribute to the expression of more than one mental disorder? A view from the genetics of Alzheimer's disease. Mol Psychiatry 2000; 5: 131-136.
    • (2000) Mol Psychiatry , vol.5 , pp. 131-136
    • Zubenko, G.S.1
  • 39
    • 26944493073 scopus 로고    scopus 로고
    • The importance of modelling heterogeneity in complex disease: Application to NIMH schizophrenia genetics initiative data
    • Holliday E, Mowry B, Chant D, Nyholt D. The importance of modelling heterogeneity in complex disease: application to NIMH schizophrenia genetics initiative data. Hum Genet 2005; 117: 160-167.
    • (2005) Hum Genet , vol.117 , pp. 160-167
    • Holliday, E.1    Mowry, B.2    Chant, D.3    Nyholt, D.4
  • 40
    • 0024435379 scopus 로고
    • Confirming unexpressed genotypes for schizophrenia. Risks in the offspring of Fischer's Danish identical and fraternal discordant twins
    • Gottesman II, Bertelsen A. Confirming unexpressed genotypes for schizophrenia. Risks in the offspring of Fischer's Danish identical and fraternal discordant twins. Arch Gen Psychiatry 1989; 46: 867-872.
    • (1989) Arch Gen Psychiatry , vol.46 , pp. 867-872
    • Gottesman, I.I.1    Bertelsen, A.2
  • 41
    • 18344396274 scopus 로고    scopus 로고
    • Strategy for investigating interactions between measured genes and measured environments
    • Moffitt TE, Caspi A, Rutter M. Strategy for investigating interactions between measured genes and measured environments. Arch Gen Psychiatry 2005; 62: 473-481.
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 473-481
    • Moffitt, T.E.1    Caspi, A.2    Rutter, M.3
  • 42
    • 2542424674 scopus 로고    scopus 로고
    • Why genetic investigation of psychiatric disorders is so difficult
    • Bearden CE, Reus VI, Freimer NB. Why genetic investigation of psychiatric disorders is so difficult. Curr Opin Genet Dev 2004; 14: 280-286.
    • (2004) Curr Opin Genet Dev , vol.14 , pp. 280-286
    • Bearden, C.E.1    Reus, V.I.2    Freimer, N.B.3
  • 43
    • 0025174987 scopus 로고
    • Heterogeneity of schizophrenia. Conceptual models and analytic strategies
    • Tsuang MT, Lyons MJ, Faraone SV. Heterogeneity of schizophrenia. Conceptual models and analytic strategies. Br J Psychiatry 1990; 156: 17-26.
    • (1990) Br J Psychiatry , vol.156 , pp. 17-26
    • Tsuang, M.T.1    Lyons, M.J.2    Faraone, S.V.3
  • 45
    • 0025276598 scopus 로고
    • Psychometric deviance in offspring at risk for schizophrenia: II. Resolving heterogeneity through admixture analysis
    • Moldin SO, Rice JP, Gottesman II, Erlenmeyer-Kimling L. Psychometric deviance in offspring at risk for schizophrenia: II. Resolving heterogeneity through admixture analysis. Psychiatry Res 1990; 32: 311-322.
    • (1990) Psychiatry Res , vol.32 , pp. 311-322
    • Moldin, S.O.1    Rice, J.P.2    Gottesman, I.I.3    Erlenmeyer-Kimling, L.4
  • 47
    • 0003986742 scopus 로고
    • Reprinted English translation: Arno Press: New York
    • [Reprinted English translation: Textbook of Psychiatry. Arno Press: New York, 1976.].
    • (1976) Textbook of Psychiatry
  • 49
    • 0344305525 scopus 로고    scopus 로고
    • Schizophrenia as a complex trait. Evidence from a meta-analysis of twin studies
    • Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait. Evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 2003; 60: 1187-1192.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 1187-1192
    • Sullivan, P.F.1    Kendler, K.S.2    Neale, M.C.3
  • 50
    • 0036258079 scopus 로고    scopus 로고
    • Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia
    • Badner JA, Gershon ES. Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 2002; 7: 405-411.
    • (2002) Mol Psychiatry , vol.7 , pp. 405-411
    • Badner, J.A.1    Gershon, E.S.2
  • 53
    • 0037223814 scopus 로고    scopus 로고
    • Distinguishing between the validity and utility of psychiatric diagnoses
    • Kendell R, Jablensky A. Distinguishing between the validity and utility of psychiatric diagnoses. Am J Psychiatry 2003; 160: 4-12.
    • (2003) Am J Psychiatry , vol.160 , pp. 4-12
    • Kendell, R.1    Jablensky, A.2
  • 54
    • 0023857229 scopus 로고
    • Familial syndrome patterns in schizophrenia, schizoaffective disorder, mania, and depression
    • Stassen HH, Scharfetter C, Winokur G, Angst J. Familial syndrome patterns in schizophrenia, schizoaffective disorder, mania, and depression. Eur Arch Psychiatry Clin Neurosci 1988; 237: 115-123.
    • (1988) Eur Arch Psychiatry Clin Neurosci , vol.237 , pp. 115-123
    • Stassen, H.H.1    Scharfetter, C.2    Winokur, G.3    Angst, J.4
  • 55
    • 4143082615 scopus 로고    scopus 로고
    • Recent findings in bipolar affective disorder
    • Bebbington P. Recent findings in bipolar affective disorder. Psychol Med 2004; 34: 767-776.
    • (2004) Psychol Med , vol.34 , pp. 767-776
    • Bebbington, P.1
  • 56
    • 0029895435 scopus 로고    scopus 로고
    • Clinical characteristics of Kraepelinian schizophrenia: Replication and extension of previous findings
    • Keefe RSE, Frescka E, Apter SH, Davidson M, Macaluso JM, Hirschowitz J et al. Clinical characteristics of Kraepelinian schizophrenia: replication and extension of previous findings. Am J Psychiatry 1996; 153: 806-811.
    • (1996) Am J Psychiatry , vol.153 , pp. 806-811
    • Keefe, R.S.E.1    Frescka, E.2    Apter, S.H.3    Davidson, M.4    Macaluso, J.M.5    Hirschowitz, J.6
  • 57
    • 0037200644 scopus 로고    scopus 로고
    • Clinical characteristics and risk factors for Kraepelinian subtype of schizophrenia: Replication of previous findings and relation to summer birth
    • Bralet M-C, Loas G, Yon V, Maréchal V. Clinical characteristics and risk factors for Kraepelinian subtype of schizophrenia: replication of previous findings and relation to summer birth. Psychiatry Res 2002; 111: 147-154.
    • (2002) Psychiatry Res , vol.111 , pp. 147-154
    • Bralet, M.-C.1    Loas, G.2    Yon, V.3    Maréchal, V.4
  • 59
    • 0002396084 scopus 로고
    • The acute schizoaffective psychosis
    • Kasanin J. The acute schizoaffective psychosis. Am J Psychiatry 1933; 90: 97-126.
    • (1933) Am J Psychiatry , vol.90 , pp. 97-126
    • Kasanin, J.1
  • 60
    • 33748070262 scopus 로고
    • The prognosis of schizophrenia
    • Munksgaard: Copenhagen
    • Langfeld G. The prognosis of schizophrenia. Acta Psychiatria Neurologica Scandinavica (Suppl 110). Munksgaard: Copenhagen, 1956.
    • (1956) Acta Psychiatria Neurologica Scandinavica , Issue.110 SUPPL.
    • Langfeld, G.1
  • 61
    • 0000608910 scopus 로고
    • Prognosis in 'process' and 'non-process' schizophrenia
    • Stephens JH, Astrup C. Prognosis in 'process' and 'non-process' schizophrenia. Am J Psychiatry 1963; 119: 945-953.
    • (1963) Am J Psychiatry , vol.119 , pp. 945-953
    • Stephens, J.H.1    Astrup, C.2
  • 62
    • 0016184306 scopus 로고
    • Criteria for subtyping schizophrenia
    • Tsuang MT, Winokur G. Criteria for subtyping schizophrenia. Arch Gen Psychiatry 1974; 31: 43-47.
    • (1974) Arch Gen Psychiatry , vol.31 , pp. 43-47
    • Tsuang, M.T.1    Winokur, G.2
  • 65
    • 0018082913 scopus 로고
    • Research diagnostic criteria. Rationale and reliability
    • Spitzer RL, Endicott J, Robins E. Research diagnostic criteria. Rationale and reliability. Arch Gen Psychiatry 1978; 35: 773-782.
    • (1978) Arch Gen Psychiatry , vol.35 , pp. 773-782
    • Spitzer, R.L.1    Endicott, J.2    Robins, E.3
  • 68
    • 0033939684 scopus 로고    scopus 로고
    • Factor structure and familiality of first-rank symptoms in sibling pairs with schizophrenia and schizoaffective disorder
    • Loftus J, DeLisi LE, Crow TJ. Factor structure and familiality of first-rank symptoms in sibling pairs with schizophrenia and schizoaffective disorder. Br J Psychiatry 2000; 177: 15-19.
    • (2000) Br J Psychiatry , vol.177 , pp. 15-19
    • Loftus, J.1    DeLisi, L.E.2    Crow, T.J.3
  • 70
    • 0034100029 scopus 로고    scopus 로고
    • Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish Study of High-Density Schizophrenia Families
    • Kendler KS, Myers JM, O'Neill FA, Martin R, Murphy B, MacLean CJ, et al. Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish Study of High-Density Schizophrenia Families. Am J Psychiatry 2000; 157: 402-408.
    • (2000) Am J Psychiatry , vol.157 , pp. 402-408
    • Kendler, K.S.1    Myers, J.M.2    O'Neill, F.A.3    Martin, R.4    Murphy, B.5    MacLean, C.J.6
  • 73
    • 0031964107 scopus 로고    scopus 로고
    • Different genetic background of schizophrenia spectrum psychoses: A twin study
    • Franzek E, Beckmann H. Different genetic background of schizophrenia spectrum psychoses: a twin study. Am J Psychiatry 1998; 155: 76-83.
    • (1998) Am J Psychiatry , vol.155 , pp. 76-83
    • Franzek, E.1    Beckmann, H.2
  • 75
    • 0033754079 scopus 로고    scopus 로고
    • Splitting schizophrenia: Periodic catatonia-susceptibility locus on chromosome 15q15
    • Stöber G, Saar K, Rüschendorf F, Meyer J, Nürnberg G, Jatzke S et al. Splitting schizophrenia: periodic catatonia-susceptibility locus on chromosome 15q15. Am J Hum Genet 2000; 67: 1201-1207.
    • (2000) Am J Hum Genet , vol.67 , pp. 1201-1207
    • Stöber, G.1    Saar, K.2    Rüschendorf, F.3    Meyer, J.4    Nürnberg, G.5    Jatzke, S.6
  • 76
    • 0036780845 scopus 로고    scopus 로고
    • Periodic catatonia: Confirmation of linkage to chromosome 15 and further evidence for genetic heterogeneity
    • Stöber G, Seelow D, Rüschendorf F, Ekici A, Beckmann H, Reis A. Periodic catatonia: confirmation of linkage to chromosome 15 and further evidence for genetic heterogeneity. Hum Genet 2002; 111: 323-330.
    • (2002) Hum Genet , vol.111 , pp. 323-330
    • Stöber, G.1    Seelow, D.2    Rüschendorf, F.3    Ekici, A.4    Beckmann, H.5    Reis, A.6
  • 77
    • 85047697752 scopus 로고    scopus 로고
    • Exclusion of the neuronal nicotinic acetylcholine receptor alpha7 subunit gene as a candidate for catatonic schizophrenia in a large family supporting the chromosome 15q13-22 locus
    • Meyer J, Ortega G, Schraut K, Nürnberg G, Rüschendorf F, Saar K et al. Exclusion of the neuronal nicotinic acetylcholine receptor alpha7 subunit gene as a candidate for catatonic schizophrenia in a large family supporting the chromosome 15q13-22 locus. Mol Psychiatry 2002; 7: 220-223.
    • (2002) Mol Psychiatry , vol.7 , pp. 220-223
    • Meyer, J.1    Ortega, G.2    Schraut, K.3    Nürnberg, G.4    Rüschendorf, F.5    Saar, K.6
  • 78
    • 0344196966 scopus 로고    scopus 로고
    • Mutation analysis of the zinc transporter gene SLC30A4 reveals no association with periodic catatonia on chromosome 15q15
    • Kury S, Rubie C, Moisan JP, Stöber G. Mutation analysis of the zinc transporter gene SLC30A4 reveals no association with periodic catatonia on chromosome 15q15. J Neural Transm 2003; 110: 1329-1332.
    • (2003) J Neural Transm , vol.110 , pp. 1329-1332
    • Kury, S.1    Rubie, C.2    Moisan, J.P.3    Stöber, G.4
  • 80
    • 17744384259 scopus 로고    scopus 로고
    • A missense mutation in a novel gene encoding a putative cation channel is associated with catatonic schizophrenia in a large pedigree
    • Meyer J, Huberth A, Ortega G, Syagailo YV, Jatzke S, Mössner R et al. A missense mutation in a novel gene encoding a putative cation channel is associated with catatonic schizophrenia in a large pedigree. Mol Psychiatry 2001; 6: 302-306.
