Design, synthesis and structure-activity relationship of a series of arginine aldehyde factor Xa inhibitors. Part 1: Structures based on the (D)- Arg-Gly-Arg tripeptide sequence

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 1, 2000, Pages 13-16

  Marlowe, Charles K ^a   Sinha, Uma ^a   Gunn, Alice C ^a   Scarborough, Robert M ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DERIVATIVE; ARGININE DERIVATIVE; BLOOD CLOTTING FACTOR 10A INHIBITOR;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HYDROGEN BOND; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANTICOAGULANTS; ARGININE; DRUG DESIGN; FACTOR XA; FORMIC ACID ESTERS; GLYCINE; OLIGOPEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THROMBOPLASTIN;

EID: 0034598319     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00582-X     Document Type: Article

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