Multiple phenotype modeling in gene-mapping studies of quantitative traits: Power advantages

American Journal of Human Genetics

Volumn 63, Issue 4, 1998, Pages 1190-1201

  Allison, David B ^a   Thiel, Bonnie ^b   St Jean, Pamela ^b   Elston, Robert C ^b   Infante, Ming C ^a   Schork, Nicholas J ^b,c,d,e  

^a The New York Presbyterian Hospital   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d JACKSON LABORATORY   (United States)

^e METROHEALTH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; HUMAN; MARKER GENE; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE GENETICS; QUANTITATIVE TRAIT;

EID: 0032231766     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302038     Document Type: Article

References (54)

1. Allison DB (1996) The use of discordant sibling pairs for finding genetic loci linked to obesity: practical considerations. Int J Obes Relat Metab Disord 20:553-560
2. Allison DB, Beasley M (1998) A method and computer program for controlling the family-wise alpha rate in gene association studies involving multiple phenotypes. Genet Epidemiol 15:87-101
3. Allison DB, Schork NJ (1997) Selected methodological issues in meiotic mapping of obesity genes in humans: issues of power and efficiency. Behav Genet 27:401-421
4. Almasy L, Blangero J (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62: 1198-1211
5. Amos CI, Elston RC, Bonney GE, Keats BJB, Berenson GS (1990) A multivariate approach for detecting linkage, with application to a pedigree with an adverse lipoprotein phenotype. Am J Hum Genet 47:247-254
6. Amos CI, Liang AE (1993) A comparison of univariate and multivariate tests for genetic linkage. Genet Epidemiol 10: 671-676
7. Amos CI, Wilson AF, Rosenbaum PA, Srinivasan SR, Weber LS, Elston RC, Berenson GS (1986) An approach to the multivariate analysis of high-density-lipoprotein cholesterol in a large kindred: the Bogalusa Heart Study. Genet Epidemiol 3:255-268
8. Bailey KD (1973) Monothetic and polythetic typologies and their relation to conceptualization, measurement and scaling. Am Sociol Rev 38:18-33
9. Blackwelder WC, Elston RC (1982) Power and robustness of sib-pair linkage tests and extensions to large sibships. Commun Stat (Theory Meth) 11:449-484
10. Blangero J, Konigsberg LW (1991) Multivariate segregation analysis using the mixed model. Genet Epidemiol 8:299-316
11. Blangero J, Williams-Blangero S, Mahaney MC (1993) Multivariate genetic analysis of APO A1 concentration and HDL subtractions: evidence for major locus pleiotropy. Genet Epidemiol 10:617-622
12. Bonney GE, Lathrop GM, Lalouel J-M (1988) Combined linkage and segregation analysis using regressive models. Am J Hum Genet 43:29-37
13. Boomsma DI (1996) Using multivariate genetic modeling to detect pleiotropic quantitative trait loci. Behav Genet 26: 161-166
14. Churchill GA, Doerge RW (1994) Empirical threshold values for quantitative trait mapping. Genetics 138(3): 963-971
15. Doerge RW, Churchill GA (1996) Permutation tests for multiple loci affecting a quantitative character. Genetics 142(1): 285-294
16. Duggirala R, Stern MP, Mitchell BD, Reinhart LJ, Shipman PA, Uresandi OC, Chung WK, et al (1996) Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7. Am J Hum Genet 59:694-703
17. Dupuis J, Brown PE, Siegmund D (1995) Statistical methods for linkage analysis of complex traits from high-resolution maps of identity by descent. Genetics 140:843-856
18. Eaves LJ (1994) Effect of genetic architecture on the power of human linkage studies to resolve the contribution of quantitative trait loci. Heredity 72:175-195
19. Eaves L, Meyer J (1994) Locating human quantitative trait loci: guidelines for the selection of sibling pairs for genotyping. Behav Genet 24:443-455
20. Eaves LJ, Neale MC, Macs H (1996) Multivariate multipoint linkage analysis of quantitative trait loci. Behav Genet 26: 519-525
21. Elston RC (1991) Genetic analysis of multivariate traits. In: Anderson VE, Hauser IE, Leppik JL, Noebels JL, Rich SS (eds) Genetic strategies in epilepsy research. Epilepsy Res Suppl 4:161-171
22. Elston RC (1995) The genetic dissection of multifactorial traits. Clin Exp Allergy 25, Suppl 2:103-106
23. Fulker DW, Cherny SS (1996) An improved multipoint sibpair analysis of quantitative traits. Behav Genet 26:527-532
24. Fulker DW, Cherny SS, Cardon LR (1995) Multipoint interval mapping of quantitative trait loci, using sib pairs. Am J Hum Genet 56:1224-1233
