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Volumn 9, Issue 4, 2006, Pages 393-398

Elevated plasma homocysteine levels: Risk factor or risk marker for the development of dementia and Alzheimer's disease?

Author keywords

Alzheimer disease; Dementia; Homocysteine; Plasma; Risk factor

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PYRIDOXINE;

EID: 33747391975     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2006-9404     Document Type: Review
Times cited : (168)

References (67)
  • 1
    • 72949132104 scopus 로고
    • Factors of risk in the development of coronary heart disease-six year follow-up experience. The Framingham Study
    • July
    • W.B. Kannel, T.R. Dawber, A. Kagan, N. Revotskie and J.I. Stokes, Factors of risk in the development of coronary heart disease-six year follow-up experience. The Framingham Study, Ann Intern Med 55 (July, 1961), 33-50.
    • (1961) Ann Intern Med , vol.55 , pp. 33-50
    • Kannel, W.B.1    Dawber, T.R.2    Kagan, A.3    Revotskie, N.4    Stokes, J.I.5
  • 2
    • 0024808210 scopus 로고
    • Hypertriglyceridemia-independent risk factor or risk marker?
    • M. Hanefeld and K. Luthke, Hypertriglyceridemia-independent risk factor or risk marker? Przegl Lek 46(7) (1989), 588-594.
    • (1989) Przegl Lek , vol.46 , Issue.7 , pp. 588-594
    • Hanefeld, M.1    Luthke, K.2
  • 3
    • 0018354637 scopus 로고
    • Risk marker for Wernicke's encephalopathy
    • 23 June
    • R.K. Nadella, Risk marker for Wernicke's encephalopathy, Lancet 1(8130) (23 June, 1979), 1354.
    • (1979) Lancet , vol.1 , Issue.8130 , pp. 1354
    • Nadella, R.K.1
  • 5
    • 0000562506 scopus 로고
    • Homocystinuria: A new inborn error of metabolism associated with mental deficiency
    • October
    • N.A. Carson, D.C. Cusworth, C.E. Dent, C.M. Field, D.W. Neill and R.G. Westall, Homocystinuria: A new inborn error of metabolism associated with mental deficiency, Arch Dis Child 38 (October 1963), 425-436.
    • (1963) Arch Dis Child , vol.38 , pp. 425-436
    • Carson, N.A.1    Cusworth, D.C.2    Dent, C.E.3    Field, C.M.4    Neill, D.W.5    Westall, R.G.6
  • 6
    • 0014545138 scopus 로고
    • Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis
    • July
    • K.S. McCully, Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis, Am J Pathol 56(1) (July 1969), 111-128.
    • (1969) Am J Pathol , vol.56 , Issue.1 , pp. 111-128
    • McCully, K.S.1
  • 7
    • 0033533435 scopus 로고    scopus 로고
    • Nonfasting plasma total homocysteine levels and stroke incidence in elderly persons: The Framingham Study
    • 7 September
    • A.G. Bostom, I.H. Rosenberg, H. Silbershatz et al., Nonfasting plasma total homocysteine levels and stroke incidence in elderly persons: the Framingham Study, Ann Intern Med 131(5) (7 September 1999), 352-355.
    • (1999) Ann Intern Med , vol.131 , Issue.5 , pp. 352-355
    • Bostom, A.G.1    Rosenberg, I.H.2    Silbershatz, H.3
  • 8
    • 0033599973 scopus 로고    scopus 로고
    • Nonfasting plasma total homocysteine levels and all-cause and cardiovascular disease mortality in elderly Framingham men and women
    • 24 May
    • A.G. Bostom, H. Silbershatz, I.H. Rosenberg et al., Nonfasting plasma total homocysteine levels and all-cause and cardiovascular disease mortality in elderly Framingham men and women, Arch Intern Med 159(10) (24 May 1999), 1077-1080.
    • (1999) Arch Intern Med , vol.159 , Issue.10 , pp. 1077-1080
    • Bostom, A.G.1    Silbershatz, H.2    Rosenberg, I.H.3
  • 9
    • 0023946537 scopus 로고
    • Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis
    • 30 June
    • J. Lindenbaum, E.B. Healton, D.G. Savage et al., Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis, N Engl J Med 318(26) (30 June 1988), 1720-1728.