    • (2001) Mol Psychiatry , vol.6 , pp. 302-306
    • Meyer, J.1    Huberth, A.2    Ortega, G.3    Syagailo, Y.V.4    Jatzke, S.5    Mössner, R.6
  • 82
    • 0003717470 scopus 로고
    • Studien über Vererbung und Enstehung geistiger Störungen, I: Zur Vererbung und Neuenstehung der Dementia praecox (Studies on the inheritance and origin of mental Illness, I: the problem of the inheritance and primary origin of Dementia praecox)
    • Springer Verlag: Berlin
    • Rüdin E. Studien über Vererbung und Enstehung geistiger Störungen, I: Zur Vererbung und Neuenstehung der Dementia praecox (Studies on the inheritance and origin of mental Illness, I: The problem of the inheritance and primary origin of Dementia praecox). Monographien aus dem Gesamtgebeit der Neurologie und Psychiatrie, No. 12. Springer Verlag: Berlin, 1916.
    • (1916) Monographien Aus Dem Gesamtgebeit der Neurologie und Psychiatrie , vol.12
    • Rüdin, E.1
  • 84
    • 0021280380 scopus 로고
    • An independent analysis of the Danish Adoption Study of Schizophrenia. VI. The relationship between psychiatric disorders as defined by DSM-III in the relatives and adoptees
    • Kendler KS, Gruenberg AM. An independent analysis of the Danish Adoption Study of Schizophrenia. VI. The relationship between psychiatric disorders as defined by DSM-III in the relatives and adoptees. Arch Gen Psychiatry 1984; 41: 555-564.
    • (1984) Arch Gen Psychiatry , vol.41 , pp. 555-564
    • Kendler, K.S.1    Gruenberg, A.M.2
  • 85
    • 0023476019 scopus 로고
    • The spectrum concept of schizophrenia: Evidence for a genetic-environmental continuum
    • Baron M, Risch N. The spectrum concept of schizophrenia: evidence for a genetic-environmental continuum. J Psychiatry Res 1987; 21: 257-267.
    • (1987) J Psychiatry Res , vol.21 , pp. 257-267
    • Baron, M.1    Risch, N.2
  • 86
    • 0002884441 scopus 로고
    • Theory and therapy: The theory of schizotypal organization and its application to the treatment of decompensated schizotypal behaviour
    • Scher SC, Davis HR (eds) Grune and Stratton: New York
    • Rado S. Theory and therapy: the theory of schizotypal organization and its application to the treatment of decompensated schizotypal behaviour. In: Scher SC, Davis HR (eds) The Outpatient Treatment of Schizophrenia. Grune and Stratton: New York, 1960.
    • (1960) The Outpatient Treatment of Schizophrenia
    • Rado, S.1
  • 87
    • 84912502314 scopus 로고
    • Schizotaxia, schizotypy, schizophrenia
    • Meehl PE. Schizotaxia, schizotypy, schizophrenia. American Psychologist 1962; 17: 827-838
    • (1962) American Psychologist , vol.17 , pp. 827-838
    • Meehl, P.E.1
  • 88
    • 0004242980 scopus 로고
    • Reprinted University of Minnesota Press: Minneapolis
    • [Reprinted in Meehl PE. Psychodiagnosis: selected papers. University of Minnesota Press: Minneapolis, 1973, pp 135-155.].
    • (1973) Psychodiagnosis: Selected Papers , pp. 135-155
    • Meehl, P.E.1
  • 89
    • 0018884882 scopus 로고
    • Scales for rating psychotic and psychotic-like experiences as continua
    • Chapman LJ, Chapman JP. Scales for rating psychotic and psychotic-like experiences as continua. Schizophr Bull 1980; 6: 476-489.
    • (1980) Schizophr Bull , vol.6 , pp. 476-489
    • Chapman, L.J.1    Chapman, J.P.2
  • 91
    • 0028964788 scopus 로고
    • Evaluating the spectrum concept of schizophrenia in the Roscommon Family Study
    • Kendler KS, Neale MC, Walsh D. Evaluating the spectrum concept of schizophrenia in the Roscommon Family Study. Am J Psychiatry 1995; 152: 749-754.
    • (1995) Am J Psychiatry , vol.152 , pp. 749-754
    • Kendler, K.S.1    Neale, M.C.2    Walsh, D.3
  • 92
    • 0642282707 scopus 로고    scopus 로고
    • Genetic boundaries of the schizophrenia spectrum: Evidence from the Finnish Adoptive Family Study of Schizophrenia
    • Tienari P,Wynne LC, Läksy K, Moring J, Nieminen P, Sorri A et al. Genetic boundaries of the schizophrenia spectrum: evidence from the Finnish Adoptive Family Study of Schizophrenia. Am J Psychiatry 2003; 160: 1587-1594.
    • (2003) Am J Psychiatry , vol.160 , pp. 1587-1594
    • Tienari, P.1    Wynne, L.C.2    Läksy, K.3    Moring, J.4    Nieminen, P.5    Sorri, A.6
  • 93
    • 0032743350 scopus 로고    scopus 로고
    • The factor structure of schizophrenia spectrum personality disorders: Signs and symptoms in relatives of psychotic patients from the UCLA family members study
    • Fogelson DL, Nuechterlein KH, Asarnow RF, Payne DL, Subotnik KL, Giannini CA. The factor structure of schizophrenia spectrum personality disorders: signs and symptoms in relatives of psychotic patients from the UCLA family members study. Psychiatry Res 1999; 87: 137-146.
    • (1999) Psychiatry Res , vol.87 , pp. 137-146
    • Fogelson, D.L.1    Nuechterlein, K.H.2    Asarnow, R.F.3    Payne, D.L.4    Subotnik, K.L.5    Giannini, C.A.6
  • 94
    • 0035098418 scopus 로고    scopus 로고
    • Latent class analysis of DSM-IV schizotypal personality disorder criteria in psychiatric patients
    • Fosatti A, Maffei C, Battaglia M, Bagnato M, Donati D, Donini M et al. Latent class analysis of DSM-IV schizotypal personality disorder criteria in psychiatric patients. Schizophr Bull 2001; 27: 59-71.
    • (2001) Schizophr Bull , vol.27 , pp. 59-71
    • Fosatti, A.1    Maffei, C.2    Battaglia, M.3    Bagnato, M.4    Donati, D.5    Donini, M.6
  • 95
    • 0035575642 scopus 로고    scopus 로고
    • Factor versus cluster models of schizotypal traits. I. A comparison of unselected and highly schizotypal samples
    • Suhr JA, Spitznagel MB. Factor versus cluster models of schizotypal traits. I. A comparison of unselected and highly schizotypal samples. Schizophr Res 2001; 52: 231-239.
    • (2001) Schizophr Res , vol.52 , pp. 231-239
    • Suhr, J.A.1    Spitznagel, M.B.2
  • 97
    • 0027525058 scopus 로고
    • 'True' schizotypal personality disorder: A study of co-twins and relatives of schizophrenic probands
    • Torgersen S, Onstad S, Skre I, Edvardsen J, Kringlen E. 'True' schizotypal personality disorder: a study of co-twins and relatives of schizophrenic probands. Am J Psychiatry 1993; 150: 1661-1667.
    • (1993) Am J Psychiatry , vol.150 , pp. 1661-1667
    • Torgersen, S.1    Onstad, S.2    Skre, I.3    Edvardsen, J.4    Kringlen, E.5
  • 98
    • 0034940620 scopus 로고    scopus 로고
    • Relationship between positive and negative symptoms of schizophrenia and schizotypal symptoms in nonpsychotic relatives
    • Fanous A, Gardner C, Walsh D, Kendler KS. Relationship between positive and negative symptoms of schizophrenia and schizotypal symptoms in nonpsychotic relatives. Arch Gen Psychiatry 2001; 58: 669-673.
    • (2001) Arch Gen Psychiatry , vol.58 , pp. 669-673
    • Fanous, A.1    Gardner, C.2    Walsh, D.3    Kendler, K.S.4
  • 99
  • 100
    • 0036498842 scopus 로고    scopus 로고
    • The structure of schizotypy: Relationships between neurocognitive and personality disorder features in relatives of schizophrenic patients in the UCLA Family Study
    • Nuechterlein KH, Asarnow RF, Subotnik KL, Fogelson DL, Payne DL, Kendler KS et al. The structure of schizotypy: relationships between neurocognitive and personality disorder features in relatives of schizophrenic patients in the UCLA Family Study. Schizophr Res 2002; 54: 121-130.
    • (2002) Schizophr Res , vol.54 , pp. 121-130
    • Nuechterlein, K.H.1    Asarnow, R.F.2    Subotnik, K.L.3    Fogelson, D.L.4    Payne, D.L.5    Kendler, K.S.6
  • 101
    • 0036498540 scopus 로고    scopus 로고
    • Neurocognitive functioning and schizophrenia spectrum disorders can be independent expressions of familial liability for schizophrenia in community control children: The UCLA Family Study
    • Asarnow RF, Nuechterlein KH, Asamen J, Fogelson D, Subotnik KL, Zaucha K et al. Neurocognitive functioning and schizophrenia spectrum disorders can be independent expressions of familial liability for schizophrenia in community control children: the UCLA Family Study. Schizophr Res 2002; 54: 111-120.
    • (2002) Schizophr Res , vol.54 , pp. 111-120
    • Asarnow, R.F.1    Nuechterlein, K.H.2    Asamen, J.3    Fogelson, D.4    Subotnik, K.L.5    Zaucha, K.6
  • 102
    • 0036181459 scopus 로고    scopus 로고
    • The brain in schizotypal personality disorder: A review of structural MRI and CT findings
    • Dickey CD, McCarley RW, Shenton ME. The brain in schizotypal personality disorder: a review of structural MRI and CT findings. Harv Rev Psychiatry 2002; 10: 1-15.
    • (2002) Harv Rev Psychiatry , vol.10 , pp. 1-15
    • Dickey, C.D.1    McCarley, R.W.2    Shenton, M.E.3
  • 103
    • 0016142450 scopus 로고
    • The diagnosis and understanding of schizophrenia. Part III. Speculations on the processes that underlie schizophrenic symptoms and signs
    • Winter
    • Strauss JS, Carpenter Jr WT, Bartko JJ. The diagnosis and understanding of schizophrenia. Part III. Speculations on the processes that underlie schizophrenic symptoms and signs. Schizophr Bull 1974; Winter: 61-69.
    • (1974) Schizophr Bull , pp. 61-69
    • Strauss, J.S.1    Carpenter Jr., W.T.2    Bartko, J.J.3
  • 104
    • 0018899460 scopus 로고
    • Molecular pathology of schizophrenia: More than one disease process?
    • Crow TJ. Molecular pathology of schizophrenia: more than one disease process? BMJ 1980; 280: 66-68.
    • (1980) BMJ , vol.280 , pp. 66-68
    • Crow, T.J.1
  • 105
    • 0019977946 scopus 로고
    • Negative v positive schizophrenia. Definition and validation
    • Andreasen NC, Olsen S. Negative v positive schizophrenia. Definition and validation. Arch Gen Psychiatry 1982; 39: 789-794.
    • (1982) Arch Gen Psychiatry , vol.39 , pp. 789-794
    • Andreasen, N.C.1    Olsen, S.2
  • 106
    • 0021882606 scopus 로고
    • The two-syndrome concept: Origins and current status
    • Crow TJ. The two-syndrome concept: origins and current status. Schizophr Bull 1985; 11: 471-486.
    • (1985) Schizophr Bull , vol.11 , pp. 471-486
    • Crow, T.J.1
  • 107
    • 0022005284 scopus 로고
    • Positive and negative symptoms and Jackson. A conceptual history
    • Berrios GE. Positive and negative symptoms and Jackson. A conceptual history. Arch Gen Psychiatry 1985; 42: 95-97.
    • (1985) Arch Gen Psychiatry , vol.42 , pp. 95-97
    • Berrios, G.E.1
  • 108
    • 0021850189 scopus 로고
    • 'Negative symptoms': Conceptual and methodological problems
    • Sommers AA. 'Negative symptoms': conceptual and methodological problems. Schizophr Bull 1985; 11: 364-379.
    • (1985) Schizophr Bull , vol.11 , pp. 364-379
    • Sommers, A.A.1
  • 109
    • 0025910277 scopus 로고
    • Negative symptoms of schizophrenia: The need for conceptual clarity
    • Tandon R, Greden JF. Negative symptoms of schizophrenia: the need for conceptual clarity. Biol Psychiatry 1991; 30: 321-325.
    • (1991) Biol Psychiatry , vol.30 , pp. 321-325
    • Tandon, R.1    Greden, J.F.2
  • 110
    • 0028947704 scopus 로고
    • Positive and negative symptoms/syndromes in schizophrenia: Reliability and validity of different diagnostic systems
    • Peralta V, Cuesta MJ, De Leon J. Positive and negative symptoms/syndromes in schizophrenia: reliability and validity of different diagnostic systems. Psychol Med 1995; 25: 43-50.
