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Volumn 24, Issue 3, 2004, Pages 317-325

Alcohol and iron

Author keywords

Alcohol and iron; Apoptosis; Fibrogenesis; Hemochromatosis; Iron overload; Lipid peroxidation; Necrosis; Oxidative stress

Indexed keywords

ALCOHOL; IRON;

EID: 4444287777     PISSN: 02728087     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-832943     Document Type: Review
Times cited : (56)

References (90)
  • 1
    • 0029933296 scopus 로고    scopus 로고
    • Metal-induced hepatoxicity
    • Britton RS. Metal-induced hepatoxicity. Semin Liver Dis 1996;16:3-12
    • (1996) Semin Liver Dis , vol.16 , pp. 3-12
    • Britton, R.S.1
  • 2
    • 0029913626 scopus 로고    scopus 로고
    • Long-term survival in patients with hereditary hemochromatosis
    • Niederau C, Fischer R, Purschel A, et al. Long-term survival in patients with hereditary hemochromatosis. Gastroenterology 1996;110:1107-1119
    • (1996) Gastroenterology , vol.110 , pp. 1107-1119
    • Niederau, C.1    Fischer, R.2    Purschel, A.3
  • 3
    • 0025157647 scopus 로고
    • The pathology of hepatic iron overload: A free radical-mediated process?
    • Bacon BR, Britton RS. The pathology of hepatic iron overload: A free radical-mediated process? Hepatology 1990; 11:127-137
    • (1990) Hepatology , vol.11 , pp. 127-137
    • Bacon, B.R.1    Britton, R.S.2
  • 4
    • 0029922315 scopus 로고    scopus 로고
    • Metals, oxidative stress, and hepatic fibrogenesis
    • Pietrangelo A. Metals, oxidative stress, and hepatic fibrogenesis. Semin Liver Dis 1996;16:13-30
    • (1996) Semin Liver Dis , vol.16 , pp. 13-30
    • Pietrangelo, A.1
  • 6
    • 0020698041 scopus 로고
    • Hepatic lipid peroxidation in vivo in rats with chronic iron overload
    • Bacon BR, Tavill AS, Brittenham GM, et al. Hepatic lipid peroxidation in vivo in rats with chronic iron overload. J Clin Invest 1983;71:429-439
    • (1983) J Clin Invest , vol.71 , pp. 429-439
    • Bacon, B.R.1    Tavill, A.S.2    Brittenham, G.M.3
  • 7
    • 0028118654 scopus 로고
    • Enhanced hepatic collagen type I mRNA expression into fat-storing cells in a rodent model of hemochromatosis
    • Pietrangelo A, Gualdi R, Casalgrandi G, et al. Enhanced hepatic collagen type I mRNA expression into fat-storing cells in a rodent model of hemochromatosis. Hepatology 1994; 19:714-721
    • (1994) Hepatology , vol.19 , pp. 714-721
    • Pietrangelo, A.1    Gualdi, R.2    Casalgrandi, G.3
  • 8
    • 0028956616 scopus 로고
    • Molecular and cellular aspects of iron-induced hepatic cirrhosis in rodents
    • Pietrangelo A, Gualdi R, Casalgrandi G, et al. Molecular and cellular aspects of iron-induced hepatic cirrhosis in rodents. J Clin Invest 1995;95:1824-1831
    • (1995) J Clin Invest , vol.95 , pp. 1824-1831
    • Pietrangelo, A.1    Gualdi, R.2    Casalgrandi, G.3
  • 9
    • 0018114375 scopus 로고
    • Organelle pathology in primary and secondary haemochromatosis with special reference to lysosomal changes
    • Seymour CA, Peters TJ. Organelle pathology in primary and secondary haemochromatosis with special reference to lysosomal changes. Br J Haematol 1978;40:239-253
    • (1978) Br J Haematol , vol.40 , pp. 239-253
    • Seymour, C.A.1    Peters, T.J.2
  • 10
    • 0018860041 scopus 로고
    • Studies on the concentration and intracellular localization of iron proteins in liver biopsy specimens from patients with iron overload with special reference to their role in lysosomal disruption
    • Selden C, Owen M, Hopkins JMP, et al. Studies on the concentration and intracellular localization of iron proteins in liver biopsy specimens from patients with iron overload with special reference to their role in lysosomal disruption. Br J Haematol 1980;44:593-603
    • (1980) Br J Haematol , vol.44 , pp. 593-603
    • Selden, C.1    Owen, M.2    Hopkins, J.M.P.3
  • 11
    • 0021856398 scopus 로고
    • The role of iron in ferritin and haemosiderin-mediated lipid peroxidation in lysosomes
