Nonfasting plasma total homocysteine levels and stroke incidence in elderly persons: The Framingham Study

Annals of Internal Medicine

Volumn 131, Issue 5, 1999, Pages 352-355

  Bostom, Andrew G ^b   Rosenberg, Irwin H ^a   Silbershatz, Halit ^c   Jacques, Paul F ^a   Selhub, Jacob ^a   D'Agostino, Ralph B ^c   Wilson, Peter W F ^d   Wolf, Philip A ^e  

^a TUFTS UNIVERSITY   (United States)

^b MEMORIAL HOSPITAL OF RHODE ISLAND   (United States)

^c BOSTON UNIVERSITY   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMOCYSTEINE;

ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; INCIDENCE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; STROKE;

EID: 0033533435     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-131-5-199909070-00006     Document Type: Article

References (20)

1. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA. 1995;274:1049-57.
2. Omenn GS, Beresford SA, Motulsky AG. Preventing coronary heart disease: B vitamins and homocysteine [Editorial]. Circulation. 1998;97:421-4.
3. Alfthan G, Pekkanen J, Jauhiainen M, Pitkaniemi J, Karvonen M, Tuomilehto J, et al. Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study. Atherosclerosis. 1994;106:9-19.
4. Verhoef P, Hennekens CH, Malinow MR, Kok FJ, Willett WC, Stampfer MJ. A prospective study of plasma homocysteine and risk of ischemic stroke. Stroke. 1994;25:1924-30.
5. Perry IJ, Refsum H, Morris RW, Ebrahim SB, Ueland PM, Shaper AG. Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet. 1995;346:1395-8.
6. Petri M, Roubenoff R, Dallal GE, Nadeau MR, Selhub J, Rosenberg IM. Plasma homocysteine as a risk factor for atherothrombotic events in systemic lupus erythematosus. Lancet 1996;348:1120-4.
7. Robins M, Baum HM. The National Survey of Stroke. Incidence. Stroke. 1981;12(2 Pt 2):145-157.
8. Kannel WB, Wolf PA, Garrison RJ. Section 34: Some risk factors related to the annual incidence of cardiovascular disease and death using pooled repeated biennial measurements: Framingham Heart Study 30-year follow-up. In: The Framingham Study: An Epidemiological Investigation of Cardiovascular Disease. Springfield, VA: National Technical Information Service; 1987:1-459.
9. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation: a major contributor to stroke in the elderly. The Framingham Study. Arch Intern Med. 1987;147: 1561-4.
10. Ueland PM, Refsum H, Stabler SP, Malinow MR, Andersson A, Allen RH. Total homocysteine in plasma or serum: methods and applications. Clin Chem. 1993;39:1764-9.
11. Wolf PA, D'Agostino RB, Belanger AJ, Kannel WB. Probability of stroke: a risk profile from the Framingham Study. Stroke. 1991;22:312-8.
12. Manolio TA, Kronmal RA, Burke GL, O'Leary DH, Price TR. Short-term predictors of incident stroke in older adults. The Cardiovascular Health Study. Stroke. 1996;27:1479-86.
13. Evans RW, Shaten BJ, Hempel JD, Cutler JA, Kuller LH. Homocysteine and risk of cardiovascular disease in the Multiple Risk Factor Intervention Trial. Arterioscler Thromb Vasc Biol. 1997;17:1947-53.
14. Brattstrom L, Wilcken DE, Ohrvik J, Brudin L. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation. 1998;98:2520-6.
15. Mudd SH, Skovby F, Levy HL, Pettigrew KD, Wilcken B, Pyeritz RE, et al. The natural history of homocystinuria due to cystathionine beta synthase deficiency. Am J Hum Genet. 1985;37:1-31
16. Wilcken DE, Wilcken B. The natural history of vascular disease in homocystinuria and the effects of treatment. J Inherit Metab Dis. 1997;20:295-300.
17. Peterson JC, Spence JD. Vitamins and progression of atherosclerosis in hyper-homocyst(e)inaemia [Letter], Lancet. 1998;351:263.
18. Bellamy MF, McDowell IF, Ramsey MW, Brownlee M, Bones C, Newcombe RG, et al. Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. Circulation. 1998;98: 1848-52.
19. Lentz SR, Sobey CG, Piegors DJ, Bhopatkar MY, Faraci FM, Malinow MR, et al. Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. J Clin Invest. 1996;98:24-9.
20. Rolland PH, Friggi A, Barlaiter A, Piquet P, Latrille V, Faye MM, et al. Hyperhomocysteinemia-induced vascular damage in the minipig. Captoprilhydrochlorothiazide combination prevents elastic alterations. Circulation. 1995; 91:1161-74.