Protocol for Project FACT: A randomised controlled trial on the effect of a walking program and vitamin B supplementation on the rate of cognitive decline and psychosocial wellbeing in older adults with mild cognitive impairment [ISRCTN19227688]

BMC Geriatrics

Volumn 5, Issue , 2005, Pages

  Van Uffelen, Jannique G Z ^a,b   Hopman Rock, Marijke ^a,b   Chin A Paw, Marijke J M ^a   Van Mechelen, Willem ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; PLACEBO; PYRIDOXINE; VITAMIN B GROUP; VITAMIN B COMPLEX;

ARTICLE; CARDIOVASCULAR FUNCTION; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; ENDURANCE; EXERCISE; FREQUENCY ANALYSIS; HEALTH PROGRAM; HUMAN; MAJOR CLINICAL STUDY; MENTAL HEALTH; OUTCOMES RESEARCH; PHYSICAL ACTIVITY; POPULATION RESEARCH; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SOCIAL PSYCHOLOGY; STRETCHING; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; WALKING; WELLBEING; AGED; CLINICAL PROTOCOL; COGNITION DISORDERS; DOUBLE BLIND PROCEDURE; KINESIOTHERAPY; MULTIMODALITY CANCER THERAPY; PSYCHOLOGY; RANDOMIZED CONTROLLED TRIAL (TOPIC); SEVERITY OF ILLNESS INDEX; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CLINICAL PROTOCOLS; COGNITION DISORDERS; COMBINED MODALITY THERAPY; DOUBLE-BLIND METHOD; EXERCISE THERAPY; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SEVERITY OF ILLNESS INDEX; VITAMIN B COMPLEX; WALKING;

EID: 32344447413     PISSN: 14712318     EISSN: 14712318     Source Type: Journal    
DOI: 10.1186/1471-2318-5-18     Document Type: Article

References (68)

1. Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, Ritchie K, Rossor M, Thal L, Winblad B: Current concepts in mild cognitive impairment. Arch Neurol 2001, 58:1985-1992.
2. Ganguli M, Dodge HH, Shen CY, DeKosky ST: Mild cognitive impairment, amnestic type - An epidemiologic study. Neurology 2004, 63:115-121.
3. Jungwirth S, Weissgram S, Zehetmayer S, Tragl KH, Fischer P: VITA: subtypes of mild cognitive impairment in a communitybased cohort at the age of 75 years. International Journal of Geriatric Psychiatry 2005, 20:452-458.
4. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E: Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999, 56:303-308.
5. Ritchie K, Touchon J: Mild cognitive impairment: conceptual basis and current nosological status. Lancet 2000, 355:225-228.
6. Petersen RC, Stevens JC, Ganguli M, Tangalos EG, Cummings JL, DeKosky ST: Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2001, 56:1133-1142.
7. Chertkow H: Mild cognitive impairment. Curr Opin Neurol 2002, 15:401-407.
8. Yesavage JA, O'Hara R, Kraemer H, Noda A, Taylor JL, Ferris S, Gely-Nargeot MC, Rosen A, Friedman L, Sheikh J, Derouesne C: Modeling the prevalence and incidence of Alzheimer's disease and mild cognitive impairment. J Psychiatr Res 2002, 36:281-286.
9. Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K: Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol 2001, 58:498-504.
10. Schuit AJ, Feskens EJ, Launer LJ, Kromhout D: Physical activity and cognitive decline, the role of the apolipoprotein e4 allele. Med Sci Sports Exerc 2001, 33:772-777.
11. Yaffe K, Barnes D, Nevitt M, Lui LY, Covinsky K: A prospective study of physical activity and cognitive decline in elderly women: women who walk. Arch Intern Med 2001, 161:1703-1708.
12. Podewils LJ, Guallar E, Kuller LH, Fried LP, Lopez OL, Carlson M, Lyketsos CG: Physical activity, APOE genotype, and dementia risk: Findings from the Cardiovascular Health Cognition Study. American Journal of Epidemiology 2005, 161:639-651.
13. Weuve J, Kang JH, Manson JE, Breteler MMB, Ware JH, Grodstein F: Physical activity, including walking, and cognitive function in older women. JAMA 2004, 292:1454-1461.
14. Fabre C, Chamari K, Mucci P, Masse-Biron J, Prefaut C: Improvement of cognitive function by mental and/or individualized aerobic training in healthy elderly subjects. Int J Sports Med 2002, 23:415-421.
15. Kramer AF, Hahn S, Cohen NJ, Banich MT, McAuley E, Harrison CR, Chason J, Vakil E, Bardell L, Boileau RA, Colcombe A: Ageing, fitness and neurocognitive function. Nature 1999, 400:418-419.
16. Williams P, Lord SR: Effects of group exercise on cognitive functioning and mood in older women. Aust N Z J Public Health 1997, 21:45-52.
17. Hassmen P, Koivula N: Mood, physical working capacity and cognitive performance in the elderly as related to physical activity. Aging (Milano) 1997, 9:136-142.
18. Tomporowski PD, Ellis NR: Effects of exercise on cognitive processes: a review. Psychological bulletin 1986, 99:338-346.
19. van Sickle TD, Hersen M, Simco ER, Melton MA, van Hasselt VB: Effects of physical exercise on cognitive functioning in the elderly. Int J Rehab Health 1996, 2:67-100.
20. Etnier JL, Salazar W, Landers DM, Petruzello SJ, Myungwoo H, Nowell P: The influence of physical fitness and exercise upon cognitive functioning: a meta-analysis. Journal of Sports & Exercise Psychology 1997, 19:249-277.
21. Colcombe S, Kramer AF: Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci 2003, 14:125-130.
22. Heyn P, Abreu BC, Ottenbacher KJ: The effects of exercise training on elderly persons with cognitive impairment and dementia: A meta-analysis. Arch Phys Med Rehabil 2004, 85:1694-1704.
23. Biddle S, Faulkner G: Psychological and Social Benefits of Physical Activity. In Active Aging Edited by: Chan KM. Hong Kong, Lippinicott, Williams & Wilkins Asia Ltd.; 2002:89-164.
24. Churchill JD, Galvez R, Colcombe S, Swain RA, Kramer AF, Greenough WT: Exercise, experience and the aging brain. Neurobiol Aging 2002, 23:941-955.
25. Etnier JL, Landers DM: Brain function and exercise. Current perspectives. Sports Med 1995, 19:81-85.
26. Baik HW, Russell RM: Vitamin B12 deficiency in the elderly. Annu Rev Nutr 1999, 19:357-377.
27. Konings EJ, Roomans HH, Dorant E, Goldbohm RA, Saris WH, van den Brandt PA: Folate intake of the Dutch population according to newly established liquid chromatography data for foods. Am J Clin Nutr 2001, 73:765-776.
28. Naurath HJ, Joosten E, Riezler R, Stabler SP, Allen RH, Lindenbaum J: Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations. Lancet 1995, 346:85-89.
29. Riggs KM, Spiro AIII, Tucker K, Rush D: Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. Am J Clin Nutr 1996, 63:306-314.
30. Robins Wahlin TB, Wahlin A, Winblad B, Backman L: The influence of serum vitamin B12 and folate status on cognitive functioning in very old age. Biol Psychol 2001, 56:247-265.
31. Kado DM, Karlamangla AS, Huang MH, Troen A, Rowe JW, Selhub J, Seeman TE: Homocysteine versus the vitamins folate, B-6, and B-12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur studies of successful aging. American Journal of Medicine 2005, 118:161-167.
32. Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH: Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 1993, 270:2693-2698.
33. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA: Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002, 346:476-483.
34. Budge MM, de Jager C, Hogervorst E, Smith AD: Total plasma homocysteine, age, systolic blood pressure, and cognitive performance in older people. J Am Geriatr Soc 2002, 50:2014-2018.
