Ceramide in apoptosis signaling: Relationship with oxidative stress

Free Radical Biology and Medicine

Volumn 31, Issue 6, 2001, Pages 717-728

  Andrieu Abadie, Nathalie ^a   Gouazé, Valérie ^a   Salvayre, Robert ^a   Levade, Thierry ^a  

^a CHU RANGUEIL   (France)

Author keywords

Apoptosis; Ceramide; Free radicals; Mitochondria; Reactive oxygen species

Indexed keywords

ANTIOXIDANT; CERAMIDE; CYTOCHROME C; GLYCOSPHINGOLIPID; LACTOSYLCERAMIDE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SPHINGOSINE;

ANIMAL CELL; APOPTOSIS; CELL ACTIVITY; CELL LINE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID METABOLISM; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; RESPIRATORY CHAIN; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CERAMIDES; HUMANS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SPHINGOLIPIDS;

EID: 0035884726     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00655-4     Document Type: Review

References (116)

1. An update of the enzymology and regulation of sphingomyelin metabolism
2. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets
3. Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation
4. The role of sphingolipids in the process of signal transduction
5. Regulation of ceramide production and apoptosis
6. Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 α,25-dihydroxyvitamin D3-induced HL-60 cell differentiation
7. Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene
8. Signalling sphingomyelinases: Which, where, how, and why?
9. Ceramide in the eukaryotic stress response
10. Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis
11. prICE: A downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2
12. Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-α: CrmA and Bcl-2 target distinct components in the apoptotic pathway
13. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis
14. TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase
15. CD40 signals apoptosis through FAN-regulated activation of the sphingomyelin-ceramide pathway
16. Distinct sites of action of Bcl-2 and Bcl-xL in the ceramide pathway of apoptosis
17. Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation
18. The central executioner of apoptosis: Multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis
19. Mitochondria, oxygen free radicals, disease, and aging
20. Hydroperoxide metabolism in mammalian organs
21. Enzymatic mechanisms of superoxide production
22. Reactive oxygen species in cell signaling
23. Oxidative stress as a mediator of apoptosis
24. Dual regulation of caspase activity by hydrogen peroxide: Implications for apoptosis
25. 2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells
26. Lipid hydroperoxides induce apoptosis in T cells displaying a HIV-associated glutathione peroxidase deficiency
27. Nitric oxide-mediated apoptosis in murine peritoneal macrophages
28. Reactive oxygen species and programmed cell death
29. Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2
30. Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-α-induced cell death
31. Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation, and apoptosis induced by daunorubicin
32. Autocrine production of extracellular catalase prevents apoptosis of the human CEM T-cell line in serum-free medium
33. Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic
34. Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway
35. Bcl-2 functions in an antioxidant pathway to prevent apoptosis
36. The baculovirus antiapoptotic p35 gene also functions via an oxidant-dependent pathway
37. Effect of bcl-2 on Fas antigen-mediated cell death
38. Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody
39. Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis
40. Cytokine-mediated induction of ceramide production is redox-sensitive. Implications to proinflammatory cytokine-mediated apoptosis in demyelinating diseases
41. Oxidative stress-induced activation of Lyn recruits sphingomyelinase and is requisite for its stimulation by Ara-C
42. Phthalocyanine 4-photodynamic therapy induces ceramide generation and apoptosis in acid sphingomyelinase-deficient mouse embryonic fibroblasts
43. Niemann-Pick human lymphoblasts are resistant to phthalocyanine 4-photodynamic therapy-induced apoptosis
44. Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)- retinamide in neuroblastoma cell lines
45. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis
46. UVA radiation stimulates ceramide production: Relationship to oxidative stress and potential role in ERK, JNK, and p38 activation
47. Involvement of the acid sphingomyelinase pathway in UVA-induced apoptosis
48. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
49. Nonenzymatic triggering of the ceramide signalling cascade by solar UVA radiation
50. Free radicals in biology: Oxidative stress and the effects of ionizing radiation
51. Glutathione peroxidase-1 overexpression prevents ceramide production and partially inhibits apoptosis in doxorubicin-treated human breast carcinoma cells
52. Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione
53. Role of plasma membrane coenzyme Q on the regulation of apoptosis
54. Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3
55. Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death
56. Ceramide path in human lung cell death
57. Coenzyme Q protects cells against serum withdrawal-induced apoptosis by inhibition of ceramide release and caspase-3 activation
58. Rapid activation of neutral sphingomyelinase by hypoxia-reoxygenation of cardiac myocytes
59. Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells
60. Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis
61. Mitochondrial free radical generation, oxidative stress, and aging
62. Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat
63. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
64. Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis
65. Mitochondria and cells produce reactive oxygen species in virtual anaerobiosis: Relevance to ceramide-induced apoptosis
66. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide
67. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation
68. Effects of adriamycin on respiratory chain activities in mitochondria from rat liver, rat heart, and bovine heart. Evidence for a preferential inhibition of complex III and IV
69. Effects of tamoxifen on the electron transport chain of isolated rat liver mitochondria
70. Ceramide induces cytochrome c release from isolated mitochondria. Importance of mitochondrial redox state
71. Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents
72. Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells
73. The biochemistry of apoptosis
74. Mitochondrial free radical signal in ceramide-dependent apoptosis: A putative mechanism for neuronal death in Parkinson's disease
75. Ceramide interaction with the respiratory chain of heart mitochondria
76. Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction
77. Occurrence of ceramides and neutral glycolipids with unusual long-chain base composition in purified rat liver mitochondria
78. Nitric oxide induces apoptosis in mouse thymocytes
79. Nitric oxide stimulates chronic ceramide formation in glomerular endothelial cells
80. Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide
81. Nitric oxide inhibits tumor necrosis factor-α-induced apoptosis by reducing the generation of ceramide
82. The p75(NTR)-induced apoptotic program develops through a ceramide-caspase pathway negatively regulated by nitric oxide
83. Nitric oxide inhibits the tumor necrosis factor-α-regulated endocytosis of human dendritic cells in a cyclic GMP-dependent way
84. Divergence in regulation of nitric oxide synthase and its cofactor tetrahydrobiopterin by tumor necrosis factor-α. Ceramide potentiates nitric oxide synthesis without affecting GTP cyclohydrolase I activity
85. Sphingomyelinase and ceramide stimulate the expression of inducible nitric oxide synthase in rat primary astrocytes
86. Ceramide-mediated stimulation of inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation in murine macrophages requires tyrosine kinase activity
87. Role of nuclear factor-κB activation in cytokine- and sphingomyelinase-stimulated inducible nitric oxide synthase gene expression in vascular smooth muscle cells
88. Reactive oxygen species enhances the induction of inducible nitric oxide synthase by sphingomyelinase in RAW264.7 cells
89. Glutathione and its role in cellular functions
90. Oxalate-induced ceramide accumulation in Madin-Darby canine kidney and LLC-PK1 cells
91. Redox-sensitive events in Fas-induced apoptosis in human NK cells include ceramide generation and protein tyrosine dephosphorylation
92. Human placenta sphingomyelinase, an exogenous acidic pH-optimum sphingomyelinase, induces oxidative stress, glutathione depletion, and apoptosis in rat hepatocytes
93. The role of ascorbate in antioxidant protection of biomembranes: Interaction with vitamin E and coenzyme Q
94. Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal
95. Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-κB and activated protein-1
96. TNF-α and IL-1α induce apoptosis in subconfluent rat mesangial cells. Evidence for the involvement of hydrogen peroxide and lipid peroxidation as second messengers
97. Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide
98. Activation of NF-κB protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration
99. Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation
100. Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells
101. Redox-regulated signaling by lactosylceramide in the proliferation of human aortic smooth muscle cells
102. Lactosylceramide stimulates human neutrophils to upregulate Mac-1, adhere to endothelium, and generate reactive oxygen metabolites in vitro
103. Bcl-2 and mitochondrial oxygen radicals. New approaches with reactive oxygen species-sensitive probes
104. Protective role of Bcl2 in metabolic oxidative stress-induced cell death
105. Oxidative stress induced by ascorbate causes neuronal damage in an in vitro system
106. Apoptosis and activation of the sphingomyelin-ceramide pathway induced by oxidized low-density lipoproteins are not causally related in ECV-304 endothelial cells
107. Oxidized low-density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms
108. Ceramide induces aSMase expression: Implications for oxLDL-induced apoptosis
109. Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion
110. Lethal forebrain ischemia stimulates sphingomyelin hydrolysis and ceramide generation in the gerbil hippocampus
111. Sphingomyelin changes in rat cerebral cortex during focal ischemia
112. Role of enhanced ceramide generation in DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells
113. Protective roles for ATM in cellular response to oxidative stress
114. Effect of ceramide on intracellular glutathione determines apoptotic or necrotic cell death of JB6 tumor cells
115. Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependent
116. Modulation of ceramide-induced NF-κB-binding activity and apoptotic response by caffeic acid in U937 cells: Comparison with other antioxidants