Use of a quantitative trait to map a locus associated with severity of positive symptoms in familial schizophrenia to chromosome 6p

American Journal of Human Genetics

Volumn 61, Issue 6, 1997, Pages 1388-1396

  Brzustowicz, L M ^a,d   Honer, W G ^b   Chow, E W C ^c   Hogan, J ^c   Hodgkinson, K ^c   Bassett, A S ^c  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ARTICLE; CANADA; CHROMOSOME 6P; CHROMOSOME MAP; DISEASE SEVERITY; FAMILIAL DISEASE; FAMILY STUDY; FEMALE; GENETIC MARKER; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SCHIZOPHRENIA; SIBLING; SYMPTOMATOLOGY;

EID: 0031459372     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/301623     Document Type: Article

References (33)

1. Andreasen NC, Nopoulos P, Schultz S, Miller D, Gupta S, Swayze V, Flaum M (1994) Positive and negative symptoms of schizophrenia: past, present, and future. Acta Psychiatr Scand 90:51-59
2. Antonarakis SE, Blouin JL, Pulver AE, Wolyniec P, Lasseter VK, Nestadt G, Kasch L, et al (1995) Schizophrenia susceptibility and chromosome 6p2422. Nat Genet 11:235-236
3. Arndt S, Andreasen NC, Flaum M, Miller D, Nopoulos P (1995) A longitudinal study of symptom dimensions in schizophrenia. Arch Gen Psychiatry 52:352-360
4. Bassett AS, Collins EJ, Nuttall SE, Honer WG (1993) Positive and negative symptoms in families with schizophrenia. Schizophr Res11:9-19
5. Bassett AS, Honer WG (1994) Evidence for anticipation in schizophrenia. Am J Hum Genet 54:864-870
6. Dworkin RH, Bernstein G, Kaplansky LM, Lipsitz JD, Rinaldi A, Slater SL, Cornblatt BA, et al (1991) Social competence and positive and negative symptoms: a longitudinal study of children and adolescents at risk for schizophrenia and affective disorder. Am J Psychiatry 148:1182-1188
7. Eaton WW, Thara R, Federman B, Melton B, Liang K-Y (1995) Structure and course of positive and negative symptoms in schizophrenia. Arch Gen Psychiatry 52:127-134
8. Faraone SV, Kremen WS, Lyons MJ, Pepple JR, Seidman LJ, Tsuang MT (1995) Diagnostic accuracy and linkage analysis: how useful are schizophrenia spectrum phenotypes? Am J Psychiatry 152:1286-1290
9. Farmer AE, Williams J, Jones I (1994) Phenotypic definitions of psychotic illness for molecular genetic research. Am J Med Genet 54:365-371
10. Gottesman II, Shields J (1982) Schizophrenia: the epigenetic puzzle. Cambridge University Press, Cambridge
11. Gurling H, Kalsi G, Chen AH-S, Green M, Butler R, Read T, Murphy P, et al (1995) Schizophrenia susceptibility and chromosome 6p24-22. Nat Genet 11:234-235
12. Haseman JK, Elston RC (1972) The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2:3-19
13. Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13:261-275
14. Kendler KS, Diehl SR (1993) The genetics of schizophrenia: a current, genetic-epidemiologic perspective. Schizophr Bull 19:261-284
15. Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
16. Malla AK, Norman RMG, Williamson P (1993) Stability of positive and negative symptoms in schizophrenia. Can J Psychiatry 38:617-621
17. Matthysse S, Levy DL, Kinney D, Deutsch C, Lajonchere C, Yurgelun-Todd D, Woods B, et al (1992) Gene expression in mental illness: a navigation chart to future progress. J Psychiatr Res 26:461-473
18. McGuffin P, Asherson P, Owen M, Farmer A (1994) The strength of the genetic effect: is there room for an environmental influence in the aetiology of schizophrenia? Br J Psychiatry 164:593-599
19. McGuffin P, Harvey I, Williams M (1991) The negative/positive dichotomy: does it make sense from the perspective of the genetic researcher? In: Marneros A, Andreasen NC, Tsuang MT (eds) Negative versus positive schizophrenia. Springer, Berlin, pp 250-264
20. Moises HW, Yang L, Kristbjarnarson H, Wiese C, Byerley W, Macciardi R, Arolt V, et al (1995) An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat Genet 11:321-324
21. Mowry BJ, Nancarrrow DJ, Lennon DP, Sandkuijl LA, Crowe RR, Silverman JM, Mohs RC, et al (1995) Schizophrenia susceptibility and chromosome 6p24-22. Nat Genet 11: 233-234
22. Rey ER, Bailer J, Brauer W, Handel M, Laubenstein D, Stein A (1994) Stability trends and longitudinal correlations of negative and positive syndromes within a three-year follow-up of initially hospitalized schizophrenics. Acta Psychiatr Scand 90:405-412
23. Risch N (1990) Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet 46:229-241
24. Rutter M (1994) Psychiatric genetics: research challenges and pathways forward. Am J Med Genet 54:185-198
25. Schwab SG, Albus M, Hallmayer J, Honig S, Borrmann M, Lichtermann D, Ebstein RP, et al (1995) Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sibpair linkage analysis. Nat Genet 11: 325-327
26. Straub RE, MacLean CJ, O'Neill FA, Burke J, Murphy B, Duke F, Shinkwin R, et al (1995) A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity. Nat Genet 11:287-293
27. Terwilliger JD, Ott J (1994) Handbook of human genetic linkage. Johns Hopkins University Press, Baltimore
28. Tran LD, Elston RC, Keats BJB, Wilson AF (1995) Sibpair linkage program (SIBPAL) version 2.6 user's manual. Available from Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland
29. Tsuang MT (1993) Genotypes, phenotypes, and the brain: a search for connections in schizophrenia. Br J Psychiatry 163: 299-307
30. Tsuang MT, Gilbertson MW, Faraone SV (1991) Genetic transmission of negative and positive symptoms in the biological relatives of schizophrenics. In: Marneros A, Andreasen NC, Tsuang MT (eds) Negative versus positive schizophrenia. Springer, Berlin, pp 265-291
31. Wang S, Detera-Wadleigh SD, Coon H, Sun C-E, Goldin LR, Duffy DL, Byerley WF, et al (1996) Evidence of linkage disequilibrium between schizophrenia and the SCA1 CAG repeat on chromosome 6p23. Am J Hum Genet 59:731-736
32. Wang S, Sun C, Walczak CA, Ziegle JS, Kipps BR, Goldin LR, Diehl SR (1995) Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22. Nat Genet 10: 41-46
33. Young A (1995) GAS 2.0 analysis modules manual. Available from author, Oxford University, Oxford (also available from http://users.ox.ac.uk/ayoung/gas.html)