    • (1988) N Engl J Med , vol.318 , Issue.26 , pp. 1720-1728
    • Lindenbaum, J.1    Healton, E.B.2    Savage, D.G.3
  • 10
    • 0031026879 scopus 로고    scopus 로고
    • Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study
    • 18 January
    • A. Hofman, A. Ott, M.M. Breteler et al., Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study, Lancet 349(946) (18 January 1997), 151-154.
    • (1997) Lancet , vol.349 , Issue.946 , pp. 151-154
    • Hofman, A.1    Ott, A.2    Breteler, M.M.3
  • 11
    • 0031054674 scopus 로고    scopus 로고
    • Brain infarction and the clinical expression of Alzheimer disease, The Nun Study
    • 12 March
    • D.A. Snowdon, L.H. Greiner, J.A. Mortimer, K.P. Riley, P.A. Greiner and W.R. Markesbery, Brain infarction and the clinical expression of Alzheimer disease, The Nun Study, JAMA 277(10) (12 March 1997), 813-817.
    • (1997) JAMA , vol.277 , Issue.10 , pp. 813-817
    • Snowdon, D.A.1    Greiner, L.H.2    Mortimer, J.A.3    Riley, K.P.4    Greiner, P.A.5    Markesbery, W.R.6
  • 12
    • 0031597388 scopus 로고    scopus 로고
    • Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease
    • November
    • R. Clarke, A.D. Smith, K.A. Jobst, H. Refsum, L. Sutton and P.M. Ueland, Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease, Arch Neurol 55(11) (November 1998), 1449-1455.
    • (1998) Arch Neurol , vol.55 , Issue.11 , pp. 1449-1455
    • Clarke, R.1    Smith, A.D.2    Jobst, K.A.3    Refsum, H.4    Sutton, L.5    Ueland, P.M.6
  • 13
    • 0031768722 scopus 로고    scopus 로고
    • Early diagnosis of cognitive impairment in the elderly with the focus on Alzheimer's disease
    • C.G. Gottfries, W. Lehmann and B. Regland, Early diagnosis of cognitive impairment in the elderly with the focus on Alzheimer's disease, J Neural Transm 105(8-9) (1998), 773-786.
    • (1998) J Neural Transm , vol.105 , Issue.8-9 , pp. 773-786
    • Gottfries, C.G.1    Lehmann, W.2    Regland, B.3
  • 14
    • 0035050096 scopus 로고    scopus 로고
    • Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey
    • May
    • M.S. Morris, P.F. Jacques, I.H. Rosenberg and J. Selhub, Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey, American Journal of Clinical Nutrition 73(5) (May 2001), 927-933.
    • (2001) American Journal of Clinical Nutrition , vol.73 , Issue.5 , pp. 927-933
    • Morris, M.S.1    Jacques, P.F.2    Rosenberg, I.H.3    Selhub, J.4
  • 15
    • 0037069282 scopus 로고    scopus 로고
    • Homocysteine and cognitive function in the elderly - The Rotterdam Scan Study
    • 12 November
    • N.D. Prins, T. den Heijer, A. Hofman et al., Homocysteine and cognitive function in the elderly - The Rotterdam Scan Study, Neurology 59(9) (12 November 2002), 1375-1380.
    • (2002) Neurology , vol.59 , Issue.9 , pp. 1375-1380
    • Prins, N.D.1    Den Heijer, T.2    Hofman, A.3
  • 17
    • 31844443695 scopus 로고
    • The Enironment and Disease: Association or Causation?
    • May
    • A.B. Hill, The Enironment and Disease: Association or Causation? Proc R Soc Med 58 (May 1965), 295-300.
    • (1965) Proc R Soc Med , vol.58 , pp. 295-300
    • Hill, A.B.1
  • 18
    • 0037075257 scopus 로고    scopus 로고
    • Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
    • 14 February
    • S. Seshadri, A. Beiser, J. Selhub et al., Plasma homocysteine as a risk factor for dementia and Alzheimer's disease, New England Journal of Medicine 346(7) (14 February 2002), 476-483.