    • O'Connell MJ, Ward RJ, Baum H, Peters TJ. The role of iron in ferritin and haemosiderin-mediated lipid peroxidation in lysosomes. Biochem J 1985;229:135-139
    • (1985) Biochem J , vol.229 , pp. 135-139
    • O'Connell, M.J.1    Ward, R.J.2    Baum, H.3    Peters, T.J.4
  • 12
    • 0021233287 scopus 로고
    • Isolation of two lysosomal populations from iron-overload rat liver with different iron concentration and proteolytic activity
    • Hultcrantz R, Ahlberg J, Glaumann H. Isolation of two lysosomal populations from iron-overload rat liver with different iron concentration and proteolytic activity. Virchows Arch [B] 1984;47:55-65
    • (1984) Virchows Arch [B] , vol.47 , pp. 55-65
    • Hultcrantz, R.1    Ahlberg, J.2    Glaumann, H.3
  • 13
    • 0025925346 scopus 로고
    • Alterations in structure, physicochemical properties, and pH of hepatocyte lysosomes in experimental iron overload
    • Myers BM, Prendergast FG, Holman R, et al. Alterations in structure, physicochemical properties, and pH of hepatocyte lysosomes in experimental iron overload. J Clin Invest 1991; 88:1207-1215
    • (1991) J Clin Invest , vol.88 , pp. 1207-1215
    • Myers, B.M.1    Prendergast, F.G.2    Holman, R.3
  • 14
    • 0018114375 scopus 로고
    • Organelle pathology in primary and secondary haemochromatosis with special reference to lysosomal changes
    • Seymour CA, Peters TJ. Organelle pathology in primary and secondary haemochromatosis with special reference to lysosomal changes. Br J Haematol 1978;40:239-253
    • (1978) Br J Haematol , vol.40 , pp. 239-253
    • Seymour, C.A.1    Peters, T.J.2
  • 17
    • 1642347584 scopus 로고    scopus 로고
    • Iron-induced mitochondrial permeability transition in cultured hepatocytes
    • Rauen U, Petrat F, Sustmann R, de Groon H. Iron-induced mitochondrial permeability transition in cultured hepatocytes. J Hepatol 2004;40:607-615
    • (2004) J Hepatol , vol.40 , pp. 607-615
    • Rauen, U.1    Petrat, F.2    Sustmann, R.3    De Groon, H.4
  • 18
    • 1642412428 scopus 로고    scopus 로고
    • Rusty notions of cell injury
    • LeMasters JL. Rusty notions of cell injury. J Hepatol 2004; 40:696-698
    • (2004) J Hepatol , vol.40 , pp. 696-698
    • LeMasters, J.L.1
  • 19
    • 0022628856 scopus 로고
    • Hemochromatosis: How much iron is too much?
    • Tavill AS, Bacon BR. Hemochromatosis: how much iron is too much? Hepatology 1986;6:142-145
    • (1986) Hepatology , vol.6 , pp. 142-145
    • Tavill, A.S.1    Bacon, B.R.2
  • 20
    • 0025341054 scopus 로고
    • Identification of homozygous hemochromatosis subjects by measurement of hepatic iron index
    • Summers KM, Halliday JW, Powell LW. Identification of homozygous hemochromatosis subjects by measurement of hepatic iron index. Hepatology 1990;12:20-25
    • (1990) Hepatology , vol.12 , pp. 20-25
    • Summers, K.M.1    Halliday, J.W.2    Powell, L.W.3
  • 21
    • 0022656390 scopus 로고
    • Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis
    • Bassett ML, Halliday JW, Powell LW. Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology 1986;6:24-29
    • (1986) Hepatology , vol.6 , pp. 24-29
    • Bassett, M.L.1    Halliday, J.W.2    Powell, L.W.3
  • 22
    • 0026058496 scopus 로고
    • Confirmation of the efficacy of the hepatic iron index in differentiating genetic haemochromatosis from alcoholic liver disease complicated by alcoholic haemosiderosis
    • Sallie R, Reed WD, Shilkin KB. Confirmation of the efficacy of the hepatic iron index in differentiating genetic haemochromatosis from alcoholic liver disease complicated by alcoholic haemosiderosis. Gut 1991;32:207-210
    • (1991) Gut , vol.32 , pp. 207-210
    • Sallie, R.1    Reed, W.D.2    Shilkin, K.B.3
  • 23
    • 0036727322 scopus 로고    scopus 로고
    • Noninvasive prediction of cirrhosis in C282Y-linked hemochromatosis
    • Beaton M, Guyader D, Deugnier Y, et al. Noninvasive prediction of cirrhosis in C282Y-linked hemochromatosis. Hepatology 2002;36:673-678
