The melanocortin circuit in obese and lean strains of chicks

Journal of Endocrinology

Volumn 190, Issue 2, 2006, Pages 527-535

  Hen, Gideon ^b   Yosefi, Sara ^b   Simchaev, Victoria ^b   Shinder, Dmitry ^b   Hruby, Victor J ^a   Friedman Einat, Miriam ^b  

^a The University of Arizona   (United States)

^b VOLCANI CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; ANOREXIGENIC AGENT; CORTICOTROPIN; MELANOCORTIN; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOTAN II; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHICK; CONTROLLED STUDY; DIET RESTRICTION; DOWN REGULATION; FEMALE; FOOD INTAKE; GENE EXPRESSION; HYPOTHALAMUS; LEAN BODY WEIGHT; LIPID STORAGE; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; STATISTICAL SIGNIFICANCE; STRAIN DIFFERENCE;

ALPHA-MSH; ANIMALS; CHICKENS; FEMALE; GENE EXPRESSION; HYPOTHALAMUS; OBESITY; PEPTIDES, CYCLIC; PHENOTYPE; PRO-OPIOMELANOCORTIN; RECEPTOR, MELANOCORTIN, TYPE 4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPECIES SPECIFICITY;

EID: 33747892308     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.1.06783     Document Type: Article

References (86)