    • (2002) New England Journal of Medicine , vol.346 , Issue.7 , pp. 476-483
    • Seshadri, S.1    Beiser, A.2    Selhub, J.3
  • 19
    • 27244445944 scopus 로고    scopus 로고
    • Homocysteine and folate as risk factors for dementia and Alzheimer disease
    • September
    • G. Ravaglia, P. Forti, F. Maioli et al., Homocysteine and folate as risk factors for dementia and Alzheimer disease, Am J Clin Nutr 82(3) (September 2005), 636-643.
    • (2005) Am J Clin Nutr , vol.82 , Issue.3 , pp. 636-643
    • Ravaglia, G.1    Forti, P.2    Maioli, F.3
  • 20
    • 2942538501 scopus 로고    scopus 로고
    • Plasma homocysteine levels and risk of Alzheimer disease
    • 8 June
    • J.A. Luchsinger, M.X. Tang, S. Shea, J. Miller, R. Green and R. Mayeux, Plasma homocysteine levels and risk of Alzheimer disease, Neurology 62(11) (8 June 2004), 1972-1976.
    • (2004) Neurology , vol.62 , Issue.11 , pp. 1972-1976
    • Luchsinger, J.A.1    Tang, M.X.2    Shea, S.3    Miller, J.4    Green, R.5    Mayeux, R.6
  • 21
    • 26444496445 scopus 로고    scopus 로고
    • Homocysteine and cognitive performance in the Framingham offspring study: Age is important
    • 1 October
    • M.F. Elias, L.M. Sullivan, R.B. D'Agostino et al., Homocysteine and cognitive performance in the Framingham offspring study: age is important, Am J Epidemiol 162(7) (1 October 2005), 644-653.
    • (2005) Am J Epidemiol , vol.162 , Issue.7 , pp. 644-653
    • Elias, M.F.1    Sullivan, L.M.2    D'Agostino, R.B.3
  • 22
    • 3042553995 scopus 로고    scopus 로고
    • Homocysteine and cognitive performance in healthy elderly subjects
    • G. Ravaglia, P. Forti, F. Maioli et al., Homocysteine and cognitive performance in healthy elderly subjects, Arch Gerontol Geriatr Suppl (9) (2004), 349-357.
    • (2004) Arch Gerontol Geriatr Suppl , Issue.9 , pp. 349-357
    • Ravaglia, G.1    Forti, P.2    Maioli, F.3
  • 23
  • 24
    • 20444410004 scopus 로고    scopus 로고
    • Total homocysteine is associated with white matter hyperintensity volume: The Northern Manhattan Study
    • June
    • C.B. Wright, M.C. Paik, T.R. Brown et al., Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study, Stroke 36(6) (June 2005), 1207-1211.
    • (2005) Stroke , vol.36 , Issue.6 , pp. 1207-1211
    • Wright, C.B.1    Paik, M.C.2    Brown, T.R.3
  • 25
    • 0347949639 scopus 로고    scopus 로고
    • Plasma total homocysteine levels and cranial magnetic resonance imaging findings in elderly persons: The Cardiovascular Health Study
    • January
    • W.T. Longstreth, Jr., R. Katz, J. Olson et al., Plasma total homocysteine levels and cranial magnetic resonance imaging findings in elderly persons: the Cardiovascular Health Study, Arch Neurol 61(1) (January 2004), 67-72.
    • (2004) Arch Neurol , vol.61 , Issue.1 , pp. 67-72
    • Longstreth Jr., W.T.1    Katz, R.2    Olson, J.3
  • 26
    • 0037226674 scopus 로고    scopus 로고
    • Homocysteine and brain atrophy on MRI of non-demented elderly
    • January
    • H.T. Den, S.E. Vermeer, R. Clarke et al., Homocysteine and brain atrophy on MRI of non-demented elderly, Brain 126(Pt 1) (January 2003), 170-175.