    • (1995) Psychol Med , vol.25 , pp. 43-50
    • Peralta, V.1    Cuesta, M.J.2    De Leon, J.3
  • 111
    • 0009351310 scopus 로고    scopus 로고
    • Symptoms of schizophrenia
    • Henn F, Sartorius N, Helmchen H, Lauter H (eds). Springer Verlag: Berlin
    • Jablensky A. Symptoms of schizophrenia. In: Henn F, Sartorius N, Helmchen H, Lauter H (eds). Contemporary Psychiatry. Vol 3. Specific Psychiatric Disorders. Springer Verlag: Berlin, 2001, pp. 3-36.
    • (2001) Contemporary Psychiatry. Vol 3. Specific Psychiatric Disorders , vol.3 , pp. 3-36
    • Jablensky, A.1
  • 115
    • 0034730804 scopus 로고    scopus 로고
    • Family characteristics of deficit and nondeficit schizophrenia in the Roscommon family study
    • Kirkpatrick B, Ross DE, Walsh D, Karkowski L, Kendler KS. Family characteristics of deficit and nondeficit schizophrenia in the Roscommon family study. Schizophr Res 2000; 45: 57-64.
    • (2000) Schizophr Res , vol.45 , pp. 57-64
    • Kirkpatrick, B.1    Ross, D.E.2    Walsh, D.3    Karkowski, L.4    Kendler, K.S.5
  • 118
    • 0025886496 scopus 로고
    • Cognitive functioning and positive and negative symptoms in schizophrenia
    • Addington J, Addington D, Maticka-Tyndale E. Cognitive functioning and positive and negative symptoms in schizophrenia. Schizophr Res 1991; 5: 123-134.
    • (1991) Schizophr Res , vol.5 , pp. 123-134
    • Addington, J.1    Addington, D.2    Maticka-Tyndale, E.3
  • 119
    • 0033762733 scopus 로고    scopus 로고
    • The deficit syndrome and eye tracking disorder may reflect a distinct subtype within the syndrome of schizophrenia
    • Ross DE. The deficit syndrome and eye tracking disorder may reflect a distinct subtype within the syndrome of schizophrenia. Schizophr Bull 2000; 26: 855-866.
    • (2000) Schizophr Bull , vol.26 , pp. 855-866
    • Ross, D.E.1
  • 120
    • 0035280529 scopus 로고    scopus 로고
    • Saccadic and smooth-pursuit eye movements in deficit and non-deficit schizophrenia
    • Nkam I, Thibaut F, Denise P, Van Der Elst A, Ségard L, Brazo P et al. Saccadic and smooth-pursuit eye movements in deficit and non-deficit schizophrenia. Schizophr Res 2001; 48: 145-153.
    • (2001) Schizophr Res , vol.48 , pp. 145-153
    • Nkam, I.1    Thibaut, F.2    Denise, P.3    Van Der Elst, A.4    Ségard, L.5    Brazo, P.6
  • 121
    • 0042206867 scopus 로고    scopus 로고
    • Components of the smooth pursuit function in deficit and nondeficit schizophrenia
    • Hong LE, Avila MT, Adami H, Elliot A, Thaker GK. Components of the smooth pursuit function in deficit and nondeficit schizophrenia. Schizophr Res 2003; 63: 39-48.
    • (2003) Schizophr Res , vol.63 , pp. 39-48
    • Hong, L.E.1    Avila, M.T.2    Adami, H.3    Elliot, A.4    Thaker, G.K.5
  • 122
    • 0034073101 scopus 로고    scopus 로고
    • Neurological signs and the heterogeneity of schizophrenia
    • Arango C, Kirkpatrick B, Buchanan RW. Neurological signs and the heterogeneity of schizophrenia. Am J Psychiatry 2000; 157: 560-565.
    • (2000) Am J Psychiatry , vol.157 , pp. 560-565
    • Arango, C.1    Kirkpatrick, B.2    Buchanan, R.W.3
  • 123
    • 0036274790 scopus 로고    scopus 로고
    • Historical, psychopathological, neurological, and neuropsychological aspects of deficit schizophrenia: A multicenter study
    • Galderisi S, Maj M, Mucci A, Cassano GB, Invernizzi G, Rossi A et al. Historical, psychopathological, neurological, and neuropsychological aspects of deficit schizophrenia: a multicenter study. Am J Psychiatry 2002; 159: 983-990.
    • (2002) Am J Psychiatry , vol.159 , pp. 983-990
    • Galderisi, S.1    Maj, M.2    Mucci, A.3    Cassano, G.B.4    Invernizzi, G.5    Rossi, A.6
  • 124
    • 23444454179 scopus 로고    scopus 로고
    • Examining the latent structure of negative symptoms: Is there a distinct subtype of negative symptom schizophrenia?
    • Blanchard JJ, Horan WP, Collins LM. Examining the latent structure of negative symptoms: is there a distinct subtype of negative symptom schizophrenia? Schizophr Res 2005; 77: 151-165.
    • (2005) Schizophr Res , vol.77 , pp. 151-165
    • Blanchard, J.J.1    Horan, W.P.2    Collins, L.M.3
  • 128
    • 0023260373 scopus 로고
    • The symptoms of chronic schizophrenia. A re-examination of the positive-negative dichotomy
    • Liddle PF. The symptoms of chronic schizophrenia. A re-examination of the positive-negative dichotomy. Br J Psychiatry 1987; 151: 145-151.
    • (1987) Br J Psychiatry , vol.151 , pp. 145-151
    • Liddle, P.F.1
  • 129
    • 0030016169 scopus 로고    scopus 로고
    • Validation of three dimensions of schizophrenic symptoms in a large unselected sample of patients
    • Johnstone EC, Frith CD. Validation of three dimensions of schizophrenic symptoms in a large unselected sample of patients. Psychol Med 1996; 26: 669-679.
    • (1996) Psychol Med , vol.26 , pp. 669-679
    • Johnstone, E.C.1    Frith, C.D.2
  • 130
    • 0032565592 scopus 로고    scopus 로고
    • Meta-analysis of symptom factors in schizophrenia
    • Grube BS, Bilder RM, Goldman RS. Meta-analysis of symptom factors in schizophrenia. Schizophr Res 1998; 31: 113-120.
    • (1998) Schizophr Res , vol.31 , pp. 113-120
    • Grube, B.S.1    Bilder, R.M.2    Goldman, R.S.3
  • 131
    • 0032482113 scopus 로고    scopus 로고
    • The structure of schizophrenic symptoms: A meta-analytic confirmatory factor analysis
    • Smith DA, Mar CM, Turoff BK. The structure of schizophrenic symptoms: a meta-analytic confirmatory factor analysis. Schizophr Res 1998; 31: 57-70.
    • (1998) Schizophr Res , vol.31 , pp. 57-70
    • Smith, D.A.1    Mar, C.M.2    Turoff, B.K.3
  • 132
    • 0029003189 scopus 로고
    • A longitudinal study of symptom dimensions in schizophrenia. Prediction and patterns of change
    • Arndt S, Andreasen NC, Flaum M, Miller D, Nopoulos P. A longitudinal study of symptom dimensions in schizophrenia. Prediction and patterns of change. Arch Gen Psychiatry 1995; 52: 352-360.
    • (1995) Arch Gen Psychiatry , vol.52 , pp. 352-360
    • Arndt, S.1    Andreasen, N.C.2    Flaum, M.3    Miller, D.4    Nopoulos, P.5
  • 133
    • 0029122570 scopus 로고
    • Three syndromes in schizophrenia: Validity in young patients with recent onset of illness
    • Gureje O, Aderibigbe YA, Obikoya O. Three syndromes in schizophrenia: validity in young patients with recent onset of illness. Psychol Med 1995; 25: 715-725.
    • (1995) Psychol Med , vol.25 , pp. 715-725
    • Gureje, O.1    Aderibigbe, Y.A.2    Obikoya, O.3
  • 134
    • 0035281246 scopus 로고    scopus 로고
    • The factor structure for positive and negative symptoms in South African Xhosa patients with schizophrenia
    • Emsley RA, Niehaus DJH, Mbanga NI, Oosthuizen PP, Stein DJ, Maritz JS et al. The factor structure for positive and negative symptoms in South African Xhosa patients with schizophrenia. Schizophr Res 2001; 47: 149-157.
    • (2001) Schizophr Res , vol.47 , pp. 149-157
    • Emsley, R.A.1    Niehaus, D.J.H.2    Mbanga, N.I.3    Oosthuizen, P.P.4    Stein, D.J.5    Maritz, J.S.6
  • 135
    • 0031915953 scopus 로고    scopus 로고
    • Characterization of psychotic conditions. Use of the domains of psychopathology model
    • Ratakonda S, Gorman JM, Yale SA, Amador XF. Characterization of psychotic conditions. Use of the domains of psychopathology model. Arch Gen Psychiatry 1998; 55: 75-81.
    • (1998) Arch Gen Psychiatry , vol.55 , pp. 75-81
    • Ratakonda, S.1    Gorman, J.M.2    Yale, S.A.3    Amador, X.F.4
  • 136
    • 0023606101 scopus 로고
    • The Positive and Negative Syndrome Scale (PANSS) for schizophrenia
    • Kay SR, Fizbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull 1987; 13: 261-276.
    • (1987) Schizophr Bull , vol.13 , pp. 261-276
    • Kay, S.R.1    Fizbein, A.2    Opler, L.A.3
  • 137
    • 0002370297 scopus 로고
    • The Brief Psychiatric Rating Scale (BPRS): Recent developments in ascertainment and scaling
    • Overall JE, Gorham DR. The Brief Psychiatric Rating Scale (BPRS): recent developments in ascertainment and scaling. Psychopharmacol Bull 1988; 24: 97-99.
    • (1988) Psychopharmacol Bull , vol.24 , pp. 97-99
    • Overall, J.E.1    Gorham, D.R.2
  • 138
    • 0026410654 scopus 로고
    • A polydiagnostic application of operational criteria in studies of psychotic illness: Development and reliability of the OPCRIT system
    • McGuffin P, Farmer AE, Harvey IH. A polydiagnostic application of operational criteria in studies of psychotic illness: development and reliability of the OPCRIT system. Arch Gen Psychiatry 1991a; 48: 764-770.
    • (1991) Arch Gen Psychiatry , vol.48 , pp. 764-770
    • McGuffin, P.1    Farmer, A.E.2    Harvey, I.H.3
  • 139
    • 0027999831 scopus 로고
    • Stability trends and longitudinal correlations of negative and positive syndromes within a three-year follow-up of initially hospitalized schizophrenics
    • Rey E-R, Bailer J, Bräuer W, Händel M, Laubenstein D, Stein A. Stability trends and longitudinal correlations of negative and positive syndromes within a three-year follow-up of initially hospitalized schizophrenics. Acta Psychiatry Scand 1994; 90: 405-412.
    • (1994) Acta Psychiatry Scand , vol.90 , pp. 405-412
    • Rey, E.-R.1    Bailer, J.2    Bräuer, W.3    Händel, M.4    Laubenstein, D.5    Stein, A.6
  • 140
    • 0028890068 scopus 로고
    • Five factor model of schizophrenia: Replication across samples
    • Lindenmayer J-P, Grochowski S, Hyman RB. Five factor model of schizophrenia: replication across samples. Schizophr Res 1995; 14: 229-234.
    • (1995) Schizophr Res , vol.14 , pp. 229-234
    • Lindenmayer, J.-P.1    Grochowski, S.2    Hyman, R.B.3
  • 143
    • 0029943582 scopus 로고    scopus 로고
    • The dimensions of schizophrenia phenomenology. Not one or two, at least three, perhaps four
    • Lenzenweger MF, Dworkin RH. The dimensions of schizophrenia phenomenology. Not one or two, at least three, perhaps four. Br J Psychiatry 1996; 168: 432-440.
    • (1996) Br J Psychiatry , vol.168 , pp. 432-440
    • Lenzenweger, M.F.1    Dworkin, R.H.2
  • 144
    • 0030783811 scopus 로고    scopus 로고
    • Empirical assessment of the factorial structure of clinical symptoms in schizophrenia
    • White L, Harvey PD, Opler L, Lindenmayer JP, The PANSS Study Group. Empirical assessment of the factorial structure of clinical symptoms in schizophrenia. Psychopathology 1997; 30: 263-274.
    • (1997) Psychopathology , vol.30 , pp. 263-274
    • White, L.1    Harvey, P.D.2    Opler, L.3    Lindenmayer, J.P.4
  • 145
  • 146
    • 0035575505 scopus 로고    scopus 로고
    • Integrating psychopathological dimensions in functional psychoses: A hierarchical approach
    • Cuesta MJ, Peralta V. Integrating psychopathological dimensions in functional psychoses: a hierarchical approach. Schizophr Res 2001; 52: 215-229.
    • (2001) Schizophr Res , vol.52 , pp. 215-229
    • Cuesta, M.J.1    Peralta, V.2
  • 147
    • 0020685357 scopus 로고
    • Heterogeneity in schizophrenia: A cluster-analytic approach
    • Farmer AE, McGuffin P, Spitznagel EL. Heterogeneity in schizophrenia: a cluster-analytic approach. Psychiatry Res 1983; 8: 1-12.