35. Garcia A, Zanibbi K: Homocysteine and cognitive function in elderly people. Canadian Medical Association Journal 2004, 171:897-904.
36. Ravaglia G, Forti P, Maioli F, Scali RC, Sacchetti L, Talerico T, Mantovani V, Bianchin M: Homocysteine and cognitive performance in healthy elderly subjects. Arch Gerontol Geriatr 2004:349-357.
37. Morris MS, Jacques PF, Rosenberg IH, Selhub J: Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey. Am J Clin Nutr 2001, 73:927-933.
38. Schafer JH, Glass TA, Bolla KI, Mintz M, Jedlicka AE, Schwartz BS: Homocysteine and cognitive function in a population-based study of older adults. Journal of the American Geriatrics Society 2005, 53:381-388.
39. Prins ND, Den Heijer T, Hofman A, Koudstaal PJ, Jolles J, Clarke R, Breteler MM: Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study. Neurology 2002, 59:1375-1380.
40. Dufouil C, Alperovitch A, Ducros V, Tzourio C: Homocysteine, white matter hyperintensities, and cognition in healthy elderly people. Ann Neurol 2003, 53:214-221.
41. Kado DM, Selhub J, Seeman TE: Plasma total homocysteine levels and cognitive function in older high functioning adults; MacArthur studies of successful aging. American Geriatric Society, Paper abstracts 2001:S13.
42. Rydlewicz A, Simpson JA, Taylor RJ, Bond CM, Golden MH: The effect of folic acid supplementation on plasma homocysteine in an elderly population. QJM 2002, 95:27-35.
43. Woo KS, Chook P, Chan LL, Cheung AS, Fung WH, Qiao M, Lolin YI, Thomas GN, Sanderson JE, Metreweli C, Celermajer DS: Long-term improvement in homocysteine levels and arterial endothelial function after 1-year folic acid supplementation. Am J Med 2002, 112:535-539.
44. Lowering blood homocysteine with folic acid based supplements: meta- analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration. BMJ 1998, 316:894-898.
45. Bryan J, Calvaresi E, Hughes D: Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects memory performance but not mood in women of various ages. Journal of Nutrition 2002, 132:1345-1356.
46. Fioravanti M, Ferrario E, Massaia M, Cappa G, Rivolta G, Grossi E, Buckley AE: Low folate levels in the cognitive decline of elderly patients and the efficacy of folate as a treatment for improving memory deficits. Arch Gerontol Geriatr 2002, 26:1-13.
47. van Asselt DZ, Pasman JW, van Lier HJ, Vingerhoets DM, Poels PJ, Kuin Y, Blom HJ, Hoefnagels WH: Cobalamin supplementation improves cognitive and cerebral function in older, cobalamin-deficient persons. J Gerontol A Biol Sci Med Sci 2001, 56:M775-M779.
48. Nilsson K, Gustafson L, Hultberg B: Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine. Int J Geriatr Psychiatry 2001, 16:609-614.
49. Calvaresi E, Bryan J: B vitamins, cognition, and aging: a review. J Gerontol B Psychol Sci Soc Sci 2001, 56:P327-P339.
50. Strawbridge WJ, Shema SJ, Balfour JL, Higby HR, Kaplan GA: Antecedents of frailty over three decades in an older cohort. J Gerontol B Psychol Sci Soc Sci 1998, 53:S9-16.
51. Kempen GI, Miedema I, Ormel J, Molenaar W: The assessment of disability with the Groningen Activity Restriction Scale. Conceptual framework and psychometric properties. Soc Sci Med 1996, 43:1601-1610.
52. Brandt J, Spencer M, Folstein M: The Telephone Interview for Cognitive Status. Neuropsychiatry, Neuropsychology and Behavioral Neurology 1988, 1:111-117.
53. Morris JC, Heyman A, Mohs RC, Hughes JP, van Belle G, Fillenbaum G, Mellits ED, Clark C: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 1989, 39:1159-1165.
54. Welsh KA, Butters N, Mohs RC, Beekly D, Edland S, Fillenbaum G, Heyman A: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part V. A normative study of the neuropsychological battery. Neurology 1994, 44:609-614.
55. Stel VS, Smit JH, Pluijm SMF, Visser M, Deeg DJH, Lips P: Comparison of the LASA Physical Activity Questionnaire with a 7-day diary and pedometer. Journal of Clinical Epidemiology 2004, 57:252-258.
56. Stahl T, Laukkanen R: A way of healthy walking - A guidebook for health promotion practice. 2000 [http://www.reumaliitto.fi/walking-guide/guide/guide. doc].
57. Folstein MF, Folstein SE, McHugh PR: "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975, 12:189-198.
58. Rey A: L'examen clinique en psychologie Paris, Presses Universitaires de France; 1964.
59. Lezak MD: Neuropsychological assessment 3rd edition. New York, Oxford University Press, Inc.; 1995.
60. Uiterwijk JM: WAIS-III-NL/V Lisse, Swets & Zeitlinger; 2001.
61. Klein M: Cognitive Aging, Attention, and Mild Traumatic Brain Injury. Universiteit Maastricht; 1997:95-105.
62. de Jonghe JF, Schmand B, Ooms ME, Ribbe MW: [Abbreviated form of the Informant Questionnaire on cognitive decline in the elderly]. Tijdschr Gerontol Geriatr 1997, 28:224-229.
63. Jorm AF: A short form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): development and cross-validation. Psychol Med 1994, 24:145-153.
64. Ware JE, Kosinski M, Keller SD: SF-12: How to score the SF-12 physical and mental health summary scales Second edition edition. Boston, MA, The health institute, New England Medical Center; 1995.
65. Brod M, Stewart AL, Sands L, Walton P: Conceptualization and measurement of quality of life in dementia: the dementia quality of life instrument (DQoL). Gerontologist 1999, 39:25-35.
66. EuroQol - a new facility for the measurement of health-related quality of life. The EuroQol Group. Health Policy 1990, 16:199-208.
67. Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, Leirer VO: Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 1982, 17:37-49.
68. Lemmink K: De Groninger fitheidstest voor ouderen: ontwikkeling van een meetinstrument. Rijksuniversiteit Groningen; 1996.