    • (2003) Brain , vol.126 , Issue.1 PART , pp. 170-175
    • Den, H.T.1    Vermeer, S.E.2    Clarke, R.3
  • 27
    • 0036863956 scopus 로고    scopus 로고
    • Minimal hippocampal width relates to plasma homocysteine in community-dwelling older people
    • November
    • J.H. Williams, E.A. Pereira, M.M. Budge and K.M. Bradley, Minimal hippocampal width relates to plasma homocysteine in community-dwelling older people, Age Ageing 31(6) (November 2002), 440-444.
    • (2002) Age Ageing , vol.31 , Issue.6 , pp. 440-444
    • Williams, J.H.1    Pereira, E.A.2    Budge, M.M.3    Bradley, K.M.4
  • 28
    • 0034840099 scopus 로고    scopus 로고
    • Elevated plasma homocysteine levels and risk of silent brain infarction in elderly people
    • May
    • T. Matsui, H. Arai, T. Yuzuriha et al., Elevated plasma homocysteine levels and risk of silent brain infarction in elderly people, Stroke 32(5) (May 2001), 1116-1119.
    • (2001) Stroke , vol.32 , Issue.5 , pp. 1116-1119
    • Matsui, T.1    Arai, H.2    Yuzuriha, T.3
  • 29
    • 0034678050 scopus 로고    scopus 로고
    • Homocysteine accelerates endothelial cell senescence
    • 17 March
    • D. Xu, R. Neville and T. Finkel, Homocysteine accelerates endothelial cell senescence, FEBS Lett 470(1) (17 March 2000), 20-24.
    • (2000) FEBS Lett , vol.470 , Issue.1 , pp. 20-24
    • Xu, D.1    Neville, R.2    Finkel, T.3
  • 30
    • 11144331539 scopus 로고    scopus 로고
    • Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study
    • February
    • J. Stessman, Y. Maaravi, R. Hammerman-Rozenberg et al., Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study, Mech Ageing Dev 126(2) (February 2005), 333-339.
    • (2005) Mech Ageing Dev , vol.126 , Issue.2 , pp. 333-339
    • Stessman, J.1    Maaravi, Y.2    Hammerman-Rozenberg, R.3
  • 31
    • 0036892748 scopus 로고    scopus 로고
    • Multiple aspects of homocysteine neurotoxicity: Glutamate excitotoxicity, kinase hyperactivation and DNA damage
    • 1 December
    • P.I. Ho, D. Ortiz, E. Rogers and T.B. Shea, Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage, J Neurosci Res 70(5) (1 December 2002), 694-702.
    • (2002) J Neurosci Res , vol.70 , Issue.5 , pp. 694-702
    • Ho, P.I.1    Ortiz, D.2    Rogers, E.3    Shea, T.B.4
  • 32
    • 0036523032 scopus 로고    scopus 로고
    • Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease
    • 1 March
    • I.I. Kruman, T.S. Kumaravel, A. Lohani et al., Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease, J Neurosci 22(5) (1 March 2002), 1752-1762.
    • (2002) J Neurosci , vol.22 , Issue.5 , pp. 1752-1762
    • Kruman, I.I.1    Kumaravel, T.S.2    Lohani, A.3
  • 33
    • 1242317074 scopus 로고    scopus 로고
    • Glutamate-induced homocysteic acid release from astrocytes: Possible implication in glia-neuron signaling
    • B. Benz, G. Grima and K.Q. Do, Glutamate-induced homocysteic acid release from astrocytes: possible implication in glia-neuron signaling, Neuroscience 124(2) (2004), 377-386.
    • (2004) Neuroscience , vol.124 , Issue.2 , pp. 377-386
    • Benz, B.1    Grima, G.2    Do, K.Q.3
  • 34
    • 0024267748 scopus 로고    scopus 로고
    • Homocysteic acid as a putative excitatory amino acid neurotransmitter: I. Postsynaptic characteristics at N-methyl-D-aspartate-type receptors on striatal cholinergic interneurons
    • December
    • J. Lehmann, C. Tsai and P.L. Wood, Homocysteic acid as a putative excitatory amino acid neurotransmitter: I. Postsynaptic characteristics at N-methyl-D-aspartate-type receptors on striatal cholinergic interneurons, J Neurochem 51(6) (December 1998), 1765-1770.