    • (1983) Psychiatry Res , vol.8 , pp. 1-12
    • Farmer, A.E.1    McGuffin, P.2    Spitznagel, E.L.3
  • 149
  • 151
    • 0031798932 scopus 로고    scopus 로고
    • The structure of psychosis. Latent class analysis of probands from the Roscommon Family Study
    • Kendler KS, Karkowski LM, Walsh D. The structure of psychosis. Latent class analysis of probands from the Roscommon Family Study. Arch Gen Psychiatry 1998; 55: 492-499.
    • (1998) Arch Gen Psychiatry , vol.55 , pp. 492-499
    • Kendler, K.S.1    Karkowski, L.M.2    Walsh, D.3
  • 152
    • 17344366490 scopus 로고    scopus 로고
    • Dimensions and classes of psychosis in a population cohort: A four-class, four-dimension model of schizophrenia and affective psychoses
    • Murray V, McKee I, Miller PM, Young D, Muir WJ, Pelosi AJ et al. Dimensions and classes of psychosis in a population cohort: a four-class, four-dimension model of schizophrenia and affective psychoses. Psychol Med 2005; 35: 499-510.
    • (2005) Psychol Med , vol.35 , pp. 499-510
    • Murray, V.1    McKee, I.2    Miller, P.M.3    Young, D.4    Muir, W.J.5    Pelosi, A.J.6
  • 153
    • 0018100512 scopus 로고
    • Mathematical typology: A grade of membership technique for obtaining disease definition
    • Woodbury MA, Clive J, Garson A. Mathematical typology: a grade of membership technique for obtaining disease definition. Comput Biomed Res 1978; 11: 277-298.
    • (1978) Comput Biomed Res , vol.11 , pp. 277-298
    • Woodbury, M.A.1    Clive, J.2    Garson, A.3
  • 155
    • 0028346077 scopus 로고
    • Symptom profiles of psychiatric disorders based on graded disease classes: An illustration using data from the WHO International Pilot Study of Schizophrenia
    • Manton KG, Korten A, Woodbury MA, Anker M, Jablensky A. Symptom profiles of psychiatric disorders based on graded disease classes: an illustration using data from the WHO International Pilot Study of Schizophrenia. Psychol Med 1994; 24: 133-144.
    • (1994) Psychol Med , vol.24 , pp. 133-144
    • Manton, K.G.1    Korten, A.2    Woodbury, M.A.3    Anker, M.4    Jablensky, A.5
  • 157
    • 0020410147 scopus 로고
    • Familial and sporadic schizophrenia: A symptomatic, prognostic, and EEG comparison
    • Kendler KS, Hayes P. Familial and sporadic schizophrenia: a symptomatic, prognostic, and EEG comparison. Am J Psychiatry 1982; 139: 1557-1562.
    • (1982) Am J Psychiatry , vol.139 , pp. 1557-1562
    • Kendler, K.S.1    Hayes, P.2
  • 158
    • 0023600006 scopus 로고
    • Clinical genetics as clues to the 'real' genetics of schizophrenia (A decade of modest gains while playing for time)
    • Gottesman II, McGuffin P, Farmer AE. Clinical genetics as clues to the 'real' genetics of schizophrenia (A decade of modest gains while playing for time). Schizophr Bull 1987; 13: 23-47.
    • (1987) Schizophr Bull , vol.13 , pp. 23-47
    • Gottesman, I.I.1    McGuffin, P.2    Farmer, A.E.3
  • 159
    • 0005131286 scopus 로고
    • Investigating putative genetic and environmental forms of schizophrenia: Methods and findings
    • Lyons MJ, Kremen WS, Tsuang MT, Faraone SV. Investigating putative genetic and environmental forms of schizophrenia: methods and findings. Int Rev Psychiatr 1989; 1: 259-276.
    • (1989) Int Rev Psychiatr , vol.1 , pp. 259-276
    • Lyons, M.J.1    Kremen, W.S.2    Tsuang, M.T.3    Faraone, S.V.4
  • 160
    • 0028308426 scopus 로고
    • Validity of the familial and sporadic subtypes of schizophrenia
    • Roy M-A, Crowe RR. Validity of the familial and sporadic subtypes of schizophrenia. Am J Psychiatry 1994; 151: 805-814.
    • (1994) Am J Psychiatry , vol.151 , pp. 805-814
    • Roy, M.-A.1    Crowe, R.R.2
  • 161
    • 0028798244 scopus 로고
    • Gender and age at onset in schizophrenia: Impact of family history
    • Gorwood P, Leboyer M, Jay M, Payan C, Feingold J. Gender and age at onset in schizophrenia: impact of family history. Am J Psychiatry 1995; 152: 208-212.
    • (1995) Am J Psychiatry , vol.152 , pp. 208-212
    • Gorwood, P.1    Leboyer, M.2    Jay, M.3    Payan, C.4    Feingold, J.5
  • 164
    • 0023522707 scopus 로고
    • Obstetric complications, neurodevelopmental deviance, and risk of schizophrenia
    • Lewis SW, Murray RM. Obstetric complications, neurodevelopmental deviance, and risk of schizophrenia. J Psychiatry Res 1987; 21: 413-421.
    • (1987) J Psychiatry Res , vol.21 , pp. 413-421
    • Lewis, S.W.1    Murray, R.M.2
  • 165
    • 0024600588 scopus 로고
    • Perinatal complications and genetic loading in schizophrenia: Preliminary findings
    • Schwarzkopf SB, Nasrallah HA, Olson SC. Perinatal complications and genetic loading in schizophrenia: preliminary findings. Psychiatry Res 1989; 27: 233-239.
    • (1989) Psychiatry Res , vol.27 , pp. 233-239
    • Schwarzkopf, S.B.1    Nasrallah, H.A.2    Olson, S.C.3
  • 166
    • 0025008513 scopus 로고
    • Obstetric complications, the putative familial-sporadic distinction, and tardive dyskinesia in schizophrenia
    • O'Callaghan E, Larkin C, Kinsella A, Waddington JL. Obstetric complications, the putative familial-sporadic distinction, and tardive dyskinesia in schizophrenia. Br J Psychiatry 1990; 157: 578-584.
    • (1990) Br J Psychiatry , vol.157 , pp. 578-584
    • O'Callaghan, E.1    Larkin, C.2    Kinsella, A.3    Waddington, J.L.4
  • 167
    • 0020032465 scopus 로고
    • Season of birth in high and low genetic risk schizophrenics
    • Shur E. Season of birth in high and low genetic risk schizophrenics. Br J Psychiatry 1982; 140: 410-415.
    • (1982) Br J Psychiatry , vol.140 , pp. 410-415
    • Shur, E.1
  • 168
    • 0025755638 scopus 로고
    • Season of birth in schizophrenia: Evidence for confinement of an excess of winter births to patients without a family history of mental disorder
    • O'Callaghan E, Gibson T, Colohan HA, Walshe D, Buckley P, Larkin C et al. Season of birth in schizophrenia: evidence for confinement of an excess of winter births to patients without a family history of mental disorder. Br J Psychiatry 1991; 158: 764-769.
    • (1991) Br J Psychiatry , vol.158 , pp. 764-769
    • O'Callaghan, E.1    Gibson, T.2    Colohan, H.A.3    Walshe, D.4    Buckley, P.5    Larkin, C.6
  • 169
    • 0021345397 scopus 로고
    • Cerebral ventricular enlargement in non-genetic schizophrenia: A controlled twin study
    • Reveley AM, Reveley MA, Murray RM. Cerebral ventricular enlargement in non-genetic schizophrenia: a controlled twin study. Br J Psychiatry 1984; 144: 89-93.
    • (1984) Br J Psychiatry , vol.144 , pp. 89-93
    • Reveley, A.M.1    Reveley, M.A.2    Murray, R.M.3
  • 171
    • 0022209417 scopus 로고
    • Tardive dyskinesia: Marked predominance of nongenetic schizophrenia
    • Bartels M, Mann K, Friedrich W. Tardive dyskinesia: marked predominance of nongenetic schizophrenia. Biol Psychiatry 1985; 20: 94-119.
    • (1985) Biol Psychiatry , vol.20 , pp. 94-119
    • Bartels, M.1    Mann, K.2    Friedrich, W.3
  • 172
    • 0026772669 scopus 로고
    • The Nithdale schizophrenia surveys: X. Obstetrical complications, family history and abnormal movements
    • McCreadie RG, Hall DJ, Berry IJ, Robertson LJ, Ewing JI, Geals MF. The Nithdale schizophrenia surveys: X. Obstetrical complications, family history and abnormal movements. Br J Psychiatry 1992; 161: 799-805.
    • (1992) Br J Psychiatry , vol.161 , pp. 799-805
    • McCreadie, R.G.1    Hall, D.J.2    Berry, I.J.3    Robertson, L.J.4    Ewing, J.I.5    Geals, M.F.6
  • 174
    • 0019996023 scopus 로고
    • Familial schizophrenia. A predictor of neuromotor and attentional abnormalities in schizophrenia
    • Walker E, Shaye J. Familial schizophrenia. A predictor of neuromotor and attentional abnormalities in schizophrenia. Arch Gen Psychiatry 1982; 39: 1153-1156.
    • (1982) Arch Gen Psychiatry , vol.39 , pp. 1153-1156
    • Walker, E.1    Shaye, J.2
  • 175
    • 0027534005 scopus 로고
    • A case-control study of family history and cerebral cortical abnormalities in schizophrenia
    • Jones PB, Owen MJ, Lewis SW, Murray RM. A case-control study of family history and cerebral cortical abnormalities in schizophrenia. Acta Psychiatry Scand 1993; 87: 6-12.
    • (1993) Acta Psychiatry Scand , vol.87 , pp. 6-12
    • Jones, P.B.1    Owen, M.J.2    Lewis, S.W.3    Murray, R.M.4
  • 177
    • 0019981730 scopus 로고
    • Problems in the assessment of relative risk of chronic disease among biological relatives of affected individuals
    • Weiss KM, Chakraborty R, Majumder PP. Problems in the assessment of relative risk of chronic disease among biological relatives of affected individuals. J Chron Dis 1982; 35: 539-551.
    • (1982) J Chron Dis , vol.35 , pp. 539-551
    • Weiss, K.M.1    Chakraborty, R.2    Majumder, P.P.3
  • 178
    • 0022871664 scopus 로고
    • The familial sporadic classification: Its power for the resolution of genetic and environmental etiologic factors
    • Eaves LJ, Kendler KS, Schulz SC. The familial sporadic classification: its power for the resolution of genetic and environmental etiologic factors. J Psychiatry Res 1986; 20: 115-130.
    • (1986) J Psychiatry Res , vol.20 , pp. 115-130
    • Eaves, L.J.1    Kendler, K.S.2    Schulz, S.C.3
  • 179
    • 0031459372 scopus 로고    scopus 로고
    • Use of a quantitative trait to map a locus associated with severity of positive symptoms in familial schizophrenia to chromosome 6p
    • Brzustowicz LM, Honer WG, Chow EWC, Hogan J, Hodgkinson K, Bassett AS. Use of a quantitative trait to map a locus associated with severity of positive symptoms in familial schizophrenia to chromosome 6p. Am J Hum Genet 1997; 61: 1388-1396.
    • (1997) Am J Hum Genet , vol.61 , pp. 1388-1396
    • Brzustowicz, L.M.1    Honer, W.G.2    Chow, E.W.C.3    Hogan, J.4    Hodgkinson, K.5    Bassett, A.S.6
  • 180
    • 0033646792 scopus 로고    scopus 로고
    • Genetic heterogeneity in schizophrenia: Stratification of genome scan data using co-segregating related phenotypes
    • Pulver AE, Mulle J, Nestadt G, Swartz KL, Blouin J-L, Dombroski B et al. Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes. Mol Psychiatry 2000; 5: 650-653.
    • (2000) Mol Psychiatry , vol.5 , pp. 650-653
    • Pulver, A.E.1    Mulle, J.2    Nestadt, G.3    Swartz, K.L.4    Blouin, J.-L.5    Dombroski, B.6
  • 181
    • 0036024272 scopus 로고    scopus 로고
    • Genetic heterogeneity in schizophrenia II: Conditional analyses of affected schizophrenia sibling pairs provide evidence for an interaction between markers on chromosome 8p and 14q
    • Chiu YF, McGrath JA, Thornquist MH, Wolyniec PS, Nestadt G, Swartz KL et al. Genetic heterogeneity in schizophrenia II: conditional analyses of affected schizophrenia sibling pairs provide evidence for an interaction between markers on chromosome 8p and 14q. Mol Psychiatry 2002; 7: 658-664.
    • (2002) Mol Psychiatry , vol.7 , pp. 658-664
    • Chiu, Y.F.1    McGrath, J.A.2    Thornquist, M.H.3    Wolyniec, P.S.4    Nestadt, G.5    Swartz, K.L.6
  • 182
    • 0942268961 scopus 로고    scopus 로고
    • Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: A family based association study
    • Fanous AH, Neale MC, Straub RE, Webb BT, O'Neill AF, Walsh D et al. Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association study. Am J Med Genet B Neuropsychiatry Genet 2004; 125B: 69-78.