1. Ahima RS & Flier JS 2000 Adipose tissue as an endocrine organ. Trends in Endocrinology and Metabolism 11 327-332.
2. Al-Obeidi E Hruby VJ, Castrucci AM & Hadley ME 1989a Design of potent linear alpha-melanotropin 4-10 analogues modified in positions 5 and 10. Journal of Medicinal Chemistry 32 174-179.
3. Al-Obeidi F, Castrucci AM, Hadley ME & Hruby VJ 1989b Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics. Journal of Medicinal Chemistry 32 2555-2561.
4. Azzara AV, Sokolnicki JP & Schwartz GJ 2002 Central melanocortin receptor agonist reduces spontaneous and scheduled meal size but does not augment duodenal preload-induced feeding inhibition. Physiology and Behavior 77 411-416.
5. Bellinger L, Cepeda-Benito A, Bullard RL & Wellman PJ 2003 Effect of i.c.v. infusion of the alpha-MSH agonist MTII on meal patterns in male rats following nicotine withdrawal. Life Sciences 73 1861-1872.
6. Benoit SC, Schwartz MW, Lachey JL, Hagan MM, Rushing PA, Blake KA, Yagaloff KA, Kurylko G, Franco L, Danhoo W et al. 2000 A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. Journal of Neuroscience 20 3442-3448.
7. Benoit SC, Air EL, Coolen LM, Strauss R, Jackman A, Clegg DJ, Seeley RJ & Woods SC 2002 The catabolic action of insulin in the brain is mediated by melanocortins. Journal of Neuroscience 22 9048-9052.
8. Benoit SC, Sheldon RJ, Air EL, Messerschmidt P, Wilmer KA, Hodge KM, Jones MB, Eckstein DM, McOsker CC, Woods SC et al. 2003 Assessment of the aversive consequences of acute and chronic administration of the melanocortin agonist, MTII. International Journal of Obesity and Related Metabolic Disorders 27 550-556.
9. Bokkers EA & Koene P 2003 Eating behaviour, and preprandial and postprandial correlations in male broiler and layer chickens. British Poultry Science 44 538-544.
10. Boswell T & Takeuchi S 2005 Recent developments in our understanding of the avian melanocortin system: its involvement in the regulation of pigmentation and energy homeostasis. Peptides 26 1733-1743.
11. Cahaner A & Nitsan Z 1985 Evaluation of simultaneous selection for live body weight and against abdominal fat in broilers. Poultry Science 64 1257-1263.
12. Carlborg O, Jacobsson L, Ahgren P, Siegel P & Andersson L 2006 Epistasis and the release of genetic variation during long-term selection. Nature Genetics 38 418-420.
13. Chen AS, Marsh DJ, Trumbauer ME, Frazier EG, Guan XM, Yu H, Rosenblum CI, Vongs A, Feng Y, Cao L et al. 2000 Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nature Genetics 26 97-102.
14. Choi YH, Li C, Hartzell DL, Lin J, Della-Fera MA & Baile CA 2003 MTII administered peripherally reduces fat without invoking apoptosis in rats. Physiology and Behavior 79 331-337.
15. Dunnington EA & Siegel PB 1996 Long-term divergent selection for eight-week body weight in white Plymouth rock chickens. Poultry Science 75 1168-1179.
16. Eitan Y & Soller M 2004 In Evolutionary Theory and Processes: Modern Horizons. Papers in Honor of Eviatar Nevo, pp 153-176. Ed SP Wasser. Dordrecht, The Netherlands: Kluwer Acadeinic.
17. Fan W, Boston BA, Kesterson RA, Hruby VJ & Cone RD 1997 Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385 165-168.
18. Farooqi IS & O'Rahilly S 2005 Monogenic obesity in humans. Annual Review of Medicine 56 443-458.
19. Farooqi IS, Yeo GS, Keogh JM, Aminian S, Jebb SA, Butler G, Cheetham T & O'Rahilly S 2000 Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. Journal of Clinical Investigation 106 271-279.
20. Friedman JM 2002 The function of leptin in nutrition, weight, and physiology. Nutrition Reviews 60. S1-14; discussion S68-S84 85-17.
21. Gerets HH, Peerers K, Arckens L, Vandesande F & Berghman LR 2000 Sequence and distribution of proopiomelanocortin in the pituitary and the brain of the chicken (Gallus gallus). Journal of Comparative Neurology 417 250-262.
22. Gilbert C, Acamovic T & Bedford MR 1999 Effect of enzyme supplementation on the growth and food conversion efficiency of broiler chicks on lupin-based diets. British Poultry Science 40 (Suppl) S31-S32.
23. Griffin HD, Windsor D & Goddard C 1991 Why are young broiler chickens fatter than layer-strain chicks? Comparative Biochemistry and Physiology A 100 205-210.