    • (1998) J Neurochem , vol.51 , Issue.6 , pp. 1765-1770
    • Lehmann, J.1    Tsai, C.2    Wood, P.L.3
  • 35
    • 0032778517 scopus 로고    scopus 로고
    • Protein homocysteinylation: Possible mechanism underlying pathological consequences of elevated homocysteine levels
    • December
    • H. Jakubowski, Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels, FASEB J 13(15) (December 1999), 2277-2283.
    • (1999) FASEB J , vol.13 , Issue.15 , pp. 2277-2283
    • Jakubowski, H.1
  • 36
    • 0034837955 scopus 로고    scopus 로고
    • Roles of homocysteine in cell metabolism: Old and new functions
    • July
    • M. Medina, J.L. Urdiales and M.I. Mores-Sanchez, Roles of homocysteine in cell metabolism: old and new functions, Eur J Biochem 268(14) (July 2001), 3871-3882.
    • (2001) Eur J Biochem , vol.268 , Issue.14 , pp. 3871-3882
    • Medina, M.1    Urdiales, J.L.2    Mores-Sanchez, M.I.3
  • 37
    • 0035987842 scopus 로고    scopus 로고
    • Inhibition of Na+, K+-ATPase activity by the metabolites accumulating in homocystinuria
    • June
    • E.L. Streck, A.I. Zugno, B. Tagliari, C. Wannmacher, M. Wajner and A.T. Wyse, Inhibition of Na+, K+-ATPase activity by the metabolites accumulating in homocystinuria, Metab Brain Dis 17(2) (June 2002), 83-91.
    • (2002) Metab Brain Dis , vol.17 , Issue.2 , pp. 83-91
    • Streck, E.L.1    Zugno, A.I.2    Tagliari, B.3    Wannmacher, C.4    Wajner, M.5    Wyse, A.T.6
  • 38
    • 0037451890 scopus 로고    scopus 로고
    • Impairment of energy metabolism in hippocampus of rats subjected to chemically-induced hyperhomocysteinemia
    • 17 April
    • E.L. Streck, C. Matte, P.S. Vieira et al., Impairment of energy metabolism in hippocampus of rats subjected to chemically-induced hyperhomocysteinemia, Biochim Biophys Acta 1637(3) (17 April 2003), 187-192.
    • (2003) Biochim Biophys Acta , vol.1637 , Issue.3 , pp. 187-192
    • Streck, E.L.1    Matte, C.2    Vieira, P.S.3
  • 39
    • 0037066724 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein
    • 12 April
    • X. Sai, Y. Kawamura, K. Kokame et al., Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein, J Biol Chem 277(15) (12 April 2002), 12915-12920.
    • (2002) J Biol Chem , vol.277 , Issue.15 , pp. 12915-12920
    • Sai, X.1    Kawamura, Y.2    Kokame, K.3
  • 40
    • 0035093878 scopus 로고    scopus 로고
    • Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: Possible risk factors in the Alzheimer's-type neurodegenerative pathways
    • March
    • A.R. White, X. Huang, M.F. Jobling et al., Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways, J Neurochem 76(5) (March 2001), 1509-1520.
    • (2001) J Neurochem , vol.76 , Issue.5 , pp. 1509-1520
    • White, A.R.1    Huang, X.2    Jobling, M.F.3
  • 41
    • 0037042211 scopus 로고    scopus 로고
    • Protein phosphatase 2A methylation: A link between elevated plasma homocysteine and Alzheimer's Disease
    • 8 May
    • S.B. Vafai and J.B. Stock, Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease, FEBS Lett 518(1-3) (8 May 2002), 1-4.
    • (2002) FEBS Lett , vol.518 , Issue.1-3 , pp. 1-4
    • Vafai, S.B.1    Stock, J.B.2
  • 42
    • 0032499024 scopus 로고    scopus 로고
    • Homocysteine and atherothrombosis
    • 9 April
    • G.N. Welch and J. Loscalzo, Homocysteine and atherothrombosis, N Engl J Med 338(15) (9 April 1998), 1042-1050.