    • (2004) Am J Med Genet B Neuropsychiatry Genet , vol.125 B , pp. 69-78
    • Fanous, A.H.1    Neale, M.C.2    Straub, R.E.3    Webb, B.T.4    O'Neill, A.F.5    Walsh, D.6
  • 183
    • 33748039818 scopus 로고    scopus 로고
    • Relationship between a high-risk haplotype in the dystrobrevin-binding protein 1 (DTNBP1) gene and clinical features of schizophrenia
    • Fanous A, van den Oord E, Riley B, Aggen SH, Neale MC, O'Neill FA et al. Relationship between a high-risk haplotype in the dystrobrevin-binding protein 1 (DTNBP1) gene and clinical features of schizophrenia. Am J Psychiatry 2005; 162: 1-9.
    • (2005) Am J Psychiatry , vol.162 , pp. 1-9
    • Fanous, A.1    Van Den Oord, E.2    Riley, B.3    Aggen, S.H.4    Neale, M.C.5    O'Neill, F.A.6
  • 185
    • 4544276273 scopus 로고    scopus 로고
    • The behavioural phenotype in velo-cardio-facial syndrome
    • Murphy KC. The behavioural phenotype in velo-cardio-facial syndrome. J Intellect Disabil Res 2004; 48: 524-530.
    • (2004) J Intellect Disabil Res , vol.48 , pp. 524-530
    • Murphy, K.C.1
  • 187
    • 0033652602 scopus 로고    scopus 로고
    • Chromosome 22q11 deletion syndrome: Update and review of the clinical features, cognitive-behavioral spectrum, and psychiatric complications
    • Swillen A, Vogels A, Devriendt K, Fryns JP. Chromosome 22q11 deletion syndrome: update and review of the clinical features, cognitive-behavioral spectrum, and psychiatric complications. Am J Med Genet C Semin Med Genet 2000; 97: 128-135.
    • (2000) Am J Med Genet C Semin Med Genet , vol.97 , pp. 128-135
    • Swillen, A.1    Vogels, A.2    Devriendt, K.3    Fryns, J.P.4
  • 188
    • 11844264786 scopus 로고    scopus 로고
    • A survey of the 22q11 microdeletion in a large cohort of schizophrenia patients
    • Horowitz A, Shifman S, Rivlin N, Pisanté A, Darvasi A. A survey of the 22q11 microdeletion in a large cohort of schizophrenia patients. Schizophr Res 2005; 73: 263-267.
    • (2005) Schizophr Res , vol.73 , pp. 263-267
    • Horowitz, A.1    Shifman, S.2    Rivlin, N.3    Pisanté, A.4    Darvasi, A.5
  • 191
  • 192
    • 0036468696 scopus 로고    scopus 로고
    • Structural brain abnormalities in patients with schizophrenia and 22q11 deletion syndrome
    • Chow EWC, Zipursky RB, Mikulis DJ, Bassett AS. Structural brain abnormalities in patients with schizophrenia and 22q11 deletion syndrome. Biol Psychiatry 2002; 51: 208-215.
    • (2002) Biol Psychiatry , vol.51 , pp. 208-215
    • Chow, E.W.C.1    Zipursky, R.B.2    Mikulis, D.J.3    Bassett, A.S.4
  • 193
    • 33144456319 scopus 로고    scopus 로고
    • Abnormal patterns of cortical gyrification in velo-cardio-facial syndrome (deletion 22q11.2): An MRI study
    • Schaer M, Schmitt JE, Glaser B, Lazeyras F, Delavelle J, Eliez S. Abnormal patterns of cortical gyrification in velo-cardio-facial syndrome (deletion 22q11.2): an MRI study. Psychiatry Res Neuroim 2006; 146: 1-11.
    • (2006) Psychiatry Res Neuroim , vol.146 , pp. 1-11
    • Schaer, M.1    Schmitt, J.E.2    Glaser, B.3    Lazeyras, F.4    Delavelle, J.5    Eliez, S.6
  • 195
    • 27744554247 scopus 로고    scopus 로고
    • Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short-and long-term memory
    • Cannon TD, Hennah W, van Erp TGM, Thompson PM, Lönnqvist J, Huttunen M et al. Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short-and long-term memory. Arch Gen Psychiatry 2005; 62: 1205-1213.
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 1205-1213
    • Cannon, T.D.1    Hennah, W.2    Van Erp, T.G.M.3    Thompson, P.M.4    Lönnqvist, J.5    Huttunen, M.6
  • 200
    • 0035825219 scopus 로고    scopus 로고
    • Endophenotypes as quantitative risk factors for psychiatric disease: Rationale and study design
    • Almasy L, Blangero J. Endophenotypes as quantitative risk factors for psychiatric disease: rationale and study design. Am J Med Genet Neuropsychiatry Genet 2001; 105: 42-44.
    • (2001) Am J Med Genet Neuropsychiatry Genet , vol.105 , pp. 42-44
    • Almasy, L.1    Blangero, J.2
  • 201
    • 0015541474 scopus 로고
    • Genetic theorizing and schizophrenia
    • Gottesman II, Shields J. Genetic theorizing and schizophrenia. Br J Psychiatry 1973; 122: 15-30.
    • (1973) Br J Psychiatry , vol.122 , pp. 15-30
    • Gottesman, I.I.1    Shields, J.2
  • 202
    • 0038823525 scopus 로고    scopus 로고
    • The endophenotype concept in psychiatry: Etymology and strategic intentions
    • Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003; 160: 636-645.
    • (2003) Am J Psychiatry , vol.160 , pp. 636-645
    • Gottesman, I.I.1    Gould, T.D.2
  • 203
    • 0026327486 scopus 로고
    • Consistent linkage of the long-QT syndrome to the Harvey ras-1 locus on chromosome 11
    • Keating M, Dunn C, Atkinson D, Timothy K, Vincent GM, Leppert M. Consistent linkage of the long-QT syndrome to the Harvey ras-1 locus on chromosome 11. Am J Hum Genet 1991; 49: 1335-1339.
    • (1991) Am J Hum Genet , vol.49 , pp. 1335-1339
    • Keating, M.1    Dunn, C.2    Atkinson, D.3    Timothy, K.4    Vincent, G.M.5    Leppert, M.6
  • 204
    • 0025354907 scopus 로고
    • Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps
    • Leppert M, Burt R, Hughes JP, Samowitz W, Nakamura Y, Woodward S et al. Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps. New Engl J Med 1990; 322: 904-908.
    • (1990) New Engl J Med , vol.322 , pp. 904-908
    • Leppert, M.1    Burt, R.2    Hughes, J.P.3    Samowitz, W.4    Nakamura, Y.5    Woodward, S.6
  • 205
    • 0022219640 scopus 로고
    • Genetic analysis of idiopathic hemochromatosis using both qualitative (disease status) and quantitative (serum iron) information
    • Lalouel JM, Le Mignon L, Simon M, Fauchet R, Bourel M, Rao DC et al. Genetic analysis of idiopathic hemochromatosis using both qualitative (disease status) and quantitative (serum iron) information. Am J Hum Genet 1985; 37: 700-718.
    • (1985) Am J Hum Genet , vol.37 , pp. 700-718
    • Lalouel, J.M.1    Le Mignon, L.2    Simon, M.3    Fauchet, R.4    Bourel, M.5    Rao, D.C.6
  • 207
    • 0021322269 scopus 로고
    • Pursuit eye movement dysfunctions in schizophrenia. Family evidence for specificity
    • Holzman PS, Solomon CM, Levin S, Waternaux CS. Pursuit eye movement dysfunctions in schizophrenia. Family evidence for specificity. Arch Gen Psychiatry 1984; 41: 136-139.
    • (1984) Arch Gen Psychiatry , vol.41 , pp. 136-139
    • Holzman, P.S.1    Solomon, C.M.2    Levin, S.3    Waternaux, C.S.4
  • 208
    • 0027078428 scopus 로고
    • Behavioral markers of schizophrenia useful for genetic studies
    • Holzman PS. Behavioral markers of schizophrenia useful for genetic studies. J Psychiatry Res 1992; 26: 427-445.
    • (1992) J Psychiatry Res , vol.26 , pp. 427-445
    • Holzman, P.S.1
  • 209
    • 0035398424 scopus 로고    scopus 로고
    • Using biological indices to classify schizophrenia and other psychotic patients
    • Sponheim SR, Iacono WG, Thuras PD, Beiser M. Using biological indices to classify schizophrenia and other psychotic patients. Schizophr Res 2001; 50: 139-150.
    • (2001) Schizophr Res , vol.50 , pp. 139-150
    • Sponheim, S.R.1    Iacono, W.G.2    Thuras, P.D.3    Beiser, M.4
  • 210
    • 0035870801 scopus 로고    scopus 로고
    • Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia
    • Braff DL, Geyer MA, Light GA, Sprock J, Perry W, Cadenhead KS et al. Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia. Schizophr Res 2001; 49: 171-178.
    • (2001) Schizophr Res , vol.49 , pp. 171-178
    • Braff, D.L.1    Geyer, M.A.2    Light, G.A.3    Sprock, J.4    Perry, W.5    Cadenhead, K.S.6
  • 211
    • 0036849530 scopus 로고    scopus 로고
    • Provisional mapping of quantitative trait loci modulating the acoustic startle response and prepulse inhibition of acoustic startle
    • Joober R, Zarate J-M, Rouleau G-A, Skamene E, Boksa P. Provisional mapping of quantitative trait loci modulating the acoustic startle response and prepulse inhibition of acoustic startle. Neuropsychopharmacology 2002; 27: 765-781.
    • (2002) Neuropsychopharmacology , vol.27 , pp. 765-781
    • Joober, R.1    Zarate, J.-M.2    Rouleau, G.-A.3    Skamene, E.4    Boksa, P.5
  • 212
    • 33644876567 scopus 로고    scopus 로고
    • Reduced prepulse inhibition in unaffected siblings of schizophrenia patients
    • Kumari V, Das M, Zachariah E, Ettinger U, Sharma T. Reduced prepulse inhibition in unaffected siblings of schizophrenia patients. Psychophysiology 2005; 42: 588-594.
    • (2005) Psychophysiology , vol.42 , pp. 588-594
    • Kumari, V.1    Das, M.2    Zachariah, E.3    Ettinger, U.4    Sharma, T.5
  • 213
    • 0033032776 scopus 로고    scopus 로고
    • Elementary phenotypes in the neurobiological and genetic study of schizophrenia
    • Adler LE, Freedman R, Ross RG, Olincy A, Waldo MC. Elementary phenotypes in the neurobiological and genetic study of schizophrenia. Biol Psychiatry 1999; 46: 8-18.
    • (1999) Biol Psychiatry , vol.46 , pp. 8-18
    • Adler, L.E.1    Freedman, R.2    Ross, R.G.3    Olincy, A.4    Waldo, M.C.5
  • 216
    • 24944542218 scopus 로고    scopus 로고
    • Is the P300 wave an endophenotype for schizophrenia? a meta-analysis and a family study
    • Bramon E, McDonald C, Croft RJ, Landau S, Filbey F, Gruzelier JH et al. Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study. NeuroImage 2005; 27: 960-968.
    • (2005) NeuroImage , vol.27 , pp. 960-968
    • Bramon, E.1    McDonald, C.2    Croft, R.J.3    Landau, S.4    Filbey, F.5    Gruzelier, J.H.6
  • 218
    • 0036791079 scopus 로고    scopus 로고
    • Duration mismatch negativity in biological relatives of patients with schizophrenia spectrum disorders
    • Michie PT, Innes-Brown H, Todd J, Jablensky AV. Duration mismatch negativity in biological relatives of patients with schizophrenia spectrum disorders. Biol Psychiatry 2002; 52: 749-758.
    • (2002) Biol Psychiatry , vol.52 , pp. 749-758
    • Michie, P.T.1    Innes-Brown, H.2    Todd, J.3    Jablensky, A.V.4
  • 219
    • 2642517779 scopus 로고    scopus 로고
    • Mismatch negativity potentials and cognitive impairment in schizophrenia
    • Baldeweg T, Klugman A, Gruzelier J, Hirsch SR. Mismatch negativity potentials and cognitive impairment in schizophrenia. Schizophr Res 2004; 69: 203-217.
    • (2004) Schizophr Res , vol.69 , pp. 203-217
    • Baldeweg, T.1    Klugman, A.2    Gruzelier, J.3    Hirsch, S.R.4
  • 221
    • 20444501679 scopus 로고    scopus 로고
    • Mismatch negativity in schizophrenia: A meta-analysis
    • Umbricht D, Krljes S. Mismatch negativity in schizophrenia: a meta-analysis. Schizophr Res 2005; 76: 1-23.
    • (2005) Schizophr Res , vol.76 , pp. 1-23
    • Umbricht, D.1    Krljes, S.2
  • 222
    • 0023894061 scopus 로고
    • A single dominant gene can account for eye tracking dysfunctions and schizophrenia in offspring of discordant twins
    • Holzman PS, Kringlen E, Matthysse S, Flanagan SD, Lipton RB, Cramer G et al. A single dominant gene can account for eye tracking dysfunctions and schizophrenia in offspring of discordant twins. Arch Gen Psychiatry 1988; 45: 641-647.
