Vitamin B12, folic acid, and the prevention of dementia

New England Journal of Medicine

Volumn 354, Issue 26, 2006, Pages 2817-2819

  Clarke, Robert ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PYRIDOXINE; VITAMIN B COMPLEX;

ALZHEIMER DISEASE; BRAIN CIRCULATION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLINICAL FEATURE; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; CYANOCOBALAMIN DEFICIENCY; DEMENTIA; DIET SUPPLEMENTATION; EDITORIAL; HUMAN; MANDATORY PROGRAM; MEDICAL RESEARCH; META ANALYSIS; MINI MENTAL STATE EXAMINATION; PRIORITY JOURNAL; PUBLIC HEALTH; SYSTEMATIC REVIEW; UNITED STATES; UNSPECIFIED SIDE EFFECT; VITAMIN SUPPLEMENTATION; AGED; DRUG EFFECT; HYPERHOMOCYSTEINEMIA; NOTE;

AGED; COGNITION; COGNITION DISORDERS; DEMENTIA; DIETARY SUPPLEMENTS; FOLIC ACID; FOOD, FORTIFIED; HUMANS; HYPERHOMOCYSTEINEMIA; VITAMIN B 12; VITAMIN B COMPLEX;

EID: 33745617460     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMe068086     Document Type: Editorial

References (15)

1. Cummings JL. Alzheimer's disease. N Engl J Med 2004;351:56-67.
2. 12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55:1449-55.
3. Clarke R, Daly L, Robinson K, et al. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 1991;324:1149-55.
4. Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002;346:476-83.
5. Vermeer SE, van Dijk EJ, Koudstaal PJ, et al. Homocysteine, silent brain infarcts, and white matter lesions: the Rotterdam Scan Study. Ann Neurol 2002;51:285-9.
6. den Heijer T, Vermeer S, Clarke R, et al. Homocysteine and brain atrophy on MRI of non-demented elderly. Brain 2003;126:170-5.
7. Prins ND, Den Heijer T, Hofman A, et al. Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study. Neurology 2002;59:1375-80.
8. Homocysteine Lowering Trialists' Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr 2005;82:806-12.
9. McMahon JA, Green TJ, Skeaff CM, Knight RG, Mann JI, Williams SM. A controlled trial of homocysteine lowering and cognitive performance. N Engl J Med 2006;354:2764-72.
10. B-Vitamin Treatment Trialists' Collaboration. Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials. Am Heart J 2006;151:282-7.
11. Pfeiffer CM, Caudill SP, Gunter EW, Osterloh J, Sampson EJ. Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000. Am J Clin Nutr 2005;82:442-50.
12. 12 intake and cognitive decline among community-dwelling older persons. Arch Neurol 2005;62:641-5.
13. 12 and folate deficiency in later life. Age Ageing 2004;33:34-41.
14. 12 Study. Age Ageing 2006;35:416-22.
15. Department of Health. Folate and disease prevention. London: Scientific Advisory Committee on Nutrition, 2006.