    • (1998) N Engl J Med , vol.338 , Issue.15 , pp. 1042-1050
    • Welch, G.N.1    Loscalzo, J.2
  • 43
    • 0036845131 scopus 로고    scopus 로고
    • Hyperhomocysteinemia due to short-term folate deprivation is related to electron microscopic changes in the rat brain
    • November
    • J.M. Kim, H. Lee and N. Chang, Hyperhomocysteinemia due to short-term folate deprivation is related to electron microscopic changes in the rat brain, J Nutr 132(11) (November 2002), 3418-3421.
    • (2002) J Nutr , vol.132 , Issue.11 , pp. 3418-3421
    • Kim, J.M.1    Lee, H.2    Chang, N.3
  • 44
    • 0038387939 scopus 로고    scopus 로고
    • Homocysteine and Alzheimer's disease
    • July
    • M.S. Morris, Homocysteine and Alzheimer's disease, Lancet Neurol 2(7) (July 2003), 425-428.
    • (2003) Lancet Neurol , vol.2 , Issue.7 , pp. 425-428
    • Morris, M.S.1
  • 45
    • 0034936213 scopus 로고    scopus 로고
    • Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine
    • June
    • K. Nilsson, L. Gustafson and B. Hultberg, Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine, Int J Geriatr Psychiatry 16(6) (June 2001), 609-614.
    • (2001) Int J Geriatr Psychiatry , vol.16 , Issue.6 , pp. 609-614
    • Nilsson, K.1    Gustafson, L.2    Hultberg, B.3
  • 46
    • 1342309318 scopus 로고    scopus 로고
    • Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: The Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial
    • 4 February
    • J.F. Toole, M.R. Malinow, L.E. Chambless et al., Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial, JAMA 291(5) (4 February 2004), 565-575.
    • (2004) JAMA , vol.291 , Issue.5 , pp. 565-575
    • Toole, J.F.1    Malinow, M.R.2    Chambless, L.E.3
  • 47
    • 33645796222 scopus 로고    scopus 로고
    • Homocysteine Lowering and Cardiovascular Events after Acute Myocardial Infarction
    • 12 March NEJMoa055227
    • K.H. Bonaa, I. Njolstad, P.M. Ueland et al., Homocysteine Lowering and Cardiovascular Events after Acute Myocardial Infarction, N Engl J Med (12 March 2006), NEJMoa055227.
    • (2006) N Engl J Med
    • Bonaa, K.H.1    Njolstad, I.2    Ueland, P.M.3
  • 48
    • 33645753544 scopus 로고    scopus 로고
    • Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease
    • 12 March NEJMoa060900
    • The Heart Outcomes Prevention Evaluation (HOPE). Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease, N Engl J Med (12 March 2006), NEJMoa060900.
    • (2006) N Engl J Med
  • 49
    • 33645743547 scopus 로고    scopus 로고
    • Improvement in stroke mortality in Canada and the United States, 1990 to 2002
    • 14 March
    • Q. Yang, L.D. Botto, J.D. Erickson et al., Improvement in stroke mortality in Canada and the United States, 1990 to 2002, Circulation 113(10) (14 March 2006), 1335-1343.
    • (2006) Circulation , vol.113 , Issue.10 , pp. 1335-1343
    • Yang, Q.1    Botto, L.D.2    Erickson, J.D.3
  • 50
    • 0036090588 scopus 로고    scopus 로고
    • Dietary intake of folate and risk of stroke in US men and women: NHANES I Epidemiologic Follow-up Study
    • National Health and Nutrition Examination Survey, May
    • L.A. Bazzano, J. He, L.G. Ogden et al., Dietary intake of folate and risk of stroke in US men and women: NHANES I Epidemiologic Follow-up Study. National Health and Nutrition Examination Survey, Stroke 33(5) (May 2002), 1183-1188.
    • (2002) Stroke , vol.33 , Issue.5 , pp. 1183-1188
    • Bazzano, L.A.1    He, J.2    Ogden, L.G.3
  • 51
    • 9744267474 scopus 로고    scopus 로고
    • Mild hyperhomocysteinemia: Risk factor or just risk predictor for cardiovascular diseases?
    • November
    • N. Weiss, R. Hilge and U. Hoffmann, Mild hyperhomocysteinemia: risk factor or just risk predictor for cardiovascular diseases? Vasa 33(4) (November 2004), 191-203.