    • (2002) Hepatology , vol.36 , pp. 673-678
    • Beaton, M.1    Guyader, D.2    Deugnier, Y.3
  • 24
    • 1642494711 scopus 로고    scopus 로고
    • Serum ferritin levels predict advanced hepatic fibrosis among U. S. patients with phenotypic hemochromatosis
    • Morrison ED, Brandhagen DJ, Phatak PD, et al. Serum ferritin levels predict advanced hepatic fibrosis among U. S. patients with phenotypic hemochromatosis. Ann Intern Med 2003;138:627-633
    • (2003) Ann Intern Med , vol.138 , pp. 627-633
    • Morrison, E.D.1    Brandhagen, D.J.2    Phatak, P.D.3
  • 25
    • 0025296596 scopus 로고
    • Liver gene expression during chronic dietary iron overload in rats
    • Pietrangelo A, Rocchi E, Schiaffonoti L, et al. Liver gene expression during chronic dietary iron overload in rats. Hepatology 1990;11:798-804
    • (1990) Hepatology , vol.11 , pp. 798-804
    • Pietrangelo, A.1    Rocchi, E.2    Schiaffonoti, L.3
  • 26
    • 0028792178 scopus 로고
    • Antioxidant activity of silybin in vivo during long-term iron overload in rats
    • Pietrangelo A, Borella F, Casalgrandi G, et al. Antioxidant activity of silybin in vivo during long-term iron overload in rats. Gastroenterology 1995;109:1941-1949
    • (1995) Gastroenterology , vol.109 , pp. 1941-1949
    • Pietrangelo, A.1    Borella, F.2    Casalgrandi, G.3
  • 27
    • 0030866199 scopus 로고    scopus 로고
    • Excess iron induces hepatic oxidative stress and transforming growth factor B1 in genetic hemochromatosis
    • Houglum K, Grant AR, Crawford DHG, et al. Excess iron induces hepatic oxidative stress and transforming growth factor B1 in genetic hemochromatosis. Hepatology 1997;26:605-610
    • (1997) Hepatology , vol.26 , pp. 605-610
    • Houglum, K.1    Grant, A.R.2    Crawford, D.H.G.3
  • 28
    • 0033209610 scopus 로고    scopus 로고
    • 4-Hydroxy-2, 3-alkenals as molecular mediators of oxidative stress in the pathogenesis of liver fibrosis
    • Parola M, Robino G, Dianzani MU. 4-hydroxy-2, 3-alkenals as molecular mediators of oxidative stress in the pathogenesis of liver fibrosis. Int J Mol Med 1999;4:425-432
    • (1999) Int J Mol Med , vol.4 , pp. 425-432
    • Parola, M.1    Robino, G.2    Dianzani, M.U.3
  • 29
    • 0001376313 scopus 로고    scopus 로고
    • HFE gene knockout produces mouse model of hereditary hemochromatosis
    • Zhou XY, Tomatsu S, Fleming RE, et al. HFE gene knockout produces mouse model of hereditary hemochromatosis. Proc Natl Acad Sci USA 1998;95:2492-2497
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 2492-2497
    • Zhou, X.Y.1    Tomatsu, S.2    Fleming, R.E.3
  • 30
    • 0028133060 scopus 로고
    • Serum ferritin and transferrin saturation in patients with chronic alcoholic and non-alcoholic liver disease
    • Bell H, Skinningsrud A, Raknerud N, Try K. Serum ferritin and transferrin saturation in patients with chronic alcoholic and non-alcoholic liver disease. J Intern Med 1994;236:315-322
    • (1994) J Intern Med , vol.236 , pp. 315-322
    • Bell, H.1    Skinningsrud, A.2    Raknerud, N.3    Try, K.4
  • 31
    • 75949159823 scopus 로고
    • Parenchymal siderosis in patients with preexisting portal cirrhosis. A pathologic entity simulating idiopathic and transfusional hemochromatosis
    • Sabesin SM, Thomas LB. Parenchymal siderosis in patients with preexisting portal cirrhosis. A pathologic entity simulating idiopathic and transfusional hemochromatosis. Gastroenterology 1964;46:477-485
    • (1964) Gastroenterology , vol.46 , pp. 477-485
    • Sabesin, S.M.1    Thomas, L.B.2
  • 32
    • 0013911977 scopus 로고
    • Normal human iron storage and its relation to ethanol consumption
    • Powell LW. Normal human iron storage and its relation to ethanol consumption. Australas Ann Med 1966;15:110-115
    • (1966) Australas Ann Med , vol.15 , pp. 110-115
    • Powell, L.W.1
  • 35
    • 0013979846 scopus 로고
    • Primary hemochromatosis: Inherited or acquired?
