-
1
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G, Whyte DB, Martínez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science. 2002;298:1912-34.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martínez, R.3
Hunter, T.4
Sudarsanam, S.5
-
2
-
-
0037392444
-
Issues and progress with protein kinase inhibitors for cancer treatment
-
Dancey J, Sausville EA. Issues and progress with protein kinase inhibitors for cancer treatment. Nat Rev Drug Discov. 2003;2:296-313.
-
(2003)
Nat Rev Drug Discov.
, vol.2
, pp. 296-313
-
-
Dancey, J.1
Sausville, E.A.2
-
3
-
-
0036527429
-
Protein kinases - The major drug targets of the twenty-first century?
-
Cohen P: Protein kinases - the major drug targets of the twenty-first century? Nat Rev Drug Discov 2002;1:509-15.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 509-515
-
-
Cohen, P.1
-
4
-
-
1642323740
-
Protein kinase inhibitors: Insights into drug design from structure
-
Noble ME, Endicott JA, Johnson LN. Protein kinase inhibitors: Insights into drug design from structure. Science. 2004; 303:1800-5.
-
(2004)
Science
, vol.303
, pp. 1800-1805
-
-
Noble, M.E.1
Endicott, J.A.2
Johnson, L.N.3
-
5
-
-
0037954572
-
Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions
-
Biondi RM, Nebrada AR. Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions. Biochem J. 2003;372:1-13.
-
(2003)
Biochem J
, vol.372
, pp. 1-13
-
-
Biondi, R.M.1
Nebrada, A.R.2
-
6
-
-
13844312725
-
Dual specificity protein phosphatases: Therapeutic targets for cancer and Alzheimer's disease
-
Ducruet AP, Vogt A, Wipf P, Lazo JS. Dual specificity protein phosphatases: Therapeutic targets for cancer and Alzheimer's disease. Annu Rev Pharmacol Toxicol. 2005; 45:725-50.
-
(2005)
Annu Rev Pharmacol Toxicol.
, vol.45
, pp. 725-750
-
-
Ducruet, A.P.1
Vogt, A.2
Wipf, P.3
Lazo, J.S.4
-
7
-
-
22044442973
-
Tyrosine kinases as targets for cancer therapy
-
Krause DS, Van Etten RA. Tyrosine kinases as targets for cancer therapy. N Engl J Med. 2005;355:172-87.
-
(2005)
N Engl J Med.
, vol.355
, pp. 172-187
-
-
Krause, D.S.1
Van Etten, R.A.2
-
9
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 2000;105:211-25.
-
(2000)
Cell
, vol.105
, pp. 211-225
-
-
Schlessinger, J.1
-
11
-
-
4143066760
-
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
-
Sordella R, Bell DW, Haber DA, Settleman J. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science. 2004;505:1163-7.
-
(2004)
Science
, vol.505
, pp. 1163-1167
-
-
Sordella, R.1
Bell, D.W.2
Haber, D.A.3
Settleman, J.4
-
12
-
-
4544358147
-
Suppressor of cytokine signalling-1 gene silencing in acute myeloid leukaemia and human haematopoietic cell lines
-
Watanabe D, Ezoe S, Fujimoto M, et al. Suppressor of cytokine signalling-1 gene silencing in acute myeloid leukaemia and human haematopoietic cell lines. Br J Haematol. 2004;126:726-35.
-
(2004)
Br J Haematol.
, vol.126
, pp. 726-735
-
-
Watanabe, D.1
Ezoe, S.2
Fujimoto, M.3
-
13
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;544:785-92.
-
(2001)
N Engl J Med.
, vol.544
, pp. 785-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
14
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Druker BJ, Sawyers CL, Kantarjian H, et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med. 2001; 344;1038-42.
-
(2001)
N Engl J Med.
, vol.344
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
-
15
-
-
27644566271
-
Dual tyrosine kinase inhibitors in chronic myeloid leukemia
-
Martinelli G, Soverini S, Rosti G, Baccarani M. Dual tyrosine kinase inhibitors in chronic myeloid leukemia. Leukemia 2005;19:1872-9.
-
(2005)
Leukemia
, vol.19
, pp. 1872-1879
-
-
Martinelli, G.1
Soverini, S.2
Rosti, G.3
Baccarani, M.4
-
16
-
-
3142676436
-
Overriding imatinib resistance with a novel ABL kinase inhibitor
-
Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science. 2004;505:399-401.
-
(2004)
Science
, vol.505
, pp. 399-401
-
-
Shah, N.P.1
Tran, C.2
Lee, F.Y.3
Chen, P.4
Norris, D.5
Sawyers, C.L.6
-
17
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002;547:472-80.