24. Hansen MJ, Schioth HB & Morris MJ 2005 Feeding responses to a melanocortin agonist and antagonist in obesity induced by a palatable high-fat diet. Brain Research 1039 137-145.
25. Haskell-Luevano C, Miwa H, Dickinson C, Hruby VJ, Yamada T & Gantz I 1994 Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R. Biochemical and Biophysical Research Communications 204 1137-1142.
26. Hocking PM & Robertson GW 2005 Limited effect of intense genetic selection for broiler traits on ovarian function and follicular sensitivity in broiler breeders at the onset of lay. British Poultry Science 46 354-360.
27. Hocking PM, Hughes BO & Keer-Keer S 1997 Comparison of food intake, rate of consumption, pecking activity and behaviour in layer and broiler breeder males. British Poultry Science 38 237-240.
28. Hohmann JG, Teal TH, Chfton DK, Davis J, Hruby VJ, Han G & Steiner RA 2000 Differential role of melanocortins in mediating leptin's central effects on feeding and reproduction. American Journal of Physiology. Regulatory Integrative and Comparative Physiology 278 R50-R59.
29. Horev G, Einat P, Aharoni T, Eshdat Y & Friedman-Einat M 2000 Molecular cloning and properties of the chicken leptin-receptor (CLEPR) gene. Molecular and Cellular Endocrinology 162 95-106.
30. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD et al. 1997 Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88 131-141.
31. Jacobsson L, Park HB, Wahlberg P, Fredriksson R, Perez-Enciso M, Siegel PB & Andersson L 2005 Many QTLs with minor additive effects are associated with a large difference in growth between two selection lines in chickens. Genetical Research 86 115-125.
32. Kask A & Schioth HB 2000 Tonic inhibition of food intake during inactive phase is reversed by the injection of the melanocortin receptor antagonist into the paraventricular nucleus of the hypothalamus and central amygdala of the rat. Brain Research 887 460-464.
33. Kawakami S, Bungo T, Ando R, Ohgushi A, Shimojo M, Masuda Y & Furuse M 2000 Central administration of alpha-melanocyte stimulating hormone inhibits fasting- and neuropeptide Y-induced feeding in neonatal chicks. European Journal of Pharmacology 398 361-364.
34. Kim MS, Small CJ, Stanley SA, Morgan DG, Seal LJ, Kong WM, Edwards CM, Abusnana S, Sunter D, Ghatei MA et al. 2000 The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. Journal of Clinical Investigation 105 1005-1011.
35. Kuenzel WJ & Kuenzel NT 1977 Basal metabolic rate in growing chicks Gallus domesticus. Poultry Science 56 619-627.
36. Leenstra FR & Pit R 1988 Fat deposition in a broiler sire strain, 3. Heritability of and genetic correlations among body weight, abdominal fat, and feed conversion. Poultry Science 67 1-9.
37. Ling MK, Hotta E, Kilianova Z, Haitina T, Ringholm A, Johansson L, Gallo-Payet N, Takeuchi S & Schioth HB 2004 The melanocortin receptor subtypes in chicken have high preference to ACTH-derived peptides. British Journal of Pharmacology 143 626-637.
38. MacLeod MG, Bernard K, McNeill L & Knox A 1999 Comparison of food intake, body weight gain and food conversion efficiency on broiler starter diets formulated on merabolisable and net energy. British Poultry Science 40 (Suppl) S38-S39.
39. Marks HL 1980 Growth, feed intake, and feed conversion of dwarf and nondwarf broiler-type chickens, Poultry Science 59 2183-2188.
40. Marsh DJ, Hollopeter G, Huszar D, Laufer R, Yagaloff KA, Fisher SL, Burn P & Palmiter RD 1999 Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nature Genetics 21 119-122.
41. Matsumura R, Takagi C, Kakeya T, Okuda K, Takeuchi S & Takahashi S 2003 Alpha-melanocyte stimulating hormone stimulates prolactin secretion through melanocortin-3 receptors expressed in mammotropes in the mouse pituitary. Neuroendocrinology 78 96-104.
42. Mench JA 2002 Broiler breeders: feed restriction and welfare. Worlds Poultry Science Journal 58 20-29.
43. Moran TH, Lee P, Ladenheim EE & Schwartz GJ 2002 Responsivity to NPY and melanocortins in obese OLETF rats lacking CCK-A receptors Physiology and Behavior 75 397-402.
44. Morris TR & Njuru DM 1990 Protein requirement of fast- and slow-growing chicks. British Poultry Science 31 803-810.