    • MacDonald RA. Primary hemochromatosis: inherited or acquired? Prog Hematol 1966;5:324-353
    • (1966) Prog Hematol , vol.5 , pp. 324-353
    • MacDonald, R.A.1
  • 36
    • 0017698209 scopus 로고
    • Idiopathic hemochromatosis. Demonstration of recessive transmission and early detection by family HLA typing
    • Simon M, Bourel M, Genetet B, Fauchet R. Idiopathic hemochromatosis. Demonstration of recessive transmission and early detection by family HLA typing. N Engl J Med 1977;297:1017-1021
    • (1977) N Engl J Med , vol.297 , pp. 1017-1021
    • Simon, M.1    Bourel, M.2    Genetet, B.3    Fauchet, R.4
  • 37
    • 0017709689 scopus 로고
    • Idiopathic hemochromatosis and iron overload in alcoholic liver disease: Differentiation by HLA phenotype
    • Simon M, Bourel M, Genetet B, et al. Idiopathic hemochromatosis and iron overload in alcoholic liver disease: differentiation by HLA phenotype. Gastroenterology 1977;73:655-658
    • (1977) Gastroenterology , vol.73 , pp. 655-658
    • Simon, M.1    Bourel, M.2    Genetet, B.3
  • 38
    • 0017688144 scopus 로고
    • Heredity of idiopathic haemochromatosis: A study of 106 families
    • Simon M, Alexandre JL, Bourel M, et al. Heredity of idiopathic haemochromatosis: a study of 106 families. Clin Genet 1977;11:327-341
    • (1977) Clin Genet , vol.11 , pp. 327-341
    • Simon, M.1    Alexandre, J.L.2    Bourel, M.3
  • 39
    • 0017698209 scopus 로고
    • Idiopathic haemochromatosis: Demonstration of recessive transmission and early detection by family HLA typing
    • Simon M, Bourel M, Genetet B, Fauchet R. Idiopathic haemochromatosis: demonstration of recessive transmission and early detection by family HLA typing. N Engl J Med 1977;297:1017-1022
    • (1977) N Engl J Med , vol.297 , pp. 1017-1022
    • Simon, M.1    Bourel, M.2    Genetet, B.3    Fauchet, R.4
  • 40
    • 0001257976 scopus 로고
    • Idiopathic hemochromatosis, an iron storage disease. A. Iron metabolism in hemochromatosis
    • Finch SC, Finch CA. Idiopathic hemochromatosis, an iron storage disease. A. Iron metabolism in hemochromatosis. Medicine 1955;34:381-430
    • (1955) Medicine , vol.34 , pp. 381-430
    • Finch, S.C.1    Finch, C.A.2
  • 42
    • 0013809027 scopus 로고
    • Iron storage in relatives of patients with haemochromatosis and in relatives of patients with alcoholic cirrhosis and haemochromatosis. A comparative study of 27 families
    • Powell LW, Iron storage in relatives of patients with haemochromatosis and in relatives of patients with alcoholic cirrhosis and haemochromatosis. A comparative study of 27 families. QJ Med 1965;34:427-442
    • (1965) QJ Med , vol.34 , pp. 427-442
    • Powell, L.W.1
  • 43
    • 0037132786 scopus 로고    scopus 로고
    • Penetrance of 845G → A (C282Y) HFE hereditary haemochromatosis mutation in the USA
    • Beutler E, Felitti V, Koziol JA, et al. Penetrance of 845G → A (C282Y) HFE hereditary haemochromatosis mutation in the USA. Lancet 2002;359:211-218
    • (2002) Lancet , vol.359 , pp. 211-218
    • Beutler, E.1    Felitti, V.2    Koziol, J.A.3
  • 45
    • 0024847570 scopus 로고
    • Oxygen radical generation by microsomes: Role of iron and implications for alcohol metabolism and toxicity
    • Cederbaum AI. Oxygen radical generation by microsomes: role of iron and implications for alcohol metabolism and toxicity. Free Radic Biol Med 1989;7:559-567
    • (1989) Free Radic Biol Med , vol.7 , pp. 559-567
    • Cederbaum, A.I.1
  • 46
    • 0024546914 scopus 로고
    • Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P450 (P-459 IIE1)