    • (2004) Vasa , vol.33 , Issue.4 , pp. 191-203
    • Weiss, N.1    Hilge, R.2    Hoffmann, U.3
  • 52
    • 33645777279 scopus 로고    scopus 로고
    • Homocysteine Trials - Clear Outcomes for Complex Reasons
    • 14 March
    • J. Loscalzo, Homocysteine Trials - Clear Outcomes for Complex Reasons, N Engl J Med (14 March 2006).
    • (2006) N Engl J Med
    • Loscalzo, J.1
  • 53
    • 0037076486 scopus 로고    scopus 로고
    • Functional vitamin B(12) deficiency and Alzheimer disease
    • 14 May
    • A. McCaddon, B. Regland, P. Hudson and G. Davies, Functional vitamin B(12) deficiency and Alzheimer disease, Neurology 58(9) (14 May 2002), 1395-1399.
    • (2002) Neurology , vol.58 , Issue.9 , pp. 1395-1399
    • McCaddon, A.1    Regland, B.2    Hudson, P.3    Davies, G.4
  • 54
    • 27844544230 scopus 로고    scopus 로고
    • Plasma homocysteine levels are not increased in murine models of Alzheimer's disease
    • December
    • D. Santiard-Baron, J. Aupetit and N. Janel, Plasma homocysteine levels are not increased in murine models of Alzheimer's disease, Neurosci Res 53(4) (December 2005), 447-449.
    • (2005) Neurosci Res , vol.53 , Issue.4 , pp. 447-449
    • Santiard-Baron, D.1    Aupetit, J.2    Janel, N.3
  • 55
    • 33744788667 scopus 로고    scopus 로고
    • Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels
    • 2 March
    • J. Pacheco-Quinto, E.B. Rodriguez de Turco, S. Derosa et al., Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels, Neurobiol Dis (2 March 2006).
    • (2006) Neurobiol Dis
    • Pacheco-Quinto, J.1    Rodriguez De Turco, E.B.2    Derosa, S.3
  • 57
    • 0036187533 scopus 로고    scopus 로고
    • The VITATOPS (Vitamins to Prevent Stroke) Trial: Rationale and design of an international, large, simple, randomised trial of homocysteine-lowering multivitamin therapy in patients with recent transient ischaemic attack or stroke
    • The VITATOPS (Vitamins to Prevent Stroke) Trial: rationale and design of an international, large, simple, randomised trial of homocysteine-lowering multivitamin therapy in patients with recent transient ischaemic attack or stroke, Cerebrovasc Dis 13(2) (2002), 120-126.
    • (2002) Cerebrovasc Dis , vol.13 , Issue.2 , pp. 120-126
  • 58
    • 20244361897 scopus 로고    scopus 로고
    • A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer disease
    • March
    • P.S. Aisen, S. Egelko, H. Andrews et al., A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer disease, Am J Geriatr Psychiatry 11(2) (March 2003), 246-249.
    • (2003) Am J Geriatr Psychiatry , vol.11 , Issue.2 , pp. 246-249
    • Aisen, P.S.1    Egelko, S.2    Andrews, H.3
  • 59
    • 55049095215 scopus 로고    scopus 로고
    • Folic acid with or without vitamin B12 for cognition and dementia
    • M. Malouf, E.J. Grimley and S.A. Areosa, Folic acid with or without vitamin B12 for cognition and dementia, Cochrane Database Syst Rev (4) (2003), CD004514.
    • (2003) Cochrane Database Syst Rev , Issue.4
    • Malouf, M.1    Grimley, E.J.2    Areosa, S.A.3
  • 60
    • 0034084815 scopus 로고    scopus 로고
    • The preclinical phase of alzheimer disease: A 22-year prospective study of the Framingham Cohort
    • June
    • M.F. Elias, A. Beiser, P.A. Wolf, R. Au, R.F. White and R.B. D'Agostino, The preclinical phase of alzheimer disease: A 22-year prospective study of the Framingham Cohort, Arch Neurol 57(6) (June 2000), 808-813.