    • (1988) Arch Gen Psychiatry , vol.45 , pp. 641-647
    • Holzman, P.S.1    Kringlen, E.2    Matthysse, S.3    Flanagan, S.D.4    Lipton, R.B.5    Cramer, G.6
  • 226
    • 0028335658 scopus 로고
    • Saccadic system functioning among schizophrenia patients and their first-degree relatives
    • Clementz BA, McDowell JE, Zisook S. Saccadic system functioning among schizophrenia patients and their first-degree relatives. J Abnorm Psychol 1994; 103: 277-287.
    • (1994) J Abnorm Psychol , vol.103 , pp. 277-287
    • Clementz, B.A.1    McDowell, J.E.2    Zisook, S.3
  • 227
    • 0036036587 scopus 로고    scopus 로고
    • Error rate on the antisaccade task: Heritability and developmental change in performance among preadolescent and late-adolescent female twin youth
    • Malone SM, Iacono WG. Error rate on the antisaccade task: heritability and developmental change in performance among preadolescent and late-adolescent female twin youth. Psychophysiology 2002; 39: 664-673.
    • (2002) Psychophysiology , vol.39 , pp. 664-673
    • Malone, S.M.1    Iacono, W.G.2
  • 230
    • 33745218264 scopus 로고    scopus 로고
    • A multivariate electrophysiological endophenotype, from a unitary cohort, shows greater research utility than any single feature in theWestern Australian Family Study of Schizophrenia
    • Pre-publication version available online 20 December
    • Price GW, Michie PT, Johnston J, Innes-Brown H, Kent A, Clissa P et al. A multivariate electrophysiological endophenotype, from a unitary cohort, shows greater research utility than any single feature in theWestern Australian Family Study of Schizophrenia. Biol Psychiatry, Pre-publication version available online 20 December 2005, http:///www.sciencedirect.com/science/article/B6T4S- 4HVDJK7-3/2/da823e5eacd44ad891541fe0c0c3acfe.
    • (2005) Biol Psychiatry
    • Price, G.W.1    Michie, P.T.2    Johnston, J.3    Innes-Brown, H.4    Kent, A.5    Clissa, P.6
  • 232
    • 5044225424 scopus 로고    scopus 로고
    • Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes
    • McDonald C, Bullmore ET, Sham PC, Chitnis X, Wickham H, Bramon E et al. Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes. Arch Gen Psychiatry 2004; 61: 974-984.
    • (2004) Arch Gen Psychiatry , vol.61 , pp. 974-984
    • McDonald, C.1    Bullmore, E.T.2    Sham, P.C.3    Chitnis, X.4    Wickham, H.5    Bramon, E.6
  • 233
    • 0037395330 scopus 로고    scopus 로고
    • Structural brain abnormalities among relatives of patients with schizophrenia: Implications for linkage studies
    • Faraone SV, Seidman LJ, Kremen WS, Kennedy D, Makris N, Caviness VS et al. Structural brain abnormalities among relatives of patients with schizophrenia: implications for linkage studies. Schizophr Res 2003; 60: 125-140.
    • (2003) Schizophr Res , vol.60 , pp. 125-140
    • Faraone, S.V.1    Seidman, L.J.2    Kremen, W.S.3    Kennedy, D.4    Makris, N.5    Caviness, V.S.6
  • 234
    • 27744509503 scopus 로고    scopus 로고
    • Whole-brain morphometric study of schizophrenia revealing a spatially complex set of focal abnormalities
    • Davatzikos C, Shen D, Gur RC, Wu X, Liu D, Fan Y et al. Whole-brain morphometric study of schizophrenia revealing a spatially complex set of focal abnormalities. Arch Gen Psychiatry 2005; 62: 1218-1227.
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 1218-1227
    • Davatzikos, C.1    Shen, D.2    Gur, R.C.3    Wu, X.4    Liu, D.5    Fan, Y.6
  • 235
    • 0037441795 scopus 로고    scopus 로고
    • Quantification of frontal and temporal lobe brain-imaging findings in schizophrenia: A meta-analysis
    • Davidson LL, Heinrichs RW. Quantification of frontal and temporal lobe brain-imaging findings in schizophrenia: a meta-analysis. Psychiatry Res Neuroim 2003; 122: 69-87.
    • (2003) Psychiatry Res Neuroim , vol.122 , pp. 69-87
    • Davidson, L.L.1    Heinrichs, R.W.2
  • 236
    • 0033051235 scopus 로고    scopus 로고
    • Atrophic and static (neurodevelopmental) schizophrenic psychoses: Premorbid functioning, symptoms and neuroleptic response
    • Garver DL, Nair TR, Christensen JD, Holcomb J, Ramberg J, Kingsbury S. Atrophic and static (neurodevelopmental) schizophrenic psychoses: premorbid functioning, symptoms and neuroleptic response. Neuropsychopharmacology 1999; 21: 82-92.
    • (1999) Neuropsychopharmacology , vol.21 , pp. 82-92
    • Garver, D.L.1    Nair, T.R.2    Christensen, J.D.3    Holcomb, J.4    Ramberg, J.5    Kingsbury, S.6
  • 237
    • 0000412025 scopus 로고    scopus 로고
    • Neurocognitive vulnerability factors for schizophrenia: Convergence across genetic risk studies and longitudinal trait-state studies
    • Lenzenweger MF and Dworkin RH (eds). American Psychological Association: Washington, DC
    • Nuechterlein KH, Asarnow RF, Subotnik KL, Fogelson DL, Ventura J, Torquato RD et al. Neurocognitive vulnerability factors for schizophrenia: convergence across genetic risk studies and longitudinal trait-state studies. In: Lenzenweger MF and Dworkin RH (eds). Origins and Development of Schizophrenia: Advances in Experimental Psychopathology. American Psychological Association: Washington, DC, 1998, pp 299-327.
    • (1998) Origins and Development of Schizophrenia: Advances in Experimental Psychopathology , pp. 299-327
    • Nuechterlein, K.H.1    Asarnow, R.F.2    Subotnik, K.L.3    Fogelson, D.L.4    Ventura, J.5    Torquato, R.D.6
  • 239
    • 2342590773 scopus 로고    scopus 로고
    • Sustained attention deficits in nonpsychotic relatives of schizophrenic patients: A recurrence risk ratio analysis
    • Chen WJ, Chang C-H, Liu SK, Hwang TJ, Hwu H-G. Sustained attention deficits in nonpsychotic relatives of schizophrenic patients: a recurrence risk ratio analysis. Biol Psychiatry 2004; 55: 995-1000.
    • (2004) Biol Psychiatry , vol.55 , pp. 995-1000
    • Chen, W.J.1    Chang, C.-H.2    Liu, S.K.3    Hwang, T.J.4    Hwu, H.-G.5
  • 241
    • 0036790920 scopus 로고    scopus 로고
    • Memory-delineated subtypes of schizophrenia: Relationship to clinical, neuroanatonical, and neurophysiological measures
    • Turetsky BI, Moberg PJ, Mozley LH, Moelter ST, Agrin RN, Gur RC et al. Memory-delineated subtypes of schizophrenia: relationship to clinical, neuroanatonical, and neurophysiological measures. Neuropsychology 2002; 16: 481-490.
    • (2002) Neuropsychology , vol.16 , pp. 481-490
    • Turetsky, B.I.1    Moberg, P.J.2    Mozley, L.H.3    Moelter, S.T.4    Agrin, R.N.5    Gur, R.C.6
  • 242
    • 0141791141 scopus 로고    scopus 로고
    • Executive subprocesses in working memory. Relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia
    • Goldberg TE, Egan MF, Gscheidle T, Coppola R, Weickert T, Kolachana BS et al. Executive subprocesses in working memory. Relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia. Arch Gen Psychiatry 2003; 60: 889-896.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 889-896
    • Goldberg, T.E.1    Egan, M.F.2    Gscheidle, T.3    Coppola, R.4    Weickert, T.5    Kolachana, B.S.6
  • 243
    • 4944248060 scopus 로고    scopus 로고
    • Heterogeneity of schizophrenia: A study of individual neuropsychological profiles
    • Kremen WS, Seidman LJ, Faraone SV, Toomey R, Tsuang MT. Heterogeneity of schizophrenia: a study of individual neuropsychological profiles. Schizophr Res 2004; 71: 307-321.
    • (2004) Schizophr Res , vol.71 , pp. 307-321
    • Kremen, W.S.1    Seidman, L.J.2    Faraone, S.V.3    Toomey, R.4    Tsuang, M.T.5
  • 246
    • 1942473004 scopus 로고    scopus 로고
    • Verbal memory in schizophrenia: Additional evidence of subtypes having different cognitive deficits
    • Bruder GE, Wexler BE, Sage MM, Gil RB, Gorman JM. Verbal memory in schizophrenia: additional evidence of subtypes having different cognitive deficits. Schizophr Res 2004; 68: 137-147.
    • (2004) Schizophr Res , vol.68 , pp. 137-147
    • Bruder, G.E.1    Wexler, B.E.2    Sage, M.M.3    Gil, R.B.4    Gorman, J.M.5
  • 247
    • 23944474042 scopus 로고    scopus 로고
    • Genetic evidence for a distinct subtype of schizophrenia characterized by pervasive cognitive deficit
    • Hallmayer JF, Kalaydjieva L, Badcock J, Dragovic M, Howell S, Michie PT et al. Genetic evidence for a distinct subtype of schizophrenia characterized by pervasive cognitive deficit. Am J Hum Genet 2005; 77: 468-476.
    • (2005) Am J Hum Genet , vol.77 , pp. 468-476
    • Hallmayer, J.F.1    Kalaydjieva, L.2    Badcock, J.3    Dragovic, M.4    Howell, S.5    Michie, P.T.6
  • 248
    • 0031931372 scopus 로고    scopus 로고
    • Neurological abnormalities in familial and sporadic schizophrenia
    • Griffiths TD, Sigmundsson T, Takei N, Rowe D, Murray RM. Neurological abnormalities in familial and sporadic schizophrenia. Brain 1998; 121: 191-203.
    • (1998) Brain , vol.121 , pp. 191-203
    • Griffiths, T.D.1    Sigmundsson, T.2    Takei, N.3    Rowe, D.4    Murray, R.M.5
  • 249
    • 0033545220 scopus 로고    scopus 로고
    • Neurologic signs of cerebellar and cortical sensory dysfunction in schizophrenics and their relatives
    • Kinney DK, Yurgelun-Todd DA, Woods BT. Neurologic signs of cerebellar and cortical sensory dysfunction in schizophrenics and their relatives. Schizophr Res 1999; 35: 99-104.
    • (1999) Schizophr Res , vol.35 , pp. 99-104
    • Kinney, D.K.1    Yurgelun-Todd, D.A.2    Woods, B.T.3
  • 250
    • 0042206785 scopus 로고    scopus 로고
    • Neurological soft-signs and minor physical anomalies in schizophrenia: Differential transmission within families
    • Gourion D, Goldberger C, Bourdel M-C, Bayle FJ, Millet B, Olie J-P et al. Neurological soft-signs and minor physical anomalies in schizophrenia: differential transmission within families. Schizophr Res 2003; 63: 181-187.
    • (2003) Schizophr Res , vol.63 , pp. 181-187
    • Gourion, D.1    Goldberger, C.2    Bourdel, M.-C.3    Bayle, F.J.4    Millet, B.5    Olie, J.-P.6
  • 251
    • 0042477755 scopus 로고    scopus 로고
    • Diagnostic specificity and neuroanatomical validity of neurological abnormalities in first-episode psychoses
    • Keshavan MS, Sanders RD, Sweeney JA, Diwadkar VA, Goldstein G, Pettegrew JW et al. Diagnostic specificity and neuroanatomical validity of neurological abnormalities in first-episode psychoses. Am J Psychiatry 2003; 160: 1298-1304.
    • (2003) Am J Psychiatry , vol.160 , pp. 1298-1304
    • Keshavan, M.S.1    Sanders, R.D.2    Sweeney, J.A.3    Diwadkar, V.A.4    Goldstein, G.5    Pettegrew, J.W.6
  • 252
    • 24944451071 scopus 로고    scopus 로고
    • Laterality phenotypes in patients with schizophrenia, their siblings and controls: Associations with clinical and cognitive variables
    • Dragovic M, Hammond G, Badcock JC, Jablensky A. Laterality phenotypes in patients with schizophrenia, their siblings and controls: associations with clinical and cognitive variables. Br J Psychiatry 2005; 187: 221-228.
    • (2005) Br J Psychiatry , vol.187 , pp. 221-228
    • Dragovic, M.1    Hammond, G.2    Badcock, J.C.3    Jablensky, A.4
  • 253
    • 0026533428 scopus 로고
    • A family study of nailfold plexus visibility in psychotic disorders
    • Clementz BA, Iacono WG, Ficken J, Beiser M. A family study of nailfold plexus visibility in psychotic disorders. Biol Psychiatry 1992b; 31: 378-390.
    • (1992) Biol Psychiatry , vol.31 , pp. 378-390
    • Clementz, B.A.1    Iacono, W.G.2    Ficken, J.3    Beiser, M.4
  • 254
    • 0036244397 scopus 로고    scopus 로고
    • Minor physical anomalies and quantitative measures of the head and face in patients with psychosis
    • McGrath J, El-Saadi O, Grim V, Cardy S, Chapple B, Chant D et al. Minor physical anomalies and quantitative measures of the head and face in patients with psychosis. Arch Gen Psychiatry 2002; 59: 458-464.