    • Ekstrom G, Ingelman-Sundberg M. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P450 (P-459 IIE1). Biochem Pharmacol 1989;38:1313-1319
    • (1989) Biochem Pharmacol , vol.38 , pp. 1313-1319
    • Ekstrom, G.1    Ingelman-Sundberg, M.2
  • 47
    • 0027745582 scopus 로고
    • Role of cytochrome P450 2E1 in alcoholic liver disease pathogenesis
    • Morimoto M, Hagbjork AL, Nanji AA, et al. Role of cytochrome P450 2E1 in alcoholic liver disease pathogenesis. Alcohol 1993;10:459-464
    • (1993) Alcohol , vol.10 , pp. 459-464
    • Morimoto, M.1    Hagbjork, A.L.2    Nanji, A.A.3
  • 48
    • 0022649753 scopus 로고
    • Hydroxyl-radical production of ethanol oxidation by liver microsomes isolated from ethanol treated rats
    • Ekstrom G, Cronholm T, Ingelman-Sundberg M. Hydroxyl-radical production of ethanol oxidation by liver microsomes isolated from ethanol treated rats. Biochem J 1986;233:755-761
    • (1986) Biochem J , vol.233 , pp. 755-761
    • Ekstrom, G.1    Cronholm, T.2    Ingelman-Sundberg, M.3
  • 49
    • 0033134774 scopus 로고    scopus 로고
    • Hepatic lipid peroxidation in hereditary hemochromatosis and alcoholic liver injury
    • Niemela O, Parkkila S, Britton RS, et al. Hepatic lipid peroxidation in hereditary hemochromatosis and alcoholic liver injury. J Lab Clin Med 1999;133:451-460
    • (1999) J Lab Clin Med , vol.133 , pp. 451-460
    • Niemela, O.1    Parkkila, S.2    Britton, R.S.3
  • 50
    • 0021474453 scopus 로고
    • Role of the liver in normal iron metabolism
    • Bacon B, Tavill A. Role of the liver in normal iron metabolism. Semin Liver Dis 1984;4:181-192
    • (1984) Semin Liver Dis , vol.4 , pp. 181-192
    • Bacon, B.1    Tavill, A.2
  • 51
    • 0026526023 scopus 로고
    • Ferritin as a source of iron for oxidative damage
    • Reif DW. Ferritin as a source of iron for oxidative damage. Free Radic Biol Med 1992;12:417-427
    • (1992) Free Radic Biol Med , vol.12 , pp. 417-427
    • Reif, D.W.1
  • 52
    • 0024791954 scopus 로고
    • Lipid peroxidation, iron mobilization and radical generation induced by alcohol
    • Shaw S. Lipid peroxidation, iron mobilization and radical generation induced by alcohol. Free Radic Biol Med 1989;7:541-547
    • (1989) Free Radic Biol Med , vol.7 , pp. 541-547
    • Shaw, S.1
  • 53
    • 0026391123 scopus 로고
    • The mechanism of organ injury in alcoholics: Implications for therapy
    • French SW. The mechanism of organ injury in alcoholics: implications for therapy. Alcohol Alcohol Suppl 1991;1:57-63
    • (1991) Alcohol Alcohol Suppl , vol.1 , pp. 57-63
    • French, S.W.1
  • 54
    • 0024272232 scopus 로고
    • Effect of chronic ethanol administration on iron metabolism in the rat
    • Sanchez J, Casas M, Rama R. Effect of chronic ethanol administration on iron metabolism in the rat. Eur J Haematol 1988;41:321-325
    • (1988) Eur J Haematol , vol.41 , pp. 321-325
    • Sanchez, J.1    Casas, M.2    Rama, R.3
  • 55
    • 0023685817 scopus 로고
    • The effect of alcoholic beverages on iron and zinc metabolism in the rat
    • Fairweather-Tait SJ, Southon S, Piper Z. The effect of alcoholic beverages on iron and zinc metabolism in the rat. Br J Nutr 1988;60:209-215
    • (1988) Br J Nutr , vol.60 , pp. 209-215
    • Fairweather-Tait, S.J.1    Southon, S.2    Piper, Z.3
  • 56
    • 0028321696 scopus 로고
    • The oral iron-chelator, 1,2-dimethyl-3-hydroxypyrid-4-one reduces hepatic-free iron, lipid peroxidation and fat accumulation in chronically ethanol-fed rats
    • Sadrzadeh SMH, Nanji AA, Price PL. The oral iron-chelator, 1,2-dimethyl-3-hydroxypyrid-4-one reduces hepatic-free iron, lipid peroxidation and fat accumulation in chronically ethanol-fed rats. J Pharmacol Exp Ther 1994;269:632-636
