Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: Meta-analysis of case-control and family-based studies

American Journal of Psychiatry

Volumn 160, Issue 3, 2003, Pages 469-476

  Glatt, Stephen J ^b   Faraone, Stephen V ^b   Tsuang, Ming T ^a  

^a MASSACHUSETTS MENTAL HEALTH CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE;

ACCURACY; ALLELE; ARTICLE; ASIAN; DISEASE ASSOCIATION; DNA POLYMORPHISM; ETHNOLOGY; EUROPE; FAMILY; GENETIC RISK; GENOME; GEOGRAPHY; HUMAN; POPULATION RESEARCH; PRIORITY JOURNAL; RISK ASSESSMENT; SCHIZOPHRENIA; STRATIFICATION; ADULT; ASIA; CASE CONTROL STUDY; CLINICAL TRIAL; COMPARATIVE STUDY; CULTURAL FACTOR; FEMALE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; MALE; META ANALYSIS; MIDDLE AGED; REVIEW; RISK FACTOR;

ADULT; ALLELES; ASIA; CASE-CONTROL STUDIES; CATECHOL O-METHYLTRANSFERASE; CROSS-CULTURAL COMPARISON; EUROPE; FAMILY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RISK FACTORS; SCHIZOPHRENIA;

EID: 0037365978     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.160.3.469     Document Type: Article

References (48)