45. Mounijoy KG, Jenny Wu CS, Dumont LM & Wild JM 2003 Melanocortin-4 receptor messenger ribonucleic acid expression in rat cardiorespiratory, musculoskeletal, and integumentary systems. Endocrinology 144 5488-5496.
46. Murphy B, Nunes CN, Ronan JJ, Hanaway M, Fairhurst AM & Mellin TN 2000 Centrally administered MTII affects feeding, drinking, temperature, and activity in the Sprague-Dawley rat. Journal of Applied Physiology 89 273-282.
47. Ohkubo T, Tanaka M & Nakashima K 2000 Structure and tissue distribution of chicken leptin receptor (cOb-R) mRNA. Biochimica et Biophysica Acta 1491 303-308.
48. Ohta Y, Yoshida T & Tsushima N 2004 Comparison between broilers and layers for growth and protein use by embryos. Poultry Science 83 783-787.
49. Ottaviani E, Franchini A & Franceschi C 1997 Evolution of neuroendocrine thymus: studies on POMC derived peprides, cytokines and apoptosis in lower and higher vertebrates. Journal of Neuroimmunology 72 67-74.
50. Pankov Iu A 2005 [The role of leptin and its peptide mediators in neurophysiology]. Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 44-48.
51. Park HB,Jacobsson L, Wahlberg P, Siegel PB & Andersson L 2006 QTL analysis of body composition and metabolic traits in an intercross between chicken lines divergently selected for growth. Physiological Genomics 216-223.
52. Pierroz DD, Ziotopoulou M, Ungsunan L, Moschos S, Flier JS & Mantzoros CS 2002 Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity. Diabetes 51 1337-1345.
53. Saito S, Takagi T, Koutoku T, Saito ES, Hirakawa H, Tomonaga S, Tachibana T, Denbow DM & Furuse M 2004 Differences in catecholamine metabolism and behaviour in neonatal broiler and layer chicks. British Poultry Science 45 158-162.
54. Saltiel AR 2001 You are what you secrete. Nature Medicine 7 887-888.
55. Sambrook J & Russell DW 2001 Molecular Cloning: A Laboratory Manual. 3rd ed, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
56. Sato M, Tachibana T & Furuse M 2006 Heat production and lipid metabolism in broiler and layer chickens during embryonic development. Comparative Biochemistry and Physiology A. Molecular and Integrative Physiology 143 382-388.
57. Saunderson CL & Leslie S 1988 Muscle growth and protein degradation during early development in chicks of fast and slow growing strains. Comparative Biochemistry and Physiology 89 333-337.
58. Scarpace PJ, Matheny M, Zolotukhin S, Tumer N & Zhang Y 2003 Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin agonist MT II. Neuropharmacology 45 211-219.
59. Schioth HB, Muceniece R, Mutulis F, Prusis P, Lindeberg G, Sharma SD Hruby VJ & Wikberg JE 1997 Selectivity of cyclic [D-Nal7] and [D-Phe7] substituted MSH analogues for the melanocortin receptor subtypes. Peptides 18 1009-1013.
60. Schioth HB, Lagerstrom MC, Watanobe H, Jonsson L, Vergni AV, Ringholm A, Skarphedinsson JO, Skuladottir GV, Klovins J & Fredriksson R 2003 Functional role, structure, and evolution of the melanocortin-4 receptor. Annals of the New York Academy of Sciences 994 74-83.
61. Schneider JE, Buckley CA, Blum RM, Zhou D, Szymanski L, Day DE & Bartness TJ 2002 Metabolic signals, hormones and neuropeptides involved in control of energy balance and reproductive success in hamsters. European Journal of Neuroscience 16 377-379.
62. Schwartz MW, Woods SC, Porte D Jr., Seeley RJ & Baskin DG 2000 Central nervous system control of food intake. Nature 404 661-671.
63. Seeley RJ, Yagaloff KA, Fisher SL, Burn P, Thiele TE, van Dijk G, Baskin DG & Schwartz MW 1997 Melanocortin receptors in leptin effects. Nature 390 349.
64. Seeley RJ, Burklow ML, Wilmer KA, Matthews CC, Reizes O, McOsker CC, Trokhan DP, Gross MC & Sheldon RJ 2005 The effect of the melanocortin agonist, MT-II, on the defended level of body adiposity. Endocrinology 3732-3738.
65. Simon J & Leclercq B 1985 Fat and lean chickens: prefatteting period and in vivo sensitivity to insulin, atropine, and propranolol. American Journal of Physiology 249 R393-R401.
66. Small CJ, Stanley SA & Bloom SR 2002 Appetite control and reproduction: leptin and beyond. Seminars in Reproductive Medicine 20 389-398.
