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Volumn 268, Issue 14, 2001, Pages 3871-3882

Roles of homocysteine in cell metabolism: Old and new functions

Author keywords

Cardiovascular disease; Cobalamine; Folate; Homocysteine; Neural tube deffect; Protein homocysteinylation

Indexed keywords

HOMOCYSTEINE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; TETRAHYDROFOLIC ACID; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR AP 1;

EID: 0034837955     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.02278.x     Document Type: Review
Times cited : (190)

References (136)
  • 8
    • 0026533906 scopus 로고
    • The pathogenesis of homocysteinemia: Interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine
    • (1992) Am. J. Clin. Nutr. , vol.55 , pp. 131-138
    • Selhub, J.1    Miller, J.W.2
  • 10
    • 0032778517 scopus 로고    scopus 로고
    • Protein homocysteinylation: Possible mechanism underlying pathological consequences of elevated homocysteine levels
    • (1999) FASEB J. , vol.13 , pp. 2277-2283
    • Jakubowski, H.1
  • 12
    • 0032906750 scopus 로고    scopus 로고
    • Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: Metabolic significance, risks and impact on folate requirement
    • (1999) J. Nutr. , vol.129 , pp. 919-922
    • Bailey, L.B.1    Gregory III, J.F.2
  • 16
    • 0030762686 scopus 로고    scopus 로고
    • Homocysteinemia in end-stage renal disease: Prevalence, etiology, and potential relationship to arteriosclerotic outcomes
    • (1997) Kidney Int. , vol.52 , pp. 10-20
    • Bostom, A.G.1    Lathrop, L.2
  • 34
    • 0031035742 scopus 로고    scopus 로고
    • Metabolism of homocysteine thiolactone in human cell cultures: Possible mechasmism for pathological consequences of elevated homocysteine levels
    • (1997) J. Biol. Chem. , vol.272 , pp. 1935-1942
    • Jakubowski, H.1
  • 41
    • 0027753175 scopus 로고
    • Methionine synthase inactivation by nitrous oxide during methionine loading of normal human fibroblasts. Homocysteine remethylation as determinant of enzyme inactivation and homocysteine export
    • (1993) J. Pharmacol. Exp. Ther. , vol.267 , pp. 1298-1303
    • Christensen, B.1    Ueland, P.M.2
  • 52
    • 0014545138 scopus 로고
    • Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis
    • (1969) Am. J. Pathol. , vol.56 , pp. 111-128
    • McCully, K.S.1
  • 62
    • 0033914825 scopus 로고    scopus 로고
    • Increased plasma homocysteine is an independent predictor of new coronary events in older persons
    • (2000) Am. J. Cardiol. , vol.86 , pp. 346-347
    • Aronow, W.S.1    Ahn, C.2
  • 72
    • 0028128943 scopus 로고
    • The oxidation hypothesis of atherosclerosis
    • (1994) Lancet , vol.344 , pp. 793-795
    • Witzum, J.L.1
  • 76
    • 0027241856 scopus 로고
    • The pathogenesis of atherosclerosis: A perspective for the 1990s
    • (1993) Nature , vol.362 , pp. 801-809
    • Ross, R.1
  • 84
    • 0026486960 scopus 로고
    • Homocysteine and other sulfhydryl compounds enhances the binding of lipoprotein (a) to fibrin: A potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 10193-10197
    • Harpel, P.C.1    Chang, V.T.2    Borth, W.3
  • 86
    • 0024403531 scopus 로고
    • Lowered antitrombina III activity and other clotting changes in homocystinuria. Effects of a pyridoxine-folate regimen
    • (1989) Haemostasis , vol.19 , pp. 24-28
    • Palareti, G.1    Coccheri, S.2
  • 88
    • 0026773724 scopus 로고
    • An atherogenic stimulus homocysteine inhibits cofactor activity of thrombomodulin and enhances thrombomodulin expression in human umbilical vein endothelial cells
    • (1992) Blood , vol.79 , pp. 2930-2936
    • Hayashi, T.1    Honda, G.2    Suzuki, K.3
  • 89
    • 0027288252 scopus 로고
    • Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor
    • (1993) J. Clin. Invest. , vol.91 , pp. 2873-2879
    • Hajjar, K.A.1
  • 98
    • 0032483020 scopus 로고    scopus 로고
    • Can ends justify the means? Telomeres and the mechanism of replicative senescence and immortalization in mammalian cells
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9078-9081
    • Sedivy, J.M.1
  • 107
    • 0030604041 scopus 로고    scopus 로고
    • Involvement of N-methyl-D-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture
    • (1996) Neurosci. Lett. , vol.216 , pp. 117-120
    • Kim, W.K.1    Pae, Y.S.2
  • 127
    • 0034234789 scopus 로고    scopus 로고
    • Homocysteine, Alzheimer;s disease, and cognitive function
    • (2000) Nutrition , vol.16 , pp. 675-677
    • Miller, J.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.