    • (2002) Arch Gen Psychiatry , vol.59 , pp. 458-464
    • McGrath, J.1    El-Saadi, O.2    Grim, V.3    Cardy, S.4    Chapple, B.5    Chant, D.6
  • 255
    • 3042809685 scopus 로고    scopus 로고
    • Neurocognitive deficits in schizophrenia
    • Hirsch SR and Weinberger DR (eds) Blackwell Publishing: Cambridge, Massachusetts
    • Goldberg TE, David A, Gold JM. Neurocognitive deficits in schizophrenia. In: Hirsch SR and Weinberger DR (eds) Schizophrenia, 2nd edn. Blackwell Publishing: Cambridge, Massachusetts, 2003, pp. 168-184.
    • (2003) Schizophrenia, 2nd Edn. , pp. 168-184
    • Goldberg, T.E.1    David, A.2    Gold, J.M.3
  • 256
    • 0142030173 scopus 로고    scopus 로고
    • Convergence of biological and psychological perspectives on cognitive coordination in schizophrenia
    • Phillips WA, Silverstein SM. Convergence of biological and psychological perspectives on cognitive coordination in schizophrenia. Behav Brain Sci 2003; 26: 65-138.
    • (2003) Behav Brain Sci , vol.26 , pp. 65-138
    • Phillips, W.A.1    Silverstein, S.M.2
  • 257
    • 17044406214 scopus 로고    scopus 로고
    • The primacy of cognition in schizophrenia
    • Heinrichs RW. The primacy of cognition in schizophrenia. Am Psychol 2005; 60: 229-242.
    • (2005) Am Psychol , vol.60 , pp. 229-242
    • Heinrichs, R.W.1
  • 258
    • 0031957127 scopus 로고    scopus 로고
    • IQ decline during childhood and adult psychotic symptoms in a community sample: A 19-year longitudinal study
    • Kremen WS, Buka SL, Seidman LJ, Goldstein JM, Koren D, Tsuang MT. IQ decline during childhood and adult psychotic symptoms in a community sample: a 19-year longitudinal study. Am J Psychiatry 1998; 155: 672-677.
    • (1998) Am J Psychiatry , vol.155 , pp. 672-677
    • Kremen, W.S.1    Buka, S.L.2    Seidman, L.J.3    Goldstein, J.M.4    Koren, D.5    Tsuang, M.T.6
  • 259
    • 0032811224 scopus 로고    scopus 로고
    • Generalized cognitive deficits in schizophrenia. A study of first-episode patients
    • Mohamed S, Paulsen JS, O'Leary D, Arndt S, Andreasen N. Generalized cognitive deficits in schizophrenia. A study of first-episode patients. Arch Gen Psychiatry 1999; 56: 749-754.
    • (1999) Arch Gen Psychiatry , vol.56 , pp. 749-754
    • Mohamed, S.1    Paulsen, J.S.2    O'Leary, D.3    Arndt, S.4    Andreasen, N.5
  • 260
    • 7544251500 scopus 로고    scopus 로고
    • Neuropsychology of first-episode schizophrenia: Initial characterization and clinical correlates
    • Bilder RM, Goldman RS, Robinson D, Reiter G, Bell L, Bates JA et al. Neuropsychology of first-episode schizophrenia: initial characterization and clinical correlates. Am J Psychiatry 2000; 157: 549-559.
    • (2000) Am J Psychiatry , vol.157 , pp. 549-559
    • Bilder, R.M.1    Goldman, R.S.2    Robinson, D.3    Reiter, G.4    Bell, L.5    Bates, J.A.6
  • 262
    • 11844261436 scopus 로고    scopus 로고
    • Memory impairments identified in people at ultra-high risk for psychosis who later develop first-episode psychosis
    • Brewer WJ, Francey SM,Wood SJ, Jackson HJ, Pantelis C, Phillips LJ et al. Memory impairments identified in people at ultra-high risk for psychosis who later develop first-episode psychosis. Am J Psychiatry 2005; 162: 71-78.
    • (2005) Am J Psychiatry , vol.162 , pp. 71-78
    • Brewer, W.J.1    Francey, S.M.2    Wood, S.J.3    Jackson, H.J.4    Pantelis, C.5    Phillips, L.J.6
  • 263
    • 0036888330 scopus 로고    scopus 로고
    • Studies of individuals never treated with antipsychotic medications: A review
    • Torrey EF. Studies of individuals never treated with antipsychotic medications: a review. Schizophr Res 2002; 58: 101-115.
    • (2002) Schizophr Res , vol.58 , pp. 101-115
    • Torrey, E.F.1
  • 264
    • 0032858515 scopus 로고    scopus 로고
    • Longitudinal neuropsychological follow-up study of patients with first-episode schizophrenia
    • Hoff AL, Sakuma M,Wieneke M, Horon R, Kushner M, DeLisi LE. Longitudinal neuropsychological follow-up study of patients with first-episode schizophrenia. Am J Psychiatry 1999; 156: 1336-1341.
    • (1999) Am J Psychiatry , vol.156 , pp. 1336-1341
    • Hoff, A.L.1    Sakuma, M.2    Wieneke, M.3    Horon, R.4    Kushner, M.5    DeLisi, L.E.6
  • 266
    • 13444271819 scopus 로고    scopus 로고
    • Neurocognitive impairment across the lifespan in schizophrenia: An update
    • Kurtz MM. Neurocognitive impairment across the lifespan in schizophrenia: an update. Schizophr Res 2005; 74: 15-26.
    • (2005) Schizophr Res , vol.74 , pp. 15-26
    • Kurtz, M.M.1
  • 267
    • 0031281250 scopus 로고    scopus 로고
    • Parsing schizophrenia with neurocognitive tests: Evidence of stability and validity
    • Heinrichs RW, Ruttan L, Zakzanis KK, Case D. Parsing schizophrenia with neurocognitive tests: evidence of stability and validity. Brain Cogn 1997; 35: 207-224.
    • (1997) Brain Cogn , vol.35 , pp. 207-224
    • Heinrichs, R.W.1    Ruttan, L.2    Zakzanis, K.K.3    Case, D.4
  • 268
    • 0242720304 scopus 로고    scopus 로고
    • Cognitive performance in schizophrenia patients assessed before and following the first psychotic episode
    • Caspi A, Reichenberg A, Weiser M, Rabinowitz J, Kaplan Z, Knobler H et al. Cognitive performance in schizophrenia patients assessed before and following the first psychotic episode. Schizophr Res 2003; 65: 87-94.
    • (2003) Schizophr Res , vol.65 , pp. 87-94
    • Caspi, A.1    Reichenberg, A.2    Weiser, M.3    Rabinowitz, J.4    Kaplan, Z.5    Knobler, H.6
  • 269
    • 0033790904 scopus 로고    scopus 로고
    • Nithsdale Schizophrenia Surveys 20. Cognitive function in a catchment-area-based population of patients with schizophrenia
    • Kelly C, Sharkey V, Morrison G, Allardyce J, McCreadie RG. Nithsdale Schizophrenia Surveys 20. Cognitive function in a catchment-area-based population of patients with schizophrenia. Br J Psychiatry 2000; 177: 348-353.
    • (2000) Br J Psychiatry , vol.177 , pp. 348-353
    • Kelly, C.1    Sharkey, V.2    Morrison, G.3    Allardyce, J.4    McCreadie, R.G.5
  • 270
    • 0029918481 scopus 로고    scopus 로고
    • What are the functional consequences of neurocognitive deficits in schizophrenia?
    • Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry 1996; 153: 321-330.
    • (1996) Am J Psychiatry , vol.153 , pp. 321-330
    • Green, M.F.1
  • 271
  • 272
    • 0036642360 scopus 로고    scopus 로고
    • The relationship between positive symptoms and instrumental work functioning in schizophrenia: A 10 year follow-up study
    • Racenstein JM, Harrow M, Reed R, Martin E, Herbener E, Penn DL. The relationship between positive symptoms and instrumental work functioning in schizophrenia: a 10 year follow-up study. Schizophr Res 2002; 56: 95-103.
    • (2002) Schizophr Res , vol.56 , pp. 95-103
    • Racenstein, J.M.1    Harrow, M.2    Reed, R.3    Martin, E.4    Herbener, E.5    Penn, D.L.6
  • 273
    • 0346667032 scopus 로고    scopus 로고
    • The relations between cognition and the independent living skill of shopping in people with schizophrenia
    • Rempfer MV, Hamera EK, Brown CE, Cromwell RL. The relations between cognition and the independent living skill of shopping in people with schizophrenia. Psychiatry Res 2003; 117: 103-112.
    • (2003) Psychiatry Res , vol.117 , pp. 103-112
    • Rempfer, M.V.1    Hamera, E.K.2    Brown, C.E.3    Cromwell, R.L.4
  • 274
    • 33645895595 scopus 로고    scopus 로고
    • Neurocognitive and symptom correlates of daily problem-solving skills in schizophrenia
    • Revheim N, Schecter I, Kim D, Silipo G, Allingham B, Butler P et al. Neurocognitive and symptom correlates of daily problem-solving skills in schizophrenia. Schizophr Res 2006; 83: 237-245.
    • (2006) Schizophr Res , vol.83 , pp. 237-245
    • Revheim, N.1    Schecter, I.2    Kim, D.3    Silipo, G.4    Allingham, B.5    Butler, P.6
  • 276
    • 0035192558 scopus 로고    scopus 로고
    • Neuropsychological differences among empirically derived clinical subtypes of schizophrenia
    • Hill SK, Ragland JD, Gur RC, Gur RE. Neuropsychological differences among empirically derived clinical subtypes of schizophrenia. Neuropsychology 2001; 15: 492-501.
    • (2001) Neuropsychology , vol.15 , pp. 492-501
    • Hill, S.K.1    Ragland, J.D.2    Gur, R.C.3    Gur, R.E.4
  • 278
    • 13544276942 scopus 로고    scopus 로고
    • Cognitive function in schizoaffective disorder and clinical subtypes of schizophrenia
    • Goldstein G, Shemansky WJ, Allen DN. Cognitive function in schizoaffective disorder and clinical subtypes of schizophrenia. Arch Clin Neuropsychol 2005; 20: 153-159.
    • (2005) Arch Clin Neuropsychol , vol.20 , pp. 153-159
    • Goldstein, G.1    Shemansky, W.J.2    Allen, D.N.3
  • 279
  • 282
    • 21044437513 scopus 로고    scopus 로고
    • Tests of executive functions in first-degree relatives of schizophrenic patients: A meta-analysis
    • Szöke A, Schürhoff F, Mathieu F, Meary A, Ionescu S, Leboyer M. Tests of executive functions in first-degree relatives of schizophrenic patients: a meta-analysis. Psychol Med 2005; 35: 771-782.
    • (2005) Psychol Med , vol.35 , pp. 771-782
    • Szöke, A.1    Schürhoff, F.2    Mathieu, F.3    Meary, A.4    Ionescu, S.5    Leboyer, M.6
  • 283
    • 20844439711 scopus 로고    scopus 로고
    • Indicators of genetic liability to schizophrenia: A sibling study of neuropsychological performance
    • Thompson JL, Watson JR, Steinhauer SR, Goldstein G, Pogue-Geile MF. Indicators of genetic liability to schizophrenia: a sibling study of neuropsychological performance. Schizophr Bull 2005; 31: 85-96.
    • (2005) Schizophr Bull , vol.31 , pp. 85-96
    • Thompson, J.L.1    Watson, J.R.2    Steinhauer, S.R.3    Goldstein, G.4    Pogue-Geile, M.F.5
  • 285
    • 0031903740 scopus 로고    scopus 로고
    • Neurocognitive deficit in schizophrenia: A quantitative review of the evidence
    • Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 1998; 12: 426-445.
    • (1998) Neuropsychology , vol.12 , pp. 426-445
    • Heinrichs, R.W.1    Zakzanis, K.K.2
  • 286
    • 0024839650 scopus 로고
    • Strategies for resolving the heretogeneity of schizophrenics and their relatives using cognitive measures
    • Chapman LJ, Chapman JP. Strategies for resolving the heretogeneity of schizophrenics and their relatives using cognitive measures. J Abnorm Psychol 1989; 98: 357-366.
    • (1989) J Abnorm Psychol , vol.98 , pp. 357-366
    • Chapman, L.J.1    Chapman, J.P.2
  • 287
    • 0025143085 scopus 로고
    • Neuropsychological heterogeneity in schizophrenia: A consideration of abstraction and problem-solving abilities
    • Goldstein G. Neuropsychological heterogeneity in schizophrenia: a consideration of abstraction and problem-solving abilities. Arch Clin Neuropsychol 1990; 5: 251-264.
    • (1990) Arch Clin Neuropsychol , vol.5 , pp. 251-264
    • Goldstein, G.1
  • 288
    • 0029002752 scopus 로고
    • The neuropsychology of schizophrenia: Relations with clinical and neurobiological dimensions
    • Elliott R, Sahakian BJ. The neuropsychology of schizophrenia: relations with clinical and neurobiological dimensions. Psychol Med 1995; 25: 581-594.