    • (1994) J Pharmacol Exp Ther , vol.269 , pp. 632-636
    • Sadrzadeh, S.M.H.1    Nanji, A.A.2    Price, P.L.3
  • 57
    • 0026065734 scopus 로고
    • Iron mediates production of a neutrophil chemoattractant by rat hepatocytes metabolizing ethanol
    • Hultcrantz R, Bissell DM, Roll FJ. Iron mediates production of a neutrophil chemoattractant by rat hepatocytes metabolizing ethanol. J Clin Invest 1991;87:45-49
    • (1991) J Clin Invest , vol.87 , pp. 45-49
    • Hultcrantz, R.1    Bissell, D.M.2    Roll, F.J.3
  • 58
    • 0022510347 scopus 로고
    • Ethanol-induced liver fibrosis in rats fed high fat diet
    • Tsukamoto H, Towner SJ, Ciafalo LM, et al. Ethanol-induced liver fibrosis in rats fed high fat diet. Hepatology 1986;6:814-822
    • (1986) Hepatology , vol.6 , pp. 814-822
    • Tsukamoto, H.1    Towner, S.J.2    Ciafalo, L.M.3
  • 60
    • 0029160569 scopus 로고
    • Experimental liver cirrhosis induced by alcohol and iron
    • Tsukamoto H, Horne W, Kamimura S, et al. Experimental liver cirrhosis induced by alcohol and iron. J Clin Invest 1995; 96:620-630
    • (1995) J Clin Invest , vol.96 , pp. 620-630
    • Tsukamoto, H.1    Horne, W.2    Kamimura, S.3
  • 61
    • 0031941121 scopus 로고    scopus 로고
    • Genotypic/phenotypic correlations in genetic hemochromatosis: Evolution of diagnostic criteria
    • Adams PC, Chakrabarti S. Genotypic/phenotypic correlations in genetic hemochromatosis: evolution of diagnostic criteria. Gastroenterology 1998;114:319-323
    • (1998) Gastroenterology , vol.114 , pp. 319-323
    • Adams, P.C.1    Chakrabarti, S.2
  • 62
    • 0025233964 scopus 로고
    • Expression of hemochromatosis in homozygous subjects, Implication for early diagnosis and prevention
    • Powell LW, Summers KM, Board PG, et al. Expression of hemochromatosis in homozygous subjects, Implication for early diagnosis and prevention. Gastroenterology 1990;98:1625-1632
    • (1990) Gastroenterology , vol.98 , pp. 1625-1632
    • Powell, L.W.1    Summers, K.M.2    Board, P.G.3
  • 63
  • 64
    • 0032147154 scopus 로고    scopus 로고
    • End-stage liver disease without hemochromatosis associated with elevated hepatic iron index
    • Cotler S, Bronner M, Press D, et al. End-stage liver disease without hemochromatosis associated with elevated hepatic iron index. J Hepatol 1998;29:257-262
    • (1998) J Hepatol , vol.29 , pp. 257-262
    • Cotler, S.1    Bronner, M.2    Press, D.3
  • 65
    • 9344224529 scopus 로고    scopus 로고
    • A novel MHC class I-like gene mutation in patients with hereditary haemochromatosis
    • Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I-like gene mutation in patients with hereditary haemochromatosis. Nat Genet 1996;13:399-408
    • (1996) Nat Genet , vol.13 , pp. 399-408
    • Feder, J.N.1    Gnirke, A.2    Thomas, W.3
  • 66
    • 0032955556 scopus 로고    scopus 로고
    • Molecular medicine and hemochromatosis: At the crossroads
    • Bacon BR, Powell LW, Adams PC, et al. Molecular medicine and hemochromatosis: at the crossroads. Gastroenterology 1999;116:193-207
    • (1999) Gastroenterology , vol.116 , pp. 193-207
    • Bacon, B.R.1    Powell, L.W.2    Adams, P.C.3
  • 67
    • 0033564146 scopus 로고    scopus 로고
    • HFE genotype in patients with hemochromatosis and other liver diseases
    • Bacon BR, Olynyk JK, Brunt EM, et al. HFE genotype in patients with hemochromatosis and other liver diseases. Ann Intern Med 1999;130:953-962
    • (1999) Ann Intern Med , vol.130 , pp. 953-962
    • Bacon, B.R.1    Olynyk, J.K.2    Brunt, E.M.3