-
(2002)
N Engl J Med
, vol.547
, pp. 472-480
-
-
Demetri, G.D.1
von Mehren, M.2
Blanke, C.D.3
-
19
-
-
30344478587
-
Is Cyclin D1-CDK4 kinase a bona fide cancer target?
-
Malumbres M, Barbacid M. Is Cyclin D1-CDK4 kinase a bona fide cancer target?. Cancer Cell. 2006;9:2-4.
-
(2006)
Cancer Cell
, vol.9
, pp. 2-4
-
-
Malumbres, M.1
Barbacid, M.2
-
20
-
-
21644456228
-
Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors
-
Collins I, Garrett MD. Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors. Curr Opin Pharmacol. 2005;5:566-73.
-
(2005)
Curr Opin Pharmacol.
, vol.5
, pp. 566-573
-
-
Collins, I.1
Garrett, M.D.2
-
21
-
-
0038418869
-
Chk1 and Chk2 kinases in checkpoint control and cancer
-
Bartek J, Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell. 2003;3:421-9.
-
(2003)
Cancer Cell
, vol.3
, pp. 421-429
-
-
Bartek, J.1
Lukas, J.2
-
22
-
-
22244478043
-
Decoding the links between mitosis, cancer, and chemotherapy: The mototic checkpoint, adaptation, and cell death
-
Weaver BA, Cleveland DW. Decoding the links between mitosis, cancer, and chemotherapy: The mototic checkpoint, adaptation, and cell death. Cancer Cell. 2005;8: 7-12.
-
(2005)
Cancer Cell
, vol.8
, pp. 7-12
-
-
Weaver, B.A.1
Cleveland, D.W.2
-
24
-
-
18044391525
-
Aurora kinases, aneuploidy and cancer, a coincidence or a real link?
-
Giet R, Petretti C., Prigent C. Aurora kinases, aneuploidy and cancer, a coincidence or a real link? Trends Cell Biol. 2005;15: 241-50.
-
(2005)
Trends Cell Biol.
, vol.15
, pp. 241-250
-
-
Giet, R.1
Petretti, C.2
Prigent, C.3
-
25
-
-
17644368237
-
ONO 1910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent
-
Gumiredy K, Reddy MV, Consenza SC, et al. ONO 1910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell. 2005;7:275-86.
-
(2005)
Cancer Cell
, vol.7
, pp. 275-286
-
-
Gumiredy, K.1
Reddy, M.V.2
Consenza, S.C.3
-
26
-
-
23744503085
-
Aurora kinases: Shining lights on the therapeutic horizon?
-
Andrews PD. Aurora kinases: Shining lights on the therapeutic horizon? Oncogene. 2005;24:5005-15.
-
(2005)
Oncogene.
, vol.24
, pp. 5005-5015
-
-
Andrews, P.D.1
-
27
-
-
10344236486
-
Aurora-kinase inhibitors as anticancer agents
-
Keen N, Taylor S. Aurora-kinase inhibitors as anticancer agents. Nat Rev Cancer. 2004;4:927-36.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 927-936
-
-
Keen, N.1
Taylor, S.2
-
28
-
-
27844445642
-
Perturbations of the AKT signaling pathway in human cancer
-
Altomare DA, Testa JR. Perturbations of the AKT signaling pathway in human cancer. Oncogene. 2005;24:7455-64.
-
(2005)
Oncogene.
, vol.24
, pp. 7455-7464
-
-
Altomare, D.A.1
Testa, J.R.2
-
29
-
-
27844598284
-
The Akt/PKB pathway: Molecular target for cancer drug discovery
-
Cheng JQ, Lindsley CW, Cheng GZ, Yang H, Nicosia SV. The Akt/PKB pathway: Molecular target for cancer drug discovery. Oncogene. 2005;24:7482-92.
-
(2005)
Oncogene.
, vol.24
, pp. 7482-7492
-
-
Cheng, J.Q.1
Lindsley, C.W.2
Cheng, G.Z.3
Yang, H.4
Nicosia, S.V.5
-
30
-
-
27844553839
-
AKT crystal structure and AKT-specific inhibitors
-
Kumar CC, Madison V: AKT crystal structure and AKT-specific inhibitors. Oncogene. 2005;24:7493-501.
-
(2005)
Oncogene.
, vol.24
, pp. 7493-7501
-
-
Kumar, C.C.1
Madison, V.2
-
31
-
-
27744507024
-
mTOR, a new therapeutic target in acute myeloid leukemia
-
Recher C, Dos Santos C, Demur C, Payrastre B. mTOR, a new therapeutic target in acute myeloid leukemia. Cell Cycle. 2005;4:1540-9.