    • (2000) Arch Neurol , vol.57 , Issue.6 , pp. 808-813
    • Elias, M.F.1    Beiser, A.2    Wolf, P.A.3    Au, R.4    White, R.F.5    D'Agostino, R.B.6
  • 61
    • 0033829137 scopus 로고    scopus 로고
    • Mild cognitive impairment. When is it a precursor to Alzheimer's disease?
    • September
    • Y. Shah, E.G. Tangalos and R.C. Petersen, Mild cognitive impairment. When is it a precursor to Alzheimer's disease? Geriatrics 55(9) (September 2000), 62, 65-2, 68.
    • (2000) Geriatrics , vol.55 , Issue.9 , pp. 62
    • Shah, Y.1    Tangalos, E.G.2    Petersen, R.C.3
  • 62
    • 24744441872 scopus 로고    scopus 로고
    • The relation between homocysteine levels and development of Alzheimer's disease in mild cognitive impairment patients
    • S. Annerbo, L.O. Wahlund and J. Lokk, The relation between homocysteine levels and development of Alzheimer's disease in mild cognitive impairment patients, Dement Geriatr Cogn Disord 20(4) (2005), 209-214.
    • (2005) Dement Geriatr Cogn Disord , vol.20 , Issue.4 , pp. 209-214
    • Annerbo, S.1    Wahlund, L.O.2    Lokk, J.3
  • 63
    • 0038009864 scopus 로고    scopus 로고
    • Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of dementia
    • July
    • R. Clarke, G. Harrison and S. Richards, Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of dementia, J Intern Med 254(1) (July 2003), 67-75.
    • (2003) J Intern Med , vol.254 , Issue.1 , pp. 67-75
    • Clarke, R.1    Harrison, G.2    Richards, S.3
  • 64
    • 33644693101 scopus 로고    scopus 로고
    • Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease
    • 1 December
    • D.J. Stott, G. Macintosh, G.D. Lowe et al., Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease, American Journal of Clinical Nutrition 82(6) (1 December 2005), 1320-1326.
    • (2005) American Journal of Clinical Nutrition , vol.82 , Issue.6 , pp. 1320-1326
    • Stott, D.J.1    Macintosh, G.2    Lowe, G.D.3
  • 65
    • 32344447413 scopus 로고    scopus 로고
    • Protocol for Project FACT: A randomised controlled trial on the effect of a walking program and vitamin B supplementation on the rate of cognitive decline and psychosocial wellbeing in older adults with mild cognitive impairment [ISRCTN19227688]
    • J. Van Uffelen, M. Hopman-Rock, A.P. Chin and W. Van Mechelen, Protocol for Project FACT: a randomised controlled trial on the effect of a walking program and vitamin B supplementation on the rate of cognitive decline and psychosocial wellbeing in older adults with mild cognitive impairment [ISRCTN19227688], BMC Geriatrics 5(1) (2005), 18.
    • (2005) BMC Geriatrics , vol.5 , Issue.1 , pp. 18
    • Van Uffelen, J.1    Hopman-Rock, M.2    Chin, A.P.3    Van Mechelen, W.4
  • 66
    • 33745652285 scopus 로고    scopus 로고
    • A controlled trial of homocysteine lowering and cognitive performance
    • 29 June
    • J.A. McMahon, T.J. Green, C.M. Skeaff, R.G. Knight, J.I. Mann and S.M. Williams, A controlled trial of homocysteine lowering and cognitive performance, N Engl J Med 354(26) (29 June 2006), 2764-2772.
    • (2006) N Engl J Med , vol.354 , Issue.26 , pp. 2764-2772
    • McMahon, J.A.1    Green, T.J.2    Skeaff, C.M.3    Knight, R.G.4    Mann, J.I.5    Williams, S.M.6
  • 67
    • 33745617460 scopus 로고    scopus 로고
    • Vitamin B12, folic acid, and the prevention of dementia
    • 29 June
    • R. Clarke, Vitamin B12, folic acid, and the prevention of dementia, N Engl J Med 354(26) (29 June 2006), 2817-2819.
    • (2006) N Engl J Med , vol.354 , Issue.26 , pp. 2817-2819
    • Clarke, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.