25. Goldgar DE (1990) Multipoint analysis of human quantitative genetic variation. Am J Hum Genet 47:957-967
26. Goldin LR, Elston RC, Graham JB, Miller CH (1980) Genetic analysis of von Willebrand's disease in two large pedigrees: a multivariate approach. Am J Med Genet 6:279-293
27. Grove WM (1994) Maximizing the heritability of a linear combination of traits. Psychol Rep 75:467-476
28. Haseman JK, Elston RC (1972) The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2:3-19
29. Hochberg Y, Tamhane AC (1987) Multiple comparison procedures. In: Wiley series in probability and mathematical statistics: applied probability and statistics. John Wiley & Sons, New York
30. Jiang C, Zeng Z (1995) Multiple trait analysis of genetic mapping for quantitative trait loci. Genetics 140:1111-1127
31. Jones MB (1971) Heritability in the construction of psychological tests. Psychol Bull 75:92-96
32. Korol AB, Ronin YI, Kirzhner VM (1995) Interval mapping of quantitative trait loci employing correlated trait complexes. Genetics 140:1137-1147
33. Lander ES, Schork NJ (1994) Genetic dissection of complex traits. Science 265:2037-2048
34. Lange K, Boehnke M (1983) Extensions to pedigree analysis. IV. Covariance components models for multivariate traits. Am J Med Genet 14:513-524
35. Markel PD, Corley RP (1994) A multivariate analysis of repeated measures: linkage of the albinism gene (Tyr) to a QTL influencing ethanol-induced anesthesia in laboratory mice. Psychiatr Genet 4:205-210
36. McGuffin P, Katz R, Rutherford J, Watkins S, Farmer AE, Gottesman II (1993) Twin studies as vital indicators of phenotypes in molecular genetic research. In: Bouchard TJ Jr, Propping P (eds) Twins as a tool for behavioral genetics. Life Sci res rep 53. John Wiley & Sons, New York, pp 243-256
37. Moldin SO, Van Eerdewegh P (1995) Multivariate genetic analysis of oligogenic disease. Genet Epidemiol 12:801-806
38. Neale MC, Cardon LR (1992) Methodology for genetic studies of twins and families. Kluwer Academic, Boston
39. Norman RA, Bogardus C, Ravussin E (1995) Linkage between obesity and a marker near the tumor necrosis factor-alpha locus in Pima Indians. J Clin Invest 96:158-168
40. Olson JM (1995) Robust multipoint linkage analysis: an extension of the Haseman-Elston method. Genet Epidemiol 12: 177-193
41. Ott J (1989) Computer simulation methods in human linkage analysis. Proc Natl Acad Sci USA 86:4175-4178
42. Reed DR, Ding Y, Xu W, Gather C, Price RA (1995) Human obesity does not segregate with the chromosomal regions of Prader-Willi, Bardet-Biedl, Cohen, Borjeson, or Wilson- Turner syndromes. Int J Obes Relat Metab Disord 19: 599-603
43. Rieger R, Michaelis A, Green MM (1991) Glossary of genetics: classical and molecular, 5th ed. Springer-Verlag, New York, pp 384-385
44. Risch N, Zhang H (1995) Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 268: 1584-1589
45. Risch NJ, Zhang H (1996) Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations. Am J Hum Genet 58:836-843
46. SAGE (1997) Statistical analysis for genetic epidemiology, release 3.0. Computer program package available from the Department of Epidemiology and Biostatistics, Rammel- kamp Center for Education and Research, Case Western Reserve University, Cleveland
47. Schork NJ (1993) Extended multipoint identity-by-descent analysis of human quantitative traits: efficiency, power, and modeling considerations. Am J Hum Genet 53:1306-1319
48. Schork NJ, Boehnke M, Terwilliger JD, Ott J (1993) Two- trait-locus linkage analysis: a powerful strategy for mapping complex genetic traits. Am J Hum Genet 55:1127-1136
49. Schork NJ, Weder AB, Schork MA (1990) On the asymmetry of biological frequency distributions. Genet Epidemiol 7(6): 427-446
50. Schork NJ, Weder AB, Trevisan M, Laurenzi M (1994) The contribution of pleiotropy to blood pressure and body-mass index variation: the Gubbio Study. Am J Hum Genet 54: 361-373
51. Schork NJ, Xu X (1997) Sibpairs versus pedigrees: what are the advantages? Diabetes Rev 5:1-7
52. Tiwari HK, Elston RC (1997) Linkage of multilocus components of variance to polymorphic markers. Ann Hum Genet 61:253-261
53. Todorov AA, Province MA, Borecki IB, Rao DC (1997) Tradeoff between sibship size and sampling scheme for detecting quantitative trait loci. Hum Hered 47:1-5
54. Zlotnik LH, Elston RC, Namboordiri KK (1983) Pedigree discriminant analysis: a method to identify monogenic segregation. Am J Med Genet 15:307-313