Impairment of energy metabolism in hippocampus of rats subjected to chemically-induced hyperhomocysteinemia

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1637, Issue 3, 2003, Pages 187-192

  Streck, Emilio L ^a   Matté, Cristiane ^a   Vieira, Paula S ^a   Calcagnotto, Thiago ^a   Wannmacher, Clóvis M D ^a   Wajner, Moacir ^a   Wyse, Angela T S ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Brain energy metabolism; Experimental model; Homocysteine; Homocystinuria

Indexed keywords

CARBON DIOXIDE; CYTOCHROME C OXIDASE; GLUCOSE; HOMOCYSTEINE; LACTIC ACID; SODIUM CHLORIDE; SUCCINATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; COGNITION; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; EXPERIMENTAL MODEL; GLUCOSE TRANSPORT; HIPPOCAMPUS; HOMOCYSTINURIA; HYPERHOMOCYSTEINEMIA; METABOLIC DISORDER; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; RAT; RAT STRAIN; STATISTICAL ANALYSIS; TISSUE HOMOGENATE;

RATTUS NORVEGICUS;

EID: 0037451890     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4439(03)00019-X     Document Type: Article

References (42)

1. Mudd S.H., Levy H.L., Skovby F. Disorders of transsulfuration. Scriver C.R., Beaudet A.L., Sly W.S., Valle D. The Metabolic and Molecular Bases of Inherited Disease. 8th ed. 2001;1279-1327 McGraw-Hill, New York.
2. Kraus J.P. Biochemistry and molecular genetics of cystathionine β-synthase deficiency. Eur. J. Pediatr. 157(Suppl. 2):1998;S50-S53.
3. Seshadri S., Beiser A., Selhub J., Jacques P.F., Rosenberg I.H., D'Agostino R.B., Wilson P.W.F., Wolf P.A. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N. Engl. J. Med. 346:2002;476-483.
4. White A.R., Huang X., Jobling M.F., Barrow C.J., Beyreuther K., Masters C.L., Bush A.I., Cappai R. Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways. J. Neurochem. 76:2001;1509-1520.
5. Temple M.E., Luzier A.B., Kaazierad D.J. Homocysteine as a risk factor for atherosclerosis. Ann. Pharmacother. 34:2000;57-65.
6. Kuhn W., Roebroek R., Blom H., Van Oppenraaij D., Przuntek H., Kretschmer A., Buttner T., Woitalla D., Muller T. Elevated plasma levels of homocysteine in Parkinson's disease. Eur. Neurol. 40:1998;225-227.
7. Leblhuber F., Walli J., Artner-Dworzak E., Vrecko K., Widner B., Reibnegger G., Fuchs D. Hyperhomocysteinemia in dementia. J. Neural Transm. 107:2000;343-353.
8. Brennan W.A., Bird E.D., Aprille J.R. Regional mitochondrial respiratory activity in Huntington's disease brain. J. Neurochem. 44:1985;1948-1950.
9. Blass J.P. Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia? J. Neurosci. Res. 66:2001;851-856.
10. Beal M.F. Does impairement of energy metabolism result in excitotoxic neuronal death in neurological illnesses? Ann. Neurol. 31:1992;119-130.
11. Heales S.J.R., Bolaños J.P., Stewart V.C., Brookes P.S., Land J.M., Clark J.B. Nitric oxide, mitochondria and neurological disease. Biochim. Biophys. Acta. 1410:1999;215-228.
12. Schurr A. Energy metabolism, stress hormones and neural recovery from cerebral ischemia/hypoxia. Neurochem. Int. 41:2002;1-8.
13. Matthias D., Becker C.H., Riezler R., Kindling P.H. Homocysteine induced arteriosclerosis-like alterations of the aorta in normotensive and hypertensive rats following application of high doses of methionine. Atherosclerosis. 122:1996;201-216.
14. McCully K.S. Homocysteine and vascular disease. Nat. Med. 2:1996;386-389.
15. +-ATPase activity in hippocampus of rats subjected to chemically-induced hyperhomocysteinemia. Neurochem. Res. 27:2002;1585-1590.
16. Kasser T.R., Deutch A., Martin R.J. Uptake and utilization of metabolites in specific sites relative to feeding status. Physiol. Behav. 36:1986;1161-1165.
17. Dutra J.C., Wajner M., Wannmacher C.F., Dutra-Filho C.S., Wannmacher C.M.D. Effects of methylmalonate and propionate on glucose and ketone bodies uptake 'in vitro' by brain of developing rats. Biochem. Med. Metabol. Res. 45:1991;56-64.
18. Shimojo N., Naka K., Nakajima C., Yoshikawa C., Okuda K., Okada K. Test-strip method for measuring lactate in whole blood. Clin. Chem. 35:1989;1992-1994.