  • 68
    • 0029927660 scopus 로고    scopus 로고
    • Alcoholism in hereditary hemochromatosis revisited: Prevalence and clinical consequences among homozygous siblings
    • Adams PC, Agnew S. Alcoholism in hereditary hemochromatosis revisited: prevalence and clinical consequences among homozygous siblings. Hepatology 1996;23:724-727
    • (1996) Hepatology , vol.23 , pp. 724-727
    • Adams, P.C.1    Agnew, S.2
  • 69
    • 0036163634 scopus 로고    scopus 로고
    • Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis
    • Fletcher L, Dixon J, Purdie D, et al. Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis. Gastroenterology 2002;122:281-289
    • (2002) Gastroenterology , vol.122 , pp. 281-289
    • Fletcher, L.1    Dixon, J.2    Purdie, D.3
  • 70
    • 2142809627 scopus 로고    scopus 로고
    • The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia
    • Ioannou GN. The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia. Gastroenterology 2004;126:1293-1301
    • (2004) Gastroenterology , vol.126 , pp. 1293-1301
    • Ioannou, G.N.1
  • 71
    • 0021254560 scopus 로고
    • Transferrin glycans: A possible link between alcoholism and alcoholic siderosis
    • Regoeczi E, Chindemi PA, Debanne MT. Transferrin glycans: a possible link between alcoholism and alcoholic siderosis. Alcohol Clin Exp Res 1984;8:287-292
    • (1984) Alcohol Clin Exp Res , vol.8 , pp. 287-292
    • Regoeczi, E.1    Chindemi, P.A.2    Debanne, M.T.3
  • 73
    • 0028238096 scopus 로고
    • 59Fe-labeled transferrin by rat liver and cerebellum
    • 59Fe-labeled transferrin by rat liver and cerebellum. Biochem Pharmacol 1994;47:1835-1841
    • (1994) Biochem Pharmacol , vol.47 , pp. 1835-1841
    • Rouach, H.1    Houze, P.2    Gentil, M.3
  • 76
    • 0028261750 scopus 로고
    • Relationships among serum iron status markers, chemical and histochemical liver iron content in 117 patients with alcohol and non-alcohol hepatic disease
    • Milman N, Graudal N, Hegnhoj J, et al. Relationships among serum iron status markers, chemical and histochemical liver iron content in 117 patients with alcohol and non-alcohol hepatic disease. Hepatogastroenterology 1994;41:20-24
    • (1994) Hepatogastroenterology , vol.41 , pp. 20-24
    • Milman, N.1    Graudal, N.2    Hegnhoj, J.3
  • 77
    • 0013543539 scopus 로고
    • Phlebotomy in the treatment of iron overload: A controlled trial (a preliminary report)
    • Abst
    • Grace ND, Greenberg MS. Phlebotomy in the treatment of iron overload: a controlled trial (a preliminary report.) Gastroenterology 1971;60:744 (Abst)
    • (1971) Gastroenterology , vol.60 , pp. 744
    • Grace, N.D.1    Greenberg, M.S.2
  • 78
    • 0018773267 scopus 로고
    • Changing patterns of dietary iron overload in black South Africans
    • MacPhail AP, Simon MO, Torrance JD, et al. Changing patterns of dietary iron overload in black South Africans. AmJ Clin Nutr 1979;32:1272-1278
    • (1979) AmJ Clin Nutr , vol.32 , pp. 1272-1278
    • MacPhail, A.P.1    Simon, M.O.2    Torrance, J.D.3
  • 79
    • 0001766803 scopus 로고
    • Siderosis in the Bantu. The relationship between iron overload and cirrhosis
    • Issacson C, Seftel H, Keeley KJ, Bothwell TH. Siderosis in the Bantu. The relationship between iron overload and cirrhosis. J Lab Clin Med 1961;58:845-853
    • (1961) J Lab Clin Med , vol.58 , pp. 845-853
    • Issacson, C.1    Seftel, H.2    Keeley, K.J.3    Bothwell, T.H.4
  • 80
    • 0026342071 scopus 로고
    • Iron overload in Africa: Interaction between a gene and dietary iron content