-
(2005)
Cell Cycle
, vol.4
, pp. 1540-1549
-
-
Recher, C.1
Dos Santos, C.2
Demur, C.3
Payrastre, B.4
-
32
-
-
12844271543
-
Mammalian target of rapamycin
-
discussion 33
-
Meric-Bernstam F, Mills GB. Mammalian target of rapamycin. Semin Oncol. 2004; 51:10-7; discussion 33.
-
(2004)
Semin Oncol.
, vol.51
, pp. 10-17
-
-
Meric-Bernstam, F.1
Mills, G.B.2
-
33
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
Downward J. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer. 2003;3:11-22.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
34
-
-
0037400510
-
Mechanisms of regulating the Raf kinase family
-
Chong H, Vikis HG, Guan KL. Mechanisms of regulating the Raf kinase family. Cell Signal. 2003;15:463-9.
-
(2003)
Cell Signal.
, vol.15
, pp. 463-469
-
-
Chong, H.1
Vikis, H.G.2
Guan, K.L.3
-
35
-
-
27244457769
-
Raf: A strategic target for therapeutic development against cancer
-
Beeram M, Patnaik A, Rowinsky EK. Raf: A strategic target for therapeutic development against cancer. J Clin Oncol. 2005; 23:6771-90.
-
(2005)
J Clin Oncol.
, vol.23
, pp. 6771-6790
-
-
Beeram, M.1
Patnaik, A.2
Rowinsky, E.K.3
-
36
-
-
10344258041
-
Targeting the mitogen-activated protein kinase cascade to treat cancer
-
Sebolt-Leopold JS, Herrera R. Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer. 2004; 4:937-47.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 937-947
-
-
Sebolt-Leopold, J.S.1
Herrera, R.2
-
37
-
-
33746211497
-
BRAF mutation predicts sensitivity to MEK inhibition
-
Solit DB, Garraway LA, Pratilas CA, et al. BRAF mutation predicts sensitivity to MEK inhibition. Nature. 2006;459:558-62.
-
(2006)
Nature
, vol.459
, pp. 558-562
-
-
Solit, D.B.1
Garraway, L.A.2
Pratilas, C.A.3
-
38
-
-
7644223136
-
p38 MAP kinase's emerging role as a tumor suppressor
-
Bulavin DV, Fornace AJ, Jr. p38 MAP kinase's emerging role as a tumor suppressor. Adv Cancer Res. 2004;92:95-118.
-
(2004)
Adv Cancer Res.
, vol.92
, pp. 95-118
-
-
Bulavin, D.V.1
Fornace Jr., A.J.2
-
39
-
-
1442274808
-
p38 MAP kinase: A convergence point in cancer therapy
-
Olson JM, Hallahan AR. p38 MAP kinase: A convergence point in cancer therapy. Trends Mol Med. 2004;10:125-9.
-
(2004)
Trends Mol Med.
, vol.10
, pp. 125-129
-
-
Olson, J.M.1
Hallahan, A.R.2
-
40
-
-
0038004740
-
Targeting JNK for therapeutic benefit: From junk to gold?
-
Manning AM, Davis RJ. Targeting JNK for therapeutic benefit: From junk to gold? Nat Rev Drug Discov. 2003;2:554-65.
-
(2003)
Nat Rev Drug Discov.
, vol.2
, pp. 554-565
-
-
Manning, A.M.1
Davis, R.J.2
-
41
-
-
0037180757
-
Inflammation and cancer
-
Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420:860-7.
-
(2002)
Nature
, vol.420
, pp. 860-867
-
-
Coussens, L.M.1
Werb, Z.2
-
42
-
-
2942581416
-
Protein tyrosine phosphatases in the human genome
-
Alonso A, Sasin J, Bottini N, et al. Protein tyrosine phosphatases in the human genome. Cell. 2004;117:699-711.
-
(2004)
Cell
, vol.117
, pp. 699-711
-
-
Alonso, A.1
Sasin, J.2
Bottini, N.3
-
44
-
-
15044348175
-
Protein serine/threonine phosphatases: Life, death, and sleeping
-
Gallego M, Virshup DM. Protein serine/threonine phosphatases: Life, death, and sleeping. Curr Opin Cell Biol. 2005;17: 197-202.
-
(2005)
Curr Opin Cell Biol.
, vol.17
, pp. 197-202
-
-
Gallego, M.1
Virshup, D.M.2
-
45
-
-
4344602002
-
The biology and clinical relevance of the PTEN tumor supressor pathway
-
Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor supressor pathway. J Clin Oncol. 2004;22: 2954-65.
-
(2004)
J Clin Oncol.
, vol.22
, pp. 2954-2965
-
-
Sansal, I.1
Sellers, W.R.2
|