19. Trinder P.A. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J. Clin. Pathol. 22:1969;158-161.
20. Fischer J.C., Ruitenbeek W., Berden J.A., Trijbels J.M., Veerkamp J.H., Stadhouders M.S., Sengers R.C., Janssen A.J. Differential investigation of the capacity of succinate oxidation in human skeletal muscle. Clin. Chim. Acta. 153:1985;23-36.
21. Rustin P., Chretien D., Bourgeron T., Gérard B., Rötig A., Saudubray J.M., Munnich A. Biochemical and Molecular investigations in respiratory chain deficiencies. Clin. Chim. Acta. 228:1994;35-51.
22. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
23. Capaldi R.A. Structure and function of cytochrome c oxidase. Ann. Rev. Biochem. 59:1995;418-427.
24. Bose R., Schnell C.P., Pinsky C., Zitko V. Effects of excitotoxins on free radical indices in mouse brain. Toxicol. Lett. 60:1992;211-219.
25. Milatovic D., Zivin M., Gupta R.C., Dettbarn W.D. Alterations in cytochrome c oxidase activity and energy metabolites in response to kainic acid-induced status epilepticus. Brain Res. 31:2001;67-78.
26. Gupta R.C., Milatovic D., Dettbarn W.D. Depletion of energy metabolites following acetylcholinesterase inhibitor-induced status epilepticus: protection by antioxidants. Neurotoxicology. 22:2002;271-282.
27. Rapoport S.I., Hatanpää K., Brady D.R., Chandrasekaram K. Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer disease. Neurodegeneration. 5:1996;473-476.
28. Di Donato S. Disorders related to mitochondrial membranes: pathology of the respiratory chain and neurodegeneration. J. Inherit. Metab. Dis. 23:2000;247-263.
29. Reis E.A., Zugno A.I., Franzon R., Tagliari B., Matté C., Lamers M.L., Netto C.A., Wyse A.T.S. Pretreatment with vitamins E and C prevent the impairment of memory caused by homocysteine administration in rats. Metab. Brain Dis. 17:2002;211-217.
30. +-ATPase activity induced by homocysteine is probably mediated by oxidative stress. Neurochem. Res. 26:2001;1195-1200.
31. Streck E.L., Zugno A.I., Tagliari B., Sarkis J.J.F., Wajner M., Wannmacher C.M.D., Wyse A.T.S. On the mechanism of the inhibition of Na(+), K(+)-ATPase activity caused by homocysteine. Int. J. Dev. Neurosci. 20:2002;77-81.
32. +-ATPase activity by the metabolites accumulating in homocystinuria. Metab. Brain Dis. 17:2002;83-91.
33. Kim W.K., Pae Y.S. Involvement of N-methyl-D-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture. Neurosci. Let. 216:1996;117-120.
34. Hertz L., Peng L. Energy metabolism at the cellular level of the CNS. Can. J. Physiol. Pharm. 70:1992;145-157.
35. Henneberry R.C., Novelli A., Cox J.A., Lysko P.G. Neurotoxicity at the N-methyl-D-aspartate receptor in energy-compromised neurons: a hypothesis for cell death in aging and disease. Ann. N.Y. Acad. Sci. 568:1989;225-233.
36. Benveniste H., Drejer J., Schousboe A., Diemer N.H. Elevation of the extracellular concentrations of glutamate and aspartate in hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43:1984;1369-1374.
37. Attwell D., Barbour S., Szatkowski M. Nonvesicular release of neurotransmitter. Neuron. 11:1993;401-407.
38. Ludolph A.C., Riepe M., Ullrich K. Excitotoxicity, energy metabolism and neurodegeneration. J. Inherit. Metab. Dis. 16:1993;716-723.
39. Schinder A.F., Olson E.C., Spitzer N.C., Montal M. Mytochondrial dysfunction is a primary event in glutamate neurotoxicity. J. Neurosci. 16:1996;6125-6133.
40. Novelli A., Reilly J.A., Lysko P.G., Haennebery R.C. Glutamate becomes neurotoxic via the NMDA receptor when intracellular energy levels are reduced. Brain Res. 451:1998;205-212.
41. Kowaltowski A.J., Vercesi A.E. Mitochondrial damage induced by conditions of oxidative stress. Free Radic. Biol. Med. 26:1999;463-471.
42. Almeida A., Delgado-Esteban M., Bolãnos J.P., Medina J.M. Oxygen and glucose deprivation induces mitochondrial dysfunction and oxidative stress in neurones but not in astrocytes in primary culture. J. Neurochem. 81:2002;207-217.