    • Gordeuk VR, Mukabi J, Hasstedt J, et al. Iron overload in Africa: interaction between a gene and dietary iron content. N Engl J Med 1992;326:95-100
    • (1992) N Engl J Med , vol.326 , pp. 95-100
    • Gordeuk, V.R.1    Mukabi, J.2    Hasstedt, J.3
  • 82
    • 0031915149 scopus 로고    scopus 로고
    • Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis
    • George DK, Goldwurm S, MacDonald GA, et al. Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. Gastroenterology 1998;114:311-318
    • (1998) Gastroenterology , vol.114 , pp. 311-318
    • George, D.K.1    Goldwurm, S.2    MacDonald, G.A.3
  • 83
    • 0033198317 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis and iron: Increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis
    • Bonkovsky HL, Jawaid Q, Tortorelli K, et al. Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis. J Hepatol 1999;31:421-429
    • (1999) J Hepatol , vol.31 , pp. 421-429
    • Bonkovsky, H.L.1    Jawaid, Q.2    Tortorelli, K.3
  • 84
    • 46149140088 scopus 로고
    • Serum ferritin in the assessment of liver iron overload and iron removal therapy in porphyria cutanea tarda
    • Rocchi E, Gilbertini P, Cassanelli M, et al. Serum ferritin in the assessment of liver iron overload and iron removal therapy in porphyria cutanea tarda. J Lab Clin Med 1986;107:36-42
    • (1986) J Lab Clin Med , vol.107 , pp. 36-42
    • Rocchi, E.1    Gilbertini, P.2    Cassanelli, M.3
  • 85
    • 0025960985 scopus 로고
    • Liver iron overload and desferrioxamine treatment of porphyria cutanea tarda
    • Rocchi E, Gilbertini P, Cassanelli M, et al. Liver iron overload and desferrioxamine treatment of porphyria cutanea tarda. Dermatologica 1991;182:27-31
    • (1991) Dermatologica , vol.182 , pp. 27-31
    • Rocchi, E.1    Gilbertini, P.2    Cassanelli, M.3
  • 86
    • 0024462592 scopus 로고
    • HLA-linked hemochromatosis alleles in sporadic porphyria cutanea tarda
    • Edwards CQ, Griffen LM, Goldgar DE, et al. HLA-linked hemochromatosis alleles in sporadic porphyria cutanea tarda. Gastroenterology 1989;97:972-981
    • (1989) Gastroenterology , vol.97 , pp. 972-981
    • Edwards, C.Q.1    Griffen, L.M.2    Goldgar, D.E.3
  • 87
    • 0031016791 scopus 로고    scopus 로고
    • Increased frequency of the haemochromatosis Cys282Tyr mutation in sporadic porphyria cutanea tarda
    • Roberts AG, Whatley SD, Morgan RR, et al. Increased frequency of the haemochromatosis Cys282Tyr mutation in sporadic porphyria cutanea tarda. Lancet 1997;349:321-323
    • (1997) Lancet , vol.349 , pp. 321-323
    • Roberts, A.G.1    Whatley, S.D.2    Morgan, R.R.3
  • 88
    • 0036142230 scopus 로고    scopus 로고
    • Iron as a comorbid factor in chronic viral hepatitis
    • Bonkovsky HL. Iron as a comorbid factor in chronic viral hepatitis. Am J Gastroenterol 2002;97:1-3
    • (2002) Am J Gastroenterol , vol.97 , pp. 1-3
    • Bonkovsky, H.L.1
  • 89
    • 0037310944 scopus 로고    scopus 로고
    • Hepatitis C, iron status, and disease severity: Relationship with HFE mutations
    • Tung BY, Emond MJ, Bronner MP, et al. Hepatitis C, iron status, and disease severity: relationship with HFE mutations. Gastroenterology 2003;124:318-326
    • (2003) Gastroenterology , vol.124 , pp. 318-326
    • Tung, B.Y.1    Emond, M.J.2    Bronner, M.P.3
  • 90
    • 0037621914 scopus 로고    scopus 로고
    • Hemochromatosis gene modifies course of hepatitis C viral infection
    • Pietrangelo A. Hemochromatosis gene modifies course of hepatitis C viral infection. Gastroenterology 2003;124:1509-1523
    • (2003) Gastroenterology , vol.124 , pp. 1509-1523
    • Pietrangelo, A.1


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