    • (1995) Psychol Med , vol.25 , pp. 581-594
    • Elliott, R.1    Sahakian, B.J.2
  • 289
    • 0242551243 scopus 로고    scopus 로고
    • Basic neuropsychological dimensions in schizophrenia
    • Jæger J, Czobor P, Berns SM. Basic neuropsychological dimensions in schizophrenia. Schizophr Res 2003; 65: 105-116.
    • (2003) Schizophr Res , vol.65 , pp. 105-116
    • Jæger, J.1    Czobor, P.2    Berns, S.M.3
  • 290
    • 7044231237 scopus 로고    scopus 로고
    • Dimensions of intelligence in schizophrenia: Evidence from patients with preserved, deteriorated and compromised intellect
    • Badcock JC, Dragovic M, Waters FA, Jablensky A. Dimensions of intelligence in schizophrenia: evidence from patients with preserved, deteriorated and compromised intellect. J Psychiatry Res 2005; 39: 11-19.
    • (2005) J Psychiatry Res , vol.39 , pp. 11-19
    • Badcock, J.C.1    Dragovic, M.2    Waters, F.A.3    Jablensky, A.4
  • 293
    • 0142197151 scopus 로고    scopus 로고
    • Verbal declarative memory dysfunction in schizophrenia: From clinical assessment to genetics and brain mechanisms
    • Cirillo MA, Seidman LJ. Verbal declarative memory dysfunction in schizophrenia: from clinical assessment to genetics and brain mechanisms. Neuropsychol Rev 2003; 13: 43-77.
    • (2003) Neuropsychol Rev , vol.13 , pp. 43-77
    • Cirillo, M.A.1    Seidman, L.J.2
  • 294
    • 28544436939 scopus 로고    scopus 로고
    • Working memory impairments in schizophrenia: A meta-analysis
    • Lee J, Park S. Working memory impairments in schizophrenia: a meta-analysis. J Abnorm Psychol 2005; 114: 599-611.
    • (2005) J Abnorm Psychol , vol.114 , pp. 599-611
    • Lee, J.1    Park, S.2
  • 295
    • 0035288315 scopus 로고    scopus 로고
    • Sources of heterogeneity in schizophrenia: The role of neuropsychological functioning
    • Seaton BE, Goldstein G, Allen DN. Sources of heterogeneity in schizophrenia: the role of neuropsychological functioning. Neuropsychol Rev 2001; 11: 45-67.
    • (2001) Neuropsychol Rev , vol.11 , pp. 45-67
    • Seaton, B.E.1    Goldstein, G.2    Allen, D.N.3
  • 297
    • 0024283662 scopus 로고
    • Splitting schizophrenia
    • Lander ES. Splitting schizophrenia. Nature 1988; 336: 105-106.
    • (1988) Nature , vol.336 , pp. 105-106
    • Lander, E.S.1
  • 301
    • 0037365978 scopus 로고    scopus 로고
    • Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: Meta-analysis of case-control and family-based studies
    • Glatt SJ, Faraone SV, Tsuang MT. Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies. Am J Psychiatry 2003; 160: 469-476.
    • (2003) Am J Psychiatry , vol.160 , pp. 469-476
    • Glatt, S.J.1    Faraone, S.V.2    Tsuang, M.T.3
  • 302
    • 0038389841 scopus 로고    scopus 로고
    • A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain
    • Bray NJ, Buckland PR, Williams NM, Williams HJ, Norton N, Owen MJ et al. A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. Am J Hum Genet 2003; 73: 152-161.
    • (2003) Am J Hum Genet , vol.73 , pp. 152-161
    • Bray, N.J.1    Buckland, P.R.2    Williams, N.M.3    Williams, H.J.4    Norton, N.5    Owen, M.J.6
  • 304
    • 23744517092 scopus 로고    scopus 로고
    • 158/108Met) gene and schizophrenia: A meta-analysis of case-control studies
    • 158/108Met) gene and schizophrenia: a meta-analysis of case-control studies. Mol Psychiatry 2005; 10: 765-770.
    • (2005) Mol Psychiatry , vol.10 , pp. 765-770
    • Munafo, M.R.1    Bowes, L.2    Clark, T.G.3    Flint, J.4
  • 305
    • 12144252916 scopus 로고    scopus 로고
    • Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: A large-scale association study plus meta-analysis
    • Fan J-B, Zhang C-S, Gu N-F, Li X-W, Sun W-W, Wang H-Y et al. Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis. Biol Psychiatry 2005; 57: 139-144.
    • (2005) Biol Psychiatry , vol.57 , pp. 139-144
    • Fan, J.-B.1    Zhang, C.-S.2    Gu, N.-F.3    Li, X.-W.4    Sun, W.-W.5    Wang, H.-Y.6
  • 306
    • 4444332521 scopus 로고    scopus 로고
    • Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q
    • Paunio T, Tuulio-Henriksson A, Hiekkalinna T, Perola M, Varilo T, Partonen T et al. Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q. Hum Mol Genet 2004; 13: 1693-1702.
    • (2004) Hum Mol Genet , vol.13 , pp. 1693-1702
    • Paunio, T.1    Tuulio-Henriksson, A.2    Hiekkalinna, T.3    Perola, M.4    Varilo, T.5    Partonen, T.6
  • 307
    • 0028820161 scopus 로고
    • A potential vulnerability locus for schizophrenia on chromosome 6p24-22: Evidence for genetic heterogeneity
    • Straub RE, MacLean CJ, O'Neill FA, Burke J, Murphy B, Duke F et al. A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity. Nat Genet 1995; 11: 287-293.
    • (1995) Nat Genet , vol.11 , pp. 287-293
    • Straub, R.E.1    MacLean, C.J.2    O'Neill, F.A.3    Burke, J.4    Murphy, B.5    Duke, F.6
  • 310
    • 0038494516 scopus 로고
    • Auffassung gewisser Symptome der Dementia praecox
    • Stransky E. Auffassung gewisser Symptome der Dementia praecox. Neurol Centralblatt 1904; 23: 1137-1143
    • (1904) Neurol Centralblatt , vol.23 , pp. 1137-1143
    • Stransky, E.1
  • 311
    • 33748059254 scopus 로고
    • English translation Cutting J, Shepherd M (eds). Cambridge University Press: Cambridge
    • [English translation In: Cutting J, Shepherd M (eds). The Clinical Roots of the Schizophrenia Concept. Cambridge University Press: Cambridge, 1985, pp 37-41.].
    • (1985) The Clinical Roots of the Schizophrenia Concept , pp. 37-41
  • 312
    • 0025322913 scopus 로고
    • Toward an integrated theory of schizotaxia, schizotypy, and schizophrenia
    • Meehl PE. Toward an integrated theory of schizotaxia, schizotypy, and schizophrenia. J Personal Disord 1990; 4: 1-99.
    • (1990) J Personal Disord , vol.4 , pp. 1-99
    • Meehl, P.E.1
  • 313
    • 0031750915 scopus 로고
    • 'Cognitive dysmetria' as an integrated theory of schizophrenia: A dysfunction in cortical-subcortical-cerebellar circuitry?
    • Andreasen NC, Paradiso S, O'Leary DS. 'Cognitive dysmetria' as an integrated theory of schizophrenia: a dysfunction in cortical-subcortical- cerebellar circuitry? Schizophr Bull 1988; 24: 203-218.
    • (1988) Schizophr Bull , vol.24 , pp. 203-218
    • Andreasen, N.C.1    Paradiso, S.2    O'Leary, D.S.3
  • 314
    • 26044465231 scopus 로고    scopus 로고
    • The rises and falls of disconnection syndromes
    • Catani M, ffytche DH. The rises and falls of disconnection syndromes. Brain 2005; 128: 2224-2239.
    • (2005) Brain , vol.128 , pp. 2224-2239
    • Catani, M.1    Ffytche, D.H.2
  • 315
    • 33746654582 scopus 로고    scopus 로고
    • Synaptic plasticity and dysconnection in schizophrenia
    • Stephan KE, Baldeweg T, Friston KJ. Synaptic plasticity and dysconnection in schizophrenia. Biol Psychiatry 2006; 59: 929-939.
    • (2006) Biol Psychiatry , vol.59 , pp. 929-939
    • Stephan, K.E.1    Baldeweg, T.2    Friston, K.J.3
  • 316
    • 30344447674 scopus 로고    scopus 로고
    • Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology
    • Craddock N, O'Donovan MC, Owen MJ. Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophr Bull 2006; 32: 9-16.
    • (2006) Schizophr Bull , vol.32 , pp. 9-16
    • Craddock, N.1    O'Donovan, M.C.2    Owen, M.J.3
  • 317
    • 24944577080 scopus 로고    scopus 로고
    • Time for a shift in focus in schizophrenia: From narrow phenotypes to broad endophenotypes
    • Weiser M, van Os J, Davidson M. Time for a shift in focus in schizophrenia: from narrow phenotypes to broad endophenotypes. Br J Psychiatry 2005; 187: 203-205.
    • (2005) Br J Psychiatry , vol.187 , pp. 203-205
    • Weiser, M.1    Van Os, J.2    Davidson, M.3
  • 320
  • 321
    • 0028263159 scopus 로고
    • Indicators of liability to schizophrenia: Perspectives from genetic epidemiology
    • Moldin SO. Indicators of liability to schizophrenia: perspectives from genetic epidemiology. Schizophr Bull 1994; 20: 169-184.
    • (1994) Schizophr Bull , vol.20 , pp. 169-184
    • Moldin, S.O.1
  • 322
  • 323
    • 0032411943 scopus 로고    scopus 로고
    • A comparison of power to detect a QTL in sib-pair data using multivariate phenotypes, mean phenotypes, and factor scores
    • Boomsma DI, Dolan CV. A comparison of power to detect a QTL in sib-pair data using multivariate phenotypes, mean phenotypes, and factor scores. Behav Genet 1998; 28: 329-340.
    • (1998) Behav Genet , vol.28 , pp. 329-340
    • Boomsma, D.I.1    Dolan, C.V.2
  • 324
    • 0032735659 scopus 로고    scopus 로고
    • Exploring the impact of extended phenotype in stratified samples
    • Kovac I, Rouillard E, Mérette C, Palmour R. Exploring the impact of extended phenotype in stratified samples. Genet Epidemiol 1999; 17(Suppl 1): S211-S216.
    • (1999) Genet Epidemiol , vol.17 , Issue.1 SUPPL.
    • Kovac, I.1    Rouillard, E.2    Mérette, C.3    Palmour, R.4
  • 326
    • 7444257916 scopus 로고    scopus 로고
    • Genetics, statistics and human disease: Analytical retooling for complexity
    • Thornton-Wells TA, Moore JH, Haines JL. Genetics, statistics and human disease: analytical retooling for complexity. Trends Genet 2004; 20: 640-647.
    • (2004) Trends Genet , vol.20 , pp. 640-647
    • Thornton-Wells, T.A.1    Moore, J.H.2    Haines, J.L.3
  • 327
    • 24344482026 scopus 로고    scopus 로고
    • Resolving the heterogeneity of psychiatric disorders: Clinical and statistical approaches
    • Zandi PP, DePaulo JR. Resolving the heterogeneity of psychiatric disorders: clinical and statistical approaches. Clin Neurosci Res 2005; 5: 45-51.
    • (2005) Clin Neurosci Res , vol.5 , pp. 45-51
    • Zandi, P.P.1    DePaulo, J.R.2
  • 328
    • 0043093272 scopus 로고
    • Structural approaches to classification
    • Millon T, Klerman GL (eds). The Guilford Press: New York, London
    • Blashfield RK. Structural approaches to classification. In: Millon T, Klerman GL (eds). Contemporary Directions in Psychopathology. Toward the DSM-IV. The Guilford Press: New York, London, 1986, pp 363-400.
    • (1986) Contemporary Directions in Psychopathology. Toward the DSM-IV , pp. 363-400
    • Blashfield, R.K.1
  • 329
    • 0002810132 scopus 로고
    • Construct validation approach to psychiatric classification
    • Millon T, Klerman GL (eds). The Guilford Press: New York, London
    • Skinner HA. Construct validation approach to psychiatric classification. In: Millon T, Klerman GL (eds). Contemporary Directions in Psychopathology. Toward the DSM-IV. The Guilford Press: New York, London, 1986, pp 307-330.
    • (1986) Contemporary Directions in Psychopathology. Toward the DSM-IV , pp. 307-330
    • Skinner, H.A.1
  • 330
    • 0018388317 scopus 로고
    • Taximetric strategies applied to psychiatric classification
    • Corning WC, Steffy RA. Taximetric strategies applied to psychiatric classification. Schizophr Bull 1979; 5: 294-305.
    • (1979) Schizophr Bull , vol.5 , pp. 294-305
    • Corning, W.C.1    Steffy, R.A.2
  • 331
    • 12344254627 scopus 로고    scopus 로고
    • Phenotype of schizophrenia: A review and formulation
    • Tamminga CA, Holcomb HH. Phenotype of schizophrenia: a review and formulation. Mol Psychiatry 2004; 10: 27-39.
    • (2004) Mol Psychiatry , vol.10 , pp. 27-39
    • Tamminga, C.A.1    Holcomb, H.H.2


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