67. Stradet AD, Schioth HB & Buntin JD 2003 The role of the melanocortin system and the melanocortin-4 receptor in ring dove (Streptopelia risoria) feeding behavior. Brain Research 960 112-121.
68. Tachibana T, Sugahara K, Ohgushi A, Ando R, Sashihara K, Yoshimatsu T & Furuse M 2001 Intracerebroventricular injection of exendin (5-39) increases food intake of layer-type chicks but not broiler chicks. Brain Research 915 234-237.
69. Tachibana T, Sato M, Oikawa D & Furuse M 2006 Involvement of CRF on the anorexic effect of GLP-1 in layer chicks. Comparative Biochemistry and Physiology A. Molecular and Integrative Physiology 143 112-117.
70. Takagi T, Bungo T, Tachibana T, Saito CS, Saito S, Yamasaki I, Tomonaga S, Denbow DM & Furuse M 2003 Intracerebroventricular administration of GABA-A and GABA-B receptor agonists attenuate feeding and sleeping-like behaviour induced by L-pipecolic acid in neonatal chicks. Journal of Neuroscience Research 73 270-275.
71. Takeuchi S & Takahashi S 1998 Melanocortin receptor genes in the chicken-tissue distributions. General and Comparative Endocrinology 112 220-231.
72. Takeuchi S & Takahashi S 1999 A possible involvement of melanocortin 3 receptor in the regulation of adrenal gland function in the chicken. Biochimica et Biophysica Acta 1448 512-518.
73. Takeuchi S, Suzuki H, Yabuuchi M & Takahashi S 1996 A possible involvement of melanocortin 1-receptor in regulating feather color pigmentation in the chicken. Biochimica et Biophysica Acta 1308 164-168.
74. Takeuchi S, Kudo T & Takahashi S 1998 Molecular cloning of the chicken melanocortin 2 (ACTH)-receptor gene. Biochimica et Biophysica Acta 1403 102-108.
75. Takeuchi S, Teshigawara K & Takahashi S 1999 Molecular cloning and characterization of the chicken proopiomelanocortin (POMC) gene. Biochimica et Biophysica Acta 1450 452-459.
76. Takeuchi S, Takahashi S, Okimoto R, Schioth HB & Boswell T 2003 Avian melanocortin system: alpha-MSH may act as an autocrine/paracrine hormone: a minireview. Annals of the New York Academy of Sciences 994 366-372.
77. Tolkamp, BJ, Sandilands V & Kyriazakis I 2005 Effects of qualitative feed restriction during rearing on the performance of broiler breeders during rearing and lay. Poultry Science 84 1286-1293.
78. Trivedi P, Jiang M, Tamvakopoulos CC, Shen X, Yu H, Mock S, Fenyk-Melody J, Van der Ploeg LH & Guan XM 2003 Exploring the site of anorectic action of peripherally administered synthetic melanocortin peptide MT-II in rats. Brain Research 977 221-230.
79. Tucci FC, White NS, Markison S, Joppa M, Tran JA, Fleck BA, Madan A, Dyck BP, Parker J, Pontillo J et al. 2005 Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines. Bioorganic and Medicinal Chemistry 2389-2395.
80. Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B & Froguel P 2000 Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. Journal of Clinical Investigation 106 253-262.
81. Watanobe H, Yoneda M, Kakizaki Y, Kohsaka A, Suda T & Schioth HB 2001 Further evidence for a significant participation of the melanocortin 4 receptor in the preovulatory prolactin surge in the rat. Brain Research Bulletin 54 521-525.
82. Wessells H, Gralnek D, Dorr R, Hruby VJ, Hadley ME & Levine N 2000 Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Urology 56 641-646.
83. Whitehead CC & Griffin HD 1984 Development of divergent lines of lean and fat broilers using plasma very low density lipoprotem concentration as selection criterion: the first three generations. British Poultry Science 25 573-582.
84. Williams DL, Kaplan JM & Grill HJ 2000 The role of the dorsal vagal complex and the vagus nerve in feeding effects of melanocortin-3/4 receptor stimulation. Endocrinology 141 1332-1337.
85. Williams G, Bing C, Cai XJ, Harrold JA, King PJ & Liu XH 2001 The hypothalamus and the control of energy horneostasis: different circuits, different purposes. Physiology and Behavior 74 683-701.
86. Yang Y, Dickinson C, Haskell-Luevano C & Gantz I 1997 Molecular basis Haskesis for the interaction of [Nle4,DPhe7] melanocyte stimulating hormone with the human melanocortin-1 receptor. Journal of Biological Chemistry 272 23000-23010.