1. Gottesman II: Schizophrenia Genesis: The Origins of Madness. New York, WH Freeman, 1991
2. Kendler KS: Overview: a current perspective on twin studies of schizophrenia. Am J Psychiatry 1983; 140:1413-1425
3. Kety SS, Rosenthal D, Wender PH, Schulsinger F: The types and prevalence of mental illness in the biological and adoptive families of adopted schizophrenics. J Psychiatr Res 1968; 1(suppl):345-362
4. McGue M, Gottesman II, Rao DC: The transmission of schizophrenia under a multifactorial threshold model. Am J Hum Genet 1983; 35:1161-1178
5. Pulver AE: Search for schizophrenia susceptibility genes. Biol Psychiatry 2000; 47:221-230
6. Faraone SV, Tsuang D, Tsuang MT: Genetics of Mental Disorders: A Guide for Students, Clinicians, and Researchers. New York, Guilford, 1999
7. Spurlock G, Williams J, McGuffin P, Aschauer HN, Lenzinger E, Fuchs K, Sieghart WC, Meszaros K, Fathi N, Laurent C, Mallet J, Macciardi F, Pedrini S, Gill M, Hawi Z, Gibson S, Jazin EE, Yang HT, Adolfsson R, Pato CN, Dourado AM, Owen MJ: European Multicentre Association Study of Schizophrenia: a study of the DRD2 Ser311Cys and DRD3 Ser9Gly polymorphisms. Am J Med Genet 1998; 81:24-28
8. Sobell JL, Lind TJ, Sigurdson DC, Zald DH, Snitz BE, Grove WM, Heston LL, Sommer SS: The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease. Hum Mol Genet 1995; 4:507-514
9. Macciardi F, Verga M, Kennedy JL, Petronis A, Bersani G, Pancheri P, Smeraldi E: An association study between schizophrenia and the dopamine receptor genes DRD3 and DRD4 using haplotype relative risk. Hum Hered 1994; 44:328-336
10. Kojima H, Ohmori O, Shinkai T, Terao T, Suzuki T, Abe K: Dopamine D1 receptor gene polymorphism and schizophrenia in Japan. Am J Med Genet 1999; 88:116-119
11. Daniels J, Williams J, Asherson P, McGuffin P, Owen M: No association between schizophrenia and polymorphisms within the genes for debrisoquine 4-hydroxylase (CYP2D6) and the dopamine transporter (DAT). Am J Med Genet 1995; 60:85-87
12. Coron B, Campion D, Thibaut F, Dollfus S, Preterre P, Langlois S, Vasse T, Moreau V, Martin C, Charbonnier F, Laurent C, Mallet J, Petit M, Frebourg T: Association study between schizophrenia and monoamine oxidase A and B DNA polymorphisms. Psychiatry Res 1996; 62:221-226
13. Speight G, Turic D, Austin J, Hoogendoorn B, Cardno AG, Jones L, Murphy KC, Sanders R, McCarthy G, Jones I, McCandless F, McGuffin P, Craddock N, Owen MJ, Buckland P, O'Donovan MC: Comparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorder. Mol Psychiatry 2000; 5:327-331
14. Kunugi H, Kawada Y, Hattori M, Ueki A, Otsuka M, Nanko S: Association study of structural mutations of the tyrosine hydroxylase gene with schizophrenia and Parkinson's disease. Am J Med Genet 1998; 81:131-133
15. Polymeropoulos MH, Coon H, Byerley W, Gershon ES, Crow TJ, Rubenstein J, Hoff M, Holik J, Smith AM, Shields G, Bass NJ, Poulter M, Lofthouse R, Vita A, Morganti C, Merril CR, DeLisi LE: Search for a schizophrenia susceptibility locus on human chromosome 22. Am J Med Genet 1994; 54:93-99
16. Pulver AE, Karayiorgou M, Wolyneic P, Lasseter VK, Kasch L, Nestadt G, Antonarakis S, Housman D, Kazazian HH, Meyers D, OH J, Lamacz M, Liang K-Y. Hanfelt J, Ullrich G, DeMarchi N, Ramu E, McHugh PR, Adler L, Thomas M, Carpenter WT, Manschreck T, Gordon CT, Kimberland M, Babb R, Puck J, Childs B: Sequential strategy to identify a susceptibility gene for schizophrenia: report of potential linkage on chromosome 22q12-q13.1, part 1. Am J Med Genet 1994; 54:36-13
17. Badner JA, Gershon ES: Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 2002; 7:405-411
18. Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melen K, Julkunen I, Taskinen J: Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 1995; 34:4202-4210
19. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR: Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 2001; 98:6917-6922
20. Joober R, Gauthier J, Lal S, Bloom D, Lalonde P, Rouleau G, Benkelfat C, Labelle A: Catechol-O-methyltransferase Val-108/158-Met gene variants associated with performance on the Wisconsin Card Sorting Test. Arch Gen Psychiatry 2002; 59:662-663
21. de Chaldee M, Laurent C, Thibaut F, Martinez M, Samolyk D, Petit M, Campion D, Mallet J: Linkage disequilibrium on the COMT gene in French schizophrenics and controls. Am J Med Genet 1999; 88:452-457
22. Norton N, Kirov G, Zammit S, Jones G, Jones S, Owen R, Krawczak M, Williams NM, O'Donovan MC, Owen MJ: Schizophrenia and functional polymorphisms in the MAOA and COMT genes: no evidence for association or epistasis. Am J Med Genet 2002; 114:491-196
23. Park TW, Yoon KS, Kim JH, Park WY, Hirvonen A, Kang D: Functional catechol-O-methyltransferase gene polymorphism and susceptibility to schizophrenia. Eur Neuropsychopharmacol 2002; 12:299-303
24. Arinami T, Ohtsuki T, Takase K, Shimizu H, Yoshikawa T, Horigome H, Nakayama J, Toru M: Screening for 22q11 deletions in a schizophrenia population. Schizophr Res 2001; 52:167-170
25. Chen C-H, Lee Y-R, Chung M-Y, Wei F-C, Koong F-J, Shaw C-K, Yeh J-I, Hsiao K-J: Systematic mutation analysis of the catechol O-methyltransferase gene as a candidate gene for schizophrenia. Am J Psychiatry 1999; 156:1273-1275
26. Daniels JK, Williams NM, Williams J, Jones LA, Cardno AG, Murphy KC, Spurlock G, Riley B, Scambler P, Asherson P, McGuffin P, Owen MJ: No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity. Am J Psychiatry 1996; 153:268-270
27. Herken H, Erdal ME: Catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association between symptomatology and prognosis. Psychiatr Genet 2001; 11:105-109
28. Karayiorgou M, Gogos JA, Galke BL, Wolyniec PS, Nestadt G, Antonarakis SE, Kazazian HH, Housman DE, Pulver AE: Identification of sequence variants and analysis of the role of the catechol-O-methyl-transferase gene in schizophrenia susceptibility. Biol Psychiatry 1998; 43:425-431
29. Kotler M, Barak P, Cohen H, Averbuch IE, Grinshpoon A, Gritsenko I, Nemanov L, Ebstein RP: Homicidal behavior in schizophrenia associated with a genetic polymorphism determining low catechol O-methyltransferase (COMT) activity. Am J Med Genet 1999; 88:628-633
30. Liou YJ, Tsai SJ, Hong CJ, Wang YC, Lai IC: Association analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenic patients in Taiwan. Neuropsychobiology 2001; 43:11-14
31. Ohmori O, Shinkai T, Kojima H, Terao T, Suzuki T, Mita T, Abe K: Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics. Neurosci Lett 1998; 243:109-112
32. Strous RD, Bark N, Woerner M, Lachman HM: Lack of association of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia. Biol Psychiatry 1997; 41:493-495
33. Fan JB, Chen WY, Tang JX, Li S, Gu NF, Feng GY, Breen G, St Clair D, He L: Family-based association studies of COMT gene polymorphisms and schizophrenia in the Chinese population. Mol Psychiatry 2002; 7:446-447
34. Li T, Ball D, Zhao J, Murray RM, Liu X, Sham PC, Collier DA: Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11. Mol Psychiatry 2000; 5:77-84
35. Kunugi H, Vallada HP, Sham PC, Hoda F, Arranz MJ, Li T, Nanko S, Murray RM, McGuffin P, Owen M, Gill M, Collier DA: Catechol-O-methyltransferase polymorphisms and schizophrenia: a transmission disequilibrium study in multiply affected families. Psychiatr Genet 1997; 7:97-101
36. Semwal P, Prasad S, Bhatia T, Deshpande SN, Wood J, Nimgaonkar VL, Thelma BK: Family-based association studies of monoaminergic gene polymorphisms among North Indians with schizophrenia. Mol Psychiatry 2001; 6:220-224
37. Spitzer RL, Endicott J, Robins E: Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders, 3rd ed. New York, New York State Psychiatric Institute, Biometrics Research, 1978
38. Knapp M, Seuchter SA, Baur MP: The haplotype-relative-risk (HRR) method for analysis of association in nuclear families. Am J Hum Genet 1993; 52:1085-1093
39. DerSimonian R, Laird N: Meta-analysis in clinical trials. Control Clin Trials 1986; 7:177-188
40. Woolf B: On estimating the relation between blood group and disease. Ann Eugen 1955; 19:251-253
41. Egger M, Davey Smith G, Schneider M, Minder C: Bias in meta-analysis detected by a simple, graphical test. Br Med J 1997; 315:629-634
42. Bacanu SA, Devlin B, Roeder K: The power of genomic control. Am J Hum Genet 2000; 66:1933-1944
43. Palmatier MA, Kang AM, Kidd KK: Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles. Biol Psychiatry 1999; 46:557-567
44. Deng HW: Population admixture may appear to mask, change or reverse genetic effects of genes underlying complex traits. Genetics 2001; 159:1319-1323
45. Begg CB, Berlin JA: Publication bias and dissemination of clinical research. J Natl Cancer Inst 1989; 81:107-115
46. Kirov G, Murphy KC, Arranz MJ, Jones I, McCandles F, Kunugi H, Murray RM, McGuffin P, Collier DA, Owen MJ, Craddock N: Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder. Mol Psychiatry 1998; 3:342-345
47. Papolos DF, Veit S, Faedda GL, Saito T, Lachman HM: Ultra-ultra rapid cycling bipolar disorder is associated with the low activity catecholamine-O-methyltransferase allele. Mol Psychiatry 1998; 3:346-349
48. Seidman LJ, Kremen WS, Koren D, Faraone SV, Goldstein JM, Tsuang MT: A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses. Schizophr Res